tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Nocardia Infections D009617 6 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Graft Occlusion, Vascular D006083 11 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Bacterial Infections D001424 21 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Genital Diseases, Female D005831 7 associated lipids
Mouth Diseases D009059 5 associated lipids
Meningococcal Infections D008589 3 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Mycobacterium Infections D009164 7 associated lipids
Sarcoidosis D012507 13 associated lipids
Hepatolenticular Degeneration D006527 3 associated lipids
Hyperglycemia D006943 21 associated lipids
Carcinoma, Squamous Cell D002294 14 associated lipids
Skin Neoplasms D012878 12 associated lipids
Burns D002056 34 associated lipids
Inflammation D007249 119 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Cataract D002386 34 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Precancerous Conditions D011230 48 associated lipids
Postoperative Complications D011183 5 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Surgical Wound Infection D013530 7 associated lipids
Neoplasm Recurrence, Local D009364 5 associated lipids
Osteonecrosis D010020 5 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Per page 10 20 50 100 | Total 613

PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

Download all related citations
Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Zarnt T et al. Time-dependent inhibition of peptidylprolyl cis-trans-isomerases by FK506 is probably due to cis-trans isomerization of the inhibitor's imide bond. 1995 Biochem. J. pmid:7529995
Zeng B et al. Chicken FK506-binding protein, FKBP65, a member of the FKBP family of peptidylprolyl cis-trans isomerases, is only partially inhibited by FK506. 1998 Biochem. J. pmid:9461498
Bandyopadhyay A et al. Calcineurin regulates ryanodine receptor/Ca(2+)-release channels in rat heart. 2000 Biochem. J. pmid:11062058
Hashii M et al. cADP-ribose potentiates cytosolic Ca2+ elevation and Ca2+ entry via L-type voltage-activated Ca2+ channels in NG108-15 neuronal cells. 2000 Biochem. J. pmid:10620496
Tomono M et al. Calcineurin is essential for DNA synthesis in Swiss 3T3 fibroblasts. 1996 Biochem. J. pmid:8760349
Miyamoto S and Safer B Immunosuppressants FK506 and rapamycin have different effects on the biosynthesis of cytoplasmic actin during the early period of T cell activation. 1999 Biochem. J. pmid:10585867
Croxtall JD et al. Differential modulation of glucocorticoid action by FK506 in A549 cells. 2003 Biochem. J. pmid:12948397
Griffiths EJ and Halestrap AP Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin. 1991 Biochem. J. pmid:1706598
Omae T et al. Transient up-regulation of P-glycoprotein reduces tacrolimus absorption after ischemia-reperfusion injury in rat ileum. 2005 Biochem. Pharmacol. pmid:15670575
Woerly G et al. Demonstration of ternary immunophilin-calcineurin complexes with the immunosuppressants cyclosporin and macrolide FK506. 1994 Biochem. Pharmacol. pmid:7514409
Edkins RD et al. Comparison of cyclosporine and FK506 effects on glutathione levels in rat cochlea, brain, liver and kidney. 1992 Biochem. Pharmacol. pmid:1371687
Akool el-S et al. Cyclosporin A and tacrolimus induce renal Erk1/2 pathway via ROS-induced and metalloproteinase-dependent EGF-receptor signaling. 2012 Biochem. Pharmacol. pmid:22100870
Richter A et al. Growth inhibitory effects of FK506 and cyclosporin A independent of inhibition of calcineurin. 1995 Biochem. Pharmacol. pmid:7531976
Kraus-Friedmann N and Feng L Reduction of ryanodine binding and cytosolic Ca2+ levels in liver by the immunosuppressant FK506. 1994 Biochem. Pharmacol. pmid:7529023
Schweizer M et al. Sensitivity of mitochondrial peptidyl-prolyl cis-trans isomerase, pyridine nucleotide hydrolysis and Ca2+ release to cyclosporine A and related compounds. 1993 Biochem. Pharmacol. pmid:7680201
Henthorn DC et al. A GAL4-based yeast three-hybrid system for the identification of small molecule-target protein interactions. 2002 Biochem. Pharmacol. pmid:12007565
Campos CB et al. Ibuprofen-induced Walker 256 tumor cell death: cytochrome c release from functional mitochondria and enhancement by calcineurin inhibition. 2004 Biochem. Pharmacol. pmid:15498510
