tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Nocardia Infections D009617 6 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Graft Occlusion, Vascular D006083 11 associated lipids
Hypercalcemia D006934 13 associated lipids
Per page 10 20 50 100 | Total 613

PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

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Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Zhu ZJ et al. [Diagnosis and treatment of de novo malignancy after liver transplantation]. 2007 Zhonghua Zhong Liu Za Zhi pmid:17649647
Dong J et al. [Osteoblastic differentiation and in vivo osteogenic activity of marrow-derived mesenchymal stem cells stimulated by Tacrolimus: experiment with rats]. 2007 Zhonghua Yi Xue Za Zhi pmid:17425851
Liang TB et al. [Graft versus host disease after liver transplantation: a report of 3 cases]. 2004 Zhonghua Yi Xue Za Zhi pmid:15200885
Wang W et al. [Relationship between MDR1 gene polymorphism and blood concentration of tacrolimus in renal transplant patients]. 2005 Zhonghua Yi Xue Za Zhi pmid:16409819
Chen YH et al. [Nephrotoxicity of tacrolimus and preventive effect of diltiazem: experiment with rats]. 2009 Zhonghua Yi Xue Za Zhi pmid:19595068
Lu AW et al. [Dual, triple, and quadruple oral tacrolimus-based immunosuppression regimens after orthotopic liver transplantation: a randomised comparative study of regimens]. 2006 Zhonghua Yi Xue Za Zhi pmid:17313848
Huang G et al. [Analysis on BK virus associated nephropathy related risk factors in renal transplant recipients]. 2015 Zhonghua Yi Xue Za Zhi pmid:26814103
Pan F et al. [Protective effect of tacrolimus postconditioning on oxidative stress injury provoked by spinal cord ischemia-reperfusion in rats]. 2013 Zhonghua Yi Xue Za Zhi pmid:24548402
Dong QE et al. [Inhibitory effects of tacrolimus on effector T cells from patients with severe aplastic anemia]. 2013 Zhonghua Yi Xue Za Zhi pmid:24028719
Li YX et al. [Preliminary experience with partial tolerance protocol in small bowel transplantation]. 2009 Zhonghua Yi Xue Za Zhi pmid:20137270
Feng HY et al. [Therapeutic efficacy and safety of tacrolimus for intractable myasthenia gravis: a report of 36 patients]. 2011 Zhonghua Yi Xue Za Zhi pmid:22333101
Huang HF et al. [Conversion from calcineurin inhibitors to sirolimus in chronic allograft nephropathy: a 4-year prospective study]. 2011 Zhonghua Yi Xue Za Zhi pmid:22333250
Chen H et al. [Mycophenolate mofetil in treatment of graft-versus-host disease after allogeneic hematopoietic cell transplantation: analysis of 44 cases]. 2008 Zhonghua Yi Xue Za Zhi pmid:19080474
Zhao SM et al. [Promotion of in vitro long term expansion of primitive multipotential hematopoietic cells by transduced JAK2 gene]. 2004 Zhonghua Yi Xue Za Zhi pmid:15329285
Chen YH et al. [Prevention of diltiazem in tacrolimus-induced nephrotoxicity: experiment with rats]. 2007 Zhonghua Yi Xue Za Zhi pmid:18001539
Li YL et al. [Measurement of tacrolimus in blood with the method of high performance liquid chromatography-mass spectrometry]. 2008 Zhonghua Yi Xue Za Zhi pmid:19087682
Cai JQ et al. [Study of the effects of immunosuppressive agents on human islet cells in vitro]. 2005 Zhonghua Yi Xue Za Zhi pmid:15932724
Wang J and Fan H [Assessment of P70S6 kinase phosphorylation after liver transplantation by phospho-flow cytometry]. 2014 Zhonghua Yi Xue Za Zhi pmid:25623311
Xia WL et al. [Effects of ciclosporin and tacrolimus on replication of hepatitis B virus in vitro: a comparative study]. 2006 Zhonghua Yi Xue Za Zhi pmid:16620716
Lü DC et al. [Effect of FK506 on axonal regeneration of rat sciatic nerve in regeneration chamber: an experimental study]. 2005 Zhonghua Yi Xue Za Zhi pmid:16313776
Zhang WG et al. [Favorable effect of chitosan sustained-release FK506 incorporated conduits on axonal regeneration in rat sciatic nerve]. 2006 Zhonghua Yi Xue Za Zhi pmid:16784713
Jin J et al. Impact of multidrug resistance 1 gene polymorphism on tacrolimus dose and concentration-to-dose ratio in Chinese liver transplantation recipients. 2005 Zhonghua Yi Xue Yi Chuan Xue Za Zhi pmid:16331555
