tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fujimoto H et al. | Immunomodulatory constituents from an Ascomycete, Eupenicillium crustaceum, and revised absolute structure of macrophorin D. | 2001 | J. Nat. Prod. | pmid:11575965 |
| Dumont FJ | Treatment of transplant rejection: are the traditional immunosuppressants good enough? | 2001 | Curr Opin Investig Drugs | pmid:11575705 |
| Gingras AC et al. | Control of translation by the target of rapamycin proteins. | 2001 | Prog. Mol. Subcell. Biol. | pmid:11575159 |
| Coley KC et al. | Lack of tacrolimus-induced cardiomyopathy. | 2001 | Ann Pharmacother | pmid:11573873 |
| Takamatsu Y et al. | Intravenous cyclosporine and tacrolimus caused anaphylaxis but oral cyclosporine capsules were tolerated in an allogeneic bone marrow transplant recipient. | 2001 | Bone Marrow Transplant. | pmid:11571519 |
| Sindhi R et al. | Sirolimus for rescue and primary immunosuppression in transplanted children receiving tacrolimus. | 2001 | Transplantation | pmid:11571449 |
| Nakao A et al. | Impact of tacrolimus and bone marrow augmentation on intestinal allograft survival and intragraft cytokine expression in rats. | 2001 | J Med | pmid:11563819 |
| Briggs WA et al. | Lymphocyte suppression by glucocorticoids with cyclosporine, tacrolimus, pentoxifylline, and mycophenolic acid. | 1999 | J Clin Pharmacol | pmid:11563403 |
| Laham G et al. | [Acute peripheral demyelinating polyneuropathy and acute renal failure after administration of FK506]. | 2001 | Medicina (B Aires) | pmid:11563175 |
| Letko E et al. | Treatment of ocular cicatricial pemphigoid with tacrolimus (FK 506). | 2001 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:11561793 |
| Cacciarelli TV et al. | Primary tacrolimus (FK506) therapy and the long-term risk of post-transplant lymphoproliferative disease in pediatric liver transplant recipients. | 2001 | Pediatr Transplant | pmid:11560756 |
| Choi CJ and Nghiem P | Tacrolimus ointment in the treatment of chronic cutaneous graft-vs-host disease: a case series of 18 patients. | 2001 | Arch Dermatol | pmid:11559218 |
| Stewart SF et al. | Mycophenolate mofetil monotherapy in liver transplantation. | 2001 | Lancet | pmid:11558493 |
| Schlitt HJ et al. | Replacement of calcineurin inhibitors with mycophenolate mofetil in liver-transplant patients with renal dysfunction: a randomised controlled study. | 2001 | Lancet | pmid:11558484 |
| Carmody M et al. | FKBP12 associates tightly with the skeletal muscle type 1 ryanodine receptor, but not with other intracellular calcium release channels. | 2001 | FEBS Lett. | pmid:11557049 |
| Dunn SE et al. | Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers. | 2001 | J. Biol. Chem. | pmid:11555650 |
| Moody BR and Sengelmann RD | Topical tacrolimus in the treatment of bovine collagen hypersensitivity. | 2001 | Dermatol Surg | pmid:11553165 |
| Aker S et al. | Different effects of cyclosporine a and FK506 on potassium transport systems in MDCK cells. | 2001 | Exp. Nephrol. | pmid:11549851 |
| Kawakami T et al. | Safe and effective treatment of refractory facial lesions in atopic dermatitis using topical tacrolimus following corticosteroid discontinuation. | 2001 | Dermatology (Basel) | pmid:11549797 |
| Lübbe J | Topical tacrolimus for atopic dermatitis: euphoria and vigilance. | 2001 | Dermatology (Basel) | pmid:11549790 |
| Furukawa M et al. | MRI in seven cases of tacrolimus (FK-506) encephalopathy: utility of FLAIR and diffusion-weighted imaging. | 2001 | Neuroradiology | pmid:11548166 |
| Mann J | Natural products as immunosuppressive agents. | 2001 | Nat Prod Rep | pmid:11548050 |
| Aw MM et al. | Calcineurin-inhibitor related nephrotoxicity- reversibility in paediatric liver transplant recipients. | 2001 | Transplantation | pmid:11544444 |
| Berg UB et al. | Renal function before and long after liver transplantation in children. | 2001 | Transplantation | pmid:11544422 |
| Kovalev GI et al. | An important role of CDK inhibitor p18(INK4c) in modulating antigen receptor-mediated T cell proliferation. | 2001 | J. Immunol. | pmid:11544316 |
| Weinbroum AA et al. | Lack of cumulative effect of tacrolimus and low flow on a rat isolated liver. | 2001 | Transplant. Proc. | pmid:11543812 |
