| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Nocardia Infections | D009617 | 6 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Graft Occlusion, Vascular | D006083 | 11 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sikma MA et al. | Association of Whole Blood Tacrolimus Concentrations with Kidney Injury in Heart Transplantation Patients. | 2018 | Eur J Drug Metab Pharmacokinet | pmid:29236211 |
| Komura Y et al. | Economic assessment of actual prescription of drugs for treatment of atopic dermatitis: Differences between dermatology and pediatrics in large-scale receipt data. | 2018 | J. Dermatol. | pmid:29168213 |
| Cho EJ et al. | Performance of the Dimension TAC assay and comparison of multiple platforms for the measurement of tacrolimus. | 2018 | J. Clin. Lab. Anal. | pmid:29148096 |
| Wu MF et al. | Combination Therapy of Tacrolimus and Chinese Herb Medicated Bath in Children with Inverse Psoriasis. | 2018 | Chin J Integr Med | pmid:28914435 |
| Akamine Y et al. | A comparison of the effects of CYP3A5 polymorphism on tacrolimus blood concentrations measured by 4 immunoassay methods in renal transplant patients. | 2018 | J Clin Pharm Ther | pmid:28891077 |
| Velioglu A et al. | Late Pulmonary Toxicity Associated With Everolimus in a Renal Transplant Patient and Review of the Literature. | 2018 | Exp Clin Transplant | pmid:27001620 |
| Hamano I et al. | Condyloma Acuminata of the Urethra in a Male Renal Transplant Recipient: A Case Report. | 2018 | Transplant. Proc. | pmid:30316397 |
| Choong CL et al. | Dose-Response Relationship Between Diltiazem and Tacrolimus and Its Safety in Renal Transplant Recipients. | 2018 | Transplant. Proc. | pmid:30316389 |
| Cheng CY et al. | Intervention of Online Percent Coefficient of Variation Reporting System Reduces the Variability of Tacrolimus Trough Concentration in Kidney Transplant Recipients. | 2018 | Transplant. Proc. | pmid:30316366 |
| Liu Y et al. | Delayed Initiation of Tacrolimus Is Safe and Effective in Renal Transplant Recipients With Delayed and Slow Graft Function. | 2018 | Transplant. Proc. | pmid:30316359 |
| Pflugrad H et al. | Longterm calcineurin inhibitor therapy and brain function in patients after liver transplantation. | 2018 | Liver Transpl. | pmid:29156491 |
| Loeschenberger B et al. | Calcineurin inhibitor-induced complement system activation via ERK1/2 signalling is inhibited by SOCS-3 in human renal tubule cells. | 2018 | Eur. J. Immunol. | pmid:29143318 |
| Sugahara S et al. | Integrin, alpha9 subunit blockade suppresses collagen-induced arthritis with minimal systemic immunomodulation. | 2018 | Eur. J. Pharmacol. | pmid:29932925 |
| Wen L et al. | Transient High Pressure in Pancreatic Ducts Promotes Inflammation and Alters Tight Junctions via Calcineurin Signaling in Mice. | 2018 | Gastroenterology | pmid:29928898 |
| Ohtsuki M et al. | Tacrolimus ointment for the treatment of adult and pediatric atopic dermatitis: Review on safety and benefits. | 2018 | J. Dermatol. | pmid:29927498 |
| Shimoda-Komatsu Y et al. | Chronological observation of surgically-treated granuloma faciale implies the necessity of circumspect management for perinasal nodular subset. | 2018 | J. Dermatol. | pmid:29905388 |
| Hou Y et al. | Management of hepatic vein occlusive disease after liver transplantation: A case report with literature review. | 2018 | Medicine (Baltimore) | pmid:29901618 |
| Özçakar ZB et al. | Transplantation within the era of anti-IL-1 therapy: case series of five patients with familial Mediterranean fever-related amyloidosis. | 2018 | Transpl. Int. | pmid:29957882 |
| Luaces-RodrÃguez A et al. | Preclinical characterization and clinical evaluation of tacrolimus eye drops. | 2018 | Eur J Pharm Sci | pmid:29705214 |
