Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Perlman RL and Rao PS | Quality of life of older patients undergoing renal transplantation: finding the right immunosuppressive treatment. | 2014 | Drugs Aging | pmid:24399579 |
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Kim EJ et al. | Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection. | 2014 | Am. J. Transplant. | pmid:24354871 |
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Bakkour W et al. | Successful use of dapsone for the management of circinate balanitis. | 2014 | Clin. Exp. Dermatol. | pmid:24635073 |
Cho JH et al. | Development of novel fast-dissolving tacrolimus solid dispersion-loaded prolonged release tablet. | 2014 | Eur J Pharm Sci | pmid:24388864 |
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Kapoor K et al. | Lip hypertrophy due to cyclosporine therapy. | 2014 | Clin. Exp. Nephrol. | pmid:23615783 |
Lankarani KB et al. | Response to: Comment on: New-onset diabetes and impaired fasting glucose after liver transplant: risk analysis and the impact of tacrolimus dose. | 2014 | Exp Clin Transplant | pmid:24471728 |
Kabir A | Comment on: New-onset diabetes and impaired fasting glucose after a liver transplant: risk analysis and the effect of tacrolimus dosage. | 2014 | Exp Clin Transplant | pmid:24471727 |
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Backes AN et al. | Effects of tacrolimus and insulin in a liver regeneration model in growing animals with portal vein stenosis: immunohistochemical and molecular studies. | 2014 | Pediatr. Surg. Int. | pmid:24468714 |
Kim H et al. | Safety of reduced dose of mycophenolate mofetil combined with tacrolimus in living-donor liver transplantation. | 2014 | Clin Mol Hepatol | pmid:25320733 |
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Curtin BF et al. | Unusually late-onset mycophenolate mofetil-related colitis. | 2014 | Am J Health Syst Pharm | pmid:25320135 |
Zheng X et al. | Patient with neuromyelitis optica spectrum disorder combined with Sjögren's syndrome relapse free following tacrolimus treatment. | 2014 | Intern. Med. | pmid:25318807 |
Grillo E et al. | Necrobiosis lipoidica. | 2014 | Aust Fam Physician | pmid:24600675 |
Nevers W et al. | Safety of tacrolimus in pregnancy. | 2014 | Can Fam Physician | pmid:25316742 |
Kimura Y et al. | Evaluation of the Multi-ImmunoTox Assay composed of 3 human cytokine reporter cells by examining immunological effects of drugs. | 2014 | Toxicol In Vitro | pmid:24603311 |
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Shilbayeh S | The impact of genetic polymorphisms on time required to attain the target tacrolimus levels and subsequent pharmacodynamic outcomes in pediatric kidney transplant patients. | 2014 | Saudi J Kidney Dis Transpl | pmid:24625991 |
Sagiroglu T et al. | Protective effect of everolimus on renal ischemia reperfusion injury in rats. | 2014 | Saudi J Kidney Dis Transpl | pmid:24625994 |
Wang XZ et al. | Increased intracellular adenosine triphosphate level as an index to predict acute rejection in kidney transplant recipients. | 2014 | Transpl. Immunol. | pmid:24211610 |
Shimizu M et al. | Successful multitarget therapy using mizoribine and tacrolimus for refractory Takayasu arteritis. | 2014 | Rheumatology (Oxford) | pmid:24609060 |
Golubović B et al. | Total plasma protein effect on tacrolimus elimination in kidney transplant patients--population pharmacokinetic approach. | 2014 | Eur J Pharm Sci | pmid:24184751 |
Ramachandran R et al. | Tacrolimus therapy in adult-onset steroid-resistant nephrotic syndrome due to a focal segmental glomerulosclerosis single-center experience. | 2014 | Nephrol. Dial. Transplant. | pmid:24771498 |
Capone F et al. | Synergistic antitumor effect of Doxorubicin and tacrolimus (FK506) on hepatocellular carcinoma cell lines. | 2014 | ScientificWorldJournal | pmid:24701168 |
Boran M et al. | Determining renal resistive and pulsatility indexes long-term after kidney transplantation in kidney transplant recipients on cyclosporine a-, tacrolimus-, or sirolimus-based regimens. | 2014 | Transplant. Proc. | pmid:24935296 |
