tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- J. Pharmacol. Exp. Ther. (1)
- Am. J. Physiol. Renal Physiol. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Springer JE et al. | Calcineurin-mediated BAD dephosphorylation activates the caspase-3 apoptotic cascade in traumatic spinal cord injury. | 2000 | J. Neurosci. | pmid:11007881 |
| Ideura T et al. | Tacrolimus/itraconazole interactions: a case report of ABO-incompatible living-related renal transplantation. | 2000 | Nephrol. Dial. Transplant. | pmid:11007866 |
| Revelo MP et al. | A 14-year-old boy with kidney allograft failure in the first month after transplantation. | 2000 | Am. J. Kidney Dis. | pmid:11007695 |
| Pham PT et al. | Cyclosporine and tacrolimus-associated thrombotic microangiopathy. | 2000 | Am. J. Kidney Dis. | pmid:11007689 |
| Dambrin C et al. | Pharmacodynamics of immunosuppressive drugs. | 2000 | Curr. Opin. Immunol. | pmid:11007359 |
| Tsaroucha AK et al. | Levels of mycophenolic acid and its glucuronide derivative in the plasma of liver, small bowel and kidney transplant patients receiving tacrolimus and cellcept combination therapy. | 2000 | Transpl. Immunol. | pmid:11005321 |
| Marchetti P and Navalesi R | The metabolic effects of cyclosporin and tacrolimus. | 2000 Jul-Aug | J. Endocrinol. Invest. | pmid:11005276 |
| Inoue T et al. | Lesser reduction in bone mineral density by the immunosuppressant, FK506, compared with cyclosporine in rats. | 2000 | Transplantation | pmid:11003356 |
| Chakrabarti P et al. | Outcome after steroid withdrawal in pediatric renal transplant patients receiving tacrolimus-based immunosuppression. | 2000 | Transplantation | pmid:11003353 |
| Nakao A et al. | Cytokine mRNA expression on rat small bowel allograft treated with tacrolimus and simultaneous bone marrow transplantation via the portal vein. | 2000 | Transplant. Proc. | pmid:10995965 |
| Tatekawa Y et al. | Intragraft expression of p38 in rat small bowel transplantation. | 2000 | Transplant. Proc. | pmid:10995948 |
| Kimura O et al. | Influence of bombesin on the intestinal mucosal immunologic response under immunosuppression. | 2000 | Transplant. Proc. | pmid:10995942 |
| Kato Y et al. | Epidermal growth factor enhances the intestinal adaptation of small bowel allografts in the postoperative period. | 2000 | Transplant. Proc. | pmid:10995935 |
| Alessiani M et al. | Correlations between functional changes and different grades of acute rejection in swine small bowel allografts. | 2000 | Transplant. Proc. | pmid:10995933 |
| Fishbein T et al. | Isolated intestinal transplantation in adults with nonreconstructible GI tracts. | 2000 | Transplant. Proc. | pmid:10995925 |
| Madariaga JR et al. | The long-term efficacy of multivisceral transplantation. | 2000 | Transplant. Proc. | pmid:10995918 |
| Alessiani M et al. | Pharmacokinetic study of intraarterial local intestinal infusion of tacrolimus. | 2000 | Transplant. Proc. | pmid:10995915 |
| Furtado A et al. | Local immunosuppression in clinical small bowel transplantation (report of two cases). | 2000 | Transplant. Proc. | pmid:10995910 |
| Lote CJ et al. | The hypomagnesaemic action of FK506: urinary excretion of magnesium and calcium and the role of parathyroid hormone. | 2000 | Clin. Sci. | pmid:10995593 |
| Kane GC and Lipsky JJ | Drug-grapefruit juice interactions. | 2000 | Mayo Clin. Proc. | pmid:10994829 |
| Lohmann T et al. | Diabetes mellitus and islet cell specific autoimmunity as adverse effects of immunsuppressive therapy by FK506/tacrolimus. | 2000 | Exp. Clin. Endocrinol. Diabetes | pmid:10989953 |
| Allen C et al. | PCL-b-PEO micelles as a delivery vehicle for FK506: assessment of a functional recovery of crushed peripheral nerve. | 2000 Jul-Sep | Drug Deliv | pmid:10989914 |
| Zhang W and Victor RG | Calcineurin inhibitors cause renal afferent activation in rats: a novel mechanism of cyclosporine-induced hypertension. | 2000 | Am. J. Hypertens. | pmid:10981550 |
| Nash RA et al. | Phase 3 study comparing methotrexate and tacrolimus with methotrexate and cyclosporine for prophylaxis of acute graft-versus-host disease after marrow transplantation from unrelated donors. | 2000 | Blood | pmid:10979948 |
