Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Wollenberg A et al. | Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment. | 2008 | Allergy | pmid:18445188 |
Simon D et al. | Inflammatory cell numbers and cytokine expression in atopic dermatitis after topical pimecrolimus treatment. | 2005 | Allergy | pmid:15932386 |
Leonardi S et al. | Efficacy and safety of tacrolimus ointment 0.03% treatment in a 1-month-old "red baby": a case report. | 2006 Nov-Dec | Allergy Asthma Proc | pmid:17176789 |
Pacor ML et al. | Tacrolimus ointment in nickel sulphate-induced steroid-resistant allergic contact dermatitis. | 2006 Nov-Dec | Allergy Asthma Proc | pmid:17176790 |
Rico MJ and Lawrence I | Tacrolimus ointment for the treatment of atopic dermatitis: clinical and pharmacologic effects. | 2002 May-Jun | Allergy Asthma Proc | pmid:12125507 |
Szema AM | Angioedema in a child with a liver transplant, intussusception, and normal c4 levels. | 2010 Jul-Aug | Allergy Asthma Proc | pmid:20615276 |
Kay AB | Immunosuppressive agents in chronic severe asthma. | 1994 May-Jun | Allergy Proc | pmid:7523242 |
Wilhelmi E et al. | Organotypic brain-slice cultures from adult rats: approaches for a prolonged culture time. | 2002 May-Jun | Altern Lab Anim | pmid:12106005 |
Mcauliffe EP | Is tacrolimus the best therapy for atopic dermatitis? | 2003 | Am Fam Physician | pmid:12751651 |
Lane JE and Johnson J | Persistent penile patch. | 2008 | Am Fam Physician | pmid:19007056 |
Russell JJ | Topical tacrolimus: a new therapy for atopic dermatitis. | 2002 | Am Fam Physician | pmid:12469964 |
Berke R et al. | Atopic dermatitis: an overview. | 2012 | Am Fam Physician | pmid:22962911 |
Hitzeman N and Kinnevey C | Topical Tacrolimus for Eczema. | 2016 | Am Fam Physician | pmid:27929217 |
Baran DA et al. | Calcineurin inhibitor-associated early renal insufficiency in cardiac transplant recipients: risk factors and strategies for prevention and treatment. | 2004 | Am J Cardiovasc Drugs | pmid:14967063 |
Ramirez R et al. | Posterior Reversible Encephalopathy Syndrome After Orthotopic Heart Transplantation: A Case Report. | 2017 | Am J Case Rep | pmid:28465499 |
Kawamura H et al. | Rapid Induction Therapy with Oral Tacrolimus in Elderly Patients with Refractory Ulcerative Colitis Can Easily Lead to Elevated Tacrolimus Concentrations in Blood: A Report of 5 Cases. | 2017 | Am J Case Rep | pmid:28411286 |
Udomkarnjananun S et al. | An Unusual Manifestation of Calcineurin Inhibitor-Induced Pain Syndrome in Kidney Transplantation: A Case Report and Literature Review. | 2018 | Am J Case Rep | pmid:29654227 |
Frankel HC and Qureshi AA | Comparative effectiveness of topical calcineurin inhibitors in adult patients with atopic dermatitis. | 2012 | Am J Clin Dermatol | pmid:22263704 |
Valdivielso-Ramos M et al. | Significant improvement in extensive lichen sclerosus with tacrolimus ointment and PUVA. | 2008 | Am J Clin Dermatol | pmid:18429647 |
Cook BA and Warshaw EM | Role of topical calcineurin inhibitors in the treatment of seborrheic dermatitis: a review of pathophysiology, safety, and efficacy. | 2009 | Am J Clin Dermatol | pmid:19222250 |