tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ramachandran R et al. | Tacrolimus combined with corticosteroids versus Modified Ponticelli regimen in treatment of idiopathic membranous nephropathy: Randomized control trial. | 2016 | Nephrology (Carlton) | pmid:26205759 |
| Tomei P et al. | Everolimus-induced epithelial to mesenchymal transition (EMT) in bronchial/pulmonary cells: when the dosage does matter in transplantation. | 2016 | J. Nephrol. | pmid:27026415 |
| Klein OR et al. | Alternative-Donor Hematopoietic Stem Cell Transplantation with Post-Transplantation Cyclophosphamide for Nonmalignant Disorders. | 2016 | Biol. Blood Marrow Transplant. | pmid:26860634 |
| Jahnukainen T et al. | The second report of the Nordic Pediatric Renal Transplantation Registry 1997-2012: More infant recipients and improved graft survivals. | 2016 | Pediatr Transplant | pmid:26857893 |
| Kanda Y et al. | A randomized controlled trial of cyclosporine and tacrolimus with strict control of blood concentrations after unrelated bone marrow transplantation. | 2016 | Bone Marrow Transplant. | pmid:26437063 |
| Stocki P et al. | Inhibition of the FKBP family of peptidyl prolyl isomerases induces abortive translocation and degradation of the cellular prion protein. | 2016 | Mol. Biol. Cell | pmid:26764098 |
| Kawamura A et al. | Teratocarcinomas Arising from Allogeneic Induced Pluripotent Stem Cell-Derived Cardiac Tissue Constructs Provoked Host Immune Rejection in Mice. | 2016 | Sci Rep | pmid:26763872 |
| Kim JM et al. | Immunosuppression status of liver transplant recipients with hepatitis C affects biopsy-proven acute rejection. | 2016 | Clin Mol Hepatol | pmid:27729628 |
| Michael M et al. | Outcomes of two-drug maintenance immunosuppression for pediatric renal transplantation: 10-yr follow-up in a single center. | 2016 | Pediatr Transplant | pmid:26916966 |
| Kabat-Koperska J et al. | The influence of exposure to immunosuppressive treatment during pregnancy on renal function and rate of apoptosis in native kidneys of female Wistar rats. | 2016 | Apoptosis | pmid:27586504 |
| Jun H et al. | Clinical advantages including medication adherence with conversion to once-daily advagraf and sirolimus combination in stable kidney recipients. | 2016 | Int J Clin Pharmacol Ther | pmid:26709601 |
| Schmutz JL | [No increased risk of cancer under pimecrolimus]. | 2016 | Ann Dermatol Venereol | pmid:26708204 |
| Valbuena H et al. | Comparing the effect of isotopically labeled or structural analog internal standards on the performance of a LC-MS/MS method to determine ciclosporin A, everolimus, sirolimus and tacrolimus in whole blood. | 2016 | Clin. Chem. Lab. Med. | pmid:26351941 |
| Tamaki M et al. | Fungal meningitis caused by Lomentospora prolificans after allogeneic hematopoietic stem cell transplantation. | 2016 | Transpl Infect Dis | pmid:27258644 |
| Wang L et al. | Therapeutic advances for primary biliary cholangitis: the old and the new. | 2016 | Eur J Gastroenterol Hepatol | pmid:26862931 |
| Ben Fredj N et al. | Modeling of Tacrolimus Exposure in Kidney Transplant According to Posttransplant Time Based on Routine Trough Concentration Data. | 2016 | Exp Clin Transplant | pmid:27506258 |
| Miyata Y et al. | Pharmacokinetics of a Once-Daily Dose of Tacrolimus Early After Liver Transplantation: With Special Reference to CYP3A5 and ABCB1 Single Nucleotide Polymorphisms. | 2016 | Ann. Transplant. | pmid:27503662 |
| Orr C et al. | Quantifying Insulin Therapy Requirements to Preserve Islet Graft Function Following Islet Transplantation. | 2016 | Cell Transplant | pmid:25853639 |