Tischer S and Fontana RJ | Drug-drug interactions with oral anti-HCV agents and idiosyncratic hepatotoxicity in the liver transplant setting. | 2014 | J. Hepatol. | pmid:24280292 |
Motomura H et al. | Inhibitory effect of tacrolimus on progression of joint damage in patients with rheumatoid arthritis. | 2014 | Int J Rheum Dis | pmid:24251619 |
Yasukochi Y et al. | Reduction of serum TARC levels in atopic dermatitis by topical anti-inflammatory treatments. | 2014 | Asian Pac. J. Allergy Immunol. | pmid:25268342 |
Zhang L et al. | Ambrisentan improves the outcome of rats with liver transplantation partially through reducing nephrotoxicity. | 2014 | Eur Rev Med Pharmacol Sci | pmid:25268107 |
Donnadieu B et al. | Central retinal vein occlusion-associated tacrolimus after liver transplantation. | 2014 | Transplantation | pmid:25955343 |
Arduino PG et al. | Pimecrolimus vs. tacrolimus for the topical treatment of unresponsive oral erosive lichen planus: a 8 week randomized double-blind controlled study. | 2014 | J Eur Acad Dermatol Venereol | pmid:23451852 |
Wasilewski G et al. | Inadequate blood pressure control in orthotopic heart transplant: is there a role of kidney function and immunosuppressive regimen? | 2014 | Transplant. Proc. | pmid:25380929 |
Wilusz M et al. | Effect of immunosuppressive therapy on the serum fatty acids of phospholipids fraction in patients after heart transplantation. | 2014 | Transplant. Proc. | pmid:25380928 |
Dannhorn E et al. | De novo use of generic tacrolimus in liver transplantation - a single center experience with one-yr follow-up. | 2014 | Clin Transplant | pmid:25142496 |
Noceti OM et al. | Tacrolimus pharmacodynamics and pharmacogenetics along the calcineurin pathway in human lymphocytes. | 2014 | Clin. Chem. | pmid:25142246 |
Guy-Viterbo V et al. | Influence of donor-recipient CYP3A4/5 genotypes, age and fluconazole on tacrolimus pharmacokinetics in pediatric liver transplantation: a population approach. | 2014 | Pharmacogenomics | pmid:25141896 |
Cavalli RC et al. | Analysis of the histology of the scar bladder and biochemical parameters of rats with a solitary kidney undergoing immunosuppression with tacrolimus. | 2014 | Acta Cir Bras | pmid:25140592 |
Zhao WY et al. | Single kidneys transplanted from small pediatric donors less than 15 kilograms into pediatric recipients. | 2014 | Transplantation | pmid:25955345 |
Elens L et al. | Impact of POR*28 on the pharmacokinetics of tacrolimus and cyclosporine A in renal transplant patients. | 2014 | Ther Drug Monit | pmid:24061445 |
Imataki O et al. | Reversible cerebral vasoconstriction syndrome resulted in cerebral infarction after allogeneic stem cell transplantation: a case report. | 2014 | Ann. Hematol. | pmid:24061786 |
Feliu J et al. | Transplant-acquired food allergy (TAFA) following cord blood stem cell transplantation in two adult patients with haematological malignancies. | 2014 | Br. J. Haematol. | pmid:24962133 |
Grossman J et al. | Nonmyeloablative allogeneic hematopoietic stem cell transplantation for GATA2 deficiency. | 2014 | Biol. Blood Marrow Transplant. | pmid:25111582 |
Grafals M et al. | Immunophenotyping and efficacy of low dose ATG in non-sensitized kidney recipients undergoing early steroid withdrawal: a randomized pilot study. | 2014 | PLoS ONE | pmid:25111080 |
Freire-Cobo C et al. | The calcineurin inhibitor Ascomicin interferes with the early stage of the epileptogenic process induced by Latrunculin A microperfusion in rat hippocampus. | 2014 | J Neuroimmune Pharmacol | pmid:25104570 |
Shen T et al. | A modified protocol with rituximab and intravenous immunoglobulin in emergent ABO-incompatible liver transplantation for acute liver failure. | 2014 | HBPD INT | pmid:25100124 |
Kaieda S et al. | Successful treatment of rectal ulcers in a patient with systemic lupus erythematosus using corticosteroids and tacrolimus. | 2014 | Mod Rheumatol | pmid:24593214 |
Bica L et al. | Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation. | 2014 | PLoS ONE | pmid:24587210 |
Little JA et al. | The safety and efficacy of noncorticosteroid triple immunosuppressive therapy in the treatment of refractory chronic noninfectious uveitis in childhood. | 2014 | J. Rheumatol. | pmid:24085549 |