| Mor E et al. | Homocysteine levels among transplant recipients: effect of immunosuppressive protocols. | 2001 | Transplant. Proc. | pmid:11543802 |
| Elinav H et al. | Plasma oxidizability and plasma carbonyls, markers of oxidative stress, in liver transplant patients. | 2001 | Transplant. Proc. | pmid:11543789 |
| Ikegame K et al. | Lethal adenovirus infection in a patient who had undergone nonmyeloablative stem cell transplantation. | 2001 | Int. J. Hematol. | pmid:11530814 |
| Tremblay JP and Vilquin JT | [Transplantation of normal or genetically modified myoblasts for the treatment of hereditary or acquired diseases]. | 2001 | J. Soc. Biol. | pmid:11530497 |
| Freyschmidt-Paul P et al. | Treatment of alopecia areata in C3H/HeJ mice with the topical immunosuppressant FK506 (Tacrolimus). | 2001 Sep-Oct | Eur J Dermatol | pmid:11525945 |
| Riboldi-Tunnicliffe A et al. | Crystal structure of Mip, a prolylisomerase from Legionella pneumophila. | 2001 | Nat. Struct. Biol. | pmid:11524681 |
| Abu-Elmagd K et al. | Clinical intestinal transplantation: a decade of experience at a single center. | 2001 | Ann. Surg. | pmid:11524593 |
| Szabo G et al. | Tacrolimus and cyclosporine A inhibit allostimulatory capacity and cytokine production of human myeloid dendritic cells. | 2001 | J. Investig. Med. | pmid:11523700 |
| Lhoëst G et al. | In vitro immunosuppressive activity of tacrolimus dihydrodiol precursors obtained by chemical oxidation and identification of a new metabolite of SDZ-RAD by electrospray and electrospray-linked scan mass spectrometry. | 2001 | J Mass Spectrom | pmid:11523088 |
| Anneser JM et al. | Immunosuppressant FK506 does not exert beneficial effects in symptomatic G93A superoxide dismutase-1 transgenic mice. | 2001 | Neuroreport | pmid:11522944 |
| Staatz C et al. | Low tacrolimus concentrations and increased risk of early acute rejection in adult renal transplantation. | 2001 | Nephrol. Dial. Transplant. | pmid:11522877 |
| Behrend M | Adverse gastrointestinal effects of mycophenolate mofetil: aetiology, incidence and management. | 2001 | Drug Saf | pmid:11522119 |
| Dmitrewski J et al. | Metabolic and hormonal effects of tacrolimus (FK506) or cyclosporin immunosuppression following renal transplantation. | 2001 | Diabetes Obes Metab | pmid:11520309 |
| Morioka M et al. | Intravenously injected FK506 failed to inhibit hippocampal calcineurin. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11520068 |
| Hashida T and Inui K | [Therapeutic drug monitoring of immunosuppresants]. | 2001 | Rinsho Byori | pmid:11519126 |
| Suzuki K et al. | FK506 facilitates chemical kindling induced by pentylenetetrazole in rats. | 2001 | Epilepsy Res. | pmid:11518629 |
| Cole O et al. | The effect of different immunosuppressants on alloantigen dependent and independent factors involved in the development of chronic rejection in an animal model. | 2001 | Ann R Coll Surg Engl | pmid:11518369 |
| Taupin JL et al. | Functional quantification of cyclosporine A and FK506 in human whole blood by flow cytometry, using the green fluorescent protein as an interleukin-2 reporter gene. | 2001 | J. Immunol. Methods | pmid:11516757 |
| Hiraga K et al. | A novel screening for inhibitors of a pleiotropic drug resistant pump, Pdr5, in Saccharomyces cerevisiae. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11515543 |
| Marx SO and Marks AR | Bench to bedside: the development of rapamycin and its application to stent restenosis. | 2001 | Circulation | pmid:11514367 |
| Hochleitner BW et al. | Increased tacrolimus levels during diarrhea. | 2001 | Transpl. Int. | pmid:11512055 |
| Tatekawa Y et al. | Intragraft expression of p38 and activated p38 MAPK (mitogen-activated protein kinase) in rat small bowel transplantation. | 2001 | Transpl. Int. | pmid:11512052 |
| Terui T et al. | Production and pharmacologic modulation of the granulocyte-associated allergic responses to ovalbumin in murine skin models induced by injecting ovalbumin-specific Th1 or Th2 cells. | 2001 | J. Invest. Dermatol. | pmid:11511299 |
| McAlister VC et al. | Orthotopic liver transplantation using low-dose tacrolimus and sirolimus. | 2001 | Liver Transpl. | pmid:11510015 |
| Hiraoka A et al. | Phase III study comparing tacrolimus (FK506) with cyclosporine for graft-versus-host disease prophylaxis after allogeneic bone marrow transplantation. | 2001 | Bone Marrow Transplant. | pmid:11509936 |