| Yaowakulpatana K et al. | Impact of CYP3A5 polymorphism on trough concentrations and outcomes of tacrolimus minimization during the early period after kidney transplantation. | 2016 | Eur. J. Clin. Pharmacol. | pmid:26635230 |
| Gastaca M et al. | Favorable longterm outcomes of liver transplant recipients treated de novo with once-daily tacrolimus: Results of a single-center cohort. | 2016 | Liver Transpl. | pmid:27434676 |
| Genvigir FD et al. | Influence of the CYP3A4/5 genetic score and ABCB1 polymorphisms on tacrolimus exposure and renal function in Brazilian kidney transplant patients. | 2016 | Pharmacogenet. Genomics | pmid:27434656 |
| Qi XM et al. | FK506 reduces albuminuria through improving podocyte nephrin and podocin expression in diabetic rats. | 2016 | Inflamm. Res. | pmid:26566632 |
| Miura K et al. | Development of the Intestinal Transplantation Model With Major Histocompatibility Complex Inbred CLAWN Miniature Swine. | 2016 | Transplant. Proc. | pmid:27320612 |
| Lee HK et al. | Expression of Endoplasmic Reticulum-Mediated Stress Proteins in FK506-Treated T-Lymphocytes. | 2016 | Transplant. Proc. | pmid:27320607 |
| Yesilipek MA et al. | Haploidentical hematopoietic stem cell transplantation with post-transplant high-dose cyclophosphamide in high-risk children: A single-center study. | 2016 | Pediatr Transplant | pmid:26707539 |
| Weiner SM | [Combination of tacrolimus and MMF for treatment of proliferative lupus nephritis]. | 2016 | Z Rheumatol | pmid:27259912 |
| Sobiak J et al. | Pharmacokinetics of mycophenolate sodium co-administered with tacrolimus in the first year after renal transplantation. | 2016 | Eur J Drug Metab Pharmacokinet | pmid:25663618 |
| Medeiros M et al. | Are Tacrolimus Pharmacokinetics Affected by Nephrotic Stage? | 2016 | Ther Drug Monit | pmid:27167176 |
| Abud TB et al. | A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease. | 2016 | Ophthalmology | pmid:27086024 |
| Nijhoff MF et al. | Glycemic Stability Through Islet-After-Kidney Transplantation Using an Alemtuzumab-Based Induction Regimen and Long-Term Triple-Maintenance Immunosuppression. | 2016 | Am. J. Transplant. | pmid:26288226 |
| Otte JB | Pediatric liver transplantation: Personal perspectives on historical achievements and future challenges. | 2016 | Liver Transpl. | pmid:27096329 |
| Anuradha D and Parsad | FK506 regulates pigmentation by maturing the melanosome and facilitating their transfer to keratinocytes. | 2016 | Dermatol Ther | pmid:27093927 |
| Tannuri AC et al. | Prognostic factors for the evolution and reversibility of chronic rejection in pediatric liver transplantation. | 2016 | Clinics (Sao Paulo) | pmid:27166772 |
| Tariciotti L et al. | Everolimus and Advagraf Ab Initio in Combined Liver and Kidney Transplant With Donor-Specific Antibodies: A Case Report. | 2016 | Transplant. Proc. | pmid:27932158 |
| Alagoz S et al. | Gangliocytoma Presenting With Tacrolimus Neurotoxicity in a Renal Transplant Recipient: Case Report. | 2016 | Transplant. Proc. | pmid:27932167 |
| Kolonko A et al. | Successful Preemptive Kidney Transplantation With Rituximab Induction in a Patient With Focal Segmental Glomerulosclerosis and Massive Nephrotic Syndrome: A Case Report. | 2016 | Transplant. Proc. | pmid:27932154 |
| Thölking G et al. | Tacrolimus Concentration/Dose Ratio is Associated with Renal Function After Liver Transplantation. | 2016 | Ann. Transplant. | pmid:27003330 |
| Krämer BK et al. | Efficacy and safety of tacrolimus compared with ciclosporin-A in renal transplantation: 7-year observational results. | 2016 | Transpl. Int. | pmid:26565071 |
| Janicki JJ et al. | Potential Effect of Liposomes and Liposome-Encapsulated Botulinum Toxin and Tacrolimus in the Treatment of Bladder Dysfunction. | 2016 | Toxins (Basel) | pmid:26999210 |
