Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Fischer L et al. | Three-year Outcomes in De Novo Liver Transplant Patients Receiving Everolimus With Reduced Tacrolimus: Follow-Up Results From a Randomized, Multicenter Study. | 2015 | Transplantation | pmid:26151607 |
Spolidorio LC et al. | The long-term administration of calcineurin inhibitors decreases antioxidant enzyme activity in the rat parotid and submandibular salivary glands. | 2015 | Life Sci. | pmid:26006038 |
Ali H et al. | Mycophenolate mofetil-based salvage as acute GVHD prophylaxis after early discontinuation of tacrolimus and/or sirolimus. | 2015 | Bone Marrow Transplant. | pmid:25365064 |
Lee SC et al. | Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides. | 2015 | Mol. Microbiol. | pmid:26010100 |
Li H et al. | Resistance reversal induced by a combination of fluconazole and tacrolimus (FK506) in Candida glabrata. | 2015 | J. Med. Microbiol. | pmid:25355935 |
Sato K et al. | Late onset of progressive speech impairment due to tacrolimus-associated leukoencephalopathy after kidney transplantation. | 2015 | Int Urol Nephrol | pmid:26071870 |
Pulk RA et al. | Multigene predictors of tacrolimus exposure in kidney transplant recipients. | 2015 | Pharmacogenomics | pmid:26067485 |
Koreth J et al. | A Bortezomib-Based Regimen Offers Promising Survival and Graft-versus-Host Disease Prophylaxis in Myeloablative HLA-Mismatched and Unrelated Donor Transplantation: A Phase II Trial. | 2015 | Biol. Blood Marrow Transplant. | pmid:26055298 |
Sikma MA et al. | Pharmacokinetics and Toxicity of Tacrolimus Early After Heart and Lung Transplantation. | 2015 | Am. J. Transplant. | pmid:26053114 |
Rozman Peterka T et al. | Solid state compatibility study and characterization of a novel degradation product of tacrolimus in formulation. | 2015 | J Pharm Biomed Anal | pmid:25804434 |
Pardi C and Oltean M | An unusual case of red blood cell immunisation following liver transplantation. | 2015 | Blood Transfus | pmid:26057497 |
Chen YB et al. | Phase II Trial of Tandem High-Dose Chemotherapy with Autologous Stem Cell Transplantation Followed by Reduced-Intensity Allogeneic Stem Cell Transplantation for Patients with High-Risk Lymphoma. | 2015 | Biol. Blood Marrow Transplant. | pmid:26009261 |
Ribero S et al. | Efficacy of topical tacrolimus for oral lichen planus: real-life experience in a retrospective cohort of patients with a review of the literature. | 2015 | J Eur Acad Dermatol Venereol | pmid:25308924 |
Revollo J | Update on the clinical utility of once-daily tacrolimus in the management of transplantation. | 2015 | Drug Des Devel Ther | pmid:26005334 |
Qasim W et al. | Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient. | 2015 | J. Hepatol. | pmid:25308176 |
Cortes X et al. | Successful use of infliximab and tacrolimus in a patient with Crohn's disease. | 2015 | Int J Clin Pharmacol Ther | pmid:25997551 |
Chan TM | Treatment of severe lupus nephritis: the new horizon. | 2015 | Nat Rev Nephrol | pmid:25421826 |
Brännström M et al. | Livebirth after uterus transplantation. | 2015 | Lancet | pmid:25301505 |
de Weerd AE et al. | ABO-incompatible kidney transplant recipients have a higher bleeding risk after antigen-specific immunoadsorption. | 2015 | Transpl. Int. | pmid:25070762 |
Andreu F et al. | Development of a population PK model of tacrolimus for adaptive dosage control in stable kidney transplant patients. | 2015 | Ther Drug Monit | pmid:25254416 |
Fussner LA et al. | Cardiovascular disease after liver transplantation: When, What, and Who Is at Risk. | 2015 | Liver Transpl. | pmid:25880971 |
