| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Nocardia Infections | D009617 | 6 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Graft Occlusion, Vascular | D006083 | 11 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Haas M et al. | Smooth muscle-specific actin levels in the urine of renal transplant recipients: correlation with cyclosporine or tacrolimus nephrotoxicity. | 1999 | Am. J. Kidney Dis. | pmid:10401019 |
| Katayama Y | [Current tendency in treatment for acute ischemic stroke]. | 1999 | Nippon Ika Daigaku Zasshi | pmid:10401232 |
| Tada H et al. | Role of diltiazem on tacrolimus pharmacokinetics in tacrolimus-induced nephrotoxic rats. | 1999 | Pharmacol. Toxicol. | pmid:10401724 |
| Timmermann W et al. | Videomicroscopic imaging of graft mucosa for monitoring immunosuppressive therapy after small intestinal transplantation in rats. | 1999 | Transplantation | pmid:10401762 |
| Banerjee C et al. | Ca2+ and calmodulin-dependent protein phosphatase from Leishmania donovani. | 1999 | Parasitology | pmid:10406035 |
| Kaibori M et al. | Immunosuppressant FK506 inhibits inducible nitric oxide synthase gene expression at a step of NF-kappaB activation in rat hepatocytes. | 1999 | J. Hepatol. | pmid:10406194 |
| Hebert MF and Lam AY | Diltiazem increases tacrolimus concentrations. | 1999 | Ann Pharmacother | pmid:10410178 |
| Rhew JH et al. | Induction of fibronectin gene expression by inhibitors of protein phosphatase type 2B in normal and transformed fibroblasts. | 1999 | Exp. Mol. Med. | pmid:10410305 |
| Muegge I et al. | Evaluation of PMF scoring in docking weak ligands to the FK506 binding protein. | 1999 | J. Med. Chem. | pmid:10411471 |
| Varghese Z et al. | Calcineurin inhibitors enhance low-density lipoprotein oxidation in transplant patients. | 1999 | Kidney Int. Suppl. | pmid:10412758 |
| Przepiorka D et al. | Tacrolimus for prevention of graft-versus-host disease after mismatched unrelated donor cord blood transplantation. | 1999 | Bone Marrow Transplant. | pmid:10414918 |
| Bavetta S et al. | The effects of FK506 on dorsal column axons following spinal cord injury in adult rats: neuroprotection and local regeneration. | 1999 | Exp. Neurol. | pmid:10415144 |
| Kuroda S et al. | The immunosuppressants cyclosporin A and FK506 equally ameliorate brain damage due to 30-min middle cerebral artery occlusion in hyperglycemic rats. | 1999 | Brain Res. | pmid:10415369 |
| Finn WF | FK506 nephrotoxicity. | 1999 May-Jul | Ren Fail | pmid:10416209 |
| Min DI et al. | Sudden hearing loss associated with tacrolimus in a kidney-pancreas allograft recipient. | 1999 | Pharmacotherapy | pmid:10417040 |
| Mrowietz U | Macrolide immunosuppressants. | 1999 Jul-Aug | Eur J Dermatol | pmid:10417434 |
| Remitz A et al. | Tacrolimus ointment improves psoriasis in a microplaque assay. | 1999 | Br. J. Dermatol. | pmid:10417522 |
| Dalvit C et al. | Use of organic solvents and small molecules for locating binding sites on proteins in solutions. | 1999 | J. Biomol. NMR | pmid:10419292 |
| Dunn SE et al. | Calcineurin is required for skeletal muscle hypertrophy. | 1999 | J. Biol. Chem. | pmid:10419511 |
| Becker JW et al. | 32-Indolyl ether derivatives of ascomycin: three-dimensional structures of complexes with FK506-binding protein. | 1999 | J. Med. Chem. | pmid:10425089 |
| Kato K et al. | Modulation of long-term potentiation induction in the hippocampus by N-methyl-D-aspartate-mediated presynaptic inhibition. | 1999 | Neuroscience | pmid:10426482 |
| Pirenne J | Contribution of large animal models to the development of clinical intestinal transplantation. | 1999 Apr-Jun | Acta Gastroenterol. Belg. | pmid:10427786 |
| Jamieson NV | Adult small intestinal transplantation in Europe. | 1999 Apr-Jun | Acta Gastroenterol. Belg. | pmid:10427790 |
| Kahan BD | An immunosuppressive triumvirate to minimize renal injuries associated with calcineurin antagonist therapy. | 1999 | Transplantation | pmid:10428260 |
