tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jain A et al. | Prospective randomized trial of tacrolimus and prednisone versus tacrolimus, prednisone, and mycophenolate mofetil: complete report on 350 primary adult liver transplantations. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267319 |
| Peltekian K et al. | De novo use of low-dose tacrolimus and sirolimus in liver transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267318 |
| Mühlbacher F | Tacrolimus versus cyclosporin microemulsion in liver transplantation: results of a 3-month study. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267317 |
| Sperschneider H | A large, multicentre trial to compare the efficacy and safety of tacrolimus with cyclosporine microemulsion following renal transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267291 |
| Busque S et al. | Canadian multicentre trial of tacrolimus/azathioprine/steroids versus tacrolimus/mycophenolate mofetil/steroids versus neoral/mycophenolate mofetil/steroids in renal transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267285 |
| Del Castillo D | Analysis of primary and recurrent rejection following renal transplantation in a large, comparative, multicentre trial. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267283 |
| Chakrabarti P et al. | Outcome after steroid withdrawal in adult renal transplant patients receiving tacrolimus-based immunosuppression. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267274 |
| Quiroga I et al. | Differential homocysteine levels in renal transplant patients receiving neoral versus tacrolimus. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267261 |
| Cailhier JF et al. | CMV in kidney transplants in the tacrolimus-mycophenolate era. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267255 |
| Evans NJ et al. | The expression of endothelin and inducible nitric oxide synthase in human renal allografts and their role in chronic renal allograft nephropathy. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267247 |
| Felipe CR et al. | Choosing the right dose of new immunossuppressive drugs for new populations: importance of pharmacokinetic studies. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267207 |
| Luke PP et al. | IVIG rescue therapy in renal transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267206 |
| Wu M et al. | Cyclosporine and tacrolimus alter renin-angiotesin system in mouse medullary-thick ascending limb cultured cells. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267198 |
| van den Berg AP et al. | Prediction of the inhibition of IL-2 production by calcineurin inhibitors. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267197 |
| Glanemann M et al. | Mycophenolate mofetil is superior in combination with tacrolimus compared to cyclosporine for immunosuppressive therapy after liver transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267194 |
| Shishido S et al. | Pharmacokinetics of tacrolimus in pediatric renal transplant recipients. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267193 |
| Aguirrezabalaga J et al. | Lipid profiles in liver transplantation in patients receiving tacrolimus or cyclosporin. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267192 |
| Zamauskaite A et al. | FK506 and CsA differ in their effect on intracellular cytokine expression following kidney transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267184 |
| Zaltzman J et al. | Tacrolimus, MMF, steroid, and ALG immunotherapy for high immunological risk renal transplant recipients. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267183 |
| Salazar A et al. | Sirolimus-tacrolimus combination for combined kidney-pancreas transplantation: effect on renal function. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267181 |
| Wang W et al. | Effect of rapamycin and FK506 on mesangial cell proliferation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267180 |
| Dudley CR | Conversion at first rejection: a prospective trial comparing cyclosporine microemulsion with tacrolimus in renal transplant recipients. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267179 |
| Kauffman HM et al. | Drug regimens affect cadaveric kidney graft survival. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267176 |