Bergmann TK et al. | Population pharmacokinetics of tacrolimus in adult kidney transplant patients: impact of CYP3A5 genotype on starting dose. | 2014 | Ther Drug Monit | pmid:24089074 |
Aelvoet SA et al. | Noninvasive bioluminescence imaging of α-synuclein oligomerization in mouse brain using split firefly luciferase reporters. | 2014 | J. Neurosci. | pmid:25471588 |
Matin M et al. | The effectiveness of excimer laser on vitiligo treatment in comparison with a combination therapy of Excimer laser and tacrolimus in an Iranian population. | 2014 | J Cosmet Laser Ther | pmid:25046236 |
de la Fuente V et al. | Calcineurin phosphatase as a negative regulator of fear memory in hippocampus: control on nuclear factor-κB signaling in consolidation and reconsolidation. | 2014 | Hippocampus | pmid:25043904 |
Klintmalm GB et al. | Belatacept-based immunosuppression in de novo liver transplant recipients: 1-year experience from a phase II randomized study. | 2014 | Am. J. Transplant. | pmid:25041339 |
Ikeuchi H et al. | Efficacy and safety of multi-target therapy using a combination of tacrolimus, mycophenolate mofetil and a steroid in patients with active lupus nephritis. | 2014 | Mod Rheumatol | pmid:24252014 |
Jaksch P et al. | Alemtuzumab in lung transplantation: an open-label, randomized, prospective single center study. | 2014 | Am. J. Transplant. | pmid:25039364 |
Bax K et al. | Rapid resolution of tacrolimus intoxication-induced AKI with a corticosteroid and phenytoin. | 2014 | Ann Pharmacother | pmid:25104567 |
Zhao J et al. | FK506-loaded chitosan conduit promotes the regeneration of injured sciatic nerves in the rat through the upregulation of brain-derived neurotrophic factor and TrkB. | 2014 | J. Neurol. Sci. | pmid:24954089 |
Wannhoff A et al. | Increased levels of rivaroxaban in patients after liver transplantation treated with cyclosporine A. | 2014 | Transplantation | pmid:25022236 |
Sureshkumar KK and Chopra B | In search of an optimal induction agent in kidney transplantation. | 2014 | Transplantation | pmid:24978038 |
Falconer SJ et al. | Conversion from twice-daily to once-daily tacrolimus in simultaneous pancreas-kidney transplant patients. | 2014 | Transplant. Proc. | pmid:24935313 |
Welberry Smith MP and Baker RJ | The author's reply. | 2014 | Transplantation | pmid:24978039 |
Hacker C et al. | Falsely elevated cyclosporin and tacrolimus concentrations over prolonged periods of time due to reversible adsorption to central venous catheters. | 2014 | Clin. Chim. Acta | pmid:24631133 |
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Goring SM et al. | A network meta-analysis of the efficacy of belatacept, cyclosporine and tacrolimus for immunosuppression therapy in adult renal transplant recipients. | 2014 | Curr Med Res Opin | pmid:24628478 |
Urbanowicz T et al. | Comparison of conventional tacrolimus versus prolong release formula as initial therapy in heart transplantation. | 2014 | Ann. Transplant. | pmid:24949728 |
Hallowell RW and Danoff SK | Interstitial lung disease associated with the idiopathic inflammatory myopathies and the antisynthetase syndrome: recent advances. | 2014 | Curr Opin Rheumatol | pmid:25203119 |
Nafar M et al. | Prevalence and risk factors of recurrent cytomegalovirus infection in kidney transplant recipients. | 2014 | Iran J Kidney Dis | pmid:24878947 |
van Gelder T | Within-patient variability in immunosuppressive drug exposure as a predictor for poor outcome after transplantation. | 2014 | Kidney Int. | pmid:24875549 |
Lalan S et al. | Effect of CYP3A5 genotype, steroids, and azoles on tacrolimus in a pediatric renal transplant population. | 2014 | Pediatr. Nephrol. | pmid:24875272 |
Ricardo E et al. | In vivo and in vitro acquisition of resistance to voriconazole by Candida krusei. | 2014 | Antimicrob. Agents Chemother. | pmid:24867987 |
Shihab F et al. | Focus on mTOR inhibitors and tacrolimus in renal transplantation: pharmacokinetics, exposure-response relationships, and clinical outcomes. | 2014 | Transpl. Immunol. | pmid:24861504 |
