tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shapiro R | The development of tacrolimus in renal transplantation. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750356 |
| Keshavamurthy M et al. | Single-center study utilizing C(2) level as monitoring tool in de novo renal transplant recipients treated with Neoral. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750338 |
| Chen JC and Ma P | Mechanism of FK506-induced renal hypoperfusion and its reversion in rats. | 2001 | Acta Pharmacol. Sin. | pmid:11749797 |
| Kihara M et al. | A small dose of the immunosuppressive agent FK506 (tacrolimus) protects peripheral nerve from ischemic fiber degeneration. | 2001 | Muscle Nerve | pmid:11745968 |
| Chan SA and Smith C | Physiological stimuli evoke two forms of endocytosis in bovine chromaffin cells. | 2001 | J. Physiol. (Lond.) | pmid:11744761 |
| Keogh AM et al. | A randomized trial of tacrolimus (FK506) versus total lymphoid irradiation for the control of repetitive rejection after cardiac transplantation. | 2001 | J. Heart Lung Transplant. | pmid:11744418 |
| Avramut M et al. | The immunosuppressant drug FK506 is a potent trophic agent for human fetal neurons. | 2001 | Brain Res. Dev. Brain Res. | pmid:11744119 |
| Nagano Y et al. | Lack of binding observed between human alpha-synuclein and Bcl-2 protein family. | 2001 | Neurosci. Lett. | pmid:11742726 |
| Boukriche Y et al. | Severe axonal polyneuropathy after a FK506 overdosage in a lung transplant recipient. | 2001 | Transplantation | pmid:11740402 |
| Benito N et al. | Alternariosis after liver transplantation. | 2001 | Transplantation | pmid:11740399 |
| Yang CW et al. | Pharmacological preconditioning with low-dose cyclosporine or FK506 reduces subsequent ischemia/reperfusion injury in rat kidney. | 2001 | Transplantation | pmid:11740384 |
| Hodgson T et al. | Topical tacrolimus and Crohn disease. | 2001 | J. Pediatr. Gastroenterol. Nutr. | pmid:11740245 |
| Khouri IF et al. | Nonablative allogeneic hematopoietic transplantation as adoptive immunotherapy for indolent lymphoma: low incidence of toxicity, acute graft-versus-host disease, and treatment-related mortality. | 2001 | Blood | pmid:11739162 |
| Vanrenterghem YF | Tailoring immunosuppressive therapy for renal transplant recipients. | 2001 | Pediatr Transplant | pmid:11737774 |
| Flynn JT et al. | Indications, results, and complications of tacrolimus conversion in pediatric renal transplantation. | 2001 | Pediatr Transplant | pmid:11737770 |
| Sano N et al. | High trough levels of oral FK506 induced by loss of small intestine. | 2001 | Pediatr Transplant | pmid:11737769 |
| Klein AW | Commentary on topical tacrolimus in the treatment of bovine collagen hypersensitivity. | 2001 | Dermatol Surg | pmid:11737142 |
| Sugiura H et al. | An open study of a lotion formulation to improve tolerance of tacrolimus in facial atopic dermatitis. | 2001 | Br. J. Dermatol. | pmid:11736904 |
| Bigby M | A thorough systematic review of treatments for atopic eczema. | 2001 | Arch Dermatol | pmid:11735714 |
| Dubowchik GM et al. | 2-Aryl-2,2-difluoroacetamide FKBP12 ligands: synthesis and X-ray structural studies. | 2001 | Org. Lett. | pmid:11735566 |
| Bartynski WS et al. | Etiology of cortical and white matter lesions in cyclosporin-A and FK-506 neurotoxicity. | 2001 Nov-Dec | AJNR Am J Neuroradiol | pmid:11733324 |
| Mayer K et al. | [FK 506 ointment 0.1 % - A new therapeutic option for atopic blepharitis. Clinical trial with 14 patients]. | 2001 | Klin Monbl Augenheilkd | pmid:11731901 |
| Pilmore HL et al. | Tacrolimus for the treatment of gout in renal transplantation: two case reports and review of the literature. | 2001 | Transplantation | pmid:11726837 |
| Washburn K et al. | Steroid elimination 24 hours after liver transplantation using daclizumab, tacrolimus, and mycophenolate mofetil. | 2001 | Transplantation | pmid:11726831 |
| Maes BD et al. | Posttransplantation diabetes mellitus in FK-506-treated renal transplant recipients: analysis of incidence and risk factors. | 2001 | Transplantation | pmid:11726827 |
| Bruce DS et al. | Multicenter survey of daclizumab induction in simultaneous kidney-pancreas transplant recipients. | 2001 | Transplantation | pmid:11726823 |
