| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Nocardia Infections | D009617 | 6 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Graft Occlusion, Vascular | D006083 | 11 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Abu-Elmagd K et al. | Hepatic and intestinal transplantation at the University of Pittsburgh. | 1998 | Clin Transpl | pmid:10503105 |
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| Linder MW and Elin RJ | Implications of methodologic bias for therapeutic drug monitoring. | 1999 | Arch. Pathol. Lab. Med. | pmid:10506447 |
| Letko E et al. | Tacrolimus (FK 506). | 1999 | Ann. Allergy Asthma Immunol. | pmid:10507260 |
| Cacciarelli TV et al. | An analysis of pretransplantation variables associated with long-term allograft outcome in pediatric liver transplant recipients receiving primary tacrolimus (FK506) therapy. | 1999 | Transplantation | pmid:10507484 |
| Cao Z et al. | Comparison of tacrolimus concentrations measured by the IMx tacrolimus II vs the PRO-TRAC II FK506 ELISA assays. | 1999 | Clin. Chem. | pmid:10508139 |
| Tredger JM et al. | Performance of the IMx tacrolimus II assay and practical limits of detection. | 1999 | Clin. Chem. | pmid:10508145 |
| Chautan M et al. | Interdigital cell death can occur through a necrotic and caspase-independent pathway. | 1999 | Curr. Biol. | pmid:10508592 |
| Sche PP et al. | Display cloning: functional identification of natural product receptors using cDNA-phage display. | 1999 | Chem. Biol. | pmid:10508685 |
| Lee WP and Mathes DW | Hand transplantation: pertinent data and future outlook. | 1999 | J Hand Surg Am | pmid:10509267 |
| Böttiger Y et al. | Tacrolimus whole blood concentrations correlate closely to side-effects in renal transplant recipients. | 1999 | Br J Clin Pharmacol | pmid:10510159 |
| Dusting GJ et al. | Cyclosporin A and tacrolimus (FK506) suppress expression of inducible nitric oxide synthase in vitro by different mechanisms. | 1999 | Br. J. Pharmacol. | pmid:10510443 |
| Robinson BV et al. | Optimal dosing of intravenous tacrolimus following pediatric heart transplantation. | 1999 | J. Heart Lung Transplant. | pmid:10512526 |
| Rostaing L et al. | Differences in Type 1 and Type 2 intracytoplasmic cytokines, detected by flow cytometry, according to immunosuppression (cyclosporine A vs. tacrolimus) in stable renal allograft recipients. | 1999 | Clin Transplant | pmid:10515221 |
| Charney DA et al. | Plasma cell-rich acute renal allograft rejection. | 1999 | Transplantation | pmid:10515379 |
| Fan L et al. | Improved artificial death switches based on caspases and FADD. | 1999 | Hum. Gene Ther. | pmid:10515447 |
| Cunningham EB | An inositolphosphate-binding immunophilin, IPBP12. | 1999 | Blood | pmid:10515881 |
| Cardenas ME et al. | Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action. | 1999 | Clin. Microbiol. Rev. | pmid:10515904 |
| Moore JM | NMR techniques for characterization of ligand binding: utility for lead generation and optimization in drug discovery. | 1999 | Biopolymers | pmid:10516573 |
| Przepiorka D et al. | Tacrolimus and minidose methotrexate for prevention of acute graft-versus-host disease after HLA-mismatched marrow or blood stem cell transplantation. | 1999 | Bone Marrow Transplant. | pmid:10516680 |
| Bekersky I et al. | Bioequivalence of 1 and 5 mg tacrolimus capsules using a replicate study design. | 1999 | J Clin Pharmacol | pmid:10516937 |
| Pacocha SE et al. | Regulation of antigen-induced human T-lymphocyte responses by calcineurin antagonists. | 1999 | J. Allergy Clin. Immunol. | pmid:10518828 |
| Yoshimoto T and Siesjö BK | Posttreatment with the immunosuppressant cyclosporin A in transient focal ischemia. | 1999 | Brain Res. | pmid:10519051 |
| Hübner GI et al. | Drug interaction between mycophenolate mofetil and tacrolimus detectable within therapeutic mycophenolic acid monitoring in renal transplant patients. | 1999 | Ther Drug Monit | pmid:10519451 |
| Mao Z and Wiedmann M | Calcineurin enhances MEF2 DNA binding activity in calcium-dependent survival of cerebellar granule neurons. | 1999 | J. Biol. Chem. | pmid:10521511 |
