| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Nocardia Infections | D009617 | 6 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Graft Occlusion, Vascular | D006083 | 11 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pompeo A et al. | Cyclosporin A, but not FK506, increases arachidonic acid release and inhibits proliferation of pituitary corticotrope tumor cells. | 1999 | Life Sci. | pmid:10096434 |
| Nogueira JM et al. | A comparison of recipient renal outcomes with laparoscopic versus open live donor nephrectomy. | 1999 | Transplantation | pmid:10096529 |
| Shapiro R et al. | Posttransplant diabetes in pediatric recipients on tacrolimus. | 1999 | Transplantation | pmid:10096540 |
| Hemenway CS and Heitman J | Calcineurin. Structure, function, and inhibition. | 1999 | Cell Biochem. Biophys. | pmid:10099825 |
| Holländer GA et al. | Molecular and biological actions of cyclosporin A and FK506 on T cell development and function. | 1994 | Transfus Sci | pmid:10155542 |
| Antoniou EA et al. | Immunosuppressive effect of combination schedules of brequinar with leflunomide or tacrolimus on rat cardiac allotransplantation. | 1999 | Microsurgery | pmid:10188834 |
| Yasutsune T et al. | Vasorelaxation and inhibition of the voltage-operated Ca2+ channels by FK506 in the porcine coronary artery. | 1999 | Br. J. Pharmacol. | pmid:10188984 |
| Zhang W et al. | Failure of calcineurin inhibitors to prevent pressure-overload left ventricular hypertrophy in rats. | 1999 | Circ. Res. | pmid:10189360 |
| Fansa H et al. | The effect of the immunosuppressant FK 506 on peripheral nerve regeneration following nerve grafting. | 1999 | J Hand Surg Br | pmid:10190602 |
| Meiser BM et al. | Combination therapy with tacrolimus and mycophenolate mofetil following cardiac transplantation: importance of mycophenolic acid therapeutic drug monitoring. | 1999 | J. Heart Lung Transplant. | pmid:10194038 |
| Azuma N et al. | Immunosuppression with FK506 in rat arterial allografts: fate of allogeneic endothelial cells. | 1999 | J. Vasc. Surg. | pmid:10194498 |
| Mollison KW et al. | Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases. | 1998 | Curr. Pharm. Des. | pmid:10197049 |
| De Lima JJ et al. | Effects of FK506 in rat and human resistance arteries. | 1999 | Kidney Int. | pmid:10201018 |
| Sloper CM et al. | Tacrolimus (FK506) in the treatment of posterior uveitis refractory to cyclosporine. | 1999 | Ophthalmology | pmid:10201592 |
| Nagasaki Y et al. | Reversal of hypopigmentation in phenylketonuria mice by adenovirus-mediated gene transfer. | 1999 | Pediatr. Res. | pmid:10203136 |
| Hortelano S et al. | Protective effect of cyclosporin A and FK506 from nitric oxide-dependent apoptosis in activated macrophages. | 1999 | Br. J. Pharmacol. | pmid:10205001 |
| Cetinkale O et al. | Modulating the functions of neutrophils and lipid peroxidation by FK506 in a rat model of thermal injury. | 1999 | Burns | pmid:10208383 |
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| Jani A et al. | Modulation of cell-mediated immunity prolongs adenovirus-mediated transgene expression in sciatic nerve. | 1999 | Hum. Gene Ther. | pmid:10210146 |
| Knoll GA and Bell RC | Tacrolimus versus cyclosporin for immunosuppression in renal transplantation: meta-analysis of randomised trials. | 1999 | BMJ | pmid:10213717 |
| Green MD and Michaels MG | Tacrolimus: effects and side effects. | 1999 | Pediatr. Infect. Dis. J. | pmid:10223694 |
| Ferrari D et al. | P2X7/P2Z purinoreceptor-mediated activation of transcription factor NFAT in microglial cells. | 1999 | J. Biol. Chem. | pmid:10224077 |
| Herr I et al. | FK506 prevents stroke-induced generation of ceramide and apoptosis signaling. | 1999 | Brain Res. | pmid:10224298 |
| Charco R et al. | Serum cholesterol changes in long-term survivors of liver transplantation: a comparison between cyclosporine and tacrolimus therapy. | 1999 | Liver Transpl Surg | pmid:10226111 |
| Taylor DO et al. | A randomized, multicenter comparison of tacrolimus and cyclosporine immunosuppressive regimens in cardiac transplantation: decreased hyperlipidemia and hypertension with tacrolimus. | 1999 | J. Heart Lung Transplant. | pmid:10226898 |