| Ponticelli C | Calcineurin-inhibitors in renal transplantation. Too precious to be abandoned. | 2000 | Nephrol. Dial. Transplant. | pmid:10978383 |
| Voggenreiter G et al. | Immunosuppression with FK506 increases bone induction in demineralized isogeneic and xenogeneic bone matrix in the rat. | 2000 | J. Bone Miner. Res. | pmid:10977002 |
| Sasakawa Y et al. | FK506 suppresses neutrophil chemoattractant production by peripheral blood mononuclear cells. | 2000 | Eur. J. Pharmacol. | pmid:10973631 |
| Königsrainer A et al. | Nonocclusive segmental mesenteric ischemia after combined pancreas kidney transplantation: mycophenolate mofetil as an etiological factor? | 2000 | Transplantation | pmid:10972233 |
| Khanna AK | Mechanism of the combination immunosuppressive effects of rapamycin with either cyclosporine or tacrolimus. | 2000 | Transplantation | pmid:10972232 |
| Jain A et al. | Comparative long-term evaluation of tacrolimus and cyclosporine in pediatric liver transplantation. | 2000 | Transplantation | pmid:10972220 |
| Burley JR and Sihra TS | A modulatory role for protein phosphatase 2B (calcineurin) in the regulation of Ca2+ entry. | 2000 | Eur. J. Neurosci. | pmid:10971631 |
| Hartmann A et al. | Intracerebral abscess caused by Nocardia otitidiscaviarum in a renal transplant patient--cured by evacuation plus antibiotic therapy. | 2000 | Nephron | pmid:10971157 |
| Mathieson PW | Cyclosporin: nephro-protective as well as nephrotoxic? | 2000 | Clin. Exp. Immunol. | pmid:10970156 |
| Teperman L | Case studies in orthotopic liver transplantation for hepatitis B: a panel discussion. | 2000 | Clin Transplant | pmid:10965964 |
| Sakamoto Y et al. | Correlation between neurotoxic events and intracerebral concentration of tacrolimus in rats. | 2000 | Biol. Pharm. Bull. | pmid:10963314 |
| Halloran PF | Sirolimus and cyclosporin for renal transplantation. | 2000 | Lancet | pmid:10963190 |
| Taylor DO | Immunosuppressive therapies after heart transplantation: best, better, and beyond. | 2000 | Curr. Opin. Cardiol. | pmid:10963148 |
| Mogi M et al. | Increase in level of tumor necrosis factor-alpha in 6-hydroxydopamine-lesioned striatum in rats is suppressed by immunosuppressant FK506. | 2000 | Neurosci. Lett. | pmid:10961655 |
| Blomberg B and Järnerot G | Clinical evaluation and management of acute severe colitis. | 2000 | Inflamm. Bowel Dis. | pmid:10961594 |
| Delaney MP et al. | Constitutive and acquired resistance to calcineurin inhibitors in renal transplantation: role of P-glycoprotein-170. | 2000 | Transpl. Int. | pmid:10959480 |
| Uchiyama H et al. | Increased urinary nitrate excretion associated with hepatic allograft rejection in experimental rat models and clinical cases. | 2000 | Transpl. Int. | pmid:10959478 |
| Stahl B et al. | [Tacrolimus treatment during pregnancy in organ-transplanted women]. | 1999 | Harefuah | pmid:10959392 |
| Hisamatsu T and Watanabe M | Tacrolimus (FK506), a novel immunosuppressive drug for inflammatory bowel disease? | 2000 | J. Gastroenterol. | pmid:10955609 |
| Matsuhashi N et al. | Tacrolimus in corticosteroid-resistant ulcerative colitis. | 2000 | J. Gastroenterol. | pmid:10955604 |
| Klauss V et al. | Cyclosporine versus tacrolimus (FK 506) for prevention of cardiac allograft vasculopathy. | 2000 | Am. J. Cardiol. | pmid:10955391 |
| Oliverio PJ et al. | Reversible tacrolimus-induced neurotoxicity isolated to the brain stem. | 2000 | AJNR Am J Neuroradiol | pmid:10954277 |
| Boxenbaum H | Cytochrome P450 3A4 in vivo ketoconazole competitive inhibition: determination of Ki and dangers associated with high clearance drugs in general. | 1999 May-Aug | J Pharm Pharm Sci | pmid:10952769 |
| Morton SJ and Powell RJ | Cyclosporin and tacrolimus: their use in a routine clinical setting for scleroderma. | 2000 | Rheumatology (Oxford) | pmid:10952740 |
| Hashimoto M et al. | Short-course immunosuppression using FK506 for rat tracheal allografts. | 2000 | J Cardiovasc Surg (Torino) | pmid:10952347 |
| Kyles AE et al. | Comparison of the in vitro antiproliferative effects of five immunosuppressive drugs on lymphocytes in whole blood from cats. | 2000 | Am. J. Vet. Res. | pmid:10951980 |