| Reichenspurner H et al. | Optimization of the immunosuppressive protocol after lung transplantation. | 1999 | Transplantation | pmid:10428269 |
| Soccal PM et al. | Improvement of drug-induced chronic renal failure in lung transplantation. | 1999 | Transplantation | pmid:10428288 |
| Levy GA | Neoral/cyclosporine-based immunosuppression. | 1999 | Liver Transpl Surg | pmid:10431016 |
| Pollock R and Rivera VM | Regulation of gene expression with synthetic dimerizers. | 1999 | Meth. Enzymol. | pmid:10432459 |
| Shinkura N et al. | Autoantibodies to FK506 binding protein 12 (FKBP12) in autoimmune diseases. | 1999 | Autoimmunity | pmid:10433096 |
| Briggs WA et al. | Lymphocyte suppression by rolipram with other immunosuppressive drugs. | 1999 | J Clin Pharmacol | pmid:10434230 |
| Harikrishnan P and Harden PN | Tacrolimus can resolve cyclosporin-induced gingival hyperplasia. | 1999 | Nephrol. Dial. Transplant. | pmid:10435907 |
| Tsuji Y et al. | Effects of cyclosporin A, FK506 and steroid hormones on hair growth. | 1999 | Exp. Dermatol. | pmid:10439282 |
| Sheikh AM et al. | Concomitant human immunodeficiency virus protease inhibitor therapy markedly reduces tacrolimus metabolism and increases blood levels. | 1999 | Transplantation | pmid:10440408 |
| Moxey-Mims MM | Increased incidence of insulin-dependent diabetes mellitus in pediatric renal transplant patients receiving tacrolimus (FK506) | 1999 | Transplantation | pmid:10440413 |
| Magee CC et al. | Nocardial infection in a renal transplant recipient on tacrolimus and mycophenolate mofetil. | 1999 | Clin. Nephrol. | pmid:10442495 |
| Kur F et al. | Tacrolimus (FK506) as primary immunosuppressant after lung transplantation. | 1999 | Thorac Cardiovasc Surg | pmid:10443520 |
| Uchiyama H et al. | Approach to withdrawal from tacrolimus in a fully allogeneic murine skin graft model. | 1999 | Immunology | pmid:10447745 |
| Volbracht C et al. | ATP controls neuronal apoptosis triggered by microtubule breakdown or potassium deprivation. | 1999 | Mol. Med. | pmid:10449809 |
| Goulet MT et al. | C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10450986 |
| Armstrong HM et al. | Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10450987 |
| Penson MG et al. | Tacrolimus-based triple-drug immunosuppression minimizes serum lipid elevations in pediatric cardiac transplant recipients. | 1999 | J. Heart Lung Transplant. | pmid:10452348 |
| Jones JW et al. | Long-term survival of an extremity composite tissue allograft with FK506-mycophenolate mofetil therapy. | 1999 | Surgery | pmid:10455910 |
| Miura S et al. | The beneficial effects of FK 506 on living-related renal transplantation in presensitized recipients. | 1999 | Transplant. Proc. | pmid:10455940 |
| Jiang H and Kobayashi M | Differences between cyclosporin A and tacrolimus in organ transplantation. | 1999 | Transplant. Proc. | pmid:10455942 |
| Kobashigawa JA | Postoperative management following heart transplantation. | 1999 | Transplant. Proc. | pmid:10455966 |
| Hachida M et al. | Combined use of deoxyspergualin and FK 506 for temporary circulatory assist. | 1999 | Transplant. Proc. | pmid:10455968 |
| Van Gelder RN and Kaplan HJ | Immunosuppression in uveitis therapy. | 1999 | Springer Semin. Immunopathol. | pmid:10457590 |
| Drachenberg CB et al. | Islet cell damage associated with tacrolimus and cyclosporine: morphological features in pancreas allograft biopsies and clinical correlation. | 1999 | Transplantation | pmid:10459544 |
| Burke GA et al. | The role of early renal biopsy in cyclosporin induced thrombotic microangiopathy. | 1999 | Pediatr. Nephrol. | pmid:10460501 |
| Morris-Stiff GJ et al. | Conversion from cyclosporin (Neoral) to tacrolimus (Prograf) in renal allograft recipients with chronic graft nephropathy: results of an observational study. | 1999 | Transpl. Int. | pmid:10460877 |
| Gold BG | FK506 and the role of the immunophilin FKBP-52 in nerve regeneration. | 1999 | Drug Metab. Rev. | pmid:10461545 |