| Torocsik HV et al. | FK506-induced leukoencephalopathy in children with organ transplants. | 1999 | Neurology | pmid:10227644 |
| Göthel SF and Marahiel MA | Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts. | 1999 | Cell. Mol. Life Sci. | pmid:10228556 |
| Uno T et al. | Pharmacokinetic advantages of a newly developed tacrolimus oil-in-water-type emulsion via the enteral route. | 1999 | Lipids | pmid:10230718 |
| Johnston A and Holt DW | Therapeutic drug monitoring of immunosuppressant drugs. | 1999 | Br J Clin Pharmacol | pmid:10233195 |
| Vente C et al. | Erosive mucosal lichen planus: response to topical treatment with tacrolimus. | 1999 | Br. J. Dermatol. | pmid:10233234 |
| Lyon CC et al. | Recalcitrant pyoderma gangrenosum treated with systemic tacrolimus. | 1999 | Br. J. Dermatol. | pmid:10233300 |
| Jolles S et al. | Combination oral and topical tacrolimus in therapy-resistant pyoderma gangrenosum. | 1999 | Br. J. Dermatol. | pmid:10233301 |
| Mollison KW et al. | A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases. | 1999 | J. Invest. Dermatol. | pmid:10233764 |
| Akahane M et al. | Osteogenic phenotype expression of allogeneic rat marrow cells in porous hydroxyapatite ceramics. | 1999 | J. Bone Miner. Res. | pmid:10234577 |
| Stratta RJ et al. | Evolution in pancreas transplantation techniques: simultaneous kidney-pancreas transplantation using portal-enteric drainage without antilymphocyte induction. | 1999 | Ann. Surg. | pmid:10235529 |
| Remy I and Michnick SW | Clonal selection and in vivo quantitation of protein interactions with protein-fragment complementation assays. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10318894 |
| Genazzani AA et al. | Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10318964 |
| Morioka M et al. | Activities of calcineurin and phosphatase 2A in the hippocampus after transient forebrain ischemia. | 1999 | Brain Res. | pmid:10320733 |
| Ferlicot S et al. | [Smooth muscle mesentery associated with Epstein-Barr virus (EBV). Report of a case in a child with a liver transplant under FK506 regimen]. | 1999 | Ann Pathol | pmid:10320913 |
| Raofi V et al. | A prospective randomized trial comparing the efficacy of tacrolimus versus cyclosporine in black recipients of primary cadaveric renal transplants. | 1999 | Am. J. Surg. | pmid:10326847 |
| Garrity ER et al. | Suggested guidelines for the use of tacrolimus in lung-transplant recipients. | 1999 | J. Heart Lung Transplant. | pmid:10328140 |
| Ruzicka T et al. | Tacrolimus: the drug for the turn of the millennium? | 1999 | Arch Dermatol | pmid:10328199 |
| Schmidt RH et al. | Haemolytic-uraemic syndrome after tacrolimus rescue therapy for cortisone-resistant rejection. | 1999 | Nephrol. Dial. Transplant. | pmid:10328486 |
| Kohyama T et al. | A potent immunosuppressant FK506 inhibits IL-8 expression in human eosinophils. | 1999 | Mol. Cell Biol. Res. Commun. | pmid:10329481 |
| Tian J and Karin M | Stimulation of Elk1 transcriptional activity by mitogen-activated protein kinases is negatively regulated by protein phosphatase 2B (calcineurin). | 1999 | J. Biol. Chem. | pmid:10329725 |
| Nakamura H et al. | Induction of autologous graft-versus-host disease after autologous peripheral blood stem cell transplantation. | 1999 | J. Allergy Clin. Immunol. | pmid:10329849 |
| Dresske B et al. | Synergistic impact of "WOFIE" on the immunosuppressive potency of FK 506 in a heterotopic heart transplantation model in the rat. | 1999 | Transplant. Proc. | pmid:10331001 |
| Okamoto H | The CD38-cyclic ADP-ribose signaling system in insulin secretion. | 1999 | Mol. Cell. Biochem. | pmid:10331647 |
| Iwamoto H et al. | Inhibitory effects of FK506 on the development of experimental allergic/immune-mediated blepharoconjunctivitis in Lewis rats by systemic but not by topical administration. | 1999 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:10333108 |
| Henley SA et al. | Lipids increase after solitary pancreas transplantation. | 1999 | Diabetes Care | pmid:10333952 |
| van den Berg JW et al. | New immunosuppressive drugs and lung transplantation: last or least? | 1999 | Thorax | pmid:10335012 |
