tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shutter LA et al. | Cortical blindness and white matter lesions in a patient receiving FK506 after liver transplantation. | 1993 | Neurology | pmid:7694189 |
| Kawauchi M et al. | Prolonged survival of orthotopically transplanted heart xenograft in infant baboons. | 1993 | J. Thorac. Cardiovasc. Surg. | pmid:7693999 |
| Tzakis AG et al. | Intestinal transplantation in children under FK 506 immunosuppression. | 1993 | J. Pediatr. Surg. | pmid:7693907 |
| Thomson AW et al. | Comparative effects of rapamycin, FK 506 and cyclosporine on antibody production, lymphocyte populations and immunoglobulin isotype switching in the rat. | 1993 | Immunopharmacol Immunotoxicol | pmid:7693791 |
| Smith DF et al. | FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts. | 1993 | J. Biol. Chem. | pmid:7693698 |
| Schwaninger M et al. | Inhibition of cAMP-responsive element-mediated gene transcription by cyclosporin A and FK506 after membrane depolarization. | 1993 | J. Biol. Chem. | pmid:7693684 |
| Timerman AP et al. | The calcium release channel of sarcoplasmic reticulum is modulated by FK-506-binding protein. Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum. | 1993 | J. Biol. Chem. | pmid:7693682 |
| Keicho N et al. | Antilymphocytic activity of erythromycin distinct from that of FK506 or cyclosporin A. | 1993 | J. Antibiot. | pmid:7693639 |
| Shafiee A et al. | Enzymatic synthesis and immunosuppressive activity of novel desmethylated immunomycins (ascomycins). | 1993 | J. Antibiot. | pmid:7693638 |
| Schmitt J et al. | Cloning and expression of a mouse cDNA encoding p59, an immunophilin that associates with the glucocorticoid receptor. | 1993 | Gene | pmid:7693550 |
| Higa A et al. | Attenuation of epithelial injury in acute experimental colitis by immunomodulators. | 1993 | Eur. J. Pharmacol. | pmid:7693488 |
| Nakamura T et al. | Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions. | 1993 | EMBO J. | pmid:7693452 |
| Wallemacq PE and Reding R | FK506 (tacrolimus), a novel immunosuppressant in organ transplantation: clinical, biomedical, and analytical aspects. | 1993 | Clin. Chem. | pmid:7693372 |
| David M et al. | [Changes in cervix cytology in women with liver transplants treated with immunosuppressive therapy]. | 1993 | Zentralbl Gynakol | pmid:7692689 |
| Liu J | FK506 and ciclosporin: molecular probes for studying intracellular signal transduction. | 1993 | Trends Pharmacol. Sci. | pmid:7692652 |
| Akita K and Mandel TE | Effect of FK 506 and anti-CD4 monoclonal antibody treatment on xenografts of organ-cultured fetal pig pancreas and host lymphoid populations. | 1993 | Transplant. Proc. | pmid:7692650 |
| Wang SC et al. | A dual mechanism of immunosuppression by FK-506. Differential suppression of IL-4 and IL-10 levels in T helper 2 cells. | 1993 | Transplantation | pmid:7692640 |
| Tabasco-Minguillan J et al. | Insulin requirements after liver transplantation and FK-506 immunosuppression. | 1993 | Transplantation | pmid:7692637 |
| McDiarmid SV et al. | A comparison of renal function in cyclosporine- and FK-506-treated patients after primary orthotopic liver transplantation. | 1993 | Transplantation | pmid:7692636 |
| Storb R et al. | FK-506 and methotrexate prevent graft-versus-host disease in dogs given 9.2 Gy total body irradiation and marrow grafts from unrelated dog leukocyte antigen-nonidentical donors. | 1993 | Transplantation | pmid:7692635 |
| Roberts JP et al. | Reversal of chronic rejection after treatment failure with FK506 and RS61443. | 1993 | Transplantation | pmid:7692634 |
| Hill CC et al. | Penile prosthesis surgery in the immunosuppressed patient. | 1993 | Transplantation | pmid:7692633 |
| Wakugami T et al. | Effect of FK506 on the development of diabetes in BB rats in comparison with that of cyclosporin. | 1993 | Tohoku J. Exp. Med. | pmid:7692621 |
| Izumi S and Okuhara M | [FK506 and kifunensine, new immunomodulators of microbial origin]. | 1993 | Tanpakushitsu Kakusan Koso | pmid:7692469 |