| Abouljoud M et al. | Conversion to neoral provides effective rescue therapy for liver and kidney transplant patients intolerant of Prograf. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267175 |
| Pretagostini R et al. | Conversion from cyclosporin to tacrolimus in chronic allograft nephropathy. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267174 |
| Calconi G and Vianello A | One-year follow-up of a large European trial comparing dual versus triple tacrolimus-based immunosuppressive regimens following renal transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267173 |
| Vincenti F | Tacrolimus (FK 506) in kidney transplantation: five-year survival results of the U.S. multicenter, randomized, comparative trial. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267172 |
| Ciancio G et al. | Daclizumab induction for primary kidney transplant recipients using tacrolimus, mycophenolate mofetil, and steroids as maintenance immunosuppression. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267169 |
| Berloco P et al. | Tacrolimus as cornerstone immunosuppressant in kidney transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267161 |
| Ettenger R | The practical problems of prednisone in pediatric renal transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267159 |
| Reutzel-Selke A et al. | Donor pretreatment of grafts from marginal donors improves long-term graft outcome. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267150 |
| Erickson LM et al. | Gene expression profiles of rat heart allografts with immunosuppression. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266960 |
| Ishibashi M et al. | Experimental study of tacrolimus immunosuppression on the mode of administration: efficacy of constant intravenous infusion avoiding C(max). | 2001 Feb-Mar | Transplant. Proc. | pmid:11266958 |
| Orsenigo R et al. | FK506 and SMS 201-995: effect on heterotopic heart transplantation in rats. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266956 |
| Jiang H et al. | IL-10: a tacrolimus-specific cytotoxic mediator in ongoing allograft rejection. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266931 |
| Opelz G | New immunosuppressants and HLA matching. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266911 |
| Janezic AL et al. | Alternatively spliced variants of IL-2 mRNA in sequential transplant kidney core needle biopsies. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266873 |
| Nakao A et al. | Changes of allo-intestinal graft survival and intragraft cytokine expression by bone marrow augmentation with tacrolimus treatment in rats. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266851 |
| Gasser M et al. | Putative regulatory function of alloreactive Th2 cells in tolerant recipients after small bowel transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266759 |
| Utsugi R et al. | Tolerance across a two-haplotype, fully MHC-mismatched barrier induced in miniature swine renal allografts treated with a 12-day course of tacrolimus. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266727 |
| Ciancio G et al. | The use of intravenous tacrolimus and mycophenolate mofetil as induction and maintenance immunosuppression in simultaneous pancreas--kidney recipients with previous transplants. | 2001 | Clin Transplant | pmid:11264642 |
| Nagashima N et al. | Decreased effect of immunosuppression on immunocompetence in African--Americans after kidney and liver transplantation. | 2001 | Clin Transplant | pmid:11264637 |
| Vasquez E et al. | Clotrimazole increases tacrolimus blood levels: a drug interaction in kidney transplant patients. | 2001 | Clin Transplant | pmid:11264634 |
| Nikiforow S et al. | CD4+ T-cell effectors inhibit Epstein-Barr virus-induced B-cell proliferation. | 2001 | J. Virol. | pmid:11264363 |
| Grotz WH et al. | Calcineurin-inhibitor induced pain syndrome (CIPS): a severe disabling complication after organ transplantation. | 2001 | Transpl. Int. | pmid:11263551 |
| Chand DH et al. | Tacrolimus: the good, the bad, and the ugly. | 2001 | Pediatr Transplant | pmid:11260486 |