| Castedal M et al. | Steroid-free immunosuppression with low-dose tacrolimus is safe and significantly reduces the incidence of new-onset diabetes mellitus following liver transplantation. | 2018 | Scand. J. Gastroenterol. | pmid:29688072 |
| Zhang Y and Zhang R | Recent advances in analytical methods for the therapeutic drug monitoring of immunosuppressive drugs. | 2018 | Drug Test Anal | pmid:28851030 |
| Niel O and Bastard P | Artificial intelligence improves estimation of tacrolimus area under the concentration over time curve in renal transplant recipients. | 2018 | Transpl. Int. | pmid:29687486 |
| Gmitterová K et al. | Tacrolimus-induced parkinsonism in a patient after liver transplantation - case report. | 2018 | BMC Neurol | pmid:29678162 |
| Liu HY et al. | Ribavirin-induced anaemia reduced tacrolimus level in a hepatitis C patient receiving haemodialysis. | 2018 | BMJ Case Rep | pmid:29669765 |
| Majeed A et al. | A 20-year experience with nocardiosis in solid organ transplant (SOT) recipients in the Southwestern United States: A single-center study. | 2018 | Transpl Infect Dis | pmid:29668074 |
| Hong D et al. | [Atopic keratoconjunctivitis: One allergy may mask another. A clinical observation with two types of hypersensitivity reactions: IgE-mediated and non-IgE-mediated]. | 2018 | J Fr Ophtalmol | pmid:29567021 |
| Ekici Günay N et al. | Administration of Extract (EGb761) Alone and in Combination with FK506 Promotes Liver Regeneration in a Rat Model of Partial Hepatectomy. | 2018 | Balkan Med J | pmid:29553465 |
| Zhang X et al. | Current progress of tacrolimus dosing in solid organ transplant recipients: Pharmacogenetic considerations. | 2018 | Biomed. Pharmacother. | pmid:29550633 |
| Komine N et al. | Influence of CYP3A5 genetic differences in tacrolimus on quantitative interstitial fibrosis and long-term graft function in kidney transplant recipients. | 2018 | Int. Immunopharmacol. | pmid:29550576 |
| Kagaya H et al. | Prediction of Tacrolimus Exposure by CYP3A5 Genotype and Exposure of Co-Administered Everolimus in Japanese Renal Transplant Recipients. | 2018 | Int J Mol Sci | pmid:29547545 |
| Yamada R et al. | A case of duodenal malignant lymphoma presenting as acute pancreatitis: systemic lupus erythematosus and immunosuppressive therapy as risk factors. | 2018 | Clin J Gastroenterol | pmid:29546569 |
| Shi D et al. | CYP3A4 and GCK genetic polymorphisms are the risk factors of tacrolimus-induced new-onset diabetes after transplantation in renal transplant recipients. | 2018 | Eur. J. Clin. Pharmacol. | pmid:29546446 |
| Qin X et al. | Multi-center Performance Evaluations of Tacrolimus and Cyclosporine Electrochemiluminescence Immunoassays in the Asia-Pacific Region. | 2018 | Ann Lab Med | pmid:29214751 |
| Wan Q et al. | Therapeutic Effect of 0.1% Tacrolimus Eye Drops in the Tarsal Form of Vernal Keratoconjunctivitis. | 2018 | Ophthalmic Res. | pmid:28803239 |
| Fu Q et al. | Risk Factors for Acute Rejection After Deceased Donor Kidney Transplantation in China. | 2018 | Transplant. Proc. | pmid:30316380 |
| Konno O et al. | Early Outcomes of Living-Donor Kidney Transplantation With Immunosuppression Therapy Induction With Tacrolimus Extended-Release: A Comparison With Cyclosporine. | 2018 | Transplant. Proc. | pmid:30316378 |
| Tsujimura K et al. | Effect of Influenza Vaccine in Patients With Kidney Transplant. | 2018 | Transplant. Proc. | pmid:30316375 |
| Yu M et al. | Pharmacokinetics, Pharmacodynamics and Pharmacogenetics of Tacrolimus in Kidney Transplantation. | 2018 | Curr. Drug Metab. | pmid:29380698 |
| Kim JH et al. | Increased Exposure of Tacrolimus by Co-administered Mycophenolate Mofetil: Population Pharmacokinetic Analysis in Healthy Volunteers. | 2018 | Sci Rep | pmid:29374217 |
