tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lo A et al. | Patterns of cytomegalovirus infection in simultaneous kidney-pancreas transplant recipients receiving tacrolimus, mycophenolate mofetil, and prednisone with ganciclovir prophylaxis. | 2001 | Transpl Infect Dis | pmid:11429034 |
| Ramm K and Plückthun A | High enzymatic activity and chaperone function are mechanistically related features of the dimeric E. coli peptidyl-prolyl-isomerase FkpA. | 2001 | J. Mol. Biol. | pmid:11428902 |
| Matsuo N et al. | Tacrolimus inhibits cytokine production and chemical mediator release following antigen stimulation of passively sensitized human lung tissues. | 2001 | Ann. Allergy Asthma Immunol. | pmid:11428741 |
| Mourad M et al. | Pharmacokinetic basis for the efficient and safe use of low-dose mycophenolate mofetil in combination with tacrolimus in kidney transplantation. | 2001 | Clin. Chem. | pmid:11427455 |
| Kanoh S et al. | FK506 inhibits Cl- secretion in airway epithelium via calcineurin-independent mechanism. | 2001 | Eur. J. Pharmacol. | pmid:11426833 |
| Hasegawa T et al. | Oral administration of tacrolimus in the presence of jejunostomy after liver transplantation. | 2001 | Pediatr Transplant | pmid:11422824 |
| Chang RK et al. | Echocardiographic findings of hypertrophic cardiomyopathy in children after orthotopic liver transplantation. | 2001 | Pediatr Transplant | pmid:11422821 |
| Kolpak S and Mehler P | Medical issues in treating renal transplant patients. | 2001 | Hosp Pract (1995) | pmid:11419536 |
| Sing A et al. | Molecular diagnosis of an Enterocytozoon bieneusi human genotype C infection in a moderately immunosuppressed human immunodeficiency virus seronegative liver-transplant recipient with severe chronic diarrhea. | 2001 | J. Clin. Microbiol. | pmid:11414246 |
| Sun J et al. | Role for p27(Kip1) in Vascular Smooth Muscle Cell Migration. | 2001 | Circulation | pmid:11413088 |
| Kaibori M et al. | FK506, but not cyclosporin A, prevents mitochondrial dysfunction during hypoxia in rat hepatocytes. | 2001 | Life Sci. | pmid:11411802 |
| Hiroi J | [Pharmacological profile and clinical effect of tacrolimus ointment (Protopic ointment) for atopic dermatitis]. | 2001 | Nippon Yakurigaku Zasshi | pmid:11411345 |
| Navarro X et al. | Effects of FK506 on nerve regeneration and reinnervation after graft or tube repair of long nerve gaps. | 2001 | Muscle Nerve | pmid:11410918 |
| Shimoishi K et al. | FK506 (tacrolimus) increases rat alpha1-acid glycoprotein expression in liver and primary cultured hepatocytes. | 2001 | Eur. J. Pharmacol. | pmid:11408029 |
| Sakuma S et al. | Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system. (Comparison with steroids). | 2001 | Int. Immunopharmacol. | pmid:11407316 |
| Land W et al. | Mycophenolate mofetil monotherapy: an optimal, safe, and efficacious immunosuppressive maintenance regimen in kidney transplant patients. | 2001 | Transplant. Proc. | pmid:11406265 |
| Weir MR | Methods and outcomes of calcineurin inhibitor reduction or withdrawal in patients with chronic allograft nephropathy after the first year posttransplantation. | 2001 | Transplant. Proc. | pmid:11406264 |
| Charpentier B | An induction versus no-induction protocol in anticalcineurin-based immunosuppression using very low-dose steroids. | 2001 | Transplant. Proc. | pmid:11406262 |
| Chan KL et al. | Porcine small bowel transplantation with FK506 as a single immunosuppressant. | 2001 | Transplant. Proc. | pmid:11406260 |
| Faivre L et al. | FK 506 dose in transplantation: from theory to practice. | 2001 | Transplant. Proc. | pmid:11406256 |
| Osako M et al. | Alloimmune response may be involved in neointimal hyperplasia in cryopreserved aortic allografts. | 2001 | Transplant. Proc. | pmid:11406250 |
| Diaz-Romero J et al. | Coexpression of CD4 and CD8alpha on rat T-cells in whole blood: a sensitive marker for monitoring T-cell immunosuppressive drugs. | 2001 | J. Immunol. Methods | pmid:11406149 |
| Allen A et al. | Significant absorption of topical tacrolimus in 3 patients with Netherton syndrome. | 2001 | Arch Dermatol | pmid:11405764 |
| Penson MG et al. | Safety and efficacy of pravastatin therapy for the prevention of hyperlipidemia in pediatric and adolescent cardiac transplant recipients. | 2001 | J. Heart Lung Transplant. | pmid:11404165 |