| Weir MR et al. | Long-term impact of discontinued or reduced calcineurin inhibitor in patients with chronic allograft nephropathy. | 2001 | Kidney Int. | pmid:11260422 |
| Queille-Roussel C et al. | The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: a randomized, double-blind controlled study. | 2001 | Br. J. Dermatol. | pmid:11260007 |
| Matsuda S et al. | Two distinct action mechanisms of immunophilin-ligand complexes for the blockade of T-cell activation. | 2000 | EMBO Rep. | pmid:11258483 |
| Ringe B et al. | A novel management strategy of steroid-free immunosuppression after liver transplantation: efficacy and safety of tacrolimus and mycophenolate mofetil. | 2001 | Transplantation | pmid:11258429 |
| St A Nunes FA and Lucey MR | Searching for a balance when applying immunosuppression after liver transplantation. | 2001 | Transplantation | pmid:11258425 |
| Wang L et al. | Effects of nitric oxide synthesis inhibition on FK506-induced nephrotoxicity in rats. | 2001 | Ren Fail | pmid:11256520 |
| Shimoyama M et al. | [Calcineurin inhibitor attenuates the development and induces the regression of cardiac hypertrophy in rats with salt-sensitive hypertension]. | 2001 | J Cardiol | pmid:11255695 |
| Fellermann K et al. | [Sweet syndrome and erythema nodosum in ulcerative colitis, refractory to steroids: successful treatment with tacrolimus]. | 2001 | Med. Klin. (Munich) | pmid:11253280 |
| StrestÃková P et al. | Inhibitory effect of FK 506 and cyclosporin A on nitric oxide production by LPS-treated cultured rat macrophages. | 2000 | Physiol Res | pmid:11252540 |
| US FDA advisory committee recommends approval of tacrolimus ointment. | 2000 | Skin Therapy Lett. | pmid:11252243 | |
| Fox DS et al. | Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans. | 2001 | Mol. Microbiol. | pmid:11251806 |
| Leinwand LA | Calcineurin inhibition and cardiac hypertrophy: a matter of balance. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11248009 |
| Yamamoto T and Nishioka K | Topical tacrolimus is effective for facial lesions of psoriasis. | 2000 Nov-Dec | Acta Derm. Venereol. | pmid:11243645 |
| Wollenberg A et al. | Topical tacrolimus (FK506) leads to profound phenotypic and functional alterations of epidermal antigen-presenting dendritic cells in atopic dermatitis. | 2001 | J. Allergy Clin. Immunol. | pmid:11240954 |
| Reitamo S | Tacrolimus: a new topical immunomodulatory therapy for atopic dermatitis. | 2001 | J. Allergy Clin. Immunol. | pmid:11240943 |
| Armstrong VW and Oellerich M | New developments in the immunosuppressive drug monitoring of cyclosporine, tacrolimus, and azathioprine. | 2001 | Clin. Biochem. | pmid:11239509 |
| Hassan-Walker AF et al. | CD8+ cytotoxic lymphocyte responses against cytomegalovirus after liver transplantation: correlation with time from transplant to receipt of tacrolimus. | 2001 | J. Infect. Dis. | pmid:11237798 |
| Riggins PS and Clipstone NA | T cell activation signals upregulate CBP-dependent transcriptional activity. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11237736 |
| GarcÃa Sánchez MJ et al. | Covariate effects on the apparent clearance of tacrolimus in paediatric liver transplant patients undergoing conversion therapy. | 2001 | Clin Pharmacokinet | pmid:11236810 |
| Günther M et al. | Rapid decline of antibodies after hepatitis A immunization in liver and renal transplant recipients. | 2001 | Transplantation | pmid:11233913 |
| Easing eczema. | 2001 | Health News | pmid:11232120 | |
| Pournaras CC et al. | Staphylococcal colonization in atopic dermatitis treatment with topical tacrolimus (Fk506). | 2001 | J. Invest. Dermatol. | pmid:11231333 |
| Cruz MC et al. | Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans. | 2001 | EMBO J. | pmid:11230126 |
| Feng FY et al. | FK506 rescues peripheral nerve allografts in acute rejection. | 2001 | J. Neurotrauma | pmid:11229713 |
| Passerini P and Ponticelli C | Treatment of focal segmental glomerulosclerosis. | 2001 | Curr. Opin. Nephrol. Hypertens. | pmid:11224693 |
| Pyrzynska B et al. | Cyclosporin A-sensitive signaling pathway involving calcineurin regulates survival of reactive astrocytes. | 2001 | Neurochem. Int. | pmid:11222921 |
| van Mourik ID and Kelly DA | Immunosuppressive drugs in paediatric liver transplantation. | 2001 | Paediatr Drugs | pmid:11220404 |