| Shirbacheh MV et al. | Pharmacokinetics of intra-arterial delivery of tacrolimus to vascularly isolated rabbit forelimb. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10336506 |
| Gold BG et al. | Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10336507 |
| Steg RE et al. | Cortical blindness and seizures in a patient receiving FK506 after bone marrow transplantation. | 1999 | Bone Marrow Transplant. | pmid:10338054 |
| Ferrand-Drake M et al. | Mitochondrial permeability transition induced DNA-fragmentation in the rat hippocampus following hypoglycemia. | 1999 | Neuroscience | pmid:10338300 |
| Conboy IM et al. | Calcineurin and vacuolar-type H+-ATPase modulate macrophage effector functions. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10339586 |
| Ma D and Carlow CK | Molecular characterization of FKBP13 from filarial parasites. | 1999 | Mol. Biochem. Parasitol. | pmid:10340490 |
| Ruddy SB et al. | Design and characterization of a surfactant-enriched tablet formulation for oral delivery of a poorly water-soluble immunosuppressive agent. | 1999 | Int J Pharm | pmid:10341307 |
| Uchio E et al. | Soluble intercellular adhesion molecule-1 (ICAM-1), CD4, CD8 and interleukin-2 receptor in patients with Behçet's disease and Vogt-Koyanagi-Harada's disease. | 1999 Mar-Apr | Clin. Exp. Rheumatol. | pmid:10342043 |
| Moffatt SD et al. | Potential for improved therapeutic index of FK506 in liposomal formulation demonstrated in a mouse cardiac allograft model. | 1999 | Transplantation | pmid:10342309 |
| Khanna A et al. | Impact of Flt-3 ligand on donor-derived antigen presenting cells and alloimmune reactivity in heart graft recipients given adjuvant donor bone marrow. | 1998 | Transpl. Immunol. | pmid:10342736 |
| Dresske B et al. | WOFIE augments the immunosuppressive potency of FK-506. Window of opportunity for immunological engagement. | 1998 | Transpl. Immunol. | pmid:10342738 |
| Tacrolimus in the prevention of graft rejection: new indication. Helpful alternative to ciclosporin. | 1998 | Prescrire Int | pmid:10342948 | |
| Boehringer M et al. | Kaposi's sarcoma after renal transplantation: treatment with liposomal doxorubicin. | 1999 | Nephrol. Dial. Transplant. | pmid:10344407 |
| Siemann G et al. | Inhibition of cyclic AMP response element-binding protein/cyclic AMP response element-mediated transcription by the immunosuppressive drugs cyclosporin A and FK506 depends on the promoter context. | 1999 | Mol. Pharmacol. | pmid:10347253 |
| Oddis CV et al. | Tacrolimus in refractory polymyositis with interstitial lung disease. | 1999 | Lancet | pmid:10347992 |
| Araki T et al. | Increases in [3H]FK-506 and [3H]L-N(G)-nitro-arginine binding in the rat brain after nigrostriatal dopaminergic denervation. | 1999 | Metab Brain Dis | pmid:10348311 |
| Möller A et al. | The disposition of 14C-labeled tacrolimus after intravenous and oral administration in healthy human subjects. | 1999 | Drug Metab. Dispos. | pmid:10348790 |
| Murata M et al. | A new preconditioning regimen with melphalan, busulphan and total body irradiation followed by low-dose immunosuppressant in allogeneic haemopoietic stem cell transplantation. | 1999 | Br. J. Haematol. | pmid:10354150 |
| Zarifian A et al. | Cyclosporine-associated thrombotic microangiopathy in renal allografts. | 1999 | Kidney Int. | pmid:10354295 |
| Yang J et al. | Sjögren's syndrome in mice carrying the Ipr(cg) gene and the therapeutic efficacy of an immunosuppressive agent FK506. | 1999 | Pathol. Int. | pmid:10355966 |
| Toung TJ et al. | Neuroprotective FK506 does not alter in vivo nitric oxide production during ischemia and early reperfusion in rats. | 1999 | Stroke | pmid:10356112 |
| Muramatsu K et al. | Limb allotransplantation in rats: combined immunosuppression by FK-506 and 15-deoxyspergualin. | 1999 | J Hand Surg Am | pmid:10357540 |
| Cheng HH et al. | Oligomerization state influences the degradation rate of 3-hydroxy-3-methylglutaryl-CoA reductase. | 1999 | J. Biol. Chem. | pmid:10358074 |
| Cao S et al. | Long-term outcomes in pediatric liver recipients: comparison between cyclosporin A and tacrolimus. | 1999 | Pediatr Transplant | pmid:10359027 |