| Krentz AJ | Posttransplantation Diabetes Mellitus in FK-506-Treated Renal Transplant Recipients: Analysis of Incidence and Risk Factors. Transplantation 2001; 72: 1655. | 2001 | Transplantation | pmid:11726815 |
| CÃfková R and Hallen H | Cyclosporin-induced hypertension. | 2001 | J. Hypertens. | pmid:11725176 |
| Granlund H et al. | Treatment of lichenified atopic eczema with tacrolimus ointment. | 2001 Aug-Sep | Acta Derm. Venereol. | pmid:11720192 |
| Nemoto H et al. | FK506 suppressed the inflammatory change of EAM in SJL/J mice. | 2001 | J. Neurol. Sci. | pmid:11718743 |
| Alemdar AY et al. | Liposomal tacrolimus administered systemically and within the donor cell suspension improves xenograft survival in hemiparkinsonian rats. | 2001 | Exp. Neurol. | pmid:11716565 |
| Almawi WY et al. | Inhibition of cytokine production and cytokine-stimulated T-cell activation by FK506 (tacrolimus)1. | 2001 | Cell Transplant | pmid:11714196 |
| Sakuma S et al. | FK506 is superior to methotrexate in therapeutic effects on advanced stage of rat adjuvant-induced arthritis. | 2001 | Inflamm. Res. | pmid:11713905 |
| Milting H et al. | FK506 does not affect cardiac contractility and adrenergic response in vitro. | 2001 | Eur. J. Pharmacol. | pmid:11711047 |
| Chu FC et al. | Oral health status, oral microflora, and non-surgical periodontal treatment of renal transplant patients receiving cyclosporin A and FK506. | 2000 | Ann R Australas Coll Dent Surg | pmid:11709958 |
| Hernández G et al. | Resolution of oral ulcerations after decreasing the dosage of tacrolimus in a liver transplantation recipient. | 2001 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod | pmid:11709689 |
| Lash LH et al. | Apoptosis, necrosis, and cell proliferation induced by S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11708895 |
| Waldman WJ et al. | Inhibition of angiogenesis-related endothelial activity by the experimental immunosuppressive agent leflunomide. | 2001 | Transplantation | pmid:11707749 |
| Trancassini M et al. | Microbiologic investigation on patients with cystic fibrosis subjected to bilateral lung transplantation. | 2001 | Transplantation | pmid:11707748 |
| Yamada T et al. | Role of T cells in development of chronic pancreatitis in male Wistar Bonn/Kobori rats: effects of tacrolimus. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11705744 |
| Takahata M et al. | Cyclosporin A-induced encephalopathy after allogeneic bone marrow transplantation with prevention of graft-versus-host disease by tacrolimus. | 2001 | Bone Marrow Transplant. | pmid:11704797 |
| Okano A et al. | Subcutaneous infection with Mycobacterium fortuitum after allogeneic bone marrow transplantation. | 2001 | Bone Marrow Transplant. | pmid:11704796 |
| Scammell JG et al. | Overexpression of the FK506-binding immunophilin FKBP51 is the common cause of glucocorticoid resistance in three New World primates. | 2001 | Gen. Comp. Endocrinol. | pmid:11703081 |
| Tsukamoto T et al. | The effects of FK506, a specific calcineurin inhibitor, on methamphetamine-induced behavioral change and its sensitization in rats. | 2001 | Psychopharmacology (Berl.) | pmid:11702083 |
| Fukatsu S et al. | Population pharmacokinetics of tacrolimus in adult recipients receiving living-donor liver transplantation. | 2001 | Eur. J. Clin. Pharmacol. | pmid:11699612 |
| Kogan-Liberman D et al. | The role of quantitative Epstein-Barr virus polymerase chain reaction and preemptive immunosuppression reduction in pediatric liver transplantation: a preliminary experience. | 2001 | J. Pediatr. Gastroenterol. Nutr. | pmid:11698761 |
| Amberg GC et al. | Regulation of A-type potassium channels in murine colonic myocytes by phosphatase activity. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11698261 |
| Miyauchi T et al. | Experimental study of combined treatment with tacrolimus and donor splenocytes via the portal vein in small bowel transplantation. | 2001 | J. Med. Invest. | pmid:11694955 |
| Cristillo AD and Bierer BE | Identification of novel targets of immunosuppressive agents by cDNA-based microarray analysis. | 2002 | J. Biol. Chem. | pmid:11694517 |
| Fukada J et al. | Long-term survival of rat cardiac allografts by intrathymic plus portal venous injections of donor bone marrow cells and short-term tacrolimus immunosuppression. | 2001 | Transpl. Int. | pmid:11692215 |