Kuromitsu S et al. 3-(13-Hydroxytridecyl)-1-[13-(3-pyridyl)tridecyl]pyridinium chloride (YM-53792), a novel inhibitor of NF-AT activation. 1997 Biochem. Pharmacol. pmid:9374420
Sigal NH et al. Observations on the mechanism of action of FK-506. A pharmacologic probe of lymphocyte signal transduction. 1990 Biochem. Pharmacol. pmid:1700909
Aicher L et al. Decrease in kidney calbindin-D 28kDa as a possible mechanism mediating cyclosporine A- and FK-506-induced calciuria and tubular mineralization. 1997 Biochem. Pharmacol. pmid:9113092
Gómez-Lechón MJ et al. The immunosuppressant drug FK506 prevents Fas-induced apoptosis in human hepatocytes. 2004 Biochem. Pharmacol. pmid:15548389
Muramoto M et al. Protective effect of FK506 against apoptosis of SH-SY5Y cells correlates with regulation of the serum inducible kinase gene. 2005 Biochem. Pharmacol. pmid:15857611
Shiraga T et al. Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes. 1994 Biochem. Pharmacol. pmid:7510480
Bell A et al. Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin. 1994 Biochem. Pharmacol. pmid:7520696
Michel G et al. Antioncogene P53 and mitogenic cytokine interleukin-8 aberrantly expressed in psoriatic skin are inversely regulated by the antipsoriatic drug tacrolimus (FK506). 1996 Biochem. Pharmacol. pmid:8787547
Henke W and Jung K Comparison of the effects of the immunosuppressive agents FK 506 and cyclosporin A on rat kidney mitochondria. 1993 Biochem. Pharmacol. pmid:7690566
van Rossum HH et al. Everolimus and sirolimus antagonize tacrolimus based calcineurin inhibition via competition for FK-binding protein 12. 2009 Biochem. Pharmacol. pmid:19154728
Vincent SH et al. Effects of the immunosuppressant FK-506 and its analog FK-520 on hepatic and renal cytochrome P450 mixed-function oxidase. 1991 Biochem. Pharmacol. pmid:1708254
Burnett D et al. Inhibition by FK506 of formyl peptide-induced neutrophil activation and associated protein synthesis. 1994 Biochem. Pharmacol. pmid:7524504
Iwata Y et al. Protective effects of Ca2+ handling drugs against abnormal Ca2+ homeostasis and cell damage in myopathic skeletal muscle cells. 2005 Biochem. Pharmacol. pmid:16009351
Forrest MJ et al. FK-506 and cyclosporin A: selective inhibition of calcium ionophore-induced polymorphonuclear leukocyte degranulation. 1991 Biochem. Pharmacol. pmid:1716098
Steinmetz RD et al. Inhibition of the functional expression of N-methyl-D-aspartate receptors in a stably transformed cell line by cyclosporin A. 2004 Biochem. Pharmacol. pmid:15242822
Tuñón MJ et al. Effects of FK506 and rapamycin on generation of reactive oxygen species, nitric oxide production and nuclear factor kappa B activation in rat hepatocytes. 2003 Biochem. Pharmacol. pmid:12907243
Doe SE et al. Early effects of the immunosuppressive drug FK-506 on signal transduction in lymphocytes. 1990 Biochem. Soc. Trans. pmid:1695581
Charters AR et al. Developmental expression of FK506 binding proteins and calcineurin in rat brain. 1995 Biochem. Soc. Trans. pmid:8566310
Charters AR et al. Immunochemical analysis of FK506 binding proteins in neuronal cell lines and rat brain. 1994 Biochem. Soc. Trans. pmid:7535258
Charters AR et al. The subcellular distribution of FK506 binding proteins in rat brain. 1994 Biochem. Soc. Trans. pmid:7535259
Fenton M and Kay JE Thapsigargin activates lymphocytes via a different pathway from ionomycin. 1993 Biochem. Soc. Trans. pmid:7510649
Pockley AG et al. Effect of cyclosporin A, FK506 and rapamycin on proliferation and soluble IL-2 receptor release from mitogenically stimulated rat spleen cells. 1995 Biochem. Soc. Trans. pmid:8654800
Hall MN The TOR signalling pathway and growth control in yeast. 1996 Biochem. Soc. Trans. pmid:8674674
Mattila PS The actions of cyclosporin A and FK506 on T-lymphocyte activation. 1996 Biochem. Soc. Trans. pmid:8674715
Ng YZ et al. Fluorescence Polarization Assay for Small Molecule Screening of FK506 Biosynthesized in 96-Well Microtiter Plates. 2017 Biochemistry pmid:28841306
Poirier SN et al. FK506 blocks intracellular Ca2+ oscillations in bovine adrenal glomerulosa cells. 2001 Biochemistry pmid:11371212
Rouviere N et al. Immunosuppressor binding to the immunophilin FKBP59 affects the local structural dynamics of a surface beta-strand: time-resolved fluorescence study. 1997 Biochemistry pmid:9200682
Galat A et al. A rapamycin-selective 25-kDa immunophilin. 1992 Biochemistry pmid:1371698