Abuabara K et al. | Atopic dermatitis disease control and age: A cohort study. | 2015 | J. Allergy Clin. Immunol. | pmid:25935107 |
Clark SL et al. | Making every drop count for pediatric kidney transplant patients. | 2015 | Hosp Pediatr | pmid:25934814 |
de Sandes-Freitas TV et al. | Subclinical Lesions and Donor-Specific Antibodies in Kidney Transplant Recipients Receiving Tacrolimus-Based Immunosuppressive Regimen Followed by Early Conversion to Sirolimus. | 2015 | Transplantation | pmid:25929604 |
Cheng S and Rodier F | Manipulating senescence in health and disease: emerging tools. | 2015 | Cell Cycle | pmid:25928330 |
Hricik DE et al. | Adverse Outcomes of Tacrolimus Withdrawal in Immune-Quiescent Kidney Transplant Recipients. | 2015 | J. Am. Soc. Nephrol. | pmid:25925687 |
Matas AJ and Gaston RS | Moving Beyond Minimization Trials in Kidney Transplantation. | 2015 | J. Am. Soc. Nephrol. | pmid:25925686 |
Falloon K et al. | Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus. | 2015 | PLoS ONE | pmid:26366742 |
Ikitimur B et al. | Long-Term Impact of Different Immunosuppressive Drugs on QT and PR Intervals in Renal Transplant Patients. | 2015 | Ann Noninvasive Electrocardiol | pmid:25367596 |
Ganetsky A et al. | Lack of a significant pharmacokinetic interaction between maraviroc and tacrolimus in allogeneic HSCT recipients. | 2015 | J. Antimicrob. Chemother. | pmid:25881619 |
Goldthorpe H et al. | Occlusive lung arterial lesions in endothelial-targeted, fas-induced apoptosis transgenic mice. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25879383 |
Chapron B et al. | Reversible, time-dependent inhibition of CYP3A-mediated metabolism of midazolam and tacrolimus by telaprevir in human liver microsomes. | 2015 | J Pharm Pharm Sci | pmid:25877445 |
Nashan B et al. | Evaluating the efficacy, safety and evolution of renal function with early initiation of everolimus-facilitated tacrolimus reduction in de novo liver transplant recipients: Study protocol for a randomized controlled trial. | 2015 | Trials | pmid:25873064 |
Ramachandran R et al. | Chronic nephrotoxicity limits successful use of Tacrolimus in the management of adult steroid-dependent minimal change disease. | 2015 | Nephrology (Carlton) | pmid:25872662 |
Shahraki M et al. | Influence of Tacrolimus (FK506) on Nerve Regeneration Using Allografts: A Rat Sciatic Nerve Model. | 2015 | J. Oral Maxillofac. Surg. | pmid:25869987 |
Zijlstra LE et al. | [Heart transplantation in the 21st century in Netherlands: improved survival in the last decade]. | 2015 | Ned Tijdschr Geneeskd | pmid:26648576 |
Söderlund C and Rådegran G | Immunosuppressive therapies after heart transplantation--The balance between under- and over-immunosuppression. | 2015 | Transplant Rev (Orlando) | pmid:25812489 |
Zegarska J et al. | Mycophenolic Acid Metabolites Acyl-Glucuronide and Glucoside Affect the Occurrence of Infectious Complications and Bone Marrow Dysfunction in Liver Transplant Recipients. | 2015 | Ann. Transplant. | pmid:26313036 |
Dave V et al. | Managing psychosis in a renal transplant recipient with bipolar affective disorder and allograft rejection. | 2015 | Nephrology (Carlton) | pmid:25807849 |
Hlavaty KA et al. | Cellular and molecular targeting for nanotherapeutics in transplantation tolerance. | 2015 | Clin. Immunol. | pmid:25805659 |
Halvorsen JA and Aasebø W | Oral tacrolimus treatment of pruritus in prurigo nodularis. | 2015 | Acta Derm. Venereol. | pmid:25804254 |