| Lee SF et al. | Cytokine receptor common beta chain as a potential activator of cytokine withdrawal-induced apoptosis. | 1999 | Mol. Cell. Biol. | pmid:10523628 |
| Shadidy M et al. | Biochemical analysis of mouse FKBP60, a novel member of the FKPB family. | 1999 | Biochim. Biophys. Acta | pmid:10524204 |
| Grimbert P et al. | Tacrolimus (FK506)-induced severe and late encephalopathy in a renal transplant recipient. | 1999 | Nephrol. Dial. Transplant. | pmid:10528682 |
| Cannon RD et al. | Clinical efficacy of the Abbott Tacrolimus II assay for the IMx. | 1999 Oct-Dec | Ann. Clin. Lab. Sci. | pmid:10528829 |
| Morita H et al. | Immunosuppressive effect of leukotriene B(4) receptor antagonist in vitro. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10529362 |
| Okada M et al. | Successful treatment of chronic graft-versus-host disease with sulfasalazine in allogeneic bone marrow transplantation. | 1999 | Acta Haematol. | pmid:10529517 |
| Minematsu T et al. | Sustained QT prolongation induced by tacrolimus in guinea pigs. | 1999 | Life Sci. | pmid:10530807 |
| Morris-Stiff G et al. | Immunosuppression in renal transplantation. Meta-analysis should not have included one of the studies. | 1999 | BMJ | pmid:10531121 |
| Ellis D et al. | Epstein-Barr virus-related disorders in children undergoing renal transplantation with tacrolimus-based immunosuppression. | 1999 | Transplantation | pmid:10532541 |
| Migita K et al. | FK506 markedly enhances apoptosis of antigen-stimulated peripheral T cells by down-regulation of Bcl-xL. | 1999 | Transplantation | pmid:10532544 |
| Leroy-Matheron C et al. | Inhibitor against coagulation factor V after liver transplantation. | 1999 | Transplantation | pmid:10532550 |
| MistrÃková J et al. | Increased neoplasm development due to immunosuppressive treatment with FK-506 in BALB/C mice persistently infected with the mouse herpesvirus (MHV-72). | 1999 | Viral Immunol. | pmid:10532652 |
| Capone D et al. | Effects of itraconazole on tacrolimus blood concentrations in a renal transplant recipient. | 1999 | Ann Pharmacother | pmid:10534229 |
| Matsuda J | [Tacrolimus hydrate (tacrolimus)]. | 1999 | Nippon Rinsho | pmid:10543146 |
| Aoki Y and Kao PN | Erythromycin inhibits transcriptional activation of NF-kappaB, but not NFAT, through calcineurin-independent signaling in T cells. | 1999 | Antimicrob. Agents Chemother. | pmid:10543746 |
| Pearlman DA | Free energy grids: a practical qualitative application of free energy perturbation to ligand design using the OWFEG method. | 1999 | J. Med. Chem. | pmid:10543875 |
| Wiedeman PE et al. | Retention of immunosuppressant activity in an ascomycin analogue lacking a hydrogen-bonding interaction with FKBP12. | 1999 | J. Med. Chem. | pmid:10543889 |
| Himukai R et al. | Relationship between the subcellular localization and structures of catalytic domains of FKBP-type PPIases. | 1999 | J. Biochem. | pmid:10544281 |
| Klein A | Tacrolimus rescue in liver transplant patients with refractory rejection or intolerance or malabsorption of cyclosporine. The US Multicenter FK506 Liver Study Group. | 1999 | Liver Transpl Surg | pmid:10545538 |
| Dubernard JM et al. | [The first transplantation of a hand in humans. Early results]. | 1999 | Chirurgie | pmid:10546388 |
| Ocran KW et al. | Tacrolimus toxicity due to drug interaction with mibefradil in a patient after liver transplantation. | 1999 | Z Gastroenterol | pmid:10549098 |
| Rolles K et al. | A pilot study of immunosuppressive monotherapy in liver transplantation: tacrolimus versus microemulsified cyclosporin. | 1999 | Transplantation | pmid:10551650 |
| Pirsch JD | Cytomegalovirus infection and posttransplant lymphoproliferative disease in renal transplant recipients: results of the U.S. multicenter FK506 Kidney Transplant Study Group. | 1999 | Transplantation | pmid:10551653 |
| Zoppo A et al. | Trimetazidine counteracts tacrolimus nephrotoxicity in a hypertensive liver transplant patient. | 1999 | Transplantation | pmid:10551656 |
| Chen L et al. | Bastadin 10 stabilizes the open conformation of the ryanodine-sensitive Ca(2+) channel in an FKBP12-dependent manner. | 1999 | J. Biol. Chem. | pmid:10551814 |