| Petering H et al. | [Pyoderma gangrenosum: successful topical therapy with tacrolimus (FK506)]. | 2001 | Hautarzt | pmid:11220239 |
| Mahalati K and Kahan BD | Pharmacological surrogates of allograft outcome. | 2000 | Ann. Transplant. | pmid:11217202 |
| Pauli-Magnus C et al. | Short-term efficacy of tacrolimus ointment in severe uremic pruritus. | 2000 Nov-Dec | Perit Dial Int | pmid:11216583 |
| Molmenti EP et al. | Kidney transplantation for end-stage renal failure in liver transplant recipients with hepatitis C viral infection. | 2001 | Transplantation | pmid:11213072 |
| Paolillo JA et al. | Posttransplant diabetes mellitus in pediatric thoracic organ recipients receiving tacrolimus-based immunosuppression. | 2001 | Transplantation | pmid:11213069 |
| Mollevà DG et al. | Heart and liver xenotransplantation under low-dose tacrolimus: graft survival after withdrawal of immunosuppression. | 2001 | Transplantation | pmid:11213062 |
| Wang K et al. | Transplantation of infantile bladder in rats: an alternative procedure for bladder augmentation. | 2001 | Transplantation | pmid:11213059 |
| Ohashi H and Ohno R | [Immunodeficiency induced by immunosuppressive agents]. | 2000 | Ryoikibetsu Shokogun Shirizu | pmid:11212769 |
| Kasahara M et al. | Living-related liver transplantation for type II citrullinemia using a graft from heterozygote donor. | 2001 | Transplantation | pmid:11211185 |
| Leidig-Bruckner G et al. | Frequency and predictors of osteoporotic fractures after cardiac or liver transplantation: a follow-up study. | 2001 | Lancet | pmid:11210996 |
| Bekersky I et al. | Effect of low- and high-fat meals on tacrolimus absorption following 5 mg single oral doses to healthy human subjects. | 2001 | J Clin Pharmacol | pmid:11210398 |
| Wong PW et al. | ortho-substituted PCB95 alters intracellular calcium signaling and causes cellular acidification in PC12 cells by an immunophilin-dependent mechanism. | 2001 | J. Neurochem. | pmid:11208908 |
| Koshika T et al. | Pretreatment with FK506 improves survival rate and gas exchange in canine model of acute lung injury. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11208629 |
| Ierardi E et al. | Oral tacrolimus long-term therapy in patients with Crohn's disease and steroid resistance. | 2001 | Aliment. Pharmacol. Ther. | pmid:11207512 |
| Pou L et al. | Mycophenolic acid plasma concentrations: influence of comedication. | 2001 | Ther Drug Monit | pmid:11206040 |
| Odorico JS et al. | Improved solitary pancreas transplant graft survival in the modern immunosuppressive era. | 2000 Nov-Dec | Cell Transplant | pmid:11202579 |
| Pouteil-Noble C and Guebre F | [Effect of immunosuppressants on lipids]. | 2000 | Nephrologie | pmid:11200615 |
| Tenney F and Sakarcan A | Fatal cytomegalovirus disease in a high-risk renal transplant recipient. | 2001 | Pediatr. Nephrol. | pmid:11198610 |
| Okabe H et al. | Pharmacokinetics and bioavailability of tacrolimus in rats with experimental renal dysfunction. | 2000 | J. Pharm. Pharmacol. | pmid:11197074 |
| Lee RK and Wurtman RJ | Regulation of APP synthesis and secretion by neuroimmunophilin ligands and cyclooxygenase inhibitors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:11193162 |
| O'hara M et al. | Latent intracellular Epstein-Barr Virus DNA demonstrated in ocular posttransplant lymphoproliferative disorder mimicking granulomatous uveitis with iris nodules in a child. | 2001 | J AAPOS | pmid:11182679 |
| Duijnhoven EM et al. | Influence of tacrolimus on glucose metabolism before and after renal transplantation: a prospective study. | 2001 | J. Am. Soc. Nephrol. | pmid:11181807 |
| Lester LB et al. | Targeted protein kinase A and PP-2B regulate insulin secretion through reversible phosphorylation. | 2001 | Endocrinology | pmid:11181538 |
| Mancinelli LM et al. | The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups. | 2001 | Clin. Pharmacol. Ther. | pmid:11180035 |
| Schwetz BA | From the Food and Drug Administration. | 2001 | JAMA | pmid:11176890 |
| Frankel SJ and Kerdel FA | Topical tacrolimus. | 2001 | Skin Therapy Lett. | pmid:11176043 |
| Hunt SA | New immunosuppressive agents in clinical use: mycophenolate mofetil and tacrolimus. | 2000 May-Jun | Cardiol Rev | pmid:11174892 |