Kueppers P et al. Functional impact of a single mutation within the transmembrane domain of the multidrug ABC transporter Pdr5. 2013 Biochemistry pmid:23464591
Liu J et al. Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity. 1992 Biochemistry pmid:1373650
Xu RX et al. Heteronuclear 3D NMR studies of water bound to an FK506 binding protein/immunosuppressant complex. 1993 Biochemistry pmid:7680570
Harrison RK and Stein RL Substrate specificities of the peptidyl prolyl cis-trans isomerase activities of cyclophilin and FK-506 binding protein: evidence for the existence of a family of distinct enzymes. 1990 Biochemistry pmid:1693856
Egan DA et al. Equilibrium denaturation of recombinant human FK binding protein in urea. 1993 Biochemistry pmid:7680574
Gatto GJ et al. Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme. 2005 Biochemistry pmid:15835888
Yem AW et al. An active FK506-binding domain of 17,000 daltons is isolated following limited proteolysis of chicken thymus hsp56. 1993 Biochemistry pmid:7504525
Main ER et al. Context-dependent nature of destabilizing mutations on the stability of FKBP12. 1998 Biochemistry pmid:9558354
Furutani M et al. FK506 binding protein from a thermophilic archaeon, Methanococcus thermolithotrophicus, has chaperone-like activity in vitro. 2000 Biochemistry pmid:10631007
Fischer S et al. A mechanism for rotamase catalysis by the FK506 binding protein (FKBP). 1993 Biochemistry pmid:7505615
Kotaka M et al. Crystal structure of the FK506 binding domain of Plasmodium falciparum FKBP35 in complex with FK506. 2008 Biochemistry pmid:18465874
Hutchison KA et al. FK506 binding to the 56-kilodalton immunophilin (Hsp56) in the glucocorticoid receptor heterocomplex has no effect on receptor folding or function. 1993 Biochemistry pmid:7682438
Craescu CT et al. Three-dimensional structure of the immunophilin-like domain of FKBP59 in solution. 1996 Biochemistry pmid:8780506
Jana B et al. Domain structure and denaturation of a dimeric Mip-like peptidyl-prolyl cis-trans isomerase from Escherichia coli. 2012 Biochemistry pmid:22263615
Yang CJ et al. Differential Large-Amplitude Breathing Motions in the Interface of FKBP12-Drug Complexes. 2015 Biochemistry pmid:26561008
Connelly PR et al. Probing hydration contributions to the thermodynamics of ligand binding by proteins. Enthalpy and heat capacity changes of tacrolimus and rapamycin binding to FK506 binding protein in D2O and H2O. 1993 Biochemistry pmid:7684925
Tai PK et al. Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506. 1994 Biochemistry pmid:7521210
Mondragon A et al. Overexpression and purification of human calcineurin alpha from Escherichia coli and assessment of catalytic functions of residues surrounding the binuclear metal center. 1997 Biochemistry pmid:9125515
Davies TH et al. Differential control of glucocorticoid receptor hormone-binding function by tetratricopeptide repeat (TPR) proteins and the immunosuppressive ligand FK506. 2005 Biochemistry pmid:15697228
Weiwad M et al. Comparative analysis of calcineurin inhibition by complexes of immunosuppressive drugs with human FK506 binding proteins. 2006 Biochemistry pmid:17176100
Linnert M et al. The FKBP-type domain of the human aryl hydrocarbon receptor-interacting protein reveals an unusual Hsp90 interaction. 2013 Biochemistry pmid:23418784
Rosen MK et al. Proton and nitrogen sequential assignments and secondary structure determination of the human FK506 and rapamycin binding protein. 1991 Biochemistry pmid:1709363
Solomentsev G et al. Conformational Entropy of FK506 Binding to FKBP12 Determined by Nuclear Magnetic Resonance Relaxation and Molecular Dynamics Simulations. 2018 Biochemistry pmid:29412644
Cañadas O et al. Characterization of liposomal tacrolimus in lung surfactant-like phospholipids and evaluation of its immunosuppressive activity. 2004 Biochemistry pmid:15274647
Lepre CA et al. Solution structure of FK506 bound to the R42K, H87V double mutant of FKBP-12. 1994 Biochemistry pmid:7524662
Tai PK et al. P59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptors. 1993 Biochemistry pmid:7689858
Cheng JW et al. 15N NMR relaxation studies of the FK506 binding protein: backbone dynamics of the uncomplexed receptor. 1993 Biochemistry pmid:7690248
Weininger U et al. Dynamics of Aromatic Side Chains in the Active Site of FKBP12. 2017 Biochemistry pmid:27936610