| Lhoëst G et al. | Isolation and identification by FAB mass spectrometry and NMR spectroscopy of a demethylated metabolite of FK506 from erythromycin-induced rabbit liver microsomes. | 1993 | Pharm Acta Helv | pmid:7692454 |
| Nagata K et al. | Failure of FK-506, a new immunosuppressant, to prevent cerebral vasospasm in a canine two-hemorrhage model. | 1993 | J. Neurosurg. | pmid:7692019 |
| Schulz BS et al. | Increased expression of epidermal IL-8 receptor in psoriasis. Down-regulation by FK-506 in vitro. | 1993 | J. Immunol. | pmid:7691948 |
| Wesselborg S et al. | Triggering via the alternative CD2 pathway induces apoptosis in activated human T lymphocytes. | 1993 | Eur. J. Immunol. | pmid:7691614 |
| Muthukkumar S et al. | Elevation of cytosolic calcium is sufficient to induce growth inhibition in a B cell lymphoma. | 1993 | Eur. J. Immunol. | pmid:7691606 |
| Distant DA and Gonwa TA | The kidney in liver transplantation. | 1993 | J. Am. Soc. Nephrol. | pmid:7691205 |
| Mori T et al. | FK-506: a new immunosuppressive agent, failed to reduce cerebral vasospasm after experimental subarachnoid hemorrhage. | 1993 | J. Vet. Med. Sci. | pmid:7691190 |
| Liu J | FK506 and cyclosporin, molecular probes for studying intracellular signal transduction. | 1993 | Immunol. Today | pmid:7691065 |
| Wenzel-Seifert K and Seifert R | Partial inhibition of human neutrophil activation by FK-506 at supratherapeutic concentrations. | 1993 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:7690907 |
| Nakajima J | [The immunosuppressive effects of FK506 on single lung allotransplantation in Japanese monkey (Macaca fuscata)]. | 1993 | Nihon Kyobu Geka Gakkai Zasshi | pmid:7690829 |
| Piekoszewski W et al. | Disposition of tacrolimus (FK 506) in rabbits. Role of red blood cell binding in hepatic clearance. | 1993 Jul-Aug | Drug Metab. Dispos. | pmid:7690698 |
| Henke W and Jung K | Comparison of the effects of the immunosuppressive agents FK 506 and cyclosporin A on rat kidney mitochondria. | 1993 | Biochem. Pharmacol. | pmid:7690566 |
| Whitington PF et al. | Orthotopic auxiliary liver transplantation for Crigler-Najjar syndrome type 1. | 1993 | Lancet | pmid:7690444 |
| Olivera DL et al. | Divergent effects of rapamycin on mouse and rat cells following mitogenic stimulation. | 1993 | Clin. Immunol. Immunopathol. | pmid:7690317 |
| Hom JT and Estridge T | FK506 and rapamycin modulate the functional activities of human peripheral blood eosinophils. | 1993 | Clin. Immunol. Immunopathol. | pmid:7690315 |
| Cetinkale O et al. | The use of FK506 and skin allografting for the treatment of severe burns in an animal model. | 1993 | Br J Plast Surg | pmid:7690295 |
| Kobayashi J et al. | A new rat infection-heart transplant model: effect of infection on graft survival studies. | 1993 Jul-Aug | J. Heart Lung Transplant. | pmid:7690253 |
| Cheng JW et al. | 15N NMR relaxation studies of the FK506 binding protein: backbone dynamics of the uncomplexed receptor. | 1993 | Biochemistry | pmid:7690248 |
| Jain AB et al. | Pharmacokinetics of FK506 in liver transplant recipients after continuous intravenous infusion. | 1993 | J Clin Pharmacol | pmid:7690047 |
| McMichael J et al. | An intelligent and cost-effective computer dosing system for individualizing FK506 therapy in transplantation and autoimmune disorders. | 1993 | J Clin Pharmacol | pmid:7690046 |
| Lieberman R | FK506, artificial intelligence and pharmacoeconomics. | 1993 | J Clin Pharmacol | pmid:7690045 |
| Tai PK et al. | P59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptors. | 1993 | Biochemistry | pmid:7689858 |
| Mollison KW et al. | Comparison of FK-506, rapamycin, ascomycin, and cyclosporine in mouse models of host-versus-graft disease and heterotopic heart transplantation. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689812 |
| Reem GH et al. | FK-506 inhibits the IL-2-independent induction of the activation antigen CD 69. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689811 |