| Arndt C et al. | Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans. | 1999 | Microbiology (Reading, Engl.) | pmid:10463165 |
| Wandel C et al. | P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies. | 1999 | Cancer Res. | pmid:10463589 |
| Alexanian AR and Bamburg JR | Neuronal survival activity of s100betabeta is enhanced by calcineurin inhibitors and requires activation of NF-kappaB. | 1999 | FASEB J. | pmid:10463953 |
| Shuto H et al. | Inhibition of GABA system involved in cyclosporine-induced convulsions. | 1999 | Life Sci. | pmid:10465348 |
| Ivery MT | A proposed molecular model for the interaction of calcineurin with the cyclosporin A-cyclophilin A complex. | 1999 | Bioorg. Med. Chem. | pmid:10465413 |
| Johnson CE and Truong NM | Stability and compatibility of tacrolimus and fluconazole in 0.9% sodium chloride. | 1999 Jul-Aug | J Am Pharm Assoc (Wash) | pmid:10467814 |
| Ogino Y et al. | Comparison of cyclosporin A and tacrolimus concentrations in whole blood between jejunal and ileal transplanted rats. | 1999 | J. Pharm. Pharmacol. | pmid:10467956 |
| Yokogawa K et al. | P-glycoprotein-dependent disposition kinetics of tacrolimus: studies in mdr1a knockout mice. | 1999 | Pharm. Res. | pmid:10468022 |
| Grassberger M et al. | A novel anti-inflammatory drug, SDZ ASM 981, for the treatment of skin diseases: in vitro pharmacology. | 1999 | Br. J. Dermatol. | pmid:10468798 |
| Holtbäck U and Eklöf AC | Mechanism of FK 506/520 action on rat renal proximal tubular Na+, K+-ATPase activity. | 1999 | Kidney Int. | pmid:10469369 |
| MacFarlane GD et al. | Analytical validation of the PRO-Trac II ELISA for the determination of tacrolimus (FK506) in whole blood. | 1999 | Clin. Chem. | pmid:10471647 |
| Hohl CM and Altschuld RA | FK506 alters sarcoplasmic reticulum calcium release in neonatal piglet cardiac myocytes. | 1999 | Pediatr. Res. | pmid:10473047 |
| Medina J et al. | Cytokine profile of human bronchoalveolar macrophages and bronchial epithelial cells in response to inhalation particles of the cyclosporine derivative IMM 125. | 1999 | Inhal Toxicol | pmid:10477442 |
| Herrero JI et al. | Conversion of liver transplant recipients on cyclosporine with renal impairment to mycophenolate mofetil. | 1999 | Liver Transpl Surg | pmid:10477843 |
| Perry SS et al. | Direct effects of cyclosporin A on proliferation of hematopoietic stem and progenitor cells. | 1999 Jul-Aug | Cell Transplant | pmid:10478713 |
| Christner C et al. | Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties. | 1999 | J. Med. Chem. | pmid:10479292 |
| Chan MA et al. | Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506. | 1999 | Phytother Res | pmid:10479754 |
| Fredericks S and Holt DW | TGF-beta quantitation can be tricky. | 1999 | Transplantation | pmid:10480399 |
| Hughes JR et al. | Blood levels of TGFbeta1 in liver transplant recipients receiving either tacrolimus or micro-emulsified cyclosporine. | 1999 | Transplantation | pmid:10480422 |
| Hodge S et al. | Postinoculation PMPA treatment, but not preinoculation immunomodulatory therapy, protects against development of acute disease induced by the unique simian immunodeficiency virus SIVsmmPBj. | 1999 | J. Virol. | pmid:10482616 |
| Fleischer AB | Treatment of atopic dermatitis: role of tacrolimus ointment as a topical noncorticosteroidal therapy. | 1999 | J. Allergy Clin. Immunol. | pmid:10482864 |
| Mookerjee B et al. | Salvage therapy for refractory chronic graft-versus-host disease with mycophenolate mofetil and tacrolimus. | 1999 | Bone Marrow Transplant. | pmid:10482936 |
| Otsu S et al. | [T cell non-depleted bone marrow transplantation for primary refractory erythroleukemia using a partially HLA-mismatched related donor]. | 1999 | Rinsho Ketsueki | pmid:10483142 |
| Tsuji-Takayama K et al. | Interleukin-18 induces interferon-gamma production through NF-kappaB and NFAT activation in murine T helper type 1 cells. | 1999 | Cell. Immunol. | pmid:10486154 |