Xie H et al. [Effect of FK506 eye-drop combined with keratoplasty on recurrent Mooren's ulcer]. 2002 Zhonghua Yan Ke Za Zhi pmid:11955293
Chen J et al. [The study of FK506 eye drops preventing and treating immune rejection on limbal allograft transplantation]. 2003 Zhonghua Yan Ke Za Zhi pmid:14766087
Xiang DM et al. [The observation of tacrolimus eye drops preventing the early immunological rejection after penetrating keratoplasty for fungal keratitis]. 2017 Zhonghua Yan Ke Za Zhi pmid:28412805
Sun YJ et al. [Systematic review of penetrating keratoplasty rejection treated by immunosuppressants]. 2010 Zhonghua Yan Ke Za Zhi pmid:21211228
Shi WY et al. [Implantation of FK506 drug delivery system into the anterior chamber for inhibiting corneal rejection in high risk rabbit corneal allograft]. 2006 Zhonghua Yan Ke Za Zhi pmid:16762204
Fei WL et al. [The pharmacokinetics of FK506 and its nanoparticles in aqueous humor of rabbits]. 2006 Zhonghua Yan Ke Za Zhi pmid:16762205
Lü L et al. [Experimental studies on the effect of the immunosuppressant FK-506 on penetrating keratoplasty rejection model in rats]. 1999 Zhonghua Yan Ke Za Zhi pmid:11835769
Lü L and Zhang W [Immunopathologic studies on the effects of immunosuppressant FK 506 on penetrating keratoplasty rejection model in rat]. 1998 Zhonghua Yan Ke Za Zhi pmid:11877144
DU C et al. [In vitro effects of tacrolimus on platelet function]. 2014 Zhonghua Xue Ye Xue Za Zhi pmid:25339327
Zhao SM et al. [Long term regulated expansion and committed differentiation of JAK2 gene transfected hematopoietic stem/progenitor cells in vitro]. 2004 Zhonghua Xue Ye Xue Za Zhi pmid:14990041
Chen F et al. [Outcomes of allogeneic hematopoietic stem cell transplantation for 18 patients with paroxysmal nocturnal haemoglobinuria]. 2015 Zhonghua Xue Ye Xue Za Zhi pmid:26759101
Sun J et al. [A preliminary study on the biological characteristics and function of tolerogenic dendritic cells induced by tacrolimus]. 2014 Zhonghua Xue Ye Xue Za Zhi pmid:24985179
Cao KJ et al. [Immunosuppressive therapy after human lung transplantation]. 2007 Zhonghua Wai Ke Za Zhi pmid:17845780
Li YX et al. [Preliminary experience with Campath 1H induction combined with low-dose monotherapy of tacrolimus in small bowel transplantation]. 2009 Zhonghua Wai Ke Za Zhi pmid:19961008
Pan F et al. [Effect of tacrolimus on apoptosis and expression of heat shock protein 70 after acute spinal cord injury in rats]. 2006 Zhonghua Wai Ke Za Zhi pmid:17359722
Lü DC et al. [An experimental study of the neuroprotective effect of FK506 on acute spinal cord injury in dogs]. 2005 Zhonghua Wai Ke Za Zhi pmid:16194341
Zhao X et al. [A retrospective cohort study regarding the effect of sirolimus-based immunosuppression protocol on the long-term survival of hepatocellular carcinoma patients after liver transplantation]. 2014 Zhonghua Wai Ke Za Zhi pmid:24924566
Ju WQ et al. [Two-dose steroid combined with two-dose daclizumab and tacrolimus regimen in liver transplant recipients]. 2009 Zhonghua Wai Ke Za Zhi pmid:19781270
Hu AB et al. [Evaluation of efficacy and safety on steroid withdraw at the seventh day after liver transplantation]. 2008 Zhonghua Wai Ke Za Zhi pmid:19094670
Yang FC et al. [Influence of combined cyclosporine A and tacrolimus with 5-fluorouracil on hepatocellular carcinoma rats]. 2003 Zhonghua Wai Ke Za Zhi pmid:12895356
Chen YP et al. [The clinical efficacy and safety of tacrolimus in patients with myasthenia gravis]. 2013 Zhonghua Nei Ke Za Zhi pmid:24266997
Sun L et al. [Effect of FK506 on the cavernous nerve regeneration after injury]. 2005 Zhonghua Nan Ke Xue pmid:15755036
Cao ZG et al. [Effects of different immunodepressants on the sperm parameters of kidney transplant recipients]. 2006 Zhonghua Nan Ke Xue pmid:16755867
Zhao S et al. [Effects of tacrolimus (FK506) on heat-shock proteins 70, Bcl-2 and Bax expression in nervous tissue of acrylamide-induced rat]. 2010 Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi pmid:20465949
Sun YJ and Sun Z [Treatment of erosive oral lichen planus with topical tacrolimus]. 2010 Zhonghua Kou Qiang Yi Xue Za Zhi pmid:20450689