| Xia T et al. | Targeted metabolomic analysis of 33 amino acids and biogenic amines in human urine by ion-pairing HPLC-MS/MS: Biomarkers for tacrolimus nephrotoxicity after renal transplantation. | 2018 | Biomed. Chromatogr. | pmid:29369388 |
| Song JL et al. | Higher tacrolimus blood concentration is related to increased risk of post-transplantation diabetes mellitus after living donor liver transplantation. | 2018 | Int J Surg | pmid:29360611 |
| Charnaya O et al. | Results of early treatment for de novo donor-specific antibodies in pediatric kidney transplant recipients in a cross-sectional and longitudinal cohort. | 2018 | Pediatr Transplant | pmid:29356221 |
| Nishimoto M et al. | Drug interactions and safety profiles with concomitant use of caspofungin and calcineurin inhibitors in allogeneic haematopoietic cell transplantation. | 2017 | Br J Clin Pharmacol | pmid:28407449 |
| Moura Penteado LA et al. | Evaluation of the effect of tacrolimus on periodontitis induced in rats. | 2017 | Arch. Oral Biol. | pmid:28399470 |
| Desai VCA et al. | Comparative Effectiveness of Tacrolimus-Based Steroid Sparing versus Steroid Maintenance Regimens in Kidney Transplantation: Results from Discrete Event Simulation. | 2017 | Med Decis Making | pmid:28384413 |
| Niioka T et al. | Impact of the CYP3A5 genotype on the distributions of dose-adjusted trough concentrations and incidence of rejection in Japanese renal transplant recipients receiving different tacrolimus formulations. | 2017 | Clin. Exp. Nephrol. | pmid:28271256 |
| Bao LQ et al. | Tacrolimus prevents murine cerebral malaria. | 2017 | Immunology | pmid:27546479 |
| Panackal AA et al. | Spinal Arachnoiditis as a Complication of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Adults. | 2017 | Clin. Infect. Dis. | pmid:28011613 |
| Sato K et al. | Early post-transplant hyperbilirubinemia is a possible predictive factor for developing neurological complications in pediatric living donor liver transplant patients receiving tacrolimus. | 2017 | Pediatr Transplant | pmid:27804185 |
| Chakkera HA et al. | Calcineurin Inhibitors: Pharmacologic Mechanisms Impacting Both Insulin Resistance and Insulin Secretion Leading to Glucose Dysregulation and Diabetes Mellitus. | 2017 | Clin. Pharmacol. Ther. | pmid:27804122 |
| Fox BD et al. | Tacrolimus Levels Are Not Associated with Risk of Malignancy in Lung Transplant Recipients. | 2017 | Ann. Transplant. | pmid:29133776 |
| Lombardi A et al. | Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure. | 2017 | Cell Commun. Signal | pmid:29132395 |
| Cong M et al. | Novel oleyl amine-modified polymannuronic acid micelle loading tacrolimus for therapy of allergic conjunctivitis. | 2017 | Int. J. Biol. Macromol. | pmid:28655660 |
| Suda M et al. | Effectiveness of multi-target therapy in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis with early-stage interstitial lung disease. | 2017 | Scand. J. Rheumatol. | pmid:28649889 |
| Yu Y et al. | Tacrolimus downregulates inflammation by regulating pro‑/anti‑inflammatory responses in LPS‑induced keratitis. | 2017 | Mol Med Rep | pmid:28849181 |
| Schulte K et al. | Late conversion from tacrolimus to a belatacept-based immuno-suppression regime in kidney transplant recipients improves renal function, acid-base derangement and mineral-bone metabolism. | 2017 | J. Nephrol. | pmid:28540602 |
| Gouvêa ALF et al. | BK polyomavirus nephropathy in two kidney transplant patients with distinct diagnostic strategies for BK virus and similar clinical outcomes: two case reports. | 2017 | J Med Case Rep | pmid:28535782 |
| DaSilva I et al. | Rituximab for Steroid-Dependent or Frequently Relapsing Idiopathic Nephrotic Syndrome in Adults: A Retrospective, Multicenter Study in Spain. | 2017 | BioDrugs | pmid:28534103 |
| Baron PW et al. | Post-Transplant Diabetes Mellitus After Kidney Transplant in Hispanics and Caucasians Treated with Tacrolimus-Based Immunosuppression. | 2017 | Ann. Transplant. | pmid:28533501 |