| Doolabh VB and Mackinnon SE | FK506 accelerates functional recovery following nerve grafting in a rat model. | 1999 | Plast. Reconstr. Surg. | pmid:10359255 |
| Johnson KL and Lawen A | Rapamycin inhibits didemnin B-induced apoptosis in human HL-60 cells: evidence for the possible involvement of FK506-binding protein 25. | 1999 | Immunol. Cell Biol. | pmid:10361256 |
| Gummert JF et al. | Newer immunosuppressive drugs: a review. | 1999 | J. Am. Soc. Nephrol. | pmid:10361877 |
| Kanoh S et al. | Effect of FK506 on ATP-induced intracellular calcium oscillations in cow tracheal epithelium. | 1999 | Am. J. Physiol. | pmid:10362712 |
| Jiang H et al. | Tacrolimus versus cyclosporin A: a comparative study on rat renal allograft survival. | 1999 | Transpl. Int. | pmid:10363590 |
| Venz S et al. | Contribution of color and power Doppler sonography to the differential diagnosis of acute and chronic rejection, and tacrolimus nephrotoxicity in renal allografts. | 1999 | Transpl. Int. | pmid:10363595 |
| Onsager DR et al. | Efficacy of tacrolimus in the treatment of refractory rejection in heart and lung transplant recipients. | 1999 | J. Heart Lung Transplant. | pmid:10363689 |
| Ito F et al. | FK506 and cyclosporin A inhibit stem cell factor-dependent cell proliferation/survival, while inducing upregulation of c-kit expression in cells of the mast cell line MC/9. | 1999 | Arch. Dermatol. Res. | pmid:10367710 |
| Przepiorka D et al. | Relationship of tacrolimus whole blood levels to efficacy and safety outcomes after unrelated donor marrow transplantation. | 1999 | Biol. Blood Marrow Transplant. | pmid:10371361 |
| Matzinger P | Graft tolerance: a duel of two signals. | 1999 | Nat. Med. | pmid:10371494 |
| Kirk AD et al. | Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. | 1999 | Nat. Med. | pmid:10371508 |
| Lieberman DN and Mody I | Properties of single NMDA receptor channels in human dentate gyrus granule cells. | 1999 | J. Physiol. (Lond.) | pmid:10373689 |
| Cox KL et al. | Paediatric liver transplantation: indications, timing and medical complications. | 1999 | J. Gastroenterol. Hepatol. | pmid:10382641 |
| Higgins RM et al. | Conversion between cyclosporin and tacrolimus--30-fold dose prediction. | 1999 | Nephrol. Dial. Transplant. | pmid:10383044 |
| Henry ML | Cyclosporine and tacrolimus (FK506): a comparison of efficacy and safety profiles. | 1999 | Clin Transplant | pmid:10383101 |
| Koski GK et al. | Calcium mobilization in human myeloid cells results in acquisition of individual dendritic cell-like characteristics through discrete signaling pathways. | 1999 | J. Immunol. | pmid:10384103 |
| Leung W et al. | Long-term complete remission and immune tolerance after intensive chemotherapy for lymphoproliferative disorders complicating liver transplant. | 1999 | Transplantation | pmid:10385092 |
| Squadrito F et al. | Tacrolimus suppresses tumour necrosis factor-alpha and protects against splanchnic artery occlusion shock. | 1999 | Br. J. Pharmacol. | pmid:10385251 |
| Gerhardt U et al. | Blood pressure control in kidney transplant recipients: influence of immunosuppression. | 1999 | J Auton Pharmacol | pmid:10385269 |
| Liang H et al. | Regulation of angiotensin II-induced phosphorylation of STAT3 in vascular smooth muscle cells. | 1999 | J. Biol. Chem. | pmid:10391929 |
| Hasselder AS | The nursing management of a patient receiving Prograf as a primary immunosuppressive agent. | 1998 Apr-Jun | EDTNA ERCA J | pmid:10392057 |
| Horowitz MM et al. | Tacrolimus vs. cyclosporine immunosuppression: results in advanced-stage disease compared with historical controls treated exclusively with cyclosporine. | 1999 | Biol. Blood Marrow Transplant. | pmid:10392964 |
| Kochi S et al. | Effect of cyclosporin A or tacrolimus on the function of blood-brain barrier cells. | 1999 | Eur. J. Pharmacol. | pmid:10395024 |
| Magee CC et al. | Immunosuppressive agents in organ transplantation. | 1999 | Hosp Med | pmid:10396414 |
| Gold BG et al. | Efficacy of delayed or discontinuous FK506 administrations on nerve regeneration in the rat sciatic nerve crush model: lack of evidence for a conditioning lesion-like effect. | 1999 | Neurosci. Lett. | pmid:10400242 |