Stevens RB et al. | A randomized 2×2 factorial trial, part 1: single-dose rabbit antithymocyte globulin induction may improve renal transplantation outcomes. | 2015 | Transplantation | pmid:25083614 |
La Placa M et al. | Disfiguring papular sarcoidosis of the face: dramatic improvement with pimecrolimus. | 2015 | J Eur Acad Dermatol Venereol | pmid:25073484 |
Ravaioli M et al. | Immunosuppression Modifications Based on an Immune Response Assay: Results of a Randomized, Controlled Trial. | 2015 | Transplantation | pmid:25757214 |
Bis DM et al. | Characterization of the nocardiopsin biosynthetic gene cluster reveals similarities to and differences from the rapamycin and FK-506 pathways. | 2015 | Chembiochem | pmid:25755076 |
Rahman Z et al. | Comparison of X-ray powder diffraction and solid-state nuclear magnetic resonance in estimating crystalline fraction of tacrolimus in sustained-release amorphous solid dispersion and development of discriminating dissolution method. | 2015 | J Pharm Sci | pmid:25753829 |
Garritsen FM et al. | Ten years experience with oral immunosuppressive treatment in adult patients with atopic dermatitis in two academic centres. | 2015 | J Eur Acad Dermatol Venereol | pmid:25752497 |
Qian G et al. | Successful treatment of recalcitrant granulomatous rosacea with oral thalidomide and topical pimecrolimus. | 2015 | J. Dermatol. | pmid:25753523 |
Pennington CA et al. | Evaluation of a Weight-based Rabbit Anti-thymocyte Globulin Induction Dosing Regimen for Kidney Transplant Recipients. | 2015 | Pharmacotherapy | pmid:26234282 |
Zhu L et al. | Adrenergic stimulation sensitizes TRPV1 through upregulation of cystathionine β-synthetase in a rat model of visceral hypersensitivity. | 2015 | Sci Rep | pmid:26527188 |
Wu D et al. | BK Virus-Associated Nephropathy with Plasma Cell-Rich Infiltrates Treated by Bortezomib-Based Regimen. | 2015 | Exp Clin Transplant | pmid:25748726 |
Jo GA et al. | Isolation and characterization of a 17-kDa FKBP-type peptidyl-prolyl cis/trans isomerase from Vibrio anguillarum. | 2015 | Protein Expr. Purif. | pmid:25747528 |
Tachibana T et al. | Successful Engraftment and Durable Graft-versus-host Disease Control with Haploidentical Peripheral Blood and a Short-term Conditioning Regimen for Primary Graft Failure. | 2015 | Intern. Med. | pmid:26521905 |
Liu J et al. | Adherence to Immunosuppressive Medication in Renal Transplant Recipients From Follow-up Outpatient in China: Association of 2 Different Measurement Methods. | 2015 | Clin Ther | pmid:26519232 |
Vanhove T et al. | Response to 'Tacrolimus pharmacokinetics after kidney transplantation--Influence of changes in haematocrit and steroid dose'. | 2015 | Br J Clin Pharmacol | pmid:26235051 |
Hanifin JM | A Reassuring Rejoinder Against Malignant Influences of Topical Calcineurin Use in Children. | 2015 | JAMA Dermatol | pmid:25692944 |
Margolis DJ et al. | Association Between Malignancy and Topical Use of Pimecrolimus. | 2015 | JAMA Dermatol | pmid:25692459 |
Shuker N et al. | Intra-patient variability in tacrolimus exposure: causes, consequences for clinical management. | 2015 | Transplant Rev (Orlando) | pmid:25687818 |
Fan DM et al. | Successful ABO-incompatible living-related intestinal transplantation: a 2-year follow-up. | 2015 | Am. J. Transplant. | pmid:25808777 |
Kawakami K et al. | Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis. | 2015 | World J. Gastroenterol. | pmid:25684955 |
Al Gain M et al. | [Sirolimus-induced lymphedema in a kidney-transplant recipient: Partial recovery after changeover to tacrolimus]. | 2015 | Ann Dermatol Venereol | pmid:25683011 |