DiLella AG and Craig RJ Exon organization of the human FKBP-12 gene: correlation with structural and functional protein domains. 1991 Biochemistry pmid:1716149
Nielsen JB et al. Biosynthesis of the immunosuppressant immunomycin: the enzymology of pipecolate incorporation. 1991 Biochemistry pmid:2043618
Meadows RP et al. Three-dimensional structure of the FK506 binding protein/ascomycin complex in solution by heteronuclear three- and four-dimensional NMR. 1993 Biochemistry pmid:7678499
Cheng JW et al. 15N NMR relaxation studies of the FK506 binding protein: dynamic effects of ligand binding and implications for calcineurin recognition. 1994 Biochemistry pmid:7512379
Shadidy M et al. Biochemical analysis of mouse FKBP60, a novel member of the FKPB family. 1999 Biochim. Biophys. Acta pmid:10524204
Raufman JP et al. Regulation of calcium-induced exocytosis from gastric chief cells by protein phosphatase-2B (calcineurin). 1997 Biochim. Biophys. Acta pmid:9202177
Karlsson H et al. Energy levels in resting and mitogen-stimulated human lymphocytes during treatment with FK506 or cyclosporin A in vitro. 1997 Biochim. Biophys. Acta pmid:9131051
Chen Z et al. Mutations adjacent to the end of transmembrane helices 6 and 7 independently affect drug efflux capacity of yeast ABC transporter Pdr5p. 2014 Biochim. Biophys. Acta pmid:24333836
Faralli JA et al. Dexamethasone increases αvβ3 integrin expression and affinity through a calcineurin/NFAT pathway. 2013 Biochim. Biophys. Acta pmid:24100160
Ozawa T Elucidation of the ryanodine-sensitive Ca2+ release mechanism of rat pancreatic acinar cells: modulation by cyclic ADP-ribose and FK506. 2004 Biochim. Biophys. Acta pmid:15363629
Hendrych T et al. Characterization of the kinetics and mechanisms of inhibition of drugs interacting with the S. cerevisiae multidrug resistance pumps Pdr5p and Snq2p. 2009 Biochim. Biophys. Acta pmid:19111673
Stasik I et al. Ionomycin-induced apoptosis of thymocytes is independent of Nur77 NBRE or NurRE binding, but is accompanied by Nur77 mitochondrial targeting. 2007 Biochim. Biophys. Acta pmid:17588685
Yu L and Fesik SW pH titration of the histidine residues of cyclophilin and FK506 binding protein in the absence and presence of immunosuppressant ligands. 1994 Biochim. Biophys. Acta pmid:7524680
López E et al. FKBP52 is involved in the regulation of SOCE channels in the human platelets and MEG 01 cells. 2013 Biochim. Biophys. Acta pmid:23228564
Miyamoto S et al. Signal transduction pathways that contribute to increased protein synthesis during T-cell activation. 2000 Biochim. Biophys. Acta pmid:11072066
Swartz DJ et al. P-glycoprotein is fully active after multiple tryptophan substitutions. 2013 Biochim. Biophys. Acta pmid:23261390
Ãœnal CM and Steinert M FKBPs in bacterial infections. 2015 Biochim. Biophys. Acta pmid:25529296
Cen J et al. The new immunosuppressant, isogarcinol, binds directly to its target enzyme calcineurin, unlike cyclosporin A and tacrolimus. 2015 Biochimie pmid:25701551
Allen C et al. Polycaprolactone-b-poly(ethylene oxide) block copolymer micelles as a novel drug delivery vehicle for neurotrophic agents FK506 and L-685,818. 1998 Sep-Oct Bioconjug. Chem. pmid:9736490
Tamura T et al. A quantitative analysis and chemical approach for the reduction of nonspecific binding proteins on affinity resins. 2003 Nov-Dec Bioconjug. Chem. pmid:14624639
DaSilva I et al. Rituximab for Steroid-Dependent or Frequently Relapsing Idiopathic Nephrotic Syndrome in Adults: A Retrospective, Multicenter Study in Spain. 2017 BioDrugs pmid:28534103
Keating GM and Lyseng-Williamson KA Everolimus: a guide to its use in liver transplantation. 2013 BioDrugs pmid:23696253
Patel JK and Kobashigawa JA Tacrolimus in heart transplant recipients: an overview. 2007 BioDrugs pmid:17516709
Zhai J et al. Tacrolimus in the treatment of ocular diseases. 2011 BioDrugs pmid:21443273
Quesniaux VF Immunosuppressants: tools to investigate the physiological role of cytokines. 1993 Bioessays pmid:7507316
Cheng C et al. MARD: a new method to detect differential gene expression in treatment-control time courses. 2006 Bioinformatics pmid:16928738
Aldoss I et al. Cytogenetics Does Not Impact Outcomes in Adult Patients with Acute Lymphoblastic Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation. 2016 Biol. Blood Marrow Transplant. pmid:27044907