| Bekersky I et al. | Comparative tacrolimus pharmacokinetics: normal versus mildly hepatically impaired subjects. | 2001 | J Clin Pharmacol | pmid:11402631 |
| Otsuka M et al. | Long-term results of donor-specific blood transfusion with cyclosporine in living related kidney transplantation. | 2001 | Nephron | pmid:11399917 |
| Tuteja S et al. | The effect of gut metabolism on tacrolimus bioavailability in renal transplant recipients. | 2001 | Transplantation | pmid:11397967 |
| Maesaki S | [Molecular mechanize and clinical feature of azole-resistant Candida albicans strains and new strategy of treatment]. | 2001 | Jpn J Antibiot | pmid:11392683 |
| Karasu Z et al. | Acute tacrolimus overdose and treatment with phenytoin in liver transplant recipients. | 2001 | J Okla State Med Assoc | pmid:11392178 |
| Yin DP et al. | Lewis rat pancreas, but not cardiac xenografts, are resistant to anti-gal antibody mediated hyperacute rejection. | 2001 | Transplantation | pmid:11391223 |
| Utsugi R et al. | Induction of transplantation tolerance with a short course of tacrolimus (FK506): I. Rapid and stable tolerance to two-haplotype fully mhc-mismatched kidney allografts in miniature swine. | 2001 | Transplantation | pmid:11391221 |
| Boillot O et al. | Low rejection rates with tacrolimus-based dual and triple regimens following liver transplantation. | 2001 | Clin Transplant | pmid:11389705 |
| Goffin E et al. | Osteoporosis after organ transplantation. | 2001 | Lancet | pmid:11386322 |
| Wakugawa M et al. | Interferon-gamma-induced RANTES production by human keratinocytes is enhanced by IL-1beta, TNF-alpha, IL-4 and IL-13 and is inhibited by dexamethasone and tacrolimus. | 2001 | Dermatology (Basel) | pmid:11385231 |
| Barten MJ et al. | Flow cytometric quantitation of calcium-dependent and -independent mitogen-stimulation of T cell functions in whole blood: inhibition by immunosuppressive drugs in vitro. | 2001 | J. Immunol. Methods | pmid:11384672 |
| Kooman JP et al. | A comparison between office and ambulatory blood pressure measurements in renal transplant patients with chronic transplant nephropathy. | 2001 | Am. J. Kidney Dis. | pmid:11382685 |
| Teixeira R et al. | Management of recurrent hepatitis C after liver transplantation. | 2001 | J. Viral Hepat. | pmid:11380792 |
| Sandborn WJ | Transcending conventional therapies: the role of biologic and other novel therapies. | 2001 | Inflamm. Bowel Dis. | pmid:11380043 |
| van Gelder T et al. | ATP-binding cassette transporters and calcineurin inhibitors: potential clinical implications. | 2001 | Transplant. Proc. | pmid:11377580 |
| McCarter JF et al. | FK 506 protects brain tissue in animal models of stroke. | 2001 | Transplant. Proc. | pmid:11377571 |
| Molinaro M et al. | Pharmacokinetics of tacrolimus during the early phase after heart transplantation. | 2001 | Transplant. Proc. | pmid:11377570 |
| Chariat MN et al. | Basiliximab in the therapy of acute rejection after organ transplantation. | 2001 | Transplant. Proc. | pmid:11377567 |
| Nagashima N et al. | Immunocompetence assay for net effect of combined immunosuppression. | 2001 | Transplant. Proc. | pmid:11377556 |
| Langrehr JM et al. | Quadruple versus dual tacrolimus-based induction after liver transplantation: a prospective, randomized trial. | 2001 | Transplant. Proc. | pmid:11377549 |
| Schweizer RT and Meisterling LD | Tolerability of mycophenolate mofetil in organ transplant recipients. | 2001 | Transplant. Proc. | pmid:11377540 |
| Nakatani T et al. | Effect of tacrolimus on the gene expression of renin and endothelin in the rat kidney. | 2001 | Transplant. Proc. | pmid:11377534 |
| Nakache R et al. | Management of massive proteinuria following renal transplantation with mycophenolate mofetil and blood pressure normalization. | 2001 | Transplant. Proc. | pmid:11377533 |
| Migita K and Eguchi K | FK 506-mediated T-cell apoptosis induction. | 2001 | Transplant. Proc. | pmid:11377532 |
| Langrehr JM et al. | Chronic rejection after orthotopic liver transplantation is increased under induction therapy with interleukin-2 receptor antibody BT563. | 2001 | Transplant. Proc. | pmid:11377531 |