| Kakefuda T et al. | Nitrosyl hemoglobin detected by near-infrared spectroscopy in rat liver allografts. | 1999 | Transpl. Int. | pmid:10551995 |
| Mizuta K et al. | Influence of tacrolimus on bile acid and lipid composition in continuously drained bile using a rat model. Comparative study with cyclosporine. | 1999 | Transpl. Int. | pmid:10551996 |
| Reichert TE et al. | The role of endogenous interleukin-2 in proliferation of human carcinoma cell lines. | 1999 | Br. J. Cancer | pmid:10555752 |
| Gremillion RB et al. | Tacrolimus (FK506) in the treatment of severe, refractory rheumatoid arthritis: initial experience in 12 patients. | 1999 | J. Rheumatol. | pmid:10555886 |
| Myers JN et al. | Successful use of cyclosporine in a lung transplant recipient with tacrolimus-associated hemolytic uremic syndrome. | 1999 | J. Heart Lung Transplant. | pmid:10561115 |
| Müschen A et al. | Differential IL-10 receptor gene expression in acute versus chronic atopic eczema. Modulation by immunosuppressive drugs and cytokines in normal cultured keratinocytes. | 1999 | Inflamm. Res. | pmid:10563471 |
| Fansa H et al. | [Stimulation of Schwann cell growth and axon regeneration of peripheral nerves by the immunosuppressive drug FK 506]. | 1999 | Handchir Mikrochir Plast Chir | pmid:10566134 |
| Shaw LM et al. | Current opinions on therapeutic drug monitoring of immunosuppressive drugs. | 1999 | Clin Ther | pmid:10566561 |
| Asai A et al. | High level calcineurin activity predisposes neuronal cells to apoptosis. | 1999 | J. Biol. Chem. | pmid:10567426 |
| Fujiki M et al. | Role of T cells in bronchoalveolar space in the development of interstitial pneumonia induced by superantigen in autoimmune-prone mice. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10572064 |
| Shiratori T et al. | [Immunosuppressive treatment of ulcerative colitis]. | 1999 | Nippon Rinsho | pmid:10572417 |
| Burke GW et al. | Microangiopathy in kidney and simultaneous pancreas/kidney recipients treated with tacrolimus: evidence of endothelin and cytokine involvement. | 1999 | Transplantation | pmid:10573073 |
| Young AL et al. | Allo-limbal transplantation in patients with limbal stem cell deficiency. | 1999 | Br J Ophthalmol | pmid:10574823 |
| Rao SK et al. | Limbal allografting using FK-506. | 1999 | Br J Ophthalmol | pmid:10574824 |
| Zhang Y et al. | Immunosuppressant FK506 activates NF-kappaB through the proteasome-mediated degradation of IkappaBalpha. Requirement for Ikappabalpha n-terminal phosphorylation but not ubiquitination sites. | 1999 | J. Biol. Chem. | pmid:10574930 |
| Undre NA et al. | Pharmacokinetics of tacrolimus: clinically relevant aspects. | 1999 | Transplant. Proc. | pmid:10576037 |
| Mayer AD | Four-year follow-up of the European Tacrolimus Multicenter Renal Study. | 1999 | Transplant. Proc. | pmid:10576038 |
| Jordan ML et al. | Tacrolimus-based immunosuppression in pediatric renal transplantation. | 1999 | Transplant. Proc. | pmid:10576039 |
| Kliem V et al. | Conversion to tacrolimus for acute corticosteroid- and antibody-resistant rejection following kidney transplantation. | 1999 | Transplant. Proc. | pmid:10576041 |
| Friemann S et al. | Conversion to tacrolimus in hyperlipidemic patients. | 1999 | Transplant. Proc. | pmid:10576042 |
| Kohnle M et al. | Conversion from cyclosporine to tacrolimus in renal transplant recipients with gum hyperplasia. | 1999 | Transplant. Proc. | pmid:10576043 |
| van Hooff JP et al. | Tacrolimus and glucose metabolism. | 1999 | Transplant. Proc. | pmid:10576044 |
| Soriano S et al. | Single-center experience with initial intravenous dosing of tacrolimus after kidney transplantation. | 1999 | Transplant. Proc. | pmid:10576045 |
| van Hooff JP et al. | Dosing and management guidelines for tacrolimus in renal transplant patients. | 1999 | Transplant. Proc. | pmid:10576046 |
| Oliveira DB and Chang R | Report of the first 118 tacrolimus-treated patients at St George's Hospital, London. | 1999 | Transplant. Proc. | pmid:10576047 |
| Jurewicz WA | Immunological and nonimmunological risk factors with tacrolimus and Neoral in renal transplant recipients: an interim report. | 1999 | Transplant. Proc. | pmid:10576048 |