| Trautmann A et al. | Targeting keratinocyte apoptosis in the treatment of atopic dermatitis and allergic contact dermatitis. | 2001 | J. Allergy Clin. Immunol. | pmid:11692113 |
| Tucker CL and Fields S | A yeast sensor of ligand binding. | 2001 | Nat. Biotechnol. | pmid:11689849 |
| Mazariegos GV et al. | Conversion from cyclosporin to tacrolimus in paediatric liver transplant recipients. | 2001 | Paediatr Drugs | pmid:11688597 |
| Oz HS et al. | Provocative effects of the immunosuppressants rapamycin, tacrolimus, and dexamethasone on pneumonitis in contrast to the anti- pneumonitis effects of mycophenolate mofetil. | 2001 | Transplantation | pmid:11685124 |
| Ovuworie CA et al. | Vascular endothelial function in cyclosporine and tacrolimus treated renal transplant recipients. | 2001 | Transplantation | pmid:11685108 |
| Geba GP et al. | Topical tacrolimus and cyclosporin A differentially inhibit early and late effector phases of cutaneous delayed-type and immunoglobulin E hypersensitivity. | 2001 | Immunology | pmid:11683964 |
| Baan CC et al. | Conversion from cyclosporin A to tacrolimus is safe and decreases blood pressure, cholesterol levels and TGF-beta 1 type I receptor expression. | 2001 | Clin Transplant | pmid:11683823 |
| Barri YM et al. | Polyoma viral infection in renal transplantation: the role of immunosuppressive therapy. | 2001 | Clin Transplant | pmid:11683817 |
| Dietemann J et al. | Comparison of ELISA method versus MEIA method for daily practice in the therapeutic monitoring of tacrolimus. | 2001 | Nephrol. Dial. Transplant. | pmid:11682676 |
| Suehiro E et al. | The immunophilin ligand FK506 attenuates the axonal damage associated with rapid rewarming following posttraumatic hypothermia. | 2001 | Exp. Neurol. | pmid:11681852 |
| Onoe H et al. | [Interaction of immunophilin FKBP and intracellular Ca2+ release channels]. | 2001 | Fukuoka Igaku Zasshi | pmid:11681278 |
| Deters M et al. | Comparative study analyzing effects of sirolimus-cyclosporin and sirolimus-tacrolimus combinations on bile flow in the rat. | 2001 | Dig. Dis. Sci. | pmid:11680585 |
| Sakuma Y et al. | High-dose tacrolimus and lengthy survival of the combined rat pancreas/spleen graft in a high-responder combination. | 2001 | Transpl. Immunol. | pmid:11680570 |
| Arii T et al. | Neuroprotective effect of immunosuppressant FK506 in transient focal ischemia in rat: therapeutic time window for FK506 in transient focal ischemia. | 2001 | Neurol. Res. | pmid:11680517 |
| Chisholm MA et al. | Impact of clinical pharmacy services on renal transplant patients' compliance with immunosuppressive medications. | 2001 | Clin Transplant | pmid:11678959 |
| Kimikawa M et al. | Effective oral administration of tacrolimus in renal transplant recipients. | 2001 | Clin Transplant | pmid:11678958 |
| Mimura T et al. | [Treatment of steroid-resistant polymyositis and dermatomyositis]. | 2001 | Nippon Rinsho | pmid:11676154 |
| Carreras CW et al. | An FKBP12 binding assay based upon biotinylated FKBP12. | 2001 | Anal. Biochem. | pmid:11673895 |
| Fernández-Miranda C et al. | Determinants of increased plasma homocysteine in 221 stable liver transplant patients. | 2001 | Clin. Chem. | pmid:11673376 |
| Wang M et al. | Inhibition of nitric oxide synthase induces intestinal mucosal damage and increases mortality in rats treated by FK506. | 2001 | Exp. Toxicol. Pathol. | pmid:11665854 |
| Bornhövd E et al. | Macrolactam immunomodulators for topical treatment of inflammatory skin diseases. | 2001 | J. Am. Acad. Dermatol. | pmid:11606925 |
| Serrano AL et al. | Calcineurin controls nerve activity-dependent specification of slow skeletal muscle fibers but not muscle growth. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11606756 |
| Dello Strologo L et al. | Renal hemodynamic effect of tacrolimus in renal transplanted children. | 2001 | Pediatr. Nephrol. | pmid:11605779 |
| Hardinger KL et al. | Renal allograft outcomes in African American versus Caucasian transplant recipients in the tacrolimus era. | 2001 | Surgery | pmid:11602906 |
| Bultynck G et al. | The conserved sites for the FK506-binding proteins in ryanodine receptors and inositol 1,4,5-trisphosphate receptors are structurally and functionally different. | 2001 | J. Biol. Chem. | pmid:11598113 |
