tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Nocardia Infections D009617 6 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Graft Occlusion, Vascular D006083 11 associated lipids
Hypercalcemia D006934 13 associated lipids
Per page 10 20 50 100 | Total 613

PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

Download all related citations
Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Myers SA Update on new immunomodulatory agents. 2000 Adv Dermatol pmid:11094629
Gonin JM Maintenance immunosuppression: new agents and persistent dilemmas. 2000 Adv Ren Replace Ther pmid:10782729
Ginocchio L et al. Refractory Ulcerated Necrobiosis Lipoidica: Closure of a Difficult Wound with Topical Tacrolimus. 2017 Adv Skin Wound Care pmid:28914682
Balal M et al. Effects of cyclosporine and tacrolimus on maintenance therapy after renal transplantation. 2004 May-Jun Adv Ther pmid:15509135
Diao H et al. Comparison of tacrolimus, fluorometholone, and saline in mild-to-moderate contact lens-induced papillary conjunctivitis. 2012 Adv Ther pmid:22821643
Hon KL et al. Assessing itch in children with atopic dermatitis treated with tacrolimus: objective versus subjective assessment. 2007 Jan-Feb Adv Ther pmid:17526458
Mancilla UE et al. Primary immunosuppression with tacrolimus in renal transplantation: a multicenter, open-label study. 1999 Sep-Oct Adv Ther pmid:10915396
Lionetti P et al. Mucosal adaptation and destruction in response to lamina propria T cell activation in explants of human fetal intestine. 1995 Adv. Exp. Med. Biol. pmid:8525974
Mori A et al. Enhanced production and gene expression of IL-5 in bronchial asthma. Possible management of atopic diseases with IL-5 specific gene transcription inhibitor. 1996 Adv. Exp. Med. Biol. pmid:9095279
Shahidi M Thrombosis and von Willebrand Factor. 2017 Adv. Exp. Med. Biol. pmid:27628010
Clemann N and Bechter R Effects of rapamycin and FK 506 on rat Sertoli cells in vitro. 1998 Adv. Exp. Med. Biol. pmid:10026935
Thomson AW and Bonham CA Inhibition of T lymphocyte activation and apoptotic cell death by cyclosporin A and tacrolimus (FK506). Its relevance to therapy of HIV infection. 1995 Adv. Exp. Med. Biol. pmid:7572394
Abramowicz D et al. Immunosuppressive strategies in renal transplantation at the beginning of the third millennium. 2000 Adv. Nephrol. Necker Hosp. pmid:11068631
Li PK et al. The complications of newer transplant antirejection drugs: treatment with cyclosporin A, OKT3, and FK506. 1990 Adverse Drug React Acute Poisoning Rev pmid:1703724
Doren EL and Aya-ay ML Pyoderma gangrenosum following breast reduction: treatment with topical tacrolimus and steroids. 2014 Aesthet Surg J pmid:24448967
Bolton C The efficacy of cyclosporin A, FK-506 and prednisolone to modify the adoptive transfer of experimental allergic encephalomyelitis (EAE). 1992 Agents Actions pmid:1380765
Griffiths RJ et al. Characterisation of passively transferred antigen arthritis induced by methylated bovine serum albumin in the rat: effect of FK 506 on arthritis development. 1992 Agents Actions pmid:1384284
Martín-Cano FE et al. mTOR pathway and Ca²⁺ stores mobilization in aged smooth muscle cells. 2013 Aging (Albany NY) pmid:23661091
Sekigawa I et al. FK506 can inhibit apoptotic cell death induced by the HIV-1 envelope glycoprotein gp120. 1994 AIDS pmid:7531458
Antonini TM et al. Therapy with boceprevir or telaprevir in HIV/hepatitis C virus co-infected patients to treat recurrence of hepatitis C virus infection after liver transplantation. 2015 AIDS pmid:25387314
Florio G et al. The immunoglobulin superantigen-binding site of HIV-1 gp120 activates human basophils. 2000 AIDS pmid:10853974
Nowak P et al. Follow-up of antiretroviral treatment in liver transplant recipients with primary and chronic HIV type 1 infection. 2003 AIDS Res. Hum. Retroviruses pmid:12581512
Sklar EM Post-transplant neurotoxicity: what role do calcineurin inhibitors actually play? 2006 AJNR Am J Neuroradiol pmid:16971594
