tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen CH et al. | Comparison of tuberculosis infection rates in a national database of renal transplant patients with data from a single center in Taiwan. | 2014 | Transplant. Proc. | pmid:24656019 |
| Grinyó JM and Petruzzelli S | Once-daily LCP-Tacro MeltDose tacrolimus for the prophylaxis of organ rejection in kidney and liver transplantations. | 2014 | Expert Rev Clin Immunol | pmid:25407098 |
| Hattori Y et al. | Influence of cytochrome P450 3A5 polymorphisms on viral infection incidence in kidney transplant patients treated with tacrolimus. | 2014 | Transplant. Proc. | pmid:24656015 |
| Uchida J et al. | Effects of conversion from a twice-daily tacrolimus to a once-daily tacrolimus on glucose metabolism in stable kidney transplant recipients. | 2014 | Transplant. Proc. | pmid:24656005 |
| Zaltzman JS et al. | A randomized cross-over comparison of short-term exposure of once-daily extended release tacrolimus and twice-daily tacrolimus on renal function in healthy volunteers. | 2014 | Transpl. Int. | pmid:25160518 |
| Misra DP et al. | Pulmonary co-infection with Nocardia and Aspergillus in a patient with adult-onset Still's disease receiving steroids and tacrolimus. | 2014 | BMJ Case Rep | pmid:25398925 |
| Weng LC et al. | Association between use of FK506 and prevalence of post-transplantation diabetes mellitus in kidney transplant patients. | 2014 | Transplant. Proc. | pmid:24656004 |
| Takahashi K et al. | Safety and efficacy of once-daily modified-release tacrolimus in kidney transplant recipients: interim analysis of multicenter postmarketing surveillance in Japan. | 2014 | Transplant. Proc. | pmid:24655975 |
| Cho JH et al. | Development of novel fast-dissolving tacrolimus solid dispersion-loaded prolonged release tablet. | 2014 | Eur J Pharm Sci | pmid:24388864 |
| Frassetto LA et al. | Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients. | 2014 | Transplantation | pmid:24389906 |
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| Furian L et al. | Everolimus associated with low-dose calcineurin inhibitors, an option in kidney transplant recipients of very old donors. | 2014 | Transplant. Proc. | pmid:25498057 |
| Shin BH et al. | Regulation of anti-HLA antibody-dependent natural killer cell activation by immunosuppressive agents. | 2014 | Transplantation | pmid:24342979 |
| Shivaswamy V et al. | Tacrolimus and sirolimus have distinct effects on insulin signaling in male and female rats. | 2014 | Transl Res | pmid:24361102 |
| Cusinato DA et al. | Relationship of CYP3A5 genotype and ABCB1 diplotype to tacrolimus disposition in Brazilian kidney transplant patients. | 2014 | Br J Clin Pharmacol | pmid:24528196 |
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| McCormack PL | Extended-release tacrolimus: a review of its use in de novo kidney transplantation. | 2014 | Drugs | pmid:25352392 |
| Qi R et al. | FK506 inhibits the mice glomerular mesangial cells proliferation by affecting the transforming growth factor-β and Smads signal pathways. | 2014 | Ren Fail | pmid:24512120 |
| Mocchegiani F et al. | Tacrolimus and Everolimus de novo versus minimization of standard dosage of Tacrolimus provides a similar renal function at one year after liver transplantation: a case-control matched-pairs analysis. | 2014 | Ann. Transplant. | pmid:25347718 |
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| Torres IB et al. | The Interplay between inflammation and fibrosis in kidney transplantation. | 2014 | Biomed Res Int | pmid:24991565 |
| Isoda K et al. | The proton pump inhibitor lansoprazole, but not rabeprazole, the increased blood concentrations of calcineurin inhibitors in Japanese patients with connective tissue diseases. | 2014 | Intern. Med. | pmid:24990333 |
| Hu YM et al. | Casein kinase II inhibition reverses pain hypersensitivity and potentiated spinal N-methyl-D-aspartate receptor activity caused by calcineurin inhibitor. | 2014 | J. Pharmacol. Exp. Ther. | pmid:24610957 |
| Wada A et al. | Ribosome display and photo-cross-linking techniques for in vitro identification of target proteins of bioactive small molecules. | 2014 | Anal. Chem. | pmid:24380432 |