| Salizzoni M et al. | Tacrolimus-based dual therapy is as efficacious and safe as the conventional tacrolimus-based triple therapy in liver transplantation. | 2001 | Transplant. Proc. | pmid:11377521 |
| Fellermann K et al. | Tacrolimus: a new immunosuppressant for steroid refractory inflammatory bowel disease. | 2001 | Transplant. Proc. | pmid:11377517 |
| Jonas S et al. | Corticosteroid-free therapy after tacrolimus-based dual immunosuppression versus cyclosporine-based quadruple-induction therapy. | 2001 | Transplant. Proc. | pmid:11377511 |
| Mohacsi P et al. | Immunosuppression in ABO-incompatible transplantation. | 2001 | Transplant. Proc. | pmid:11377508 |
| Kelly JS and Sharkey J | Immunosuppressants-ligands as neuroprotectants. | 2001 | Transplant. Proc. | pmid:11377506 |
| McGrath JS and Shehata M | Chronic allograft nephropathy: prospective randomised trial of cyclosporin withdrawal and mycophenolate mofetil or tacrolimus substitution. | 2001 | Transplant. Proc. | pmid:11377500 |
| McGrath JS and Shehata M | The effect of differing immunosuppressive regimes on the functional and morphologic changes in a rat renal allograft model of chronic rejection. | 2001 | Transplant. Proc. | pmid:11377499 |
| Klupp J et al. | New approach in drug development: whole blood pharmacodynamic assays reflect biological activities of tacrolimus. | 2001 | Transplant. Proc. | pmid:11377491 |
| Hesse CJ et al. | The value of routine monitoring of mycophenolic acid plasma levels after clinical heart transplantation. | 2001 | Transplant. Proc. | pmid:11377487 |
| Gerhardt U et al. | High QT dispersion in tacrolimus-treated kidney transplant recipients. | 2001 | Transplant. Proc. | pmid:11377482 |
| Gerbase MW et al. | Low doses of mycophenolate mofetil with low doses of tacrolimus prevent acute rejection and long-term function loss after lung transplantation. | 2001 | Transplant. Proc. | pmid:11377481 |
| Braun F et al. | Pharmacokinetics of tacrolimus primary immunosuppression in kidney transplant recipients. | 2001 | Transplant. Proc. | pmid:11377473 |
| Bilbao I et al. | Comparison between tacrolimus and neoral cyclosporine administered by oral route in liver transplantation. | 2001 | Transplant. Proc. | pmid:11377472 |
| Ierardi E et al. | Long-term tacrolimus: a promising therapeutic approach for Crohn's disease. | 2001 | Transplant. Proc. | pmid:11377467 |
| Paul LC | Overview of side effects of immunosuppressive therapy. | 2001 | Transplant. Proc. | pmid:11377462 |
| Yamamoto-Yamaguchi Y et al. | Induction of differentiation of human myeloid leukemia cells by immunosuppressant macrolides (rapamycin and FK506) and calcium/calmodulin-dependent kinase inhibitors. | 2001 | Exp. Hematol. | pmid:11376870 |
| Neumann UP et al. | Significance of a T-lymphocytotoxic crossmatch in liver and combined liver-kidney transplantation. | 2001 | Transplantation | pmid:11374419 |
| Jain A et al. | Reasons for long-term use of steroid in primary adult liver transplantation under tacrolimus. | 2001 | Transplantation | pmid:11374410 |
| Mathis AS et al. | Sex and ethnicity may chiefly influence the interaction of fluconazole with calcineurin inhibitors. | 2001 | Transplantation | pmid:11374405 |
| Hashida T et al. | Pharmacokinetic and prognostic significance of intestinal MDR1 expression in recipients of living-donor liver transplantation. | 2001 | Clin. Pharmacol. Ther. | pmid:11371998 |
| Poirier SN et al. | FK506 blocks intracellular Ca2+ oscillations in bovine adrenal glomerulosa cells. | 2001 | Biochemistry | pmid:11371212 |
| Goldman D | Tacrolimus ointment for the treatment of steroid-induced rosacea: a preliminary report. | 2001 | J. Am. Acad. Dermatol. | pmid:11369912 |
| Morales JM et al. | Influence of cyclosporin, tacrolimus and rapamycin on renal function and arterial hypertension after renal transplantation. | 2001 | Nephrol. Dial. Transplant. | pmid:11369839 |
| Otto KG et al. | Cell proliferation through forced engagement of c-Kit and Flt-3. | 2001 | Blood | pmid:11369667 |
| Wallemacq PE and Verbeeck RK | Comparative clinical pharmacokinetics of tacrolimus in paediatric and adult patients. | 2001 | Clin Pharmacokinet | pmid:11368293 |
| Venkataramanan R et al. | Clinical utility of monitoring tacrolimus blood concentrations in liver transplant patients. | 2001 | J Clin Pharmacol | pmid:11361051 |