Matsushima M et al. | [A case of anti-PL7 antibody positive myositis and a clinical and pathological review of the anti-synthetase syndrome]. | 2015 | Rinsho Shinkeigaku | pmid:26458569 |
Kim S et al. | Reduction of increased calcineurin activity rescues impaired homeostatic synaptic plasticity in presenilin 1 M146V mutant. | 2015 | Neurobiol. Aging | pmid:26455952 |
Fukuta T et al. | Treatment of stroke with liposomal neuroprotective agents under cerebral ischemia conditions. | 2015 | Eur J Pharm Biopharm | pmid:26455340 |
Almeida-Corrêa S et al. | Calcineurin inhibition blocks within-, but not between-session fear extinction in mice. | 2015 | Learn. Mem. | pmid:25691516 |
Leneghan D and Bell A | Immunophilin-protein interactions in Plasmodium falciparum. | 2015 | Parasitology | pmid:26156578 |
Luo X et al. | Evaluation of 6β-Hydroxycortisol and 6β-Hydroxycortisone as Biomarkers for Cytochrome P450 3A Activity: Insight into Their Predictive Value for Estimating Oral Immunosuppressant Metabolism. | 2015 | J Pharm Sci | pmid:26150050 |
Herbst S et al. | Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus. | 2015 | EMBO Mol Med | pmid:25637383 |
Cuellar-Rodriguez J et al. | Matched related and unrelated donor hematopoietic stem cell transplantation for DOCK8 deficiency. | 2015 | Biol. Blood Marrow Transplant. | pmid:25636378 |
Schoettler M et al. | Treatment and outcomes of immune cytopenias following solid organ transplant in children. | 2015 | Pediatr Blood Cancer | pmid:25308853 |
Joneja U and Uppal G | Pseudo-Pelger-Huët anomaly in a patient on tacrolimus. | 2015 | Blood | pmid:26371350 |
Chung H et al. | Renal transplantation: better fat than thin. | 2015 | J. Surg. Res. | pmid:25634827 |
Ustundag UV et al. | The effects of tacrolimus on the activity and expression of tissue factor in the rat ovary with ischemia-reperfusion induced injury. | 2015 | Reprod Biol | pmid:26370456 |
Mok CC | Mycophenolate mofetil for lupus nephritis: an update. | 2015 | Expert Rev Clin Immunol | pmid:26364748 |
Satake K et al. | Olopatadine hydrochloride suppresses hot flashes induced by topical treatment with tacrolimus ointment in rats. | 2015 | Eur. J. Pharmacol. | pmid:26362749 |
Gao L and Sun Y | In vitro interactions of antifungal agents and tacrolimus against Aspergillus biofilms. | 2015 | Antimicrob. Agents Chemother. | pmid:26303797 |
Kawahara T et al. | Cyclosporine A and tacrolimus inhibit bladder cancer growth through down-regulation of NFATc1. | 2015 | Oncotarget | pmid:25638160 |
Dagher M et al. | Overweight, central obesity, and cardiometabolic risk factors in pediatric liver transplantation. | 2015 | Pediatr Transplant | pmid:25581506 |
Kita A et al. | Imp2, the PSTPIP homolog in fission yeast, affects sensitivity to the immunosuppressant FK506 and membrane trafficking in fission yeast. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25580011 |
Cortina G et al. | De novo tacrolimus-induced thrombotic microangiopathy in the early stage after renal transplantation successfully treated with conversion to everolimus. | 2015 | Pediatr. Nephrol. | pmid:25577332 |
Annunziato RA et al. | Can transition to adult care for transplant recipients be improved by intensified services while patients are still in pediatrics? | 2015 | Prog Transplant | pmid:26308783 |
Pape E et al. | Management of Tacrolimus-Telaprevir Drug-Drug Interaction in a Liver Transplant Patient With Hepatitis C Virus: Practical Considerations. | 2015 | Transplantation | pmid:26308424 |