| Bäckman L and Persson CA | An observational study evaluating tacrolimus dose, exposure, and medication adherence after conversion from twice- to once-daily tacrolimus in liver and kidney transplant recipients. | 2014 | Ann. Transplant. | pmid:24637379 |
| Buendia JA et al. | Effects of combinational CYP3A5 6986A>G polymorphism in graft liver and native intestine on the pharmacokinetics of tacrolimus in liver transplant patients: a meta-analysis. | 2014 | Ther Drug Monit | pmid:24378577 |
| Mai HL et al. | IL-7 receptor blockade following T cell depletion promotes long-term allograft survival. | 2014 | J. Clin. Invest. | pmid:24569454 |
| Eid L et al. | Late acute rejection: incidence, risk factors, and effect on graft survival and function. | 2014 | Pediatr Transplant | pmid:24372967 |
| Peng ZG and Tian J | Higher Serum Trough Levels of Tacrolimus Increase 5-Year Allograft Survival in Antibody Positive Renal Transplant Patients. | 2014 | Clin Transpl | pmid:26281147 |
| Tokuoka H et al. | Nurr1 expression is regulated by voltage-dependent calcium channels and calcineurin in cultured hippocampal neurons. | 2014 | Neurosci. Lett. | pmid:24291696 |
| Filler G et al. | Similar MPA exposure on modified release and regular tacrolimus. | 2014 | Ther Drug Monit | pmid:24365986 |
| Hancock WW | Effects of histone deacetylase inhibitors on alloresponses. | 2014 | Lancet Oncol. | pmid:24295573 |
| Jain A et al. | Delayed introduction of tacrolimus postliver transplant with intravenous mycophenolate mofetil preserves renal function without incurring rejection. | 2014 | Transplantation | pmid:25285953 |
| Czubkowski P et al. | Cardiovascular risk factors after conversion from cyclosporine to tacrolimus in children after liver transplantation. | 2014 | Ann. Transplant. | pmid:25409773 |
| Guitard J et al. | An unexpected diagnosis in a renal-transplant patient with proteinuria treated with everolimus: AL amyloidosis. | 2014 | Clin. Nephrol. | pmid:24040781 |
| Protic M et al. | The effectiveness and safety of rescue treatments in 108 patients with steroid-refractory ulcerative colitis with sequential rescue therapies in a subgroup of patients. | 2014 | J Crohns Colitis | pmid:24908178 |
| Hayashi K et al. | Delayed false elevation of circulating tacrolimus concentrations after cord blood transplantation in a patient with myelodysplastic syndrome. | 2014 | Intern. Med. | pmid:25400189 |
| Spagnoletti G et al. | Conversion from Prograf to Advagraf in stable kidney transplant recipients: better renal function after 3-year follow-up. | 2014 | Transplant. Proc. | pmid:25242756 |
| Schellekens J et al. | The Maastricht Transplant Center: clinical setting and epitope searches in HLA class II molecules: does the structural localization of a polymorphic site contribute to its immunogenicity? | 2014 | Transpl. Immunol. | pmid:25240735 |
| Sharp WW et al. | Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission. | 2014 | FASEB J. | pmid:24076965 |
| Peng L et al. | The calcineurin inhibitor tacrolimus reduces proteinuria in membranous nephropathy accompanied by a decrease in angiopoietin-like-4. | 2014 | PLoS ONE | pmid:25165975 |
| Favennec C et al. | Consideration of the switch from twice-daily to once-daily tacrolimus in pediatric kidney transplant in daily clinical practice: pharmacokinetic parameters, patient satisfaction and medical practices. | 2014 | Pediatr Transplant | pmid:25164065 |
| Gupta AK et al. | Efficient neutrophil extracellular trap induction requires mobilization of both intracellular and extracellular calcium pools and is modulated by cyclosporine A. | 2014 | PLoS ONE | pmid:24819773 |
| Hagihara Y et al. | Infliximab and/or immunomodulators inhibit immune responses to trivalent influenza vaccination in adults with inflammatory bowel disease. | 2014 | J Crohns Colitis | pmid:24011513 |
| Kilinc S et al. | The effects of preoperative immunosuppressive therapy on ischemia and reperfusion (I/R) injury in healthy rats. | 2014 | Int Urol Nephrol | pmid:24014133 |
| Gürkan A et al. | Alpha 2 integrin gene (ITGA2) polymorphism in renal transplant recipients with and without drug induced gingival overgrowth. | 2014 | Arch. Oral Biol. | pmid:24581850 |
| Spasovski G and Masin-Spasovska J | How to improve the survival of the kidney transplant - is it only the pharmaceutical management? | 2014 | Expert Opin Pharmacother | pmid:24617949 |