| Lensmeyer GL and Poquette MA | Therapeutic monitoring of tacrolimus concentrations in blood: semi-automated extraction and liquid chromatography-electrospray ionization mass spectrometry. | 2001 | Ther Drug Monit | pmid:11360032 |
| Guo X et al. | Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons. | 2001 | Eur. J. Neurosci. | pmid:11359520 |
| Ebisu T et al. | Early and delayed neuroprotective effects of FK506 on experimental focal ischemia quantitatively assessed by diffusion-weighted MRI. | 2001 | Magn Reson Imaging | pmid:11358652 |
| Sakuma S et al. | Effects of FK506 and other immunosuppressive anti-rheumatic agents on T cell activation mediated IL-6 and IgM production in vitro. | 2001 | Int. Immunopharmacol. | pmid:11357886 |
| Arima H et al. | Comparative studies of the enhancing effects of cyclodextrins on the solubility and oral bioavailability of tacrolimus in rats. | 2001 | J Pharm Sci | pmid:11357172 |
| Yang DY et al. | Simultaneous monitoring of extracellular glucose, pyruvate, lactate and glutamate in gerbil cortex during focal cerebral ischemia by dual probe microdialysis. | 2001 | J Chromatogr A | pmid:11355832 |
| Stover JF et al. | Effects of tacrolimus on hemispheric water content and cerebrospinal fluid levels of glutamate, hypoxanthine, interleukin-6, and tumor necrosis factor-alpha following controlled cortical impact injury in rats. | 2001 | J. Neurosurg. | pmid:11354410 |
| Pérgola PE et al. | Kidney transplantation during the first trimester of pregnancy: immunosuppression with mycophenolate mofetil, tacrolimus, and prednisone. | 2001 | Transplantation | pmid:11349738 |
| Ahuja M et al. | Polyoma virus infection after renal transplantation. Use of immunostaining as a guide to diagnosis. | 2001 | Transplantation | pmid:11349723 |
| Trotter JF et al. | Dyslipidemia during sirolimus therapy in liver transplant recipients occurs with concomitant cyclosporine but not tacrolimus. | 2001 | Liver Transpl. | pmid:11349259 |
| Kawamura I et al. | Induction of choleresis by immunosuppressant FK506 through stimulation of insulin-like growth factor-I production in the liver of rats. | 2001 | Eur. J. Pharmacol. | pmid:11348636 |
| Skaehill PA | Tacrolimus in dermatologic disorders. | 2001 | Ann Pharmacother | pmid:11346066 |
| Sutherland DE et al. | Pancreas transplantation for treatment of diabetes mellitus. | 2001 | World J Surg | pmid:11344403 |
| Yan M et al. | The ataxia-telangiectasia gene product may modulate DNA turnover and control cell fate by regulating cellular redox in lymphocytes. | 2001 | FASEB J. | pmid:11344081 |
| Treede H et al. | Tacrolimus versus cyclosporine after lung transplantation: a prospective, open, randomized two-center trial comparing two different immunosuppressive protocols. | 2001 | J. Heart Lung Transplant. | pmid:11343977 |
| De Bonis M et al. | Tacrolimus as a rescue immunosuppressant after heart transplantation. | 2001 | Eur J Cardiothorac Surg | pmid:11343954 |
| Obata K et al. | Role of FK506-binding protein 12 in development of the chick embryonic heart. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11341768 |
| Lee TH | Skin disease. Eczema. | 2001 | Harv Health Lett | pmid:11340028 |
| Parasrampuria DA et al. | A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function. | 2001 | Pharm. Res. | pmid:11336351 |
| Mackinnon SE et al. | Clinical outcome following nerve allograft transplantation. | 2001 | Plast. Reconstr. Surg. | pmid:11335811 |
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| Ogawa Y et al. | Successful treatment of dry eye in two patients with chronic graft-versus-host disease with systemic administration of FK506 and corticosteroids. | 2001 | Cornea | pmid:11333336 |
| Frühwirth M et al. | Elevated tacrolimus trough levels in association with mycophenolate mofetil-induced diarrhea: a case report. | 2001 | Pediatr Transplant | pmid:11328552 |
| Dobrolet NC et al. | Hematologic abnormalities in children and young adults receiving tacrolimus-based immunosuppression following cardiothoracic transplantation. | 2001 | Pediatr Transplant | pmid:11328551 |
| MacFarlane GD et al. | Therapeutic drug monitoring of tacrolimus in pediatric liver transplant patients. | 2001 | Pediatr Transplant | pmid:11328550 |