tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Nocardia Infections D009617 6 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Graft Occlusion, Vascular D006083 11 associated lipids
Hypercalcemia D006934 13 associated lipids
Per page 10 20 50 100 | Total 613

PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

Download all related citations
Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Schlegel A et al. Hypothermic Oxygenated Perfusion (HOPE) downregulates the immune response in a rat model of liver transplantation. 2014 Ann. Surg. pmid:25243553
Colombani PM et al. Liver transplantation in infants younger than 1 year of age. 1996 Ann. Surg. pmid:8645039
Stratta RJ et al. Evolution in pancreas transplantation techniques: simultaneous kidney-pancreas transplantation using portal-enteric drainage without antilymphocyte induction. 1999 Ann. Surg. pmid:10235529
Shapiro R et al. Kidney transplantation under a tolerogenic regimen of recipient pretreatment and low-dose postoperative immunosuppression with subsequent weaning. 2003 Ann. Surg. pmid:14530723
Fealy MJ et al. Efficacy of rapamycin and FK 506 in prolonging rat hind limb allograft survival. 1994 Ann. Surg. pmid:7507657
Ozawa K et al. An appraisal of pediatric liver transplantation from living relatives. Initial clinical experiences in 20 pediatric liver transplantations from living relatives as donors. 1992 Ann. Surg. pmid:1280074
Vivarelli M et al. Liver transplantation for hepatocellular carcinoma under calcineurin inhibitors: reassessment of risk factors for tumor recurrence. 2008 Ann. Surg. pmid:18948815
Abu-Elmagd K et al. Clinical intestinal transplantation: a decade of experience at a single center. 2001 Ann. Surg. pmid:11524593
Sho M et al. New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs. 2002 Ann. Surg. pmid:12409674
McCourtie AS et al. Synergistic protection in lung ischemia-reperfusion injury with calcineurin and thrombin inhibition. 2010 Ann. Thorac. Surg. pmid:20494024
Laubach VE Invited commentary. 2010 Ann. Thorac. Surg. pmid:20494025
Li S et al. Intrathymic inoculation of donor bone marrow induces long-term acceptance of lung allografts. 2003 Ann. Thorac. Surg. pmid:12537225
Sugita M et al. Pharmacologic modulation of alveolar liquid clearance in transplanted lungs by phentolamine and FK506. 2009 Ann. Thorac. Surg. pmid:19699927
Moffatt-Bruce S Invited commentary. 2009 Ann. Thorac. Surg. pmid:19699928
Thyagarajan GK et al. FK506-induced fulminant leukoencephalopathy after single-lung transplantation. 1997 Ann. Thorac. Surg. pmid:9386723
Leshnower BG et al. Cyclosporine preserves mitochondrial morphology after myocardial ischemia/reperfusion independent of calcineurin inhibition. 2008 Ann. Thorac. Surg. pmid:18805178
Chambers DJ Invited commentary. 2008 Ann. Thorac. Surg. pmid:18805179
Nathan M et al. Cyclosporin A but not FK-506 protects against dopamine-induced apoptosis in the stunned heart. 2005 Ann. Thorac. Surg. pmid:15854943
Hirai T et al. A short course of FK506 can induce limited donor-specific graft acceptance. 1994 Ann. Thorac. Surg. pmid:7520685
Armitage JM et al. Clinical trial of FK 506 immunosuppression in adult cardiac transplantation. 1992 Ann. Thorac. Surg. pmid:1379032
Oto T et al. Calcineurin inhibitor-related cholestasis complicating lung transplantation. 2010 Ann. Thorac. Surg. pmid:20417810
Groetzner J et al. Cardiac transplantation in pediatric patients: fifteen-year experience of a single center. 2005 Ann. Thorac. Surg. pmid:15620914
Inutsuka K et al. Reconstruction of trachea and carina with immediate or cryopreserved allografts in dogs. 1996 Ann. Thorac. Surg. pmid:8893587
Bolman RM Advantage--FK 506: reduced chronic rejection for lung transplant recipients. 1995 Ann. Thorac. Surg. pmid:7545888
Keenan RJ et al. Clinical trial of tacrolimus versus cyclosporine in lung transplantation. 1995 Ann. Thorac. Surg. pmid:7545889
Wilson CH et al. Prospective randomised trial of the use of Daclizumab in renal transplantation using kidneys from non heart beating donors. 2004 Ann. Transplant. pmid:15478912