Zhang J et al. [Effects of sirolimus on the growth of transplanted hepatocellular carcinoma]. 2009 Zhonghua Gan Zang Bing Za Zhi pmid:19567017
Qian SK et al. [The prevention and management of cerebrovascular complications in nine cases after orthotopic liver transplantation]. 2005 Zhonghua Gan Zang Bing Za Zhi pmid:16313741
Huang K et al. [Prophylaxis and treatment of chronic graft versus host disease]. 2005 Zhonghua Er Ke Za Zhi pmid:15833186
Deng Z et al. [Early diagnosis and comprehensive treatments of post-transplantation lymphoproliferative disorder after pediatric liver transplantation]. 2014 Zhonghua Er Ke Za Zhi pmid:25224233
Zhou DJ and Wu XC [Meta-analysis of calcineurin inhibitor in the treatment of lupus nephritis]. 2011 Zhonghua Er Ke Za Zhi pmid:21624207
Yao SH et al. [Clinical application of tacrolimus with low-dose prednisone in 21 children with steroid-resistant nephrotic syndrome]. 2011 Zhonghua Er Ke Za Zhi pmid:22336304
Wang ZL et al. [Management of pediatric patients who underwent liver transplantation]. 2007 Zhonghua Er Ke Za Zhi pmid:17880788
Wang HY et al. [Clinical and pathological features of Denys-Drash syndrome: report of 3 cases]. 2012 Zhonghua Er Ke Za Zhi pmid:23302619
Nie F et al. [Post-transplant kidney from C-III donation after cardiac death of children: a clinicopathologic study of 20 cases]. 2016 Zhonghua Bing Li Xue Za Zhi pmid:26879429
Xie SP et al. [Study on the clinical application of wuzhi capsule after renal transplantation]. 2011 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:22013798
Ding CG et al. [Clinical application and exploration on mechanism of action of Cordyceps sinensis mycelia preparation for renal transplantation recipients]. 2009 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:20329604
Gu HY et al. [Significance of calcineurin activation and CD40L expression in patients with active lupus nephritis]. 2005 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21162213
Xie ZQ et al. [Antipruritic mechanisms of pimecrolimus cream for facial dermatitis in adult women patients]. 2009 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:19317053
Wen J et al. [Regulatory effects of cyclosporin A and tacrolimus on the immunological gene expressions in renal transplant recipients]. 2012 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:23286399
Tian T et al. [Effect of tacrolimus on the growth cycle of murine hair follicles]. 2007 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:17536270
Xie ZQ and Lan YZ Effectiveness of pimecrolimus cream for women patients with sensitive skin and its underlying mechanism. 2012 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:22954121
Chen GF et al. [Peripheral nerve regeneration under immunosuppression]. 2002 Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi pmid:11944523
Xiong G et al. [Effects of immunosuppressants on proliferation of pheochromocytoma 12 and L929 cells]. 2007 Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi pmid:17694665
Kang H et al. [Combined immunosuppression of FK506 and RS-61443 in rat limb allotransplantation]. 2003 Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi pmid:12822367
Yu HQ et al. [Study of tacrolimus intranasal treatment for allergic asthma in mice]. 2012 Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi pmid:23484272
Li Q et al. [Experimental study of electrophysiologic effects of regenerative nerve fibres affected by control releasing FK506]. 2010 Zhongguo Gu Shang pmid:21254678
Li Y et al. [Study on the Effect of Immunosuppressive Agent FK506 on Growth and Migration of Lung Cancer Cell]. 2017 Zhongguo Fei Ai Za Zhi pmid:28738959
Zhou Y et al. [Effect of tacrolimus on growth-associated protein-43 expression in the hippocampus of neonatal rats with hypoxic-ischemic brain damage]. 2009 Zhongguo Dang Dai Er Ke Za Zhi pmid:19149927
Huang WY [Clinical application and side effects of immunosuppressant]. 2007 Zhongguo Dang Dai Er Ke Za Zhi pmid:17448303
Sun Y et al. [Total glucosides of peony as adjuvant therapy for prevention of cardiac allograft rejection in rats]. 2007 Zhong Xi Yi Jie He Xue Bao pmid:17854565