| Nakagawa K et al. | Immunosuppression with tacrolimus improved reproductive outcome of women with repeated implantation failure and elevated peripheral blood TH1/TH2 cell ratios. | 2015 | Am. J. Reprod. Immunol. | pmid:25394810 |
| Farnik H et al. | Telaprevir drug monitoring during antiviral therapy of hepatitis C graft infection after liver transplantation. | 2015 | Liver Int. | pmid:24649882 |
| Cantaluppi V et al. | Neutrophil Gelatinase Associated Lipocalin Is an Early and Accurate Biomarker of Graft Function and Tissue Regeneration in Kidney Transplantation from Extended Criteria Donors. | 2015 | PLoS ONE | pmid:26125566 |
| Fukahori H et al. | Effect of novel PKCθ selective inhibitor AS2521780 on acute rejection in rat and non-human primate models of transplantation. | 2015 | Int. Immunopharmacol. | pmid:26122135 |
| Langone A et al. | Switching STudy of Kidney TRansplant PAtients with Tremor to LCP-TacrO (STRATO): an open-label, multicenter, prospective phase 3b study. | 2015 | Clin Transplant | pmid:26113208 |
| Eidens M et al. | Development and validation of a rapid and reliable real-time PCR method for CYP3A5 genotyping. | 2015 | Clin. Lab. | pmid:25975003 |
| Castaneda J and Matzuk MM | DEVELOPMENTAL BIOLOGY. Toward a rapid and reversible male pill. | 2015 | Science | pmid:26494747 |
| Safa K et al. | Eculizumab for drug-induced de novo posttransplantation thrombotic microangiopathy: A case report. | 2015 | Clin. Nephrol. | pmid:24495904 |
| Staatz CE and Tett SE | Clinical Pharmacokinetics of Once-Daily Tacrolimus in Solid-Organ Transplant Patients. | 2015 | Clin Pharmacokinet | pmid:26038096 |
| Migita K et al. | Pneumococcal polysaccharide vaccination in rheumatoid arthritis patients receiving tacrolimus. | 2015 | Arthritis Res. Ther. | pmid:26036592 |
| Miyata H et al. | Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive. | 2015 | Science | pmid:26429887 |
| Tanriover B et al. | Induction Therapies in Live Donor Kidney Transplantation on Tacrolimus and Mycophenolate With or Without Steroid Maintenance. | 2015 | Clin J Am Soc Nephrol | pmid:25979971 |
| Meyer C et al. | Impact of irradiation and immunosuppressive agents on immune system homeostasis in rhesus macaques. | 2015 | Clin. Exp. Immunol. | pmid:25902927 |
| Sassi MB et al. | Involvement of CYP 3A5 In the Interaction Between Tacrolimus and Nicardipine: A Case Report. | 2015 | Curr Drug Saf | pmid:25968921 |
| Wang CY et al. | Analysis of tacrolimus blood concentrations in renal transplant patients. | 2015 | Genet. Mol. Res. | pmid:25966149 |
| Bedi M and Taylor AL | Recalcitrant Hailey-Hailey disease responds to oral tacrolimus and botulinum toxin type A. | 2015 | Cutis | pmid:26761940 |
| Nagaya M et al. | A new system to evaluate the influence of immunosuppressive drugs on pancreatic islets using epigenetic analysis in a 3-dimensional culture. | 2015 | Pancreas | pmid:25906448 |
| Wang M et al. | Enteric polymer based on pH-responsive aliphatic polycarbonate functionalized with vitamin E to facilitate oral delivery of tacrolimus. | 2015 | Biomacromolecules | pmid:25714622 |
| Gallon L et al. | Differential Effects of Calcineurin and Mammalian Target of Rapamycin Inhibitors on Alloreactive Th1, Th17, and Regulatory T Cells. | 2015 | Transplantation | pmid:25905982 |
| Gajzlerska W et al. | Use of three-carbon chain compounds as biosynthesis precursors to enhance tacrolimus production in Streptomyces tsukubaensis. | 2015 | N Biotechnol | pmid:25152525 |
| Yu Z et al. | IL-15 is decreased upon CsA and FK506 treatment of acute rejection following heart transplantation in mice. | 2015 | Mol Med Rep | pmid:25333459 |