Almeida-Paulo GN et al. | Limited sampling strategies for tacrolimus exposure (AUC0-24) prediction after Prograf(®) and Advagraf(®) administration in children and adolescents with liver or kidney transplants. | 2014 | Transpl. Int. | pmid:24861353 |
Maeda H et al. | Disappearance of GFP-positive hepatocytes transplanted into the liver of syngeneic wild-type rats pretreated with retrorsine. | 2014 | PLoS ONE | pmid:24796859 |
Du W et al. | Improved FK506 production by the precursors and product-tolerant mutant of Streptomyces tsukubaensis based on genome shuffling and dynamic fed-batch strategies. | 2014 | J. Ind. Microbiol. Biotechnol. | pmid:24788378 |
Agrawal YP et al. | Transplant patient classification and tacrolimus assays: more evidence of the need for assay standardization. | 2014 | Ther Drug Monit | pmid:24784024 |
Sageshima J et al. | Everolimus with low-dose tacrolimus in simultaneous pancreas and kidney transplantation. | 2014 | Clin Transplant | pmid:24779669 |
Lee CM et al. | Monotherapy with tacrolimus for heart and liver transplant: a case report. | 2014 | Transplant. Proc. | pmid:24767396 |
Abe T et al. | Risk factors for development of new-onset diabetes mellitus and progressive impairment of glucose metabolism after living-donor liver transplantation. | 2014 | Transplant. Proc. | pmid:24767367 |
Jin L et al. | Dipeptidyl peptidase IV inhibitor MK-0626 attenuates pancreatic islet injury in tacrolimus-induced diabetic rats. | 2014 | PLoS ONE | pmid:24959755 |
Nkongolo S et al. | Cyclosporin A inhibits hepatitis B and hepatitis D virus entry by cyclophilin-independent interference with the NTCP receptor. | 2014 | J. Hepatol. | pmid:24295872 |
Gillard P et al. | Early alteration of kidney function in nonuremic type 1 diabetic islet transplant recipients under tacrolimus-mycophenolate therapy. | 2014 | Transplantation | pmid:24770614 |
Pandey S et al. | Metabotropic glutamate receptor 1 recycles to the cell surface in protein phosphatase 2A-dependent manner in non-neuronal and neuronal cell lines. | 2014 | J. Neurochem. | pmid:25113668 |
Mitsides N et al. | Dapsone-induced methemoglobinemia in renal transplant recipients: more prevalent than previously thought. | 2014 | Transpl Infect Dis | pmid:24215452 |
Wan XC and Dimov V | Pharmacokinetic evaluation of topical calcineurin inhibitors for treatment of allergic conjunctivitis. | 2014 | Expert Opin Drug Metab Toxicol | pmid:24490943 |
Madian AG et al. | Case report: Inability to achieve a therapeutic dose of tacrolimus in a pediatric allogeneic stem cell transplant patient after generic substitution. | 2014 | BMC Pharmacol Toxicol | pmid:25472557 |
Indriolo A and Ravelli P | Clinical management of inflammatory bowel disease in the organ recipient. | 2014 | World J. Gastroenterol. | pmid:24707135 |
Huang W et al. | Tacrolimus (FK506) suppresses TREM-1 expression at an early but not at a late stage in a murine model of fungal keratitis. | 2014 | PLoS ONE | pmid:25464008 |
Philipone E et al. | Oral ulcerations as a sequela of tacrolimus and mycophenolate mofetil therapy. | 2014 | Oral Surg Oral Med Oral Pathol Oral Radiol | pmid:25457894 |
Nair S and Waters B | Telaprevir in treatment of recurrent hepatitis C infection in liver transplant recipients. | 2014 | Exp Clin Transplant | pmid:24702143 |
Chen C et al. | Rapid construction of a Bacterial Artificial Chromosomal (BAC) expression vector using designer DNA fragments. | 2014 | Plasmid | pmid:25454071 |
Olson KA et al. | Toxic tacrolimus levels after application of topical tacrolimus and use of occlusive dressings in two bone marrow transplant recipients with cutaneous graft-versus-host disease. | 2014 | Pharmacotherapy | pmid:24700567 |
Momohara S et al. | Recent trends in orthopedic surgery aiming to improve quality of life for those with rheumatoid arthritis: data from a large observational cohort. | 2014 | J. Rheumatol. | pmid:24692532 |
Navas-López VM et al. | Successful treatment for ulcerative proctitis with rectal tacrolimus in an 8-year-old girl with intolerance to mesalamine. | 2014 | Clin J Gastroenterol | pmid:26185880 |
Lee CH et al. | Raised tacrolimus level and acute renal injury associated with acute gastroenteritis in a child receiving local rectal tacrolimus. | 2014 | Clin J Gastroenterol | pmid:26183743 |