| Miyamoto T et al. | Comparison of cyclosporine and tacrolimus combined with mycophenolate mofetil in prophylaxis for graft-versus-host disease after reduced-intensity umbilical cord blood transplantation. | 2017 | Int. J. Hematol. | pmid:27686673 |
| Liu G et al. | FK506 Attenuates the Inflammation in Rat Spinal Cord Injury by Inhibiting the Activation of NF-κB in Microglia Cells. | 2017 | Cell. Mol. Neurobiol. | pmid:27572744 |
| Shah SZA et al. | Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters. | 2017 | Neurotherapeutics | pmid:28083805 |
| Koguchi-Yoshioka H et al. | Intravenous immunoglobulin contributes to the control of antimelanoma differentiation-associated protein 5 antibody-associated dermatomyositis with palmar violaceous macules/papules. | 2017 | Br. J. Dermatol. | pmid:28346662 |
| Shemesh E et al. | The Medication Level Variability Index (MLVI) Predicts Poor Liver Transplant Outcomes: A Prospective Multi-Site Study. | 2017 | Am. J. Transplant. | pmid:28321975 |
| Nambu M et al. | A calcineurin antifungal strategy with analogs of FK506. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28412204 |
| Karchin JM et al. | Small Molecule-Induced Domain Swapping as a Mechanism for Controlling Protein Function and Assembly. | 2017 | Sci Rep | pmid:28287617 |
| Kawamura H et al. | Rapid Induction Therapy with Oral Tacrolimus in Elderly Patients with Refractory Ulcerative Colitis Can Easily Lead to Elevated Tacrolimus Concentrations in Blood: A Report of 5 Cases. | 2017 | Am J Case Rep | pmid:28411286 |
| Mizuno H et al. | Extranodal NK/T cell lymphoma in a living donor liver transplant recipient. | 2017 | Ann. Hematol. | pmid:28280996 |
| Sadati MS et al. | Recalcitrant cases of pyoderma gangrenosum, responding dramatically to systemic tacrolimus. | 2017 | G Ital Dermatol Venereol | pmid:28409579 |
| de Graav GN et al. | A Randomized Controlled Clinical Trial Comparing Belatacept With Tacrolimus After De Novo Kidney Transplantation. | 2017 | Transplantation | pmid:28403127 |
| Zhang HJ et al. | Tacrolimus population pharmacokinetics according to CYP3A5 genotype and clinical factors in Chinese adult kidney transplant recipients. | 2017 | J Clin Pharm Ther | pmid:28401703 |
| Hayashi Y et al. | Neuropathological findings from an autopsied case showing posterior reversible encephalopathy syndrome-like neuroradiological findings associated with premedication including tacrolimus for autologous peripheral blood stem cell transplantation. | 2017 | J. Neurol. Sci. | pmid:28320172 |
| Sinha A et al. | Mycophenolate mofetil is inferior to tacrolimus in sustaining remission in children with idiopathic steroid-resistant nephrotic syndrome. | 2017 | Kidney Int. | pmid:28318625 |
| Genvigir FDV et al. | Influence of ABCC2, CYP2C8, and CYP2J2 Polymorphisms on Tacrolimus and Mycophenolate Sodium-Based Treatment in Brazilian Kidney Transplant Recipients. | 2017 | Pharmacotherapy | pmid:28316087 |
| Mertens JS et al. | Morphea and Eosinophilic Fasciitis: An Update. | 2017 | Am J Clin Dermatol | pmid:28303481 |
| Saeki K et al. | Endobronchial Lesions of Mycobacterium abscessus Infection in an Immunocompromised Patient. | 2017 | Am. J. Respir. Crit. Care Med. | pmid:28199133 |
| Manocha GD et al. | Defining the contribution of neuroinflammation to Parkinson's disease in humanized immune system mice. | 2017 | Mol Neurodegener | pmid:28196514 |
| Pengcheng W et al. | Validation of Donor-Specific Tolerance of Intestinal Transplant by a Secondary Heart Transplantation Model. | 2017 | Exp Clin Transplant | pmid:28122485 |
| Kannegieter NM et al. | The Effect of Tacrolimus and Mycophenolic Acid on CD14+ Monocyte Activation and Function. | 2017 | PLoS ONE | pmid:28122021 |