| Amanova A et al. | Colchicine levels in chronic kidney diseases and kidney transplant recipients using tacrolimus. | 2014 | Clin Transplant | pmid:25125128 |
| Kim JS et al. | Effects of FK-506 and CTLA4--Ig on nerve allografts in mice. | 2014 | J Plast Reconstr Aesthet Surg | pmid:24120418 |
| Schmid S et al. | Volatility of serum creatinine relative to tacrolimus levels predicts kidney transplant rejection. | 2014 | Ann. Transplant. | pmid:25123847 |
| Caraveo G et al. | Calcineurin determines toxic versus beneficial responses to α-synuclein. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25122673 |
| Gajanayake T et al. | A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft. | 2014 | Sci Transl Med | pmid:25122638 |
| Thorat A et al. | Effects of converting tacrolimus formulation from twice-daily to once-daily in liver transplantation recipients. | 2014 | Biomed Res Int | pmid:25121091 |
| Griffith RD et al. | Cells to surgery quiz: September 2014. | 2014 | J. Invest. Dermatol. | pmid:25120152 |
| Farkas K et al. | Ability of different rescue therapies to save the bowel in acute, severe, steroid-refractory ulcerative colitis. | 2014 | Expert Rev Gastroenterol Hepatol | pmid:24738535 |
| Li T et al. | Effect of FK506 nanospheres on regeneration of allogeneic nerve after transplant. | 2014 | Asian Pac J Trop Med | pmid:25066398 |
| Hamilton BK and Kalaycio M | Maximizing the benefits of mycophenolate mofetil as graft-versus-host disease prophylaxis. | 2014 | Biol. Blood Marrow Transplant. | pmid:25065905 |
| Verghese PS et al. | Calcineurin inhibitors in HLA-identical living related donor kidney transplantation. | 2014 | Nephrol. Dial. Transplant. | pmid:24414376 |
| Shimizu M et al. | Treatment of refractory polyarticular juvenile idiopathic arthritis with tacrolimus. | 2014 | Rheumatology (Oxford) | pmid:25065006 |
| Da-Long S et al. | Tacrolimus on Kimura's disease: a case report. | 2014 | Oral Surg Oral Med Oral Pathol Oral Radiol | pmid:22939325 |
| Dai YJ et al. | Effect of pharmacological intervention on MIP-1α, MIP-1β and MCP-1 expression in patients with psoriasis vulgaris. | 2014 | Asian Pac J Trop Med | pmid:25063291 |
| Kyriakou A et al. | Therapeutic efficacy of topical calcineurin inhibitors in plasma cell balanitis: case series and review of the literature. | 2014 | Dermatology (Basel) | pmid:24434685 |
| Parvizi Z et al. | Association between E23K variant in KCNJ11 gene and new-onset diabetes after liver transplantation. | 2014 | Mol. Biol. Rep. | pmid:24996284 |
| Al-Harbi NO et al. | Olmesartan attenuates tacrolimus-induced biochemical and ultrastructural changes in rat kidney tissue. | 2014 | Biomed Res Int | pmid:24987695 |
| Sun J et al. | [A preliminary study on the biological characteristics and function of tolerogenic dendritic cells induced by tacrolimus]. | 2014 | Zhonghua Xue Ye Xue Za Zhi | pmid:24985179 |
| Saracino A et al. | Multidrug-resistance 1 gene single-nucleotide polymorphisms do not influence long-term graft survival after kidney transplantation. | 2014 | Transplant. Proc. | pmid:25242754 |
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| Fuchs U et al. | Incidence of malignant neoplasia after heart transplantation--a comparison between cyclosporine a and tacrolimus. | 2014 | Ann. Transplant. | pmid:24953848 |
| Ji SM et al. | Retrospective evaluation of the effect of mycophenolate mofetil dosage on survival of kidney grafts based on biopsy results. | 2014 | Transplant. Proc. | pmid:25498056 |
| Elamin S et al. | Co-administration of ketoconazole and tacrolimus to kidney transplant recipients: cost minimization and potential metabolic benefits. | 2014 | Saudi J Kidney Dis Transpl | pmid:24969193 |
| Gibbs BF et al. | Highly specific targeting of human leukocytes using gold nanoparticle-based biologically active conjugates. | 2014 | J Biomed Nanotechnol | pmid:24804546 |
| Richards KR et al. | Tacrolimus trough level at discharge predicts acute rejection in moderately sensitized renal transplant recipients. | 2014 | Transplantation | pmid:24784360 |
| Cutler C et al. | Tacrolimus/sirolimus vs tacrolimus/methotrexate as GVHD prophylaxis after matched, related donor allogeneic HCT. | 2014 | Blood | pmid:24982504 |