| Starzl TE et al. | Allograft and xenograft acceptance under FK-506 and other immunosuppressant treatment. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689809 |
| Clardy J | Structural studies of complexed FK-506 binding protein. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689808 |
| Zenke G et al. | Molecular mechanisms of immunosuppression by cyclosporins. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689806 |
| Parsons WH et al. | FK-506--a novel immunosuppressant. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689805 |
| Kino T and Goto T | Discovery of FK-506 and update. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689804 |
| Christensen BG | FK-506: its role in immunosuppression. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689803 |
| Abu-Elmagd K et al. | Resolution of severe pyoderma gangrenosum in a patient with streaking leukocyte factor disease after treatment with tacrolimus (FK 506). | 1993 | Ann. Intern. Med. | pmid:7689802 |
| Kondo T et al. | [Antitumor sensitivity test, subrenal capsule assay using FK-506: preliminary report]. | 1993 | Nihon Geka Gakkai Zasshi | pmid:7689693 |
| Namiki Y et al. | Tautomeric phenomenon of a novel potent immunosuppressant (FK506) in solution. I. Isolation and structure determination of tautomeric compounds. | 1993 | J. Antibiot. | pmid:7689551 |
| McManus BM et al. | Direct myocardial injury by enterovirus: a central role in the evolution of murine myocarditis. | 1993 | Clin. Immunol. Immunopathol. | pmid:7689428 |
| Fesik SW | NMR structure-based drug design. | 1993 | J. Biomol. NMR | pmid:7689377 |
| Ohzato H et al. | Serum interleukin-6 levels as an indicator of acute rejection after liver transplantation in cynomologous monkeys. | 1993 | Surg. Today | pmid:7689373 |
| Ueda D et al. | Influence of FK 506 on renal blood flow. | 1993 | Transplant. Proc. | pmid:7689280 |
| Dé P et al. | Early steroid-resistant rejection following orthotopic liver transplantation: new aspects of treatment with FK 506 instead of OKT3? | 1993 | Transplant. Proc. | pmid:7689279 |
| Viebahn R et al. | Simulation of hypoxic and preservation injury in human hepatocyte cultures: influence of FK 506 and cyclosporine. | 1993 | Transplant. Proc. | pmid:7689278 |
| Winkler M et al. | Plasma level-guided low-dose FK 506 therapy in patients with early liver dysfunction after liver transplantation. | 1993 | Transplant. Proc. | pmid:7689277 |
| Jost U et al. | FK 506 treatment of intractable rejection after liver transplantation. | 1993 | Transplant. Proc. | pmid:7689276 |
| McMaster P and Buist L | FK 506 in transplantation. | 1993 | Transplant. Proc. | pmid:7689275 |
| Groth CG et al. | New immunosuppressive drugs in transplantation. | 1993 | Transplant. Proc. | pmid:7689274 |
| McCauley J et al. | Renal transplantation under FK 506 in African-Americans: early experience. | 1993 | Transplant. Proc. | pmid:7689270 |
| Odocha O et al. | Serum cholesterol levels in African Americans after renal transplantation under FK 506 immunosuppression. | 1993 | Transplant. Proc. | pmid:7689269 |
| Odocha O et al. | Posttransplant diabetes mellitus in African Americans after renal transplantation under FK 506 immunosuppression. | 1993 | Transplant. Proc. | pmid:7689268 |
| Valdivia LA et al. | Dendritic cell replacement in long-surviving liver and cardiac xenografts. | 1993 | Transplantation | pmid:7689265 |
| Shaefer MS et al. | Falsely elevated FK-506 levels caused by sampling through central venous catheters. | 1993 | Transplantation | pmid:7689264 |
| Taylor-Fishwick DA et al. | Evidence that rapamycin has differential effects of IL-4 function. Multiple IL-4 signaling pathways and implications for in vivo use. | 1993 | Transplantation | pmid:7689258 |
| Jin YJ and Burakoff SJ | The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7689229 |
| Hoof T et al. | Reversal of multidrug resistance in Chinese hamster ovary cells by the immunosuppressive agent rapamycin. | 1993 | Eur. J. Pharmacol. | pmid:7689059 |