| Müller WE et al. | Suppression of allograft rejection in the sponge Suberites domuncula by FK506 and expression of genes encoding FK506-binding proteins in allografts. | 2001 | J. Exp. Biol. | pmid:11507104 |
| Lum H et al. | Protein phosphatase 2B inhibitor potentiates endothelial PKC activity and barrier dysfunction. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11504680 |
| Takatsuki M et al. | Weaning of immunosuppression in living donor liver transplant recipients. | 2001 | Transplantation | pmid:11502975 |
| Hwang KK et al. | FK506 promotes adenosine release from endothelial cells via inhibition of adenosine kinase. | 2001 | Eur. J. Pharmacol. | pmid:11502273 |
| Gruessner RW et al. | Bone marrow augmentation in kidney transplantation: a large animal study. | 2001 | Transpl. Int. | pmid:11499905 |
| Eagle DA et al. | Gastroparesis following bone marrow transplantation. | 2001 | Bone Marrow Transplant. | pmid:11498745 |
| Weir M | Impact of immunosuppressive regimes on posttransplant diabetes mellitus. | 2001 | Transplant. Proc. | pmid:11498201 |
| Zuberbier T et al. | The ascomycin macrolactam pimecrolimus (Elidel, SDZ ASM 981) is a potent inhibitor of mediator release from human dermal mast cells and peripheral blood basophils. | 2001 | J. Allergy Clin. Immunol. | pmid:11496246 |
| Suzuki Y et al. | [Mesial temporal lobe epilepsy in a patient with Wilson's disease receiving FK506 (tacrolimus) after liver transplantation]. | 2001 | No To Hattatsu | pmid:11494578 |
| Meyer D et al. | Orthotopic liver/small bowel transplantation in rats: a microsurgical model inducing tolerance. | 2001 | Microsurgery | pmid:11494384 |
| James JA et al. | Tacrolimus is not associated with gingival overgrowth in renal transplant patients. | 2001 | J. Clin. Periodontol. | pmid:11493354 |
| Mück W et al. | Tacrolimus/cerivastatin interaction study in liver transplant recipients. | 2001 | Br J Clin Pharmacol | pmid:11488782 |
| Zager RA et al. | Renal cholesterol accumulation: a durable response after acute and subacute renal insults. | 2001 | Am. J. Pathol. | pmid:11485932 |
| Gianni LM and Sulli MM | Topical tacrolimus in the treatment of atopic dermatitis. | 2001 Jul-Aug | Ann Pharmacother | pmid:11485148 |
| Son IJ et al. | No effect of water deprivation for 48 hours on the pharmacokiinetics of intravenous tacrolimus in rats. | 2000 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:11484882 |
| Yamataka A et al. | Transplantation of newborn esophagus: an experimental study. | 2001 | J. Pediatr. Surg. | pmid:11479870 |
| Andries S et al. | Posttransplant immune hepatitis in pediatric liver transplant recipients: incidence and maintenance therapy with azathioprine. | 2001 | Transplantation | pmid:11477351 |
| Ahsan N et al. | Randomized trial of tacrolimus plus mycophenolate mofetil or azathioprine versus cyclosporine oral solution (modified) plus mycophenolate mofetil after cadaveric kidney transplantation: results at 2 years. | 2001 | Transplantation | pmid:11477347 |
| Ahmed M et al. | Quantitation of immunosuppression by tacrolimus using flow cytometric analysis of interleukin-2 and interferon-gamma inhibition in CD8(-) and CD8(+) peripheral blood T cells. | 2001 | Ther Drug Monit | pmid:11477316 |
| Miki T et al. | Hamster-to-rat bone marrow xenotransplantation and humoral graft vs. host disease. | 2001 | Xenotransplantation | pmid:11472629 |
| Hashimoto Y et al. | Novel immunosuppressive effect of FK506 by augmentation of T cell apoptosis. | 2001 | Clin. Exp. Immunol. | pmid:11472421 |
| Motohashi H et al. | Expression of peptide transporter following intestinal transplantation in the rat. | 2001 | J. Surg. Res. | pmid:11469900 |
| Theruvath TP et al. | Control of antidonor antibody production with tacrolimus and mycophenolate mofetil in renal allograft recipients with chronic rejection. | 2001 | Transplantation | pmid:11468538 |
| Squifflet JP et al. | Dose optimization of mycophenolate mofetil when administered with a low dose of tacrolimus in cadaveric renal transplant recipients. | 2001 | Transplantation | pmid:11468536 |
| Camirand G et al. | Combined immunosuppression of mycophenolate mofetil and FK506 for myoblast transplantation in mdx mice. | 2001 | Transplantation | pmid:11468532 |