Li Y et al. [Effects of tacrolimus and cyclosporine on albumin secretion in cultured human hepatocyte]. 2006 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:16859130
Peng LK et al. [Slowing progression of chronic allograft nephropathy by conversion from cyclosporin A to tacrolimus]. 2007 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:17344588
Li D et al. [Effect of genetic polymorphism on disposition of calcineurin inhibitors in solid organ transplantation]. 2010 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:20871172
Chiu MC Management strategy for idiopathic nehprotic syndrome in children. 2008 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:18245896
Liu Y and Zheng M [Suppression of Tacrolimus on the expression of MMP-9 in rhHGF-stimulated ECV304 cell line]. 2004 Zhejiang Da Xue Xue Bao Yi Xue Ban pmid:15586415
David M et al. [Changes in cervix cytology in women with liver transplants treated with immunosuppressive therapy]. 1993 Zentralbl Gynakol pmid:7692689
Lütkes P et al. [Quality of life following transplantation. The impact ofa new immunosuppressive substance]. 1999 Zentralbl Chir pmid:10209841
Weiner SM [Combination of tacrolimus and MMF for treatment of proliferative lupus nephritis]. 2016 Z Rheumatol pmid:27259912
Grube E et al. Drug eluting stents: initial experiences. 2002 Z Kardiol pmid:12641014
Scheller B et al. Comparative study of tacrolimus and paclitaxel stent coating in the porcine coronary model. 2005 Z Kardiol pmid:15997345
König A et al. Intravascular ultrasound for assessment of coronary allograft vasculopathy. 2000 Z Kardiol pmid:11151792
Ocran KW et al. Tacrolimus toxicity due to drug interaction with mibefradil in a patient after liver transplantation. 1999 Z Gastroenterol pmid:10549098
Müller MK et al. [Pathophysiologic concepts and protective possibilities in experimental pancreatic lesions]. 1993 Z Gastroenterol pmid:7504856
Petrides AS [Do immunosuppressive agents really impair glucose tolerance in liver transplant patients?]. 1995 Z Gastroenterol pmid:7571761
Arnold JC and Theilmann L [Comparison between tacrolimus (FK 506) and cyclosporin in immunosuppressive therapy after liver transplantation]. 1995 Z Gastroenterol pmid:7502559
Buechter M et al. Tacrolimus as a reasonable alternative in a patient with steroid-dependent and thiopurine-refractory autoimmune pancreatitis with IgG4-associated cholangitis. 2014 Z Gastroenterol pmid:24905108
Kanzler S et al. Complete reversal of FK 506 induced diabetes in a liver transplant recipient by change of immunosuppression to cyclosporine A. 1996 Z Gastroenterol pmid:8659188
Schwarz A [Drug-induced kidney damage]. 1996 Z Arztl Fortbild (Jena) pmid:8779233
Oh CK et al. Safety and efficacy of conversion from twice-daily tacrolimus to once-daily tacrolimus one month after transplantation: randomized controlled trial in adult renal transplantation. 2014 Yonsei Med. J. pmid:25048494
Lee JH et al. Withdrawal of immunosuppression in pediatric liver transplant recipients in Korea. 2009 Yonsei Med. J. pmid:20046418
First MR and Fitzsimmons WE Modified release tacrolimus. 2004 Yonsei Med. J. pmid:15627307
Partaledis JA et al. Saccharomyces cerevisiae contains a homolog of human FKBP-13, a membrane-associated FK506/rapamycin binding protein. 1992 Yeast pmid:1279908
Zhang GM et al. [Population pharmacokinetics of tacrolimus in Chinese renal transplant patients]. 2008 Yao Xue Xue Bao pmid:18819472
Deng CH et al. [The therapeutic drug monitoring network server of tacrolimus for Chinese renal transplant patients]. 2011 Yao Xue Xue Bao pmid:22010353
Guan Z et al. [Application of Fourier amplitude sensitivity test in Chinese healthy volunteer population pharmacokinetic model of tacrolimus]. 2010 Yao Xue Xue Bao pmid:20931787
Xue L et al. [Population pharmacokinetic study of tacrolimus in patients with hematopoietic stem cell transplant]. 2009 Yao Xue Xue Bao pmid:20055140
Zhang YJ et al. [Hypertrophy of the heart: calcineurin-NFAT pathway may be a new therapeutic target]. 2006 Yao Xue Xue Bao pmid:17184105
Fu XH et al. [Prediction of blood tacrolimus concentration in liver transplantation recipients by artificial neural network]. 2012 Yao Xue Xue Bao pmid:23227541