Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Niioka T et al. | Impact of the CYP3A5 genotype on the distributions of dose-adjusted trough concentrations and incidence of rejection in Japanese renal transplant recipients receiving different tacrolimus formulations. | 2017 | Clin. Exp. Nephrol. | pmid:28271256 |
Béland MA et al. | Higher calcineurin inhibitor levels predict better kidney graft survival in patients with de novo donor-specific anti-HLA antibodies: a cohort study. | 2017 | Transpl. Int. | pmid:28186642 |
Colombo M et al. | Influence of Drug Brittleness, Nanomilling Time, and Freeze-Drying on the Crystallinity of Poorly Water-Soluble Drugs and Its Implications for Solubility Enhancement. | 2017 | AAPS PharmSciTech | pmid:28168626 |
Gupta AK and Versteeg SG | Topical Treatment of Facial Seborrheic Dermatitis: A Systematic Review. | 2017 | Am J Clin Dermatol | pmid:27804089 |
Sukkha S et al. | Trough level from twice daily to once daily tacrolimus in early conversion kidney transplant recipients: a prospective study. | 2017 | Int J Clin Pharm | pmid:29101615 |
Song L et al. | ASP2409, A Next-Generation CTLA4-Ig, Versus Belatacept in Renal Allograft Survival in Cynomolgus Monkeys. | 2017 | Am. J. Transplant. | pmid:27598231 |
Zizzo AN et al. | Second-line Agents in Pediatric Patients With Autoimmune Hepatitis: A Systematic Review and Meta-analysis. | 2017 | J. Pediatr. Gastroenterol. Nutr. | pmid:28644343 |
Al-Uzri A et al. | Longitudinal study on the use of dried blood spots for home monitoring in children after kidney transplantation. | 2017 | Pediatr Transplant | pmid:28635157 |
Chen B et al. | Population pharmacokinetics and Bayesian estimation of tacrolimus exposure in Chinese liver transplant patients. | 2017 | J Clin Pharm Ther | pmid:28833329 |
Ekman-Joelsson BM et al. | Post-transplant lymphoproliferative disease is associated with early sternotomy and left ventricular hypoplasia during infancy: a population-based retrospective review. | 2017 | Cardiol Young | pmid:28780922 |
Dorr CR et al. | CRISPR/Cas9 Genetic Modification of in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism. | 2017 | Drug Metab. Dispos. | pmid:28533324 |
Saburi M et al. | Effects of calcineurin inhibitors on sodium excretion in recipients of allogeneic hematopoietic stem cell transplantation. | 2017 | Int. J. Hematol. | pmid:28516402 |
Ferreira A et al. | Donor-Specific Anti-Human Leukocyte Antigens Antibodies, Acute Rejection, Renal Function, and Histology in Kidney Transplant Recipients Receiving Tacrolimus and Everolimus. | 2017 | Am. J. Nephrol. | pmid:28511172 |
Mizuno H et al. | Extranodal NK/T cell lymphoma in a living donor liver transplant recipient. | 2017 | Ann. Hematol. | pmid:28280996 |
Forker R et al. | [AÂ 20-year-old woman with ulcerative colitis and acute liver failure]. | 2017 | Internist (Berl) | pmid:28271269 |
Zhang HJ et al. | Tacrolimus population pharmacokinetics according to CYP3A5 genotype and clinical factors in Chinese adult kidney transplant recipients. | 2017 | J Clin Pharm Ther | pmid:28401703 |
Zanjani H et al. | Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. | 2017 | Cornea | pmid:28399035 |
Piñana JL et al. | A Time-to-Event Model for Acute Kidney Injury after Reduced-Intensity Conditioning Stem Cell Transplantation Using a Tacrolimus- and Sirolimus-based Graft-versus-Host Disease Prophylaxis. | 2017 | Biol. Blood Marrow Transplant. | pmid:28396159 |
Wen Y et al. | Inhibition of Calcineurin A by FK506 Suppresses Seizures and Reduces the Expression of GluN2B in Membrane Fraction. | 2017 | Neurochem. Res. | pmid:28299629 |
Forns X et al. | Efficacy, safety, and pharmacokinetics of simeprevir, daclatasvir, and ribavirin in patients with recurrent hepatitis C virus genotype 1b infection after orthotopic liver transplantation: The Phase II SATURN study. | 2017 | Transpl Infect Dis | pmid:28295849 |
Dhakal P et al. | Eculizumab in Transplant-Associated Thrombotic Microangiopathy. | 2017 | Clin. Appl. Thromb. Hemost. | pmid:26259912 |
Albaghdadi AJ et al. | Tacrolimus in the prevention of adverse pregnancy outcomes and diabetes-associated embryopathies in obese and diabetic mice. | 2017 | J Transl Med | pmid:28193233 |
Wojciechowski D et al. | Early post-transplant conversion from tacrolimus to belatacept for prolonged delayed graft function improves renal function in kidney transplant recipients. | 2017 | Clin Transplant | pmid:28190259 |
Lum EL et al. | Acute Kidney Allograft Rejection Precipitated by Lenalidomide Treatment for Multiple Myeloma. | 2017 | Am. J. Kidney Dis. | pmid:28189378 |
Xie Y et al. | Delayed Donor Bone Marrow Infusion Induces Liver Transplant Tolerance. | 2017 | Transplantation | pmid:28187014 |
