Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

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To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Nocardia Infections D009617 6 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Graft Occlusion, Vascular D006083 11 associated lipids
Hypercalcemia D006934 13 associated lipids
Per page 10 20 50 100 | Total 613

PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?

Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:

Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

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Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Sugimoto K et al. Assessment of Long-Term Efficacy and Safety of Adalimumab in Patients with Ulcerative Colitis: Results from a 6-Year Real-World Clinical Practice. 2019 Dig Dis pmid:30205400
Shin TH et al. Formulation and in vivo pharmacokinetic evaluation of ethyl cellulose-coated sustained release multiple-unit system of tacrolimus. 2018 Int. J. Biol. Macromol. pmid:29277422
Moriguchi S et al. Reduced expression of Na/Ca exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice. 2018 Neuropharmacology pmid:29274751
Copacia JA et al. 70% Ethanol for Decontamination of Central Venous Lines Exposed to Calcineurin Inhibitors. 2018 Ann Pharmacother pmid:28838253
Jha AK et al. Dermoscopy as an evolving tool to assess vitiligo activity. 2018 J. Am. Acad. Dermatol. pmid:29229577
De Lemos-Bonotto M et al. A systematic review and meta-analysis of second-line immunosuppressants for autoimmune hepatitis treatment. 2018 Eur J Gastroenterol Hepatol pmid:29227329
Huo T et al. Preparation and comparison of tacrolimus-loaded solid dispersion and self-microemulsifying drug delivery system by in vitro/in vivo evaluation. 2018 Eur J Pharm Sci pmid:29222025
Gao CJ et al. Oxymatrine Sensitizes the HaCaT Cells to the IFN-γ Pathway and Downregulates MDC, ICAM-1, and SOCS1 by Activating p38, JNK, and Akt. 2018 Inflammation pmid:29218605
Karagun BS et al. Eye Movement Disorders Following Allogeneic Bone Marrow Transplantation on FK506 (Tacrolimus) and Ganciclovir. 2018 J. Pediatr. Hematol. Oncol. pmid:28731920
Butler KV et al. Targeted Gene Repression Using Novel Bifunctional Molecules to Harness Endogenous Histone Deacetylation Activity. 2018 ACS Synth Biol pmid:29073761
Watanabe N et al. The possible clinical impact of risperidone on P-glycoprotein-mediated transport of tacrolimus: A case report and in vitro study. 2018 Biopharm Drug Dispos pmid:29055041
Gupta PC and Ram J Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. 2018 Cornea pmid:29040120
Banovic F et al. Tacrolimus therapy for dermal arteritis of the nasal philtrum refractory to surgery and anti-inflammatory therapy (doxycycline/niacinamide and topical fluocinolone) in a dog. 2018 Vet. Dermatol. pmid:28990239
Altieri M et al. Conversion From Once-Daily Prolonged-Release Tacrolimus to Once-Daily Extended-Release Tacrolimus in Stable Liver Transplant Recipients. 2018 Exp Clin Transplant pmid:28697715
Sakai R et al. Efficacy and safety of multitarget therapy with cyclophosphamide and tacrolimus for lupus nephritis: a prospective, single-arm, single-centre, open label pilot study in Japan. 2018 Lupus pmid:28683654
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Almeida-Paulo GN et al. Weight of ABCB1 and POR genes on oral tacrolimus exposure in CYP3A5 nonexpressor pediatric patients with stable kidney transplant. 2018 Pharmacogenomics J. pmid:28094348
Lancia P et al. Adverse Events under Tacrolimus and Cyclosporine in the First 3 Years Post-Renal Transplantation in Children. 2018 Clin Drug Investig pmid:29236209
Zaman M et al. Application of quasi-emulsification and modified double emulsification techniques for formulation of tacrolimus microsponges. 2018 Int J Nanomedicine pmid:30127605
Asano T et al. The utility of FDG-PET/CT imaging in the evaluation of multicentric reticulohistiocytosis: A case report. 2018 Medicine (Baltimore) pmid:30113451
Liu YJ et al. Pooled analysis of the comparative efficacy between tacrolimus and infliximab for ulcerative colitis. 2018 Medicine (Baltimore) pmid:30095612
Garaix F et al. Tacrolimus Granules for Oral Suspension as Post-Transplant Immunosuppression in Routine Medical Practice in France: The OPTIMOD Study. 2018 Ann. Transplant. pmid:30093607
Belaiche S et al. Factors associated with the variability of calcineurin inhibitor blood levels in kidney recipients grafted for more than 1 year. 2018 Fundam Clin Pharmacol pmid:29069531