| Zhang Y et al. | Phosphatidylinositol 4-phosphate 5-kinase Its3 and calcineurin Ppb1 coordinately regulate cytokinesis in fission yeast. | 2000 | J. Biol. Chem. | pmid:10950958 |
| Jones JW et al. | Successful hand transplantation. One-year follow-up. Louisville Hand Transplant Team. | 2000 | N. Engl. J. Med. | pmid:10950668 |
| Verleden GM | Bronchiolitis obliterans syndrome after lung transplantation: medical treatment. | 2000 | Monaldi Arch Chest Dis | pmid:10949876 |
| Straatman LP and Coles JG | Pediatric utilization of rapamycin for severe cardiac allograft rejection. | 2000 | Transplantation | pmid:10949201 |
| Shoker A et al. | Heightened CD40 ligand gene expression in peripheral CD4+ T cells from patients with kidney allograft rejection. | 2000 | Transplantation | pmid:10949194 |
| Kohlhaw K et al. | [Clinical studies in liver transplantation]. | 2000 | Chirurg | pmid:10948733 |
| Li WE and Nagy JI | Connexin43 phosphorylation state and intercellular communication in cultured astrocytes following hypoxia and protein phosphatase inhibition. | 2000 | Eur. J. Neurosci. | pmid:10947839 |
| Sheiner PA | Hepatitis C after liver transplantation. | 2000 | Semin. Liver Dis. | pmid:10946424 |
| Masuda S et al. | Effect of intestinal P-glycoprotein on daily tacrolimus trough level in a living-donor small bowel recipient. | 2000 | Clin. Pharmacol. Ther. | pmid:10945321 |
| Misseghers BS et al. | Clinical observations of the treatment of canine perianal fistulas with topical tacrolimus in 10 dogs. | 2000 | Can. Vet. J. | pmid:10945128 |
| Youn HD et al. | Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis. | 2000 | EMBO J. | pmid:10944115 |
| Flores F and Kerdel FA | Other novel immunosuppressants. | 2000 | Dermatol Clin | pmid:10943542 |
| Hübner GI and Sziegoleit W | Response to letter from van Gelder. Drug interaction between mycophenolate mofetil and tacrolimus detectable within therapeutic mycophenolic acid monitoring in renal transplant patients. | 2000 | Ther Drug Monit | pmid:10942194 |
| Bunn SK et al. | Treatment of microvillus inclusion disease by intestinal transplantation. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:10941971 |
| Woltman AM et al. | The effect of calcineurin inhibitors and corticosteroids on the differentiation of human dendritic cells. | 2000 | Eur. J. Immunol. | pmid:10940869 |
| Bertram PG et al. | Tripartite regulation of Gln3p by TOR, Ure2p, and phosphatases. | 2000 | J. Biol. Chem. | pmid:10940301 |
| Casson DH et al. | Topical tacrolimus may be effective in the treatment of oral and perineal Crohn's disease. | 2000 | Gut | pmid:10940284 |
| Uchida N et al. | Myocardial ischemia following allogeneic bone marrow transplantation: possible implication of tacrolimus overdose. | 2000 | Blood | pmid:10939803 |
| Matsuda S and Koyasu S | [A second target of cyclosporin A and FK506]. | 2000 | Tanpakushitsu Kakusan Koso | pmid:10936966 |
| Endoh M et al. | Nonmuscle myosin heavy chain and metalloproteinase-2 expression in concordant pulmonary xenografts. | 2000 | Transplant. Proc. | pmid:10936397 |
| Goller AL et al. | Loss of serum bicarbonate after discordant liver xenotransplantation. | 2000 | Transplant. Proc. | pmid:10936383 |
| Takayama K et al. | Nonmuscle myosin heavy chain and nuclear factor-kappa B expression in pig-to-primate xenotransplanted hearts. | 2000 | Transplant. Proc. | pmid:10936372 |
| Wada Y et al. | Expression of the transcriptional factor egr-1/BTEB2 in cardiac xenograft vascular remodeling. | 2000 | Transplant. Proc. | pmid:10936371 |
| Miki T et al. | Xenogeneic humoral graft-Vs-host disease following hamster-to-Rat bone marrow transplantation. | 2000 | Transplant. Proc. | pmid:10936339 |
| Song Z et al. | Protective effect of FK-506 in pig-to-rat islet xenotransplantation is abrogated by prednisolone. | 2000 | Transplant. Proc. | pmid:10936332 |
| Yin DP et al. | Efficacy of FK506, leflunomide, anti-CD4, and CTLA4IG treatments in rat to mouse pancreas xenograft transplantation. | 2000 | Transplant. Proc. | pmid:10936320 |