Koster RA et al. | Dried blood spot validation of five immunosuppressants, without hematocrit correction, on two LC-MS/MS systems. | 2017 | Bioanalysis | pmid:28300419 |
do Valle IB et al. | Green Teeth in the Primary and Permanent Dentition. | 2017 | J. Pediatr. | pmid:28965735 |
Wang J et al. | The correlation between the expression of genes involved in drug metabolism and the blood level of tacrolimus in liver transplant receipts. | 2017 | Sci Rep | pmid:28611384 |
Chapman WC et al. | Effect of Early Everolimus-Facilitated Reduction of Tacrolimus on Efficacy and Renal Function in De Novo Liver Transplant Recipients: 24-Month Results for the North American Subpopulation. | 2017 | Transplantation | pmid:28121741 |
Sepaskhah M et al. | Comparative efficacy of topical application of tacrolimus and clotrimazole in the treatment of pityriasis versicolor: A single blind, randomised clinical trial. | 2017 | Mycoses | pmid:28120351 |
Arroyo Hornero R et al. | CD45RA Distinguishes CD4+CD25+CD127-/low TSDR Demethylated Regulatory T Cell Subpopulations With Differential Stability and Susceptibility to Tacrolimus-Mediated Inhibition of Suppression. | 2017 | Transplantation | pmid:28118317 |
Zhao YT et al. | Sensitized signalling between L-type Ca2+ channels and ryanodine receptors in the absence or inhibition of FKBP12.6 in cardiomyocytes. | 2017 | Cardiovasc. Res. | pmid:28077437 |
Dun H et al. | ASP0028 in combination with suboptimal-dose of tacrolimus in Cynomolgus monkey renal transplantation model. | 2017 | Transpl. Immunol. | pmid:28077266 |
Herskovitz J et al. | Immune Suppression During Preclinical Drug Development Mitigates Immunogenicity-Mediated Impact on Therapeutic Exposure. | 2017 | AAPS J | pmid:28070711 |
Noguchi A et al. | Differences in therapeutic effects of topically applied corticosteroid and tacrolimus on atopic dermatitis-like symptoms in NC/Nga mice. | 2017 | J. Dermatol. Sci. | pmid:28069324 |
Liberal R et al. | Expert clinical management of autoimmune hepatitis in the real world. | 2017 | Aliment. Pharmacol. Ther. | pmid:28004405 |
Størset E et al. | Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance. | 2017 | Br J Clin Pharmacol | pmid:28008657 |
Segal JP et al. | Systematic review with meta-analysis: the management of chronic refractory pouchitis with an evidence-based treatment algorithm. | 2017 | Aliment. Pharmacol. Ther. | pmid:28008631 |
Bauer JS et al. | dRNA-seq transcriptional profiling of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis NRRL18488 and general analysis of the transcriptome. | 2017 | RNA Biol | pmid:28665778 |
Kalam MA and Alshamsan A | Poly (d, l-lactide-co-glycolide) nanoparticles for sustained release of tacrolimus in rabbit eyes. | 2017 | Biomed. Pharmacother. | pmid:28772219 |
Kapoor A et al. | Posterior Reversible Encephalopathy Syndrome after Heart Transplantation: Diagnosis and Immunosuppressive Therapy. | 2017 | Tex Heart Inst J | pmid:28761402 |
Goldsmith PM et al. | Impact of intrapatient variability (IPV) in tacrolimus trough levels on long-term renal transplant function: multicentre collaborative retrospective cohort study protocol. | 2017 | BMJ Open | pmid:28756385 |
Lewis DJ et al. | Oral bexarotene for post-transplant cutaneous T-cell lymphoma. | 2017 | Dermatol Ther | pmid:28748653 |
Kobayashi I et al. | Tacrolimus in combination with methotrexate and corticosteroid for the treatment of child-onset anti-signal recognition particle antibody-positive necrotizing myopathy. | 2017 | Scand. J. Rheumatol. | pmid:27897449 |
Theile D et al. | Clementine juice has the potential for drug interactions - In vitro comparison with grapefruit and mandarin juice. | 2017 | Eur J Pharm Sci | pmid:27890698 |
Sakassegawa-Naves FE et al. | Tacrolimus Ointment for Refractory Posterior Blepharitis. | 2017 | Curr. Eye Res. | pmid:28922018 |
Iwayama T et al. | Granulomatous reaction to permanent eyebrow makeup successfully treated with topical steroids in combination with topical tacrolimus. | 2017 | Eur J Dermatol | pmid:29311043 |
Pathak S et al. | Single synchronous delivery of FK506-loaded polymeric microspheres with pancreatic islets for the successful treatment of streptozocin-induced diabetes in mice. | 2017 | Drug Deliv | pmid:28911248 |
Grinyó JM et al. | Safety and Efficacy Outcomes 3 Years After Switching to Belatacept From a Calcineurin Inhibitor in Kidney Transplant Recipients: Results From a Phase 2 Randomized Trial. | 2017 | Am. J. Kidney Dis. | pmid:27889299 |
Chucair-Elliott AJ et al. | Colony Stimulating Factor-1 Receptor Expressing Cells Infiltrating the Cornea Control Corneal Nerve Degeneration in Response to HSV-1 Infection. | 2017 | Invest. Ophthalmol. Vis. Sci. | pmid:28903153 |