Iwamoto T et al. | Effect of Genetic Polymorphism of CYP3A5 and CYP2C19 and Concomitant Use of Voriconazole on Blood Tacrolimus Concentration in Patients Receiving Hematopoietic Stem Cell Transplantation. | 2015 | Ther Drug Monit | pmid:25565672 |
Ruiz J et al. | Impact of Single Nucleotide Polymorphisms (SNPs) on Immunosuppressive Therapy in Lung Transplantation. | 2015 | Int J Mol Sci | pmid:26307985 |
Yao X et al. | Limited Sampling Strategy for Mycophenolic Acid in Chinese Kidney Transplant Recipients Receiving Enteric-Coated Mycophenolate Sodium and Tacrolimus During the Early Posttransplantation Phase. | 2015 | Ther Drug Monit | pmid:25565669 |
Nelson R et al. | Sirolimus, tacrolimus and antithymocyte globulin as GVHD prophylaxis in HLA-mismatched unrelated donor hematopoietic cell transplantation: a single institution experience. | 2015 | Bone Marrow Transplant. | pmid:26301969 |
Cavalié M et al. | Maintenance therapy of adult vitiligo with 0.1% tacrolimus ointment: a randomized, double blind, placebo-controlled study. | 2015 | J. Invest. Dermatol. | pmid:25521460 |
Reddy YN et al. | Is there a genetic predisposition to new-onset diabetes after kidney transplantation? | 2015 | Saudi J Kidney Dis Transpl | pmid:26586047 |
Bauters T et al. | Practical considerations in the use of intravenous tacrolimus in hematopoietic stem cell transplantation patients. | 2015 | J Oncol Pharm Pract | pmid:24748582 |
Yu Y et al. | Investigation into the interchangeability of generic formulations using immunosuppressants and a broad selection of medicines. | 2015 | Eur. J. Clin. Pharmacol. | pmid:26062932 |
Millner L et al. | A clinical approach to solving discrepancies in therapeutic drug monitoring results for patients on sirolimus or tacrolimus: Towards personalized medicine, immunosuppression and pharmacogenomics. | 2015 | Clin. Chim. Acta | pmid:26232156 |
Tornatore KM et al. | Influence of sex and race on mycophenolic acid pharmacokinetics in stable African American and Caucasian renal transplant recipients. | 2015 | Clin Pharmacokinet | pmid:25511793 |
Li JL et al. | Interactive effects of CYP3A4, CYP3A5, MDR1 and NR1I2 polymorphisms on tracrolimus trough concentrations in early postrenal transplant recipients. | 2015 | Pharmacogenomics | pmid:26228923 |
Zhu LQ et al. | Posterior reversible encephalopathy syndrome and graft-versus-host disease after liver transplantation: a case report and review of the literature. | 2015 | Int J Clin Pharmacol Ther | pmid:26227100 |
Zhang JJ et al. | The genetic polymorphisms of POR*28 and CYP3A5*3 significantly influence the pharmacokinetics of tacrolimus in Chinese renal transplant recipients. | 2015 | Int J Clin Pharmacol Ther | pmid:26227094 |
Peake RW et al. | Multicenter evaluation of the thermo scientific prelude for measurement of immunosuppressant drugs using sample preparation liquid chromatography-tandem mass spectrometry. | 2015 | Ther Drug Monit | pmid:25072947 |
Mettang T and Kremer AE | Uremic pruritus. | 2015 | Kidney Int. | pmid:24402092 |
Allison SJ | Lupus nephritis: Multitarget induction therapy for LN. | 2015 | Nat Rev Nephrol | pmid:25421833 |
Tan ES et al. | Effective treatment of scrotal lichen simplex chronicus with 0.1% tacrolimus ointment: an observational study. | 2015 | J Eur Acad Dermatol Venereol | pmid:24666218 |
Takeuchi S et al. | Pruritus of patients with atopic dermatitis in daily life and their experience of therapeutic effects: results of a web-based questionnaire survey. | 2015 | Br. J. Dermatol. | pmid:25421804 |