| Takayama K et al. | Hepatocyte growth factor and vascular endothelial growth factor expression in pig-to-primate xenotransplanted hearts. | 2000 | Transplant. Proc. | pmid:10936314 |
| Watanabe T et al. | Effects of the endothelin-1 receptor antagonist TAK-044 on pulmonary injury in discordant xenotransplantation. | 2000 | Transplant. Proc. | pmid:10936270 |
| Minamino T et al. | Chronic treatment with FK506 increases p70 S6 kinase activity associated with reduced nitric oxide synthase activity in rabbit hearts. | 2000 | Cardiovasc Drugs Ther | pmid:10935155 |
| Furlan V et al. | Conversion from cyclosporin A to tacrolimus in pediatric liver transplantation. | 2000 | Pediatr Transplant | pmid:10933321 |
| Chin C et al. | Lipoprotein abnormalities are highly prevalent in pediatric heart transplant recipients. | 2000 | Pediatr Transplant | pmid:10933319 |
| Gruber SA et al. | Initial results of solitary pancreas transplants performed without regard to donor/recipient HLA mismatching. | 2000 | Transplantation | pmid:10933170 |
| Kung L and Halloran PF | Immunophilins may limit calcineurin inhibition by cyclosporine and tacrolimus at high drug concentrations. | 2000 | Transplantation | pmid:10933159 |
| Schmutz J et al. | [Gingival hypertrophy and tacrolimus]. | 2000 Jun-Jul | Ann Dermatol Venereol | pmid:10930868 |
| Jimenez J and Young JB | Clinical challenges in thoracic organ transplantation: case studies in immunosuppressive therapy. | 2000 | J. Heart Lung Transplant. | pmid:10930823 |
| Sakuma S et al. | FK506 potently inhibits T cell activation induced TNF-alpha and IL-1beta production in vitro by human peripheral blood mononuclear cells. | 2000 | Br. J. Pharmacol. | pmid:10928971 |
| Sugiura H et al. | Long-term efficacy of tacrolimus ointment for recalcitrant facial erythema resistant to topical corticosteroids in adult patients with atopic dermatitis. | 2000 | Arch Dermatol | pmid:10926750 |
| Reitamo S et al. | Safety and efficacy of 1 year of tacrolimus ointment monotherapy in adults with atopic dermatitis. The European Tacrolimus Ointment Study Group. | 2000 | Arch Dermatol | pmid:10926735 |
| Puig I Marà JM et al. | Reflex sympathetic dystrophy syndrome of the lower limbs in a renal transplant patient treated with tacrolimus. | 2000 | Transplantation | pmid:10919604 |
| Higgins RM et al. | Conversion from tacrolimus to cyclosporin in stable renal transplant patients: safety, metabolic changes, and pharmacokinetic comparison. | 2000 | Transplantation | pmid:10919600 |
| Younes BS et al. | The effect of immunosuppression on posttransplant lymphoproliferative disease in pediatric liver transplant patients. | 2000 | Transplantation | pmid:10919581 |
| Peduto G et al. | Long-term host unresponsiveness to encapsulated xenogeneic myoblasts after transient immunosuppression. | 2000 | Transplantation | pmid:10919579 |
| Yanik G et al. | Tacrolimus (FK506) and methotrexate as prophylaxis for acute graft-versus-host disease in pediatric allogeneic stem cell transplantation. | 2000 | Bone Marrow Transplant. | pmid:10918426 |
| Nieto Y et al. | Acute pancreatitis during immunosuppression with tacrolimus following an allogeneic umbilical cord blood transplantation. | 2000 | Bone Marrow Transplant. | pmid:10918414 |
| Lee TJ and Kennedy LA | Tacrolimus: an alternative for graft-versus-host disease prevention. | 2000 | Ann Pharmacother | pmid:10917386 |
| Mancilla UE et al. | Primary immunosuppression with tacrolimus in renal transplantation: a multicenter, open-label study. | 1999 Sep-Oct | Adv Ther | pmid:10915396 |
| Yang GS et al. | Intratympanic immunosuppressives for prevention of immune-mediated sensorineural hearing loss. | 2000 | Am J Otol | pmid:10912694 |
| Ellis D | Growth and renal function after steroid-free tacrolimus-based immunosuppression in children with renal transplants. | 2000 | Pediatr. Nephrol. | pmid:10912544 |
| Robertson RP | Successful islet transplantation for patients with diabetes--fact or fantasy? | 2000 | N. Engl. J. Med. | pmid:10911012 |
| Shapiro AM et al. | Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. | 2000 | N. Engl. J. Med. | pmid:10911004 |