| Garrity GM et al. | Genetic relationships among actinomycetes that produce the immunosuppressant macrolides FK506, FK520/FK523 and rapamycin. | 1993 | J. Ind. Microbiol. | pmid:7688970 |
| Jacobs JC et al. | Pyoderma gangrenosum in infancy. | 1993 | J. Am. Acad. Dermatol. | pmid:7688775 |
| Smith DF et al. | Two FKBP-related proteins are associated with progesterone receptor complexes. | 1993 | J. Biol. Chem. | pmid:7688746 |
| Yamaoka K et al. | Cyclosporin A and FK506 block the negative signaling mediated by surface IgM cross-linking in normal human mature B cells. | 1993 | Immunol. Lett. | pmid:7688712 |
| Morkawa K et al. | Immunosuppressive property of bromocriptine on human B lymphocyte function in vitro. | 1993 | Clin. Exp. Immunol. | pmid:7688676 |
| Lyson T et al. | Cyclosporine- and FK506-induced sympathetic activation correlates with calcineurin-mediated inhibition of T-cell signaling. | 1993 | Circ. Res. | pmid:7688670 |
| Schmid FX | Prolyl isomerase: enzymatic catalysis of slow protein-folding reactions. | 1993 | Annu Rev Biophys Biomol Struct | pmid:7688608 |
| Machida M | [Effect of temperature on plasma concentration of FK506]. | 1993 | Nippon Hinyokika Gakkai Zasshi | pmid:7688443 |
| Pleyer U et al. | Ocular absorption of topically applied FK506 from liposomal and oil formulations in the rabbit eye. | 1993 | Invest. Ophthalmol. Vis. Sci. | pmid:7688360 |
| Ueki M et al. | Diabetogenic effects of FK506 on renal subcapsular islet isografts in rat. | 1993 | Diabetes Res. Clin. Pract. | pmid:7688276 |
| Entani C et al. | Effect of a novel immunosuppressant, FK506, on spontaneous lupus nephritis in MRL/MpJ-lpr/lpr mice. | 1993 | Nephron | pmid:7688103 |
| Hirakawa K et al. | [The effect of perioperative portal venous inoculation with donor lymphocytes in combination with immunosuppressive agents on rat cardiac allograft survivals]. | 1993 | Nihon Geka Gakkai Zasshi | pmid:7688065 |
| Heitman J et al. | The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae. | 1993 | Mol. Cell. Biol. | pmid:7687745 |
| Bram RJ et al. | Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. | 1993 | Mol. Cell. Biol. | pmid:7687744 |
| Przepiorka D et al. | Bronchiolitis obliterans organizing pneumonia in a BMT patient receiving FK506. | 1993 | Bone Marrow Transplant. | pmid:7687503 |
| Altmeyer A and Dumont FJ | Rapamycin inhibits IL-1-mediated interferon-gamma production in the YAC-1 T cell lymphoma. | 1993 | Cytokine | pmid:7687472 |
| Denesyuk AI et al. | Comparison of conformations of cyclosporin A and macrolide FK506 fragments: localization of putative binding sites with phosphatase calcineurin. | 1993 | Biochem. Biophys. Res. Commun. | pmid:7687433 |
| Antoni FA et al. | Inhibitory role for calcineurin in stimulus-secretion coupling revealed by FK506 and cyclosporin A in pituitary corticotrope tumor cells. | 1993 | Biochem. Biophys. Res. Commun. | pmid:7687429 |
| Roelen DL et al. | Differential inhibition of primed alloreactive CTLs in vitro by clinically used concentrations of cyclosporine and FK506. | 1993 | Transplantation | pmid:7687397 |
| Iwata H et al. | Suppression of allograft responses by combining donor alloantigen-specific intravenous presensitization with suboptimal doses of FK506. | 1993 | Transplantation | pmid:7687396 |
| Warty V et al. | FK506 measurement: comparison of different analytical methods. | 1993 | Ther Drug Monit | pmid:7687389 |
| Nishizawa S et al. | Therapeutic effect of a new immunosuppressant, FK-506, on vasospasm after subarachnoid hemorrhage. | 1993 | Neurosurgery | pmid:7687044 |
| Nishi M et al. | Effects of the immunosuppressant FK506 on a penetrating keratoplasty rejection model in the rat. | 1993 | Invest. Ophthalmol. Vis. Sci. | pmid:7686893 |
| Koga T et al. | Pulmonary infiltrates recovered by FK506 in a patient with Behçet's disease. | 1993 | Chest | pmid:7686837 |
| Schreier MH | Immunophilins and immunosuppression. | 1993 Mar-Apr | Clin. Exp. Rheumatol. | pmid:7686830 |