Bargalló N et al. Cortical laminar necrosis caused by immunosuppressive therapy and chemotherapy. 2000 AJNR Am J Neuroradiol pmid:10730638
Bartynski WS et al. Etiology of cortical and white matter lesions in cyclosporin-A and FK-506 neurotoxicity. 2001 Nov-Dec AJNR Am J Neuroradiol pmid:11733324
Bartynski WS et al. Pretransplantation conditioning influence on the occurrence of cyclosporine or FK-506 neurotoxicity in allogeneic bone marrow transplantation. 2004 AJNR Am J Neuroradiol pmid:14970028
Bartynski WS et al. Posterior reversible encephalopathy syndrome after solid organ transplantation. 2008 AJNR Am J Neuroradiol pmid:18272559
Schuuring J et al. Severe tacrolimus leukoencephalopathy after liver transplantation. 2003 Nov-Dec AJNR Am J Neuroradiol pmid:14625238
Oliverio PJ et al. Reversible tacrolimus-induced neurotoxicity isolated to the brain stem. 2000 AJNR Am J Neuroradiol pmid:10954277
Appignani BA et al. Neuroimaging findings in patients on immunosuppressive therapy: experience with tacrolimus toxicity. 1996 AJR Am J Roentgenol pmid:8623651
Landy J and Hart AL Commentary: short-term efficacy of tacrolimus in steroid-refractory ulcerative colitis. 2013 Aliment. Pharmacol. Ther. pmid:23336680
Hirai F et al. Letter: short-term efficacy of tacrolimus in steroid-refractory ulcerative colitis. 2013 Aliment. Pharmacol. Ther. pmid:23336690
Schmidt KJ et al. Letter: short-term efficacy of tacrolimus in steroid-refractory ulcerative colitis - authors' reply. 2013 Aliment. Pharmacol. Ther. pmid:23336691
Baumgart DC et al. Rescue therapy with tacrolimus is effective in patients with severe and refractory inflammatory bowel disease. 2003 Aliment. Pharmacol. Ther. pmid:12755840
Srinivas NR Letter: sublingual dosing of tacrolimus in transplant patients-interesting concept to overcome first pass effects. 2017 Aliment. Pharmacol. Ther. pmid:28589592
Benítez C et al. Letter: sublingual dosing of tacrolimus in transplant patients-interesting concept to overcome first pass effects. Authors' reply. 2017 Aliment. Pharmacol. Ther. pmid:28589580
Yamamoto T et al. Tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis: a retrospective observational study. 2016 Aliment. Pharmacol. Ther. pmid:26762838
Ierardi E et al. Oral tacrolimus long-term therapy in patients with Crohn's disease and steroid resistance. 2001 Aliment. Pharmacol. Ther. pmid:11207512
Travis S Review article: saving the colon in severe colitis - the case for medical therapy. 2006 Aliment. Pharmacol. Ther. pmid:16961749
Schmidt KJ et al. Short-term efficacy of tacrolimus in steroid-refractory ulcerative colitis - experience in 130 patients. 2013 Aliment. Pharmacol. Ther. pmid:23121200
Romano C et al. Oral tacrolimus (FK 506) in refractory paediatric ulcerative colitis. 2010 Aliment. Pharmacol. Ther. pmid:20148798
McSharry K et al. Systematic review: the role of tacrolimus in the management of Crohn's disease. 2011 Aliment. Pharmacol. Ther. pmid:21999607
Itoh S et al. Inhibition of CN (protein phosphatase-2B) suppresses Ca2+-mediated acid secretion in rats. 2002 Aliment. Pharmacol. Ther. pmid:11966520
Yamamoto S et al. Long-term effect of tacrolimus therapy in patients with refractory ulcerative colitis. 2008 Aliment. Pharmacol. Ther. pmid:18549460
O'Leary JG Editorial: tacrolimus-how low can you go? 2017 Aliment. Pharmacol. Ther. pmid:28589579
Beckebaum S et al. Renal function and cardiovascular risk profile after conversion from ciclosporin to tacrolimus: prospective study in 80 liver transplant recipients. 2009 Aliment. Pharmacol. Ther. pmid:19624550
Firpi RJ et al. Sirolimus-induced hyperlipidaemia in liver transplant recipients is not dose-dependent. 2004 Aliment. Pharmacol. Ther. pmid:15113371
Herrlinger KR et al. Infliximab as rescue medication for patients with severe ulcerative/indeterminate colitis refractory to tacrolimus. 2010 Aliment. Pharmacol. Ther. pmid:20175769
