tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang Y et al. | Phosphatidylinositol 4-phosphate 5-kinase Its3 and calcineurin Ppb1 coordinately regulate cytokinesis in fission yeast. | 2000 | J. Biol. Chem. | pmid:10950958 |
| Kyles AE et al. | Comparison of the in vitro antiproliferative effects of five immunosuppressive drugs on lymphocytes in whole blood from cats. | 2000 | Am. J. Vet. Res. | pmid:10951980 |
| Hashimoto M et al. | Short-course immunosuppression using FK506 for rat tracheal allografts. | 2000 | J Cardiovasc Surg (Torino) | pmid:10952347 |
| Morton SJ and Powell RJ | Cyclosporin and tacrolimus: their use in a routine clinical setting for scleroderma. | 2000 | Rheumatology (Oxford) | pmid:10952740 |
| Boxenbaum H | Cytochrome P450 3A4 in vivo ketoconazole competitive inhibition: determination of Ki and dangers associated with high clearance drugs in general. | 1999 May-Aug | J Pharm Pharm Sci | pmid:10952769 |
| Oliverio PJ et al. | Reversible tacrolimus-induced neurotoxicity isolated to the brain stem. | 2000 | AJNR Am J Neuroradiol | pmid:10954277 |
| Klauss V et al. | Cyclosporine versus tacrolimus (FK 506) for prevention of cardiac allograft vasculopathy. | 2000 | Am. J. Cardiol. | pmid:10955391 |
| Matsuhashi N et al. | Tacrolimus in corticosteroid-resistant ulcerative colitis. | 2000 | J. Gastroenterol. | pmid:10955604 |
| Hisamatsu T and Watanabe M | Tacrolimus (FK506), a novel immunosuppressive drug for inflammatory bowel disease? | 2000 | J. Gastroenterol. | pmid:10955609 |
| Stahl B et al. | [Tacrolimus treatment during pregnancy in organ-transplanted women]. | 1999 | Harefuah | pmid:10959392 |
| Uchiyama H et al. | Increased urinary nitrate excretion associated with hepatic allograft rejection in experimental rat models and clinical cases. | 2000 | Transpl. Int. | pmid:10959478 |
| Delaney MP et al. | Constitutive and acquired resistance to calcineurin inhibitors in renal transplantation: role of P-glycoprotein-170. | 2000 | Transpl. Int. | pmid:10959480 |
| Blomberg B and Järnerot G | Clinical evaluation and management of acute severe colitis. | 2000 | Inflamm. Bowel Dis. | pmid:10961594 |
| Mogi M et al. | Increase in level of tumor necrosis factor-alpha in 6-hydroxydopamine-lesioned striatum in rats is suppressed by immunosuppressant FK506. | 2000 | Neurosci. Lett. | pmid:10961655 |
| Taylor DO | Immunosuppressive therapies after heart transplantation: best, better, and beyond. | 2000 | Curr. Opin. Cardiol. | pmid:10963148 |
| Halloran PF | Sirolimus and cyclosporin for renal transplantation. | 2000 | Lancet | pmid:10963190 |
| Sakamoto Y et al. | Correlation between neurotoxic events and intracerebral concentration of tacrolimus in rats. | 2000 | Biol. Pharm. Bull. | pmid:10963314 |
| Teperman L | Case studies in orthotopic liver transplantation for hepatitis B: a panel discussion. | 2000 | Clin Transplant | pmid:10965964 |
| Mathieson PW | Cyclosporin: nephro-protective as well as nephrotoxic? | 2000 | Clin. Exp. Immunol. | pmid:10970156 |
| Hartmann A et al. | Intracerebral abscess caused by Nocardia otitidiscaviarum in a renal transplant patient--cured by evacuation plus antibiotic therapy. | 2000 | Nephron | pmid:10971157 |
| Burley JR and Sihra TS | A modulatory role for protein phosphatase 2B (calcineurin) in the regulation of Ca2+ entry. | 2000 | Eur. J. Neurosci. | pmid:10971631 |
| Jain A et al. | Comparative long-term evaluation of tacrolimus and cyclosporine in pediatric liver transplantation. | 2000 | Transplantation | pmid:10972220 |
| Khanna AK | Mechanism of the combination immunosuppressive effects of rapamycin with either cyclosporine or tacrolimus. | 2000 | Transplantation | pmid:10972232 |
| Königsrainer A et al. | Nonocclusive segmental mesenteric ischemia after combined pancreas kidney transplantation: mycophenolate mofetil as an etiological factor? | 2000 | Transplantation | pmid:10972233 |
| Sasakawa Y et al. | FK506 suppresses neutrophil chemoattractant production by peripheral blood mononuclear cells. | 2000 | Eur. J. Pharmacol. | pmid:10973631 |