| Pinna AD et al. | Unusual presentation of graft-versus-host disease in pediatric liver transplant recipients: evidence of late and recurrent disease. | 1999 | Pediatr Transplant | pmid:10487286 |
| Muthuswamy SK et al. | Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers. | 1999 | Mol. Cell. Biol. | pmid:10490623 |
| Ahlers C et al. | Cyclosporin A inhibits Ca2+-mediated upregulation of the DNA repair enzyme DNA polymerase beta in human peripheral blood mononuclear cells. | 1999 | Eur. J. Biochem. | pmid:10491144 |
| Sata M and Walsh K | Cyclosporine downregulates Fas ligand expression on vascular endothelial cells: implication for accelerated vasculopathy by immunosuppressive therapy. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10491310 |
| Yeh CN et al. | Acute overdoses of tacrolimus (FK 506). | 1999 | Dig. Dis. Sci. | pmid:10492148 |
| Jain A et al. | What have we learned about primary liver transplantation under tacrolimus immunosuppression? Long-term follow-up of the first 1000 patients. | 1999 | Ann. Surg. | pmid:10493490 |
| Woo KT | Current therapeutic strategies in glomerulonephritis. | 1999 | Ann. Acad. Med. Singap. | pmid:10497681 |
| Sengoku T et al. | Possible inhibitory mechanism of FK506 (tacrolimus hydrate) ointment for atopic dermatitis based on animal models. | 1999 | Eur. J. Pharmacol. | pmid:10497905 |
| Shapiro R | Tacrolimus in solid organ transplantation: an update. | 1999 | Transplant. Proc. | pmid:10500545 |
| Morales E et al. | Conversion from cyclosporine to FK 506 as rescue therapy in renal transplantation with poorly steroid-responsive acute rejection. | 1999 | Transplant. Proc. | pmid:10500562 |
| Gómez G et al. | Acute tacrolimus nephrotoxicity in renal transplant patients treated with clarithromycin. | 1999 | Transplant. Proc. | pmid:10500563 |
| Moreno M et al. | Clinical management of tacrolimus drug interactions in renal transplant patients. | 1999 | Transplant. Proc. | pmid:10500564 |
| GarcÃa Meseguer C et al. | The effect of different immunosuppression on the outcome of pediatric renal transplants. | 1999 | Transplant. Proc. | pmid:10500577 |
| Torregrosa JV et al. | Combined liver-kidney transplantation: our experience. | 1999 | Transplant. Proc. | pmid:10500591 |
| Cofan F et al. | Fatty acid composition in low-density lipoproteins from renal transplant recipients. | 1999 | Transplant. Proc. | pmid:10500603 |
| Cofan F et al. | Oxidation of low-density lipoproteins in renal transplant recipients. | 1999 | Transplant. Proc. | pmid:10500604 |
| GarcÃa González M et al. | Reversal of QT interval electrocardiographic alterations in cirrhotic patients undergoing liver transplantation. | 1999 | Transplant. Proc. | pmid:10500620 |
| González MG et al. | Comparison of post-liver transplantation electrocardiographic alterations between cyclosporine- and tacrolimus-treated patients. | 1999 | Transplant. Proc. | pmid:10500652 |
| González-Pinto I et al. | Usefulness of the switch to tacrolimus in liver transplantation. | 1999 | Transplant. Proc. | pmid:10500653 |
| Bárcena R et al. | Immunosuppression in liver transplantation: a European survey. | 1999 | Transplant. Proc. | pmid:10500654 |
| Chávez R et al. | Hepatotrophic effect of cyclosporine and FK 506 is not mimicked by rapamycin. | 1999 | Transplant. Proc. | pmid:10500655 |
| EscartÃn A et al. | Orthotopic small bowel transplantation in pigs without steroids. | 1999 | Transplant. Proc. | pmid:10500720 |
| Ribas Y et al. | Lack of accommodation after long-term survival of hamster xenografts in rats. | 1999 | Transplant. Proc. | pmid:10500752 |
| Toki K et al. | Histopathologic findings in routine biopsies of renal transplant allografts. | 1999 | Transplant. Proc. | pmid:10500759 |
| Nakai T et al. | Immunologic changes in heterotopic and orthotopic small bowel transplantation in rats. | 1999 | Transplant. Proc. | pmid:10500761 |