| Sarwal MM et al. | Promising early outcomes with a novel, complete steroid avoidance immunosuppression protocol in pediatric renal transplantation. | 2001 | Transplantation | pmid:11468528 |
| Parvex P et al. | Reversible encephalopathy associated with tacrolimus in pediatric renal transplants. | 2001 | Pediatr. Nephrol. | pmid:11465799 |
| Motohashi H et al. | Effects of tacrolimus and cyclosporin A on peptide transporter PEPT1 in Caco-2 cells. | 2001 | Pharm. Res. | pmid:11465431 |
| Jain A et al. | Does tacrolimus offer virtual freedom from chronic rejection after primary liver transplantation? Risk and prognostic factors in 1,048 liver transplantations with a mean follow-up of 6 years. | 2001 | Liver Transpl. | pmid:11460230 |
| Koide K et al. | A synthetic library of cell-permeable molecules. | 2001 | J. Am. Chem. Soc. | pmid:11456541 |
| Papaccio G et al. | Tacrolimus, but not cyclosporine A, significantly increases expression of ICAM-1 and IFN-gamma in the NOD mouse. | 2001 | J. Cell. Biochem. Suppl. | pmid:11455576 |
| Vennarecci G et al. | Apoptosis and rejection in rat intestinal transplantation: correlation with FK506 doses and donor specific bone marrow infusions. | 2001 | Transplantation | pmid:11455248 |
| Nagler A et al. | Amelioration of steroid-resistant chronic graft-versus-host-mediated liver disease via tacrolimus treatment. | 2001 | J. Hematother. Stem Cell Res. | pmid:11454316 |
| Strassburg CP et al. | Identification of cyclosporine A and tacrolimus glucuronidation in human liver and the gastrointestinal tract by a differentially expressed UDP-glucuronosyltransferase: UGT2B7. | 2001 | J. Hepatol. | pmid:11451170 |
| Taylor DO et al. | Suggested guidelines for the use of tacrolimus in cardiac transplant recipients. | 2001 | J. Heart Lung Transplant. | pmid:11448799 |
| Harmon JV et al. | Experimental short-term immunosuppression after bowel transplantation and donor-specific bone marrow infusion. | 2001 | Arch Surg | pmid:11448397 |
| Nowak-Wegrzyn AH et al. | Food allergy after pediatric organ transplantation with tacrolimus immunosuppression. | 2001 | J. Allergy Clin. Immunol. | pmid:11447402 |
| Railson JE et al. | Heat shock protein-56 is induced by cardiotrophin-1 and mediates its hypertrophic effect. | 2001 | J. Mol. Cell. Cardiol. | pmid:11444924 |
| Hurtova M et al. | Successful tacrolimus therapy for a severe recurrence of type 1 autoimmune hepatitis in a liver graft recipient. | 2001 | Liver Transpl. | pmid:11443588 |
| Neal DA et al. | Beneficial effects of converting liver transplant recipients from cyclosporine to tacrolimus on blood pressure, serum lipids, and weight. | 2001 | Liver Transpl. | pmid:11443583 |
| Satoh S et al. | Chrono and clinical pharmacokinetic study of tacrolimus in continuous intravenous administration. | 2001 | Int. J. Urol. | pmid:11442656 |
| Volosov A et al. | Simultaneous simple and fast quantification of three major immunosuppressants by liquid chromatography--tandem mass-spectrometry. | 2001 | Clin. Biochem. | pmid:11440728 |
| Uyeda M et al. | Pentalenolactone I and hygromycin A, immunosuppressants produced by Streptomyces filipinensis and Streptomyces hygroscopicus. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11440152 |
| Kakegawa T et al. | [Effect of rapamycin on cytoplasmic accumulation of hetero nuclear ribonucleoprotein C-like unwinding protein 2]. | 2001 | Jpn J Antibiot | pmid:11439909 |
| Singleton RH et al. | The immunophilin ligand FK506 attenuates axonal injury in an impact-acceleration model of traumatic brain injury. | 2001 | J. Neurotrauma | pmid:11437083 |
| Yamataka A et al. | Bladder transplantation in rats using FK-506. | 2001 | J. Urol. | pmid:11435882 |
| Dorn GW | Calcineurin inhibition in hypertrophy: back from the dead! | 2001 | Circulation | pmid:11435329 |
| Boldorini R et al. | Molecular characterization and sequence analysis of polyomavirus BKV-strain in a renal-allograft recipient. | 2001 | Hum. Pathol. | pmid:11431722 |
| Tanaka K et al. | FK506 ameliorates the discrimination learning impairment due to preventing the rarefaction of white matter induced by chronic cerebral hypoperfusion in rats. | 2001 | Brain Res. | pmid:11430878 |