| Forsythe J | Tacrolimus and mycophenolate mofetil in cadaveric renal transplant recipients. The European Multicentre Tacrolimus/MMF Study Group. | 1999 | Transplant. Proc. | pmid:10576049 |
| Squifflet JP et al. | The Benelux experience with the combination of tacrolimus and mycophenolate mofetil. | 1999 | Transplant. Proc. | pmid:10576050 |
| Morales JM et al. | Tacrolimus, mycophenolate mofetil and corticosteroids as primary immunosuppression after renal transplantation at the Hospital 12 de Octubre, Madrid. | 1999 | Transplant. Proc. | pmid:10576051 |
| Jordan ML et al. | Outcome of tacrolimus conversion therapy for renal allograft rejection: 5-year follow-up. | 1999 | Transplant. Proc. | pmid:10576052 |
| Woodle ES et al. | Corticosteroid withdrawal under tacrolimus primary and rescue therapy in renal transplantation: the Chicago experience. | 1999 | Transplant. Proc. | pmid:10576053 |
| Vanrenterghem Y | Vascular rejection with tacrolimus and potential long-term graft outcome. | 1999 | Transplant. Proc. | pmid:10576054 |
| Villaverde V et al. | Leg bone pain syndrome in a kidney transplant patient treated with tacrolimus (FK506) | 1999 | Ann. Rheum. Dis. | pmid:10577370 |
| Przepiorka D et al. | Practical considerations in the use of tacrolimus for allogeneic marrow transplantation. | 1999 | Bone Marrow Transplant. | pmid:10578154 |
| Watanabe Y et al. | The expression of nonmuscle myosin heavy chain in rat renal transplantation. | 1999 | Transplant. Proc. | pmid:10578260 |
| Fukushima N et al. | Role of endothelial apoptosis in delayed xenograft rejection in pig-to-baboon cardiac transplantation. | 1999 | Transplant. Proc. | pmid:10578268 |
| Moffatt SD and Metcalfe SM | FK 506 versus cyclosporine in combination with anti-CD4/CD8 monoclonal antibodies. | 1999 | Transplant. Proc. | pmid:10578271 |
| Sawai T et al. | A successful induction of tolerance by perioperative intrathymic injection in rat "high-responder" heart transplantation. | 1999 | Transplant. Proc. | pmid:10578275 |
| Uchida H et al. | Chronopharmacology of tacrolimus in rats: toxicity and efficacy in a mouse-to-rat intestinal transplant model and its pharmacokinetic profile. | 1999 | Transplant. Proc. | pmid:10578276 |
| Moffatt SD et al. | Comparative efficacy of liposomal FK 506 with FK 506 (tacrolimus) with and without anti-CD4/CD8 monoclonal antibodies. | 1999 | Transplant. Proc. | pmid:10578277 |
| Hampel G et al. | Different effects of cyclosporine and tacrolimus on the activation of mesangial metalloproteinases and their inhibitors. | 1999 | Transplant. Proc. | pmid:10578279 |
| Ishibashi M et al. | Elimination of the adverse effects of tacrolimus-based induction therapy by a 5-day exposure of optimal steady-state blood concentration in renal transplant patients in the early postoperative period. | 1999 | Transplant. Proc. | pmid:10578281 |
| Tojimbara T et al. | Oral vs intravenous tacrolimus-based induction therapy in renal transplantation. | 1999 | Transplant. Proc. | pmid:10578282 |
| Hairhara Y et al. | Effect of fluconazole on blood levels of tacrolimus. | 1999 | Transplant. Proc. | pmid:10578284 |
| Tamura A et al. | Combination effect of tacrolimus and FTY720 in liver transplantation in rats. | 1999 | Transplant. Proc. | pmid:10578290 |
| Kita J et al. | Effects of tacrolimus on small and large bowel anastomoses in the rat. | 1999 | Transplant. Proc. | pmid:10578292 |
| Azuma T et al. | Study of graft-infiltrating cells in the rat small bowel allograft using low-dose FK 506. | 1999 | Transplant. Proc. | pmid:10578293 |
| Antoniou EA et al. | Effect of donor-specific transfusion in combination with FK 506 in rat cardiac allotransplantation. | 1999 | Transplant. Proc. | pmid:10578296 |
| Uchida H et al. | Experimental intestinal transplantation using mouse fetal intestine in the rat: combination effect of FK 506 with cyclophosphamide. | 1999 | Transplant. Proc. | pmid:10578297 |
| Manu MA et al. | Tacrolimus rescue for resistant rejection, chronic rejection, and immunoglobulin A nephropathy of renal allografts under primary cyclosporine A immunosuppression. | 1999 | Transplant. Proc. | pmid:10578313 |