Geng L et al. Lower tacrolimus trough levels in the late period after living donor liver transplantation contribute to improvements in long-term clinical outcomes. 2018 HBPD INT pmid:29807766
Ding CG et al. Early Immunosuppressive Exposure of Enteric-Coated-Mycophenolate Sodium Plus Tacrolimus Associated with Acute Rejection in Expanded Criteria Donor Kidney Transplantation. 2018 Chin. Med. J. pmid:29786042
Malakasioti G et al. Converting immunosuppression from an oral suspension to a granule formulation of tacrolimus in pediatric renal transplant recipients. 2018 Pediatr Transplant pmid:29767471
Wang DD et al. Population pharmacokinetics of tacrolimus in paediatric systemic lupus erythematosus based on real-world study. 2018 J Clin Pharm Ther pmid:29766530
Rigo-Bonnin R et al. Different top-down approaches to estimate measurement uncertainty of whole blood tacrolimus mass concentration values. 2018 Clin. Biochem. pmid:29750938
Strohbehn GW et al. Large-Scale Variability of Inpatient Tacrolimus Therapeutic Drug Monitoring at an Academic Transplant Center: A Retrospective Study. 2018 Ther Drug Monit pmid:29750738
Freriksen JJM et al. Placental disposition of the immunosuppressive drug tacrolimus in renal transplant recipients and in ex vivo perfused placental tissue. 2018 Eur J Pharm Sci pmid:29655601
Udomkarnjananun S et al. An Unusual Manifestation of Calcineurin Inhibitor-Induced Pain Syndrome in Kidney Transplantation: A Case Report and Literature Review. 2018 Am J Case Rep pmid:29654227
Krzyżowska K et al. Which Kidney Transplant Recipients Can Benefit from the Initial Tacrolimus Dose Reduction? 2018 Biomed Res Int pmid:29651435
Nakagita K et al. Effect of fluconazole on the pharmacokinetics of everolimus and tacrolimus in a heart transplant recipient: Case report. 2018 Int J Clin Pharmacol Ther pmid:29648533
Kaya Z et al. Tacrolimus-Induced Autoimmune Hemolytic Anemia in a Previously Reported Child With History of Thrombocytopenia Following Liver Transplant. 2018 Exp Clin Transplant pmid:29633932
Takeuchi K et al. Comparison of Safety and Efficacy of Tacrolimus versus Infliximab for Active Ulcerative Colitis. 2018 Dig Dis pmid:29050007
Romano P et al. UPLC-MS/MS assay validation for tacrolimus quantitative determination in peripheral blood T CD4+ and B CD19+ lymphocytes. 2018 J Pharm Biomed Anal pmid:29471254
Lloberas N et al. Detection of a rare CYP3A4 variant in a transplant patient characterized by a tacrolimus poor metabolizer phenotype. 2018 Pharmacogenomics pmid:29469606
Brooks EK et al. Evaluation of Multiple Linear Regression-Based Limited Sampling Strategies for Enteric-Coated Mycophenolate Sodium in Adult Kidney Transplant Recipients. 2018 Ther Drug Monit pmid:29461443
Chen X et al. A case report of lupus erythematosus tumidus converted from discoid lupus erythematosus. 2018 Medicine (Baltimore) pmid:29668590
Mashiah J et al. Topical pimecrolimus for paediatric cutaneous mastocytosis. 2018 Clin. Exp. Dermatol. pmid:29460435
Li A et al. Atopic keratoconjunctivitis: A diagnostic dilemma-a case report. 2018 Medicine (Baltimore) pmid:29668589
Chen ZH et al. Adenovirus-mediated OX40Ig gene transfer induces long-term survival of orthotopic liver allograft in rats. 2018 Transpl. Immunol. pmid:29454984
Yu K et al. Tacrolimus nanoparticles based on chitosan combined with nicotinamide: enhancing percutaneous delivery and treatment efficacy for atopic dermatitis and reducing dose. 2018 Int J Nanomedicine pmid:29317821
Yoshizawa S et al. Exosomal miRNA Signatures for Late-Onset Acute Graft-Versus-Host Disease in Allogenic Hematopoietic Stem Cell Transplantation. 2018 Int J Mol Sci pmid:30142940
Costa D et al. Human cryptosporidiosis in immunodeficient patients in France (2015-2017). 2018 Exp. Parasitol. pmid:30107154
Yang MY et al. High rates of secondary non-adherence causes decreased efficacy of 0.1% topical tacrolimus in adult eczema patients: results from a multicenter clinical trial. 2018 J Dermatolog Treat pmid:28670943
Wang HD et al. Desensitization and Prevention of Antibody-Mediated Rejection in Vascularized Composite Allotransplantation by Syngeneic Hematopoietic Stem Cell Transplantation. 2018 Transplantation pmid:29298238
Kono M et al. False Elevation of the Blood Tacrolimus Concentration, as Assessed by an Affinity Column-mediated Immunoassay (ACMIA), Led to Acute T Cell-mediated Rejection after Kidney Transplantation. 2018 Intern. Med. pmid:29279473
Heppt MV et al. Frontal Fibrosing Alopecia: A Retrospective Analysis of 72 Patients from a German Academic Center. 2018 Facial Plast Surg pmid:29278862
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