| Selk A | A Survey of Experts Regarding the Treatment of Adult Vulvar Lichen Sclerosus. | 2015 | J Low Genit Tract Dis | pmid:25853633 |
| Hurst AL et al. | Supra-therapeutic tacrolimus concentrations associated with concomitant nicardipine in pediatric liver transplant recipients. | 2015 | Pediatr Transplant | pmid:25850753 |
| Tajdaran K et al. | A novel polymeric drug delivery system for localized and sustained release of tacrolimus (FK506). | 2015 | Biotechnol. Bioeng. | pmid:25850693 |
| Jacobo-Cabral CO et al. | Population pharmacokinetic analysis of tacrolimus in Mexican paediatric renal transplant patients: role of CYP3A5 genotype and formulation. | 2015 | Br J Clin Pharmacol | pmid:25846845 |
| Bowman LJ et al. | Tacrolimus-Induced Cardiomyopathy in an Adult Renal Transplant Recipient. | 2015 | Pharmacotherapy | pmid:26616582 |
| Miguel-Gómez L et al. | [Peristomal pyoderma gangrenosum associated with colon cancer]. | 2015 | Med Clin (Barc) | pmid:25659860 |
| Romanowski M et al. | Adiponectin and leptin gene polymorphisms in patients with post-transplant diabetes mellitus. | 2015 | Pharmacogenomics | pmid:26282401 |
| Girdlestone J et al. | Enhancement of the immunoregulatory potency of mesenchymal stromal cells by treatment with immunosuppressive drugs. | 2015 | Cytotherapy | pmid:26276002 |
| Suzuki N et al. | In vivo regulation of erythropoiesis by chemically inducible dimerization of the erythropoietin receptor intracellular domain. | 2015 | PLoS ONE | pmid:25790231 |
| Ross A and Kirsner RS | JID VisualDx Quiz: April 2015. | 2015 | J. Invest. Dermatol. | pmid:25785952 |
| Heneberg P et al. | Pimecrolimus Is a Potent Inhibitor of Allergic Reactions to Hymenopteran Venom Extracts and Birch Pollen Allergen In Vitro. | 2015 | PLoS ONE | pmid:26562153 |
| Yang CJ et al. | Differential Large-Amplitude Breathing Motions in the Interface of FKBP12-Drug Complexes. | 2015 | Biochemistry | pmid:26561008 |
| Fan J et al. | Donor IL-18 rs5744247 polymorphism as a new biomarker of tacrolimus elimination in Chinese liver transplant patients during the early post-transplantation period: results from two cohort studies. | 2015 | Pharmacogenomics | pmid:25712187 |
| Duong SQ et al. | Transition from brand to generic tacrolimus is associated with a decrease in trough blood concentration in pediatric heart transplant recipients. | 2015 | Pediatr Transplant | pmid:26497983 |
| Jóźwiak-Bębenista M et al. | The cyclic AMP effects and neuroprotective activities of PACAP and VIP in cultured astrocytes and neurons exposed to oxygen-glucose deprivation. | 2015 | Pharmacol Rep | pmid:25712659 |
| Pucci N et al. | Tacrolimus vs. cyclosporine eyedrops in severe cyclosporine-resistant vernal keratoconjunctivitis: A randomized, comparative, double-blind, crossover study. | 2015 | Pediatr Allergy Immunol | pmid:25712437 |
| Kim KW et al. | The effect of mammalian target of rapamycin inhibition on T helper type 17 and regulatory T cell differentiation in vitro and in vivo in kidney transplant recipients. | 2015 | Immunology | pmid:24974886 |
| Yessayan L et al. | Race, Calcineurin Inhibitor Exposure, and Renal Function After Solid Organ Transplantation. | 2015 | Transplant. Proc. | pmid:26707323 |
| Yoon NY et al. | Topical glucocorticoid or pimecrolimus treatment suppresses thymic stromal lymphopoietin-related allergic inflammatory mechanism in an oxazolone-induced atopic dermatitis murine model. | 2015 | Arch. Dermatol. Res. | pmid:25786383 |
| Tanaka M et al. | Corticosteroid and tacrolimus treatment in neuromyelitis optica related disorders. | 2015 | Mult. Scler. | pmid:25662352 |
| Van der Perren A et al. | FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease. | 2015 | Neurobiol. Aging | pmid:25660193 |