| Christ B et al. | Interactions of sildenafil and tacrolimus in men with erectile dysfunction after kidney transplantation. | 2001 | Urology | pmid:11597545 |
| Dipchand AI et al. | Mycophenolic acid levels in pediatric heart transplant recipients receiving mycophenolate mofetil. | 2001 | J. Heart Lung Transplant. | pmid:11595558 |
| Naka Y et al. | Effects of dexamethasone and FK506 on Helicobacter pylori-induced gastritis and bacterial viability in Mongolian gerbils. | 2001 Jan-Dec | J. Physiol. Paris | pmid:11595473 |
| Morissette P et al. | In vivo higher glucuronidation of mycophenolic acid in male than in female recipients of a cadaveric kidney allograft and under immunosuppressive therapy with mycophenolate mofetil. | 2001 | Ther Drug Monit | pmid:11591897 |
| Sezen SF et al. | Immunophilin ligand FK506 is neuroprotective for penile innervation. | 2001 | Nat. Med. | pmid:11590407 |
| Chau TN et al. | Histological patterns of rejection using oral microemulsified cyclosporine and tacrolimus (FK506) as monotherapy induction after orthotopic liver transplantation. | 2001 | Liver | pmid:11589769 |
| Patel S et al. | Prevalence and causes of low bone density and fractures in kidney transplant patients. | 2001 | J. Bone Miner. Res. | pmid:11585351 |
| Koomans HA and Ligtenberg G | Mechanisms and consequences of arterial hypertension after renal transplantation. | 2001 | Transplantation | pmid:11585243 |
| First MR | Strategies to minimize immunological and nonimmunological risk factors in the renal transplant population. | 2001 | Transplantation | pmid:11585240 |
| Pescovitz MD and Govani M | Sirolimus and mycophenolate mofetil for calcineurin-free immunosuppression in renal transplant recipients. | 2001 | Am. J. Kidney Dis. | pmid:11583940 |
| Hricik DE | Safety and efficacy of TOR inhibitors and other immunosuppressive regimens in African-American renal transplant recipients. | 2001 | Am. J. Kidney Dis. | pmid:11583939 |
| Ichimaru N et al. | Changes in lipid metabolism and effect of simvastatin in renal transplant recipients induced by cyclosporine or tacrolimus. | 2001 | Atherosclerosis | pmid:11583721 |
| Assmann T et al. | Topical tacrolimus for the treatment of inflammatory skin diseases. | 2001 | Expert Opin Pharmacother | pmid:11583067 |
| Simpson D | New developments in the prophylaxis and treatment of graft versus host disease. | 2001 | Expert Opin Pharmacother | pmid:11583062 |
| Sloper CM et al. | Tacrolimus (FK506) in the management of high-risk corneal and limbal grafts. | 2001 | Ophthalmology | pmid:11581059 |
| Jain A et al. | A prospective randomized trial of tacrolimus and prednisone versus tacrolimus, prednisone and mycophenolate mofetil in primary adult liver transplantation: a single center report. | 2001 | Transplantation | pmid:11579306 |
| Savoldo B et al. | Generation of autologous Epstein-Barr virus-specific cytotoxic T cells for adoptive immunotherapy in solid organ transplant recipients. | 2001 | Transplantation | pmid:11579304 |
| Selzner N et al. | Conversion from cyclosporine to FK506 in adult liver transplant recipients: a combined North American and European experience. | 2001 | Transplantation | pmid:11579301 |
| Staatz CE et al. | Population pharmacokinetics of tacrolimus in children who receive cut-down or full liver transplants. | 2001 | Transplantation | pmid:11579300 |
| Mourad G et al. | Induction versus noninduction in renal transplant recipients with tacrolimus-based immunosuppression. | 2001 | Transplantation | pmid:11579299 |
| Al-Uzri A et al. | Posttransplant diabetes mellitus in pediatric renal transplant recipients: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). | 2001 | Transplantation | pmid:11579294 |
| Lawrence MC et al. | Regulation of insulin gene transcription by a Ca(2+)-responsive pathway involving calcineurin and nuclear factor of activated T cells. | 2001 | Mol. Endocrinol. | pmid:11579208 |
| Oettinger-Barak O et al. | Periodontal changes in liver cirrhosis and post-transplantation patients. I: clinical findings. | 2001 | J. Periodontol. | pmid:11577956 |
| Thervet E | [Minimization of immunosuppression]. | 2001 | Presse Med | pmid:11577589 |
| Bayle F | [Focus on Islets of Langerhans transplantation]. | 2001 | Presse Med | pmid:11577579 |