Boratyńska M et al. Conversion from cyclosporine-based immunosuppression to tacrolimus/mycophenolate mofetil in patients with refractory and ongoing acute renal allograft rejection. 2006 Ann. Transplant. pmid:17494290
Grochowiecki T et al. A retrospective study of steroid elimination in simultaneous pancreas and preemptive kidney transplant (Sppre-Ktx) recipients. 2006 Ann. Transplant. pmid:17494291
Rhu J et al. Clinical Implication of Mycophenolic Acid Trough Concentration Monitoring in Kidney Transplant Patients on a Tacrolimus Triple Maintenance Regimen: A Single-Center Experience. 2017 Ann. Transplant. pmid:29180612
Rehman S et al. Effect of different tacrolimus levels on early outcomes after kidney transplantation. 2014 Ann. Transplant. pmid:24509826
Legris T et al. Humoral immunity after kidney transplantation: impact of two randomized immunosuppressive protocols. 2013 Ann. Transplant. pmid:24231646
Hakeam HA et al. Sirolimus induced dyslipidemia in tacrolimus based vs. tacrolimus free immunosuppressive regimens in renal transplant recipients. 2008 Ann. Transplant. pmid:18566560
Urbanowicz T et al. Induction therapy, tacrolimus plasma concentration, and duration if intensive care unit stay are risk factors for peripheral leucopenia following heart transplantation. 2014 Ann. Transplant. pmid:25274118
Furmańczyk A et al. Atypical calcineurin inhibitor-induced haemolytic uremic syndrome after liver transplantation. 2009 Oct-Dec Ann. Transplant. pmid:20009155
Gerlach UA et al. Aspergillus spondylodiscitis after multivisceral transplantation. 2009 Oct-Dec Ann. Transplant. pmid:20009156
Malinowski M et al. Effect of tacrolimus dosing on glucose metabolism in an experimental rat model. 2010 Jul-Sep Ann. Transplant. pmid:20877268
Miyata Y et al. Pharmacokinetics of a Once-Daily Dose of Tacrolimus Early After Liver Transplantation: With Special Reference to CYP3A5 and ABCB1 Single Nucleotide Polymorphisms. 2016 Ann. Transplant. pmid:27503662
Herden U et al. Early Initiation of Everolimus After Liver Transplantation: A Single-Center Experience. 2016 Ann. Transplant. pmid:26842532
Grenda R et al. Evaluation of the genetic background of standard-immunosuppressant-related toxicity in a cohort of 200 paediatric renal allograft recipients--a retrospective study. 2009 Jul-Sep Ann. Transplant. pmid:19644155
Ogura Y et al. Early Conversion From Twice-Daily Tacrolimus to Prolonged-Release Tacrolimus in Liver Transplantation: A Single-Center Experience. 2016 Ann. Transplant. pmid:27432248
Dedinská I et al. Waist circumference as an independent risk factor for NODAT. 2015 Ann. Transplant. pmid:25791039
Rostaing L et al. The pharmacokinetics of everolimus in de novo kidney transplant patients receiving tacrolimus: an analysis from the randomized ASSET study. 2014 Ann. Transplant. pmid:25017487
Jannot M et al. Early conversion from twice-daily tacrolimus to once-daily extended formulation in renal transplant patients before hospital discharge. 2014 Ann. Transplant. pmid:24999809
Provenzani A et al. The effect of CYP3A5 and ABCB1 single nucleotide polymorphisms on tacrolimus dose requirements in Caucasian liver transplant patients. 2009 Jan-Mar Ann. Transplant. pmid:19289993
Schnitzbauer AA et al. Delayed bottom-up and amended simple method of dosing with once-daily tacrolimus application to achieve stable trough levels in liver transplantation. 2015 Ann. Transplant. pmid:25553853
Van Laecke S et al. Effect of Magnesium Supplements on Insulin Secretion After Kidney Transplantation: A Randomized Controlled Trial. 2017 Ann. Transplant. pmid:28848225
Kitazawa F et al. Pharmacokinetic Interaction Between Tacrolimus and Fentanyl in Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation. 2017 Ann. Transplant. pmid:28947731
Hirano Y et al. Prolonged Administration of Twice-Daily Bolus Intravenous Tacrolimus in the Early Phase After Lung Transplantation. 2017 Ann. Transplant. pmid:28798289
Illsinger S et al. Effect of tacrolimus on energy metabolism in human umbilical endothelial cells. 2011 Apr-Jun Ann. Transplant. pmid:21716189
Thölking G et al. Tacrolimus Concentration/Dose Ratio is Associated with Renal Function After Liver Transplantation. 2016 Ann. Transplant. pmid:27003330