| Unadkat JV et al. | Single Implantable FK506 Disk Prevents Rejection in Vascularized Composite Allotransplantation. | 2017 | Plast. Reconstr. Surg. | pmid:28121868 |
| Sukma Dewi I et al. | Association of Serum MiR-142-3p and MiR-101-3p Levels with Acute Cellular Rejection after Heart Transplantation. | 2017 | PLoS ONE | pmid:28125729 |
| TruneÄka P | Once-daily tacrolimus in liver transplantation: a 'me-too drug', or a therapeutic advantage. | 2017 | Curr Opin Organ Transplant | pmid:28079558 |
| Riva N et al. | Adequate exposure to tacrolimus with sublingual administration in pediatric liver transplant patients. | 2017 | Int J Clin Pharmacol Ther | pmid:28079516 |
| Ericson JE et al. | A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation. | 2017 | Ther Drug Monit | pmid:28081041 |
| Rozen-Zvi B et al. | Association of the combination of time-weighted variability of tacrolimus blood level and exposure to low drug levels with graft survival after kidney transplantation. | 2017 | Nephrol. Dial. Transplant. | pmid:28025383 |
| Miyazaki D et al. | Steroid-Sparing Effect of 0.1% Tacrolimus Eye Drop for Treatment of Shield Ulcer and Corneal Epitheliopathy in Refractory Allergic Ocular Diseases. | 2017 | Ophthalmology | pmid:28017421 |
| Müller F et al. | Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery. | 2017 | Eur J Pharm Biopharm | pmid:28012989 |
| Kitazawa F et al. | Pharmacokinetic Interaction Between Tacrolimus and Fentanyl in Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation. | 2017 | Ann. Transplant. | pmid:28947731 |
| Hirano Y et al. | Prolonged Administration of Twice-Daily Bolus Intravenous Tacrolimus in the Early Phase After Lung Transplantation. | 2017 | Ann. Transplant. | pmid:28798289 |
| De Majumdar S et al. | A Low Concentration of Tacrolimus/Semifluorinated Alkane (SFA) Eyedrop Suppresses Intraocular Inflammation in Experimental Models of Uveitis. | 2017 | Curr. Mol. Med. | pmid:28782485 |
| Kim MJ et al. | The Anti-Inflammatory Effects of Oral-Formulated Tacrolimus in Mice with Experimental Autoimmune Encephalomyelitis. | 2017 | J. Korean Med. Sci. | pmid:28776347 |
| Mussin N et al. | Sirolimus and Metformin Synergistically Inhibits Colon Cancer In Vitro and In Vivo. | 2017 | J. Korean Med. Sci. | pmid:28776332 |
| Higashi H et al. | First successful perinatal management of pregnancy after ABO-incompatible liver transplantation. | 2017 | World J. Gastroenterol. | pmid:28210092 |
| Singh AR et al. | Efficacy of steroidal vs non-steroidal agents in oral lichen planus: a randomised, open-label study. | 2017 | J Laryngol Otol | pmid:27917729 |
| Veenhof H et al. | Clinical Validation of Simultaneous Analysis of Tacrolimus, Cyclosporine A, and Creatinine in Dried Blood Spots in Kidney Transplant Patients. | 2017 | Transplantation | pmid:27906832 |
| Sigurgeirsson B and Luger T | A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal - author response. | 2017 | Br. J. Dermatol. | pmid:28940181 |
| Wojciechowski D et al. | Mycophenolate Mofetil Withdrawal With Conversion to Everolimus to Treat BK Virus Infection in Kidney Transplant Recipients. | 2017 | Transplant. Proc. | pmid:28923623 |
| Nanmoku K et al. | Effective and Safe Reduction of Conventional Immunosuppressants Using Everolimus in Maintenance Kidney Transplant Recipients. | 2017 | Transplant. Proc. | pmid:28923615 |
| Tourret J et al. | Immunosuppressive Treatment Alters Secretion of Ileal Antimicrobial Peptides and Gut Microbiota, and Favors Subsequent Colonization by Uropathogenic Escherichia coli. | 2017 | Transplantation | pmid:27681266 |
| Larche M and McGonagle D | A case of resistant spondyloarthritis (SpA) that responded to tacrolimus and mycophenolate treatment initiated at the time of renal transplantation for unrelated renal failure. | 2017 | Scand. J. Rheumatol. | pmid:26971928 |