Solari S et al. Sublingual tacrolimus administration provides similar drug exposure to per-oral route employing lower doses in liver transplantation: a pilot study. 2017 Aliment. Pharmacol. Ther. pmid:28261844
Hisanaga Y et al. Implication of nitric oxide synthase activity in the genesis of water immersion stress-induced gastric lesions in rats: the protective effects of FK506. 1996 Aliment. Pharmacol. Ther. pmid:8971291
Schwrer H et al. Pantoprazole and cyclosporine or tacrolimus. 2001 Aliment. Pharmacol. Ther. pmid:11284790
Högenauer C et al. Effect of oral tacrolimus (FK 506) on steroid-refractory moderate/severe ulcerative colitis. 2003 Aliment. Pharmacol. Ther. pmid:12940927
Trotter JF et al. Effect of hepatitis C infection on tacrolimus doses and blood levels in liver transplantation recipients. 2005 Aliment. Pharmacol. Ther. pmid:15963078
Nakase H et al. Tacrolimus suppresses IL-12/IL23 p40 in Crohn's disease and heals fistulae refractory to anti-TNF-α therapy. 2011 Aliment. Pharmacol. Ther. pmid:21434949
Nakase H et al. Tacrolimus: rescue therapy or experimental drug for severe ulcerative colitis? 2011 Aliment. Pharmacol. Ther. pmid:21198700
Yamamoto T et al. Letter: which patient profile for tacrolimus in ulcerative colitis? Authors' reply. 2016 Aliment. Pharmacol. Ther. pmid:27137731
Laharie D and Poullenot F Letter: which patient profile for tacrolimus in ulcerative colitis? 2016 Aliment. Pharmacol. Ther. pmid:27137730
Hoshino H et al. Effects of FK506 on an experimental model of colitis in rats. 1995 Aliment. Pharmacol. Ther. pmid:7544633
Lawrance IC and Copeland TS Rectal tacrolimus in the treatment of resistant ulcerative proctitis. 2008 Aliment. Pharmacol. Ther. pmid:18761706
Liberal R et al. Expert clinical management of autoimmune hepatitis in the real world. 2017 Aliment. Pharmacol. Ther. pmid:28004405
Segal JP et al. Systematic review with meta-analysis: the management of chronic refractory pouchitis with an evidence-based treatment algorithm. 2017 Aliment. Pharmacol. Ther. pmid:28008631
Mehta SJ et al. Review article: strategies for the management of chronic unremitting ulcerative colitis. 2013 Aliment. Pharmacol. Ther. pmid:23718288
Yamamoto T et al. Editorial: tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis--authors' reply. 2016 Aliment. Pharmacol. Ther. pmid:27040167
Taylor KM and Sparrow MP Editorial: tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis. 2016 Aliment. Pharmacol. Ther. pmid:27040166
Haagsma EB et al. Inflammatory bowel disease after liver transplantation: the effect of different immunosuppressive regimens. 2003 Aliment. Pharmacol. Ther. pmid:12848624
Nakase H et al. Cytomegalovirus affects clinical outcome of infliximab in ulcerative colitis refractory to tacrolimus. 2010 Aliment. Pharmacol. Ther. pmid:20636704
Ortiz de Frutos FJ [New horizons in the treatment of atopic dermatitis]. Allergol Immunopathol (Madr) pmid:11988144
Mori F et al. Increase of natural killer cells in children with liver transplantation-acquired food allergy. Allergol Immunopathol (Madr) pmid:29456038
Regueiro-García A et al. Haploidentical stem cell transplantation in a boy with chronic granulomatous disease. Allergol Immunopathol (Madr) pmid:29373243
Inoue Y et al. Food allergy after cord blood stem cell transplantation with tacrolimus therapy in two patients who developed veno-occlusive disease. 2012 Allergol Int pmid:22722810
Tsuji T et al. Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 ointment (fingolimod) in NC/Nga mice. 2016 Allergol Int pmid:26666476
Miyachi Y et al. Suplatast/tacrolimus combination therapy for refractory facial erythema in adult patients with atopic dermatitis: a meta-analysis study. 2007 Allergol Int pmid:17582208
Ebihara N et al. Blood level of tacrolimus in patients with severe allergic conjunctivitis treated by 0.1% tacrolimus ophthalmic suspension. 2012 Allergol Int pmid:22361511