| Hebral AL et al. | Pregnancy after kidney transplantation: outcome and anti-human leucocyte antigen alloimmunization risk. | 2014 | Nephrol. Dial. Transplant. | pmid:24914091 |
| Zhu H et al. | Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF‑1α expression in vivo. | 2014 | Mol Med Rep | pmid:24912495 |
| Van Laecke S et al. | The effect of magnesium supplements on early post-transplantation glucose metabolism: a randomized controlled trial. | 2014 | Transpl. Int. | pmid:24909487 |
| Lin T et al. | A Chinese girl with novel PLCE1 mutations and proliferation of the mesangium responded to tacrolimus therapy. | 2014 | Nephrology (Carlton) | pmid:24533735 |
| Trkulja V et al. | Effect of cyclosporine on steady-state pharmacokinetics of MPA in renal transplant recipients is not affected by the MPA formulation: analysis based on therapeutic drug monitoring data. | 2014 | Ther Drug Monit | pmid:24518562 |
| Foroncewicz B et al. | Cyclosporine is superior to tacrolimus in liver transplant recipients with recurrent psoriasis. | 2014 | Ann. Transplant. | pmid:25163829 |
| Hayashi T and Harada N | Post-translational dual regulation of cytochrome P450 aromatase at the catalytic and protein levels by phosphorylation/dephosphorylation. | 2014 | FEBS J. | pmid:25158681 |
| Savikko J et al. | Different effects of tacrolimus and cyclosporine on PDGF induction and chronic allograft injury: evidence for improved kidney graft outcome. | 2014 | Transpl. Immunol. | pmid:25158212 |
| Akchurin OM et al. | Medication adherence in the transition of adolescent kidney transplant recipients to the adult care. | 2014 | Pediatr Transplant | pmid:24820521 |
| Marin-Casino M et al. | Significant tacrolimus and dronedarone interaction in a kidney transplant recipient. | 2014 | Transplantation | pmid:25243519 |
| Kern G et al. | Tacrolimus increases Nox4 expression in human renal fibroblasts and induces fibrosis-related genes by aberrant TGF-beta receptor signalling. | 2014 | PLoS ONE | pmid:24816588 |
| Sánchez L et al. | Topical tacrolimus for recurrent penile Crohn's disease. | 2014 | J Crohns Colitis | pmid:24815787 |
| Kalkan G et al. | An alternative treatment model: the combination therapy of narrow band ultraviolet B phototherapy and tacrolimus ointment 0.1% in biphasic amyloidosis. | 2014 | J Pak Med Assoc | pmid:25272550 |
| Reynolds BC et al. | Use of belatacept to maintain adequate early immunosuppression in calcineurin-mediated microangiopathic hemolysis post-renal transplant. | 2014 | Pediatr Transplant | pmid:24815506 |
| Kim YE and Eun SC | Effect of FK506 ointment (Protopic) on rat skin allograft model. | 2014 | Transplant. Proc. | pmid:24815165 |
| Wang J and Fan H | [Assessment of P70S6 kinase phosphorylation after liver transplantation by phospho-flow cytometry]. | 2014 | Zhonghua Yi Xue Za Zhi | pmid:25623311 |
| Bergmann TK et al. | Comparison of the influence of cyclosporine and tacrolimus on the pharmacokinetics of prednisolone in adult male kidney transplant recipients. | 2014 | Clin Drug Investig | pmid:24385281 |
| Osmola-Mańkowska A et al. | Topical tacrolimus vs medium-dose ultraviolet A1 phototherapy in the treatment of atopic dermatitis - a preliminary study in relation to parameters of the epidermal barrier function and high-frequency ultrasonography. | 2014 | Eur Rev Med Pharmacol Sci | pmid:25555886 |
| Lesche D et al. | CYP3A5*3 and POR*28 genetic variants influence the required dose of tacrolimus in heart transplant recipients. | 2014 | Ther Drug Monit | pmid:24739669 |
| Hilgers M and Megahed M | [Oral lichen planus. Insight into the pathogenesis and therapeutic options]. | 2014 | Hautarzt | pmid:24722910 |
| Shipkova M et al. | Multi-center analytical evaluation of a novel automated tacrolimus immunoassay. | 2014 | Clin. Biochem. | pmid:24721684 |
| Zhang X et al. | Profiling of drug binding proteins by monolithic affinity chromatography in combination with liquid chromatography-tandem mass spectrometry. | 2014 | J Chromatogr A | pmid:25064533 |
| Lin BW et al. | Effect of 0.025% FK-506 eyedrops on botulinum toxin B-induced mouse dry eye. | 2014 | Invest. Ophthalmol. Vis. Sci. | pmid:25491293 |
| Hsiao FY and Hsu WW | Epidemiology of post-transplant malignancy in Asian renal transplant recipients: a population-based study. | 2014 | Int Urol Nephrol | pmid:24009082 |