tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hu YN et al. | High-dose calcineurin inhibitor-free everolimus as a maintenance regimen for heart transplantation may be a risk factor for Pneumocystis pneumonia. | 2017 | Transpl Infect Dis | pmid:28425200 |
| Nishimoto M et al. | Drug interactions and safety profiles with concomitant use of caspofungin and calcineurin inhibitors in allogeneic haematopoietic cell transplantation. | 2017 | Br J Clin Pharmacol | pmid:28407449 |
| Bao LQ et al. | Tacrolimus prevents murine cerebral malaria. | 2017 | Immunology | pmid:27546479 |
| Solmaz S et al. | Tacrolimus-Induced Diabetic Ketoacidosis After Allogeneic Bone Marrow Transplant. | 2017 | Exp Clin Transplant | pmid:26643544 |
| Baluch A et al. | Successful management of Mycobacterium haemophilum lower extremity cutaneous infection in a matched-unrelated donor stem cell transplant recipient. | 2017 | Transpl Infect Dis | pmid:27775824 |
| Devaux S et al. | RhoA Inhibitor Treatment At Acute Phase of Spinal Cord Injury May Induce Neurite Outgrowth and Synaptogenesis. | 2017 | Mol. Cell Proteomics | pmid:28659490 |
| Arns W et al. | Pharmacokinetics and Clinical Outcomes of Generic Tacrolimus (Hexal) Versus Branded Tacrolimus in De Novo Kidney Transplant Patients: A Multicenter, Randomized Trial. | 2017 | Transplantation | pmid:28658202 |
| Taber DJ et al. | Tacrolimus Trough Concentration Variability and Disparities in African American Kidney Transplantation. | 2017 | Transplantation | pmid:28658199 |
| Cong M et al. | Novel oleyl amine-modified polymannuronic acid micelle loading tacrolimus for therapy of allergic conjunctivitis. | 2017 | Int. J. Biol. Macromol. | pmid:28655660 |
| Li X et al. | Tacrolimus Monotherapy after Intravenous Methylprednisolone in Adults with Minimal Change Nephrotic Syndrome. | 2017 | J. Am. Soc. Nephrol. | pmid:27807213 |
| Agarwal SK et al. | Impact of type of calcineurin inhibitor on post-transplant tuberculosis: Single-center study from India. | 2017 | Transpl Infect Dis | pmid:27775825 |
| Charman C | A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal - comment. | 2017 | Br. J. Dermatol. | pmid:28858382 |
| Yu Y et al. | Tacrolimus downregulates inflammation by regulating pro‑/anti‑inflammatory responses in LPS‑induced keratitis. | 2017 | Mol Med Rep | pmid:28849181 |
| Jin J et al. | Effects of metformin on hyperglycemia in an experimental model of tacrolimus- and sirolimus-induced diabetic rats. | 2017 | Korean J. Intern. Med. | pmid:27688296 |
| Zaza G et al. | Impact of maintenance immunosuppressive therapy on the fecal microbiome of renal transplant recipients: Comparison between an everolimus- and a standard tacrolimus-based regimen. | 2017 | PLoS ONE | pmid:28542523 |
| Neustadtl AL et al. | Reduced cortical excitatory synapse number in APOE4 mice is associated with increased calcineurin activity. | 2017 | Neuroreport | pmid:28542068 |
| Schulte K et al. | Late conversion from tacrolimus to a belatacept-based immuno-suppression regime in kidney transplant recipients improves renal function, acid-base derangement and mineral-bone metabolism. | 2017 | J. Nephrol. | pmid:28540602 |
| Miyamoto T et al. | Comparison of cyclosporine and tacrolimus combined with mycophenolate mofetil in prophylaxis for graft-versus-host disease after reduced-intensity umbilical cord blood transplantation. | 2017 | Int. J. Hematol. | pmid:27686673 |
| Liu G et al. | FK506 Attenuates the Inflammation in Rat Spinal Cord Injury by Inhibiting the Activation of NF-κB in Microglia Cells. | 2017 | Cell. Mol. Neurobiol. | pmid:27572744 |
| Shah SZA et al. | Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters. | 2017 | Neurotherapeutics | pmid:28083805 |
| Woillard JB et al. | Population Pharmacokinetics and Bayesian Estimators for Refined Dose Adjustment of a New Tacrolimus Formulation in Kidney and Liver Transplant Patients. | 2017 | Clin Pharmacokinet | pmid:28389935 |
| Koguchi-Yoshioka H et al. | Intravenous immunoglobulin contributes to the control of antimelanoma differentiation-associated protein 5 antibody-associated dermatomyositis with palmar violaceous macules/papules. | 2017 | Br. J. Dermatol. | pmid:28346662 |
| Kanate AS et al. | Recipient Immune Modulation with Atorvastatin for Acute Graft-versus-Host Disease Prophylaxis after Allogeneic Transplantation. | 2017 | Biol. Blood Marrow Transplant. | pmid:28412518 |
| Nambu M et al. | A calcineurin antifungal strategy with analogs of FK506. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28412204 |
| Ito A et al. | Sex Differences in the Blood Concentration of Tacrolimus in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients with CYP3A5*3/*3. | 2017 | Biochem. Genet. | pmid:28324194 |
| Marini BL et al. | Risk of graft-versus-host disease with rituximab-containing conditioning regimens in allogeneic hematopoietic stem cell transplant. | 2017 | J Oncol Pharm Pract | pmid:26970572 |