Yamamoto M et al. A novel atopic dermatitis model induced by topical application with dermatophagoides farinae extract in NC/Nga mice. 2007 Allergol Int pmid:17460441
Wollenberg A et al. Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment. 2008 Allergy pmid:18445188
Jensen JM et al. Gene expression is differently affected by pimecrolimus and betamethasone in lesional skin of atopic dermatitis. 2012 Allergy pmid:22142306
Bieber T et al. Efficacy and safety of methylprednisolone aceponate ointment 0.1% compared to tacrolimus 0.03% in children and adolescents with an acute flare of severe atopic dermatitis. 2007 Allergy pmid:17298428
Wollenberg A et al. Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment. 2008 Allergy pmid:18592619
Bergstrand H and Lundquist B Human basophil histamine release is differently affected by inhibitors of calmodulin, diacylglycerol kinase and peptidyl prolyl cis-trans isomerase in a secretagogue specific manner. 1992 Allergy pmid:1280915
Kaufmann R et al. Onset of pruritus relief with pimecrolimus cream 1% in adult patients with atopic dermatitis: a randomized trial. 2006 Allergy pmid:16436149
Oldhoff JM et al. Modulation of the atopy patch test: tacrolimus 0.1% compared with triamcinolone acetonide 0.1%. 2006 Allergy pmid:16629794
Simon D et al. Inflammatory cell numbers and cytokine expression in atopic dermatitis after topical pimecrolimus treatment. 2005 Allergy pmid:15932386
Leonardi S et al. Efficacy and safety of tacrolimus ointment 0.03% treatment in a 1-month-old "red baby": a case report. 2006 Nov-Dec Allergy Asthma Proc pmid:17176789
Pacor ML et al. Tacrolimus ointment in nickel sulphate-induced steroid-resistant allergic contact dermatitis. 2006 Nov-Dec Allergy Asthma Proc pmid:17176790
Rico MJ and Lawrence I Tacrolimus ointment for the treatment of atopic dermatitis: clinical and pharmacologic effects. 2002 May-Jun Allergy Asthma Proc pmid:12125507
Szema AM Angioedema in a child with a liver transplant, intussusception, and normal c4 levels. 2010 Jul-Aug Allergy Asthma Proc pmid:20615276
Kay AB Immunosuppressive agents in chronic severe asthma. 1994 May-Jun Allergy Proc pmid:7523242
Wilhelmi E et al. Organotypic brain-slice cultures from adult rats: approaches for a prolonged culture time. 2002 May-Jun Altern Lab Anim pmid:12106005
Mcauliffe EP Is tacrolimus the best therapy for atopic dermatitis? 2003 Am Fam Physician pmid:12751651
Lane JE and Johnson J Persistent penile patch. 2008 Am Fam Physician pmid:19007056
Russell JJ Topical tacrolimus: a new therapy for atopic dermatitis. 2002 Am Fam Physician pmid:12469964
Berke R et al. Atopic dermatitis: an overview. 2012 Am Fam Physician pmid:22962911
Hitzeman N and Kinnevey C Topical Tacrolimus for Eczema. 2016 Am Fam Physician pmid:27929217
Baran DA et al. Calcineurin inhibitor-associated early renal insufficiency in cardiac transplant recipients: risk factors and strategies for prevention and treatment. 2004 Am J Cardiovasc Drugs pmid:14967063
Ramirez R et al. Posterior Reversible Encephalopathy Syndrome After Orthotopic Heart Transplantation: A Case Report. 2017 Am J Case Rep pmid:28465499
Kawamura H et al. Rapid Induction Therapy with Oral Tacrolimus in Elderly Patients with Refractory Ulcerative Colitis Can Easily Lead to Elevated Tacrolimus Concentrations in Blood: A Report of 5 Cases. 2017 Am J Case Rep pmid:28411286
Udomkarnjananun S et al. An Unusual Manifestation of Calcineurin Inhibitor-Induced Pain Syndrome in Kidney Transplantation: A Case Report and Literature Review. 2018 Am J Case Rep pmid:29654227
Cheer SM and Plosker GL Tacrolimus ointment. A review of its therapeutic potential as a topical therapy in atopic dermatitis. 2001 Am J Clin Dermatol pmid:11770393
Iskedjian M et al. Topical calcineurin inhibitors in the treatment of atopic dermatitis: a meta-analysis of current evidence. 2004 Am J Clin Dermatol pmid:15301573
Tjioe M et al. Topical macrolide immunomodulators: a role in the treatment of vitiligo? 2006 Am J Clin Dermatol pmid:16489839