| Voggenreiter G et al. | Immunosuppression with FK506 increases bone induction in demineralized isogeneic and xenogeneic bone matrix in the rat. | 2000 | J. Bone Miner. Res. | pmid:10977002 |
| Ponticelli C | Calcineurin-inhibitors in renal transplantation. Too precious to be abandoned. | 2000 | Nephrol. Dial. Transplant. | pmid:10978383 |
| Nash RA et al. | Phase 3 study comparing methotrexate and tacrolimus with methotrexate and cyclosporine for prophylaxis of acute graft-versus-host disease after marrow transplantation from unrelated donors. | 2000 | Blood | pmid:10979948 |
| Zhang W and Victor RG | Calcineurin inhibitors cause renal afferent activation in rats: a novel mechanism of cyclosporine-induced hypertension. | 2000 | Am. J. Hypertens. | pmid:10981550 |
| Allen C et al. | PCL-b-PEO micelles as a delivery vehicle for FK506: assessment of a functional recovery of crushed peripheral nerve. | 2000 Jul-Sep | Drug Deliv | pmid:10989914 |
| Lohmann T et al. | Diabetes mellitus and islet cell specific autoimmunity as adverse effects of immunsuppressive therapy by FK506/tacrolimus. | 2000 | Exp. Clin. Endocrinol. Diabetes | pmid:10989953 |
| Kane GC and Lipsky JJ | Drug-grapefruit juice interactions. | 2000 | Mayo Clin. Proc. | pmid:10994829 |
| Lote CJ et al. | The hypomagnesaemic action of FK506: urinary excretion of magnesium and calcium and the role of parathyroid hormone. | 2000 | Clin. Sci. | pmid:10995593 |
| Furtado A et al. | Local immunosuppression in clinical small bowel transplantation (report of two cases). | 2000 | Transplant. Proc. | pmid:10995910 |
| Alessiani M et al. | Pharmacokinetic study of intraarterial local intestinal infusion of tacrolimus. | 2000 | Transplant. Proc. | pmid:10995915 |
| Madariaga JR et al. | The long-term efficacy of multivisceral transplantation. | 2000 | Transplant. Proc. | pmid:10995918 |
| Fishbein T et al. | Isolated intestinal transplantation in adults with nonreconstructible GI tracts. | 2000 | Transplant. Proc. | pmid:10995925 |
| Alessiani M et al. | Correlations between functional changes and different grades of acute rejection in swine small bowel allografts. | 2000 | Transplant. Proc. | pmid:10995933 |
| Kato Y et al. | Epidermal growth factor enhances the intestinal adaptation of small bowel allografts in the postoperative period. | 2000 | Transplant. Proc. | pmid:10995935 |
| Kimura O et al. | Influence of bombesin on the intestinal mucosal immunologic response under immunosuppression. | 2000 | Transplant. Proc. | pmid:10995942 |
| Tatekawa Y et al. | Intragraft expression of p38 in rat small bowel transplantation. | 2000 | Transplant. Proc. | pmid:10995948 |
| Nakao A et al. | Cytokine mRNA expression on rat small bowel allograft treated with tacrolimus and simultaneous bone marrow transplantation via the portal vein. | 2000 | Transplant. Proc. | pmid:10995965 |
| Chakrabarti P et al. | Outcome after steroid withdrawal in pediatric renal transplant patients receiving tacrolimus-based immunosuppression. | 2000 | Transplantation | pmid:11003353 |
| Inoue T et al. | Lesser reduction in bone mineral density by the immunosuppressant, FK506, compared with cyclosporine in rats. | 2000 | Transplantation | pmid:11003356 |
| Marchetti P and Navalesi R | The metabolic effects of cyclosporin and tacrolimus. | 2000 Jul-Aug | J. Endocrinol. Invest. | pmid:11005276 |
| Tsaroucha AK et al. | Levels of mycophenolic acid and its glucuronide derivative in the plasma of liver, small bowel and kidney transplant patients receiving tacrolimus and cellcept combination therapy. | 2000 | Transpl. Immunol. | pmid:11005321 |
| Dambrin C et al. | Pharmacodynamics of immunosuppressive drugs. | 2000 | Curr. Opin. Immunol. | pmid:11007359 |
| Pham PT et al. | Cyclosporine and tacrolimus-associated thrombotic microangiopathy. | 2000 | Am. J. Kidney Dis. | pmid:11007689 |
| Revelo MP et al. | A 14-year-old boy with kidney allograft failure in the first month after transplantation. | 2000 | Am. J. Kidney Dis. | pmid:11007695 |
| Ideura T et al. | Tacrolimus/itraconazole interactions: a case report of ABO-incompatible living-related renal transplantation. | 2000 | Nephrol. Dial. Transplant. | pmid:11007866 |