| Wu SC et al. | Identification of Circulating miRNAs in a Mouse Model of Nerve Allograft Transplantation under FK506 Immunosuppression by Illumina Small RNA Deep Sequencing. | 2015 | Dis. Markers | pmid:26435568 |
| Okechuku G et al. | Anorexia nervosa in a pediatric renal transplant recipient and its reversal with cyclosporine. | 2015 | Pediatr Transplant | pmid:25661468 |
| Kume K et al. | Screening for a gene deletion mutant whose temperature sensitivity is suppressed by FK506 in budding yeast and its application for a positive screening for drugs inhibiting calcineurin. | 2015 | Biosci. Biotechnol. Biochem. | pmid:25614218 |
| Garnock-Jones KP | Tacrolimus prolonged release (Envarsus®): a review of its use in kidney and liver transplant recipients. | 2015 | Drugs | pmid:25613762 |
| Li CJ and Li L | Tacrolimus in preventing transplant rejection in Chinese patients--optimizing use. | 2015 | Drug Des Devel Ther | pmid:25609922 |
| Uemoto S et al. | Early coupled up-regulation of interleukin-12 receptor beta-1 in CD8+ central memory and effector T cells for better clinical outcomes in liver transplant recipients. | 2015 | Clin. Exp. Immunol. | pmid:25603847 |
| Overk CR et al. | Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506. | 2015 | Neuroscience | pmid:26341908 |
| de Jonge H et al. | Progressive decline in tacrolimus clearance after renal transplantation is partially explained by decreasing CYP3A4 activity and increasing haematocrit. | 2015 | Br J Clin Pharmacol | pmid:26114223 |
| Kallscheuer N et al. | Single-Domain Peptidyl-Prolyl cis/trans Isomerase FkpA from Corynebacterium glutamicum Improves the Biomass Yield at Increased Growth Temperatures. | 2015 | Appl. Environ. Microbiol. | pmid:26341203 |
| Schnitzbauer AA et al. | Delayed bottom-up and amended simple method of dosing with once-daily tacrolimus application to achieve stable trough levels in liver transplantation. | 2015 | Ann. Transplant. | pmid:25553853 |
| Aruch DB and Renteria A | Simultaneous PRES and TMA secondary to tacrolimus after allogeneic bone marrow transplant. | 2015 | Blood | pmid:26287041 |
| Pagliarello C et al. | Calcipotriol/betamethasone dipropionate ointment compared with tacrolimus ointment for the treatment of erosive pustular dermatosis of the scalp: a split-lesion comparison. | 2015 | Eur J Dermatol | pmid:25786341 |
| Gong N et al. | Immunoregulatory effects of sirolimus vs. tacrolimus treatment in kidney allograft recipients. | 2015 | Cell. Immunol. | pmid:26205091 |
| Chamani G et al. | Efficacy of tacrolimus and clobetasol in the treatment of oral lichen planus: a systematic review and meta-analysis. | 2015 | Int. J. Dermatol. | pmid:26204904 |
| Muduma G et al. | Evaluating the economic implications of non-adherence and antibody-mediated rejection in renal transplant recipients: the role of once-daily tacrolimus in the UK. | 2015 | J Med Econ | pmid:26201252 |
| Mizuno K et al. | Dexamethasone but not tacrolimus suppresses TNF-α-induced thymic stromal lymphopoietin expression in lesional keratinocytes of atopic dermatitis model. | 2015 | J. Dermatol. Sci. | pmid:26198442 |
| Rathi M et al. | Conversion from tacrolimus to cyclosporine in patients with new-onset diabetes after renal transplant: an open-label randomized prospective pilot study. | 2015 | Transplant. Proc. | pmid:26036543 |
| Mohsin N et al. | Pharmacokinetics of mycophenolate mofetil in Omani patients on cyclosporine or tacrolimus. | 2015 | Transplant. Proc. | pmid:26036534 |
| Rivinius R et al. | Analysis of malignancies in patients after heart transplantation with subsequent immunosuppressive therapy. | 2015 | Drug Des Devel Ther | pmid:25552900 |