| Sauer R et al. | Good outcome of brain stem progressive multifocal leukoencephalopathy in an immunosuppressed renal transplant patient: Importance of early detection and rapid immune reconstitution. | 2017 | J. Neurol. Sci. | pmid:28320193 |
| Hayashi Y et al. | Neuropathological findings from an autopsied case showing posterior reversible encephalopathy syndrome-like neuroradiological findings associated with premedication including tacrolimus for autologous peripheral blood stem cell transplantation. | 2017 | J. Neurol. Sci. | pmid:28320172 |
| Xiang DM et al. | [The observation of tacrolimus eye drops preventing the early immunological rejection after penetrating keratoplasty for fungal keratitis]. | 2017 | Zhonghua Yan Ke Za Zhi | pmid:28412805 |
| Lepelley M et al. | [Pharmacokinetic drug interaction between miconazole mucoadhesive tablet and tacrolimus: About 3Â case-reports in transplant patients]. | 2017 | Therapie | pmid:28214069 |
| Sikma MA et al. | High tacrolimus blood concentrations early after lung transplantation and the risk of kidney injury. | 2017 | Eur. J. Clin. Pharmacol. | pmid:28132082 |
| Ayar Y et al. | Risk Factors Affecting Graft and Patient Survivals After Transplantation From Deceased Donors in a Developing Country: A Single-Center Experience. | 2017 | Transplant. Proc. | pmid:28219583 |
| Keller F et al. | Correlation between pharmacokinetics of tacrolimus and pharmacodynamics on NFAT-regulated gene expression in stable kidney transplant recipients
. | 2017 | Clin. Nephrol. | pmid:28025957 |
| Sukma Dewi I et al. | Association of Serum MiR-142-3p and MiR-101-3p Levels with Acute Cellular Rejection after Heart Transplantation. | 2017 | PLoS ONE | pmid:28125729 |
| Viklicky O et al. | Sequential Targeting of CD52 and TNF Allows Early Minimization Therapy in Kidney Transplantation: From a Biomarker to Targeting in a Proof-Of-Concept Trial. | 2017 | PLoS ONE | pmid:28085915 |
| Ren L et al. | Donors FMO3 polymorphisms affect tacrolimus elimination in Chinese liver transplant patients. | 2017 | Pharmacogenomics | pmid:28084894 |
| Zhu LB et al. | Efficacy and Safety of Tacrolimus Versus Cyclophosphamide for Primary Membranous Nephropathy: A Meta-Analysis. | 2017 | Drugs | pmid:28084563 |
| Li R et al. | Effect of narrow band ultraviolet B phototherapy as monotherapy or combination therapy for vitiligo: a meta-analysis. | 2017 | Photodermatol Photoimmunol Photomed | pmid:27696531 |
| Billing H et al. | Single-Nucleotide Polymorphism of CYP3A5 Impacts the Exposure to Tacrolimus in Pediatric Renal Transplant Recipients: A Pharmacogenetic Substudy of the TWIST Trial. | 2017 | Ther Drug Monit | pmid:28030534 |
| Rozen-Zvi B et al. | Association of the combination of time-weighted variability of tacrolimus blood level and exposure to low drug levels with graft survival after kidney transplantation. | 2017 | Nephrol. Dial. Transplant. | pmid:28025383 |
| Sathyasaikumar KV et al. | Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects. | 2017 | Neuroscience | pmid:29031603 |
| Ordóñez-Robles M et al. | Streptomyces tsukubaensis as a new model for carbon repression: transcriptomic response to tacrolimus repressing carbon sources. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28983826 |
| Qi JC et al. | Tacrolimus protects vascular endothelial cells from injuries caused by Ox-LDL by regulating endoplasmic reticulum stress. | 2017 | Eur Rev Med Pharmacol Sci | pmid:28975964 |
| Dang W et al. | Inhibition of Calcineurin or IMP Dehydrogenase Exerts Moderate to Potent Antiviral Activity against Norovirus Replication. | 2017 | Antimicrob. Agents Chemother. | pmid:28807916 |
| Dabrowska-Zamojcin E et al. | KCNJ11 and KCNQ1 Gene Polymorphisms Are Not Associated with Post-Transplant Diabetes Mellitus in Kidney Allograft Recipients Treated with Tacrolimus. | 2017 | Folia Biol. (Praha) | pmid:28805561 |
| Hirano Y et al. | Prolonged Administration of Twice-Daily Bolus Intravenous Tacrolimus in the Early Phase After Lung Transplantation. | 2017 | Ann. Transplant. | pmid:28798289 |
| Higashi H et al. | First successful perinatal management of pregnancy after ABO-incompatible liver transplantation. | 2017 | World J. Gastroenterol. | pmid:28210092 |
| Furukawa T et al. | A case of neuromyelitis optica spectrum disorder (NMOSD) with Sjögren's syndrome manifested only brain involvement by preceding parotitis. | 2017 | Rinsho Shinkeigaku | pmid:28132975 |
| Wang Y et al. | FK506 protects heart function via increasing autophagy after myocardial infarction in mice. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28965948 |
| Wood LA et al. | New tools for "hot-wiring" clathrin-mediated endocytosis with temporal and spatial precision. | 2017 | J. Cell Biol. | pmid:28954824 |