| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Nocardia Infections | D009617 | 6 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Graft Occlusion, Vascular | D006083 | 11 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- J. Pharmacol. Exp. Ther. (1)
- Am. J. Physiol. Renal Physiol. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen YS et al. | Population pharmacokinetic analysis of tacrolimus in Chinese myasthenia gravis patients. | 2017 | Acta Pharmacol. Sin. | pmid:28552913 |
| Zhang FM et al. | Effects of tacrolimus on infection of Friend murine leukemia virus to Fv-4 gene heterozygous mice. | 2004 | Acta Pharmacol. Sin. | pmid:14769211 |
| Liu S et al. | The POR rs1057868-rs2868177 GC-GT diplotype is associated with high tacrolimus concentrations in early post-renal transplant recipients. | 2016 | Acta Pharmacol. Sin. | pmid:27498776 |
| Luo X et al. | Prediction of tacrolimus metabolism and dosage requirements based on CYP3A4 phenotype and CYP3A5(*)3 genotype in Chinese renal transplant recipients. | 2016 | Acta Pharmacol. Sin. | pmid:26924289 |
| Zhang YF et al. | Pharmacokinetics of tacrolimus converted from twice-daily formulation to once-daily formulation in Chinese stable liver transplant recipients. | 2011 | Acta Pharmacol. Sin. | pmid:21963896 |
| Wang YP et al. | Novel gastroretentive sustained-release tablet of tacrolimus based on self-microemulsifying mixture: in vitro evaluation and in vivo bioavailability test. | 2011 | Acta Pharmacol. Sin. | pmid:21927013 |
| Chen JC and Ma P | Mechanism of FK506-induced renal hypoperfusion and its reversion in rats. | 2001 | Acta Pharmacol. Sin. | pmid:11749797 |
| Yu Y et al. | Electrophysiological actions of cyclosporin A and tacrolimus on rat hippocampal CA1 pyramidal neurons. | 2007 | Acta Pharmacol. Sin. | pmid:18031601 |
| Khan SA et al. | Improvement in baroreflex control of renal sympathetic nerve activity in obese Sprague Dawley rats following immunosuppression. | 2017 | Acta Physiol (Oxf) | pmid:28456134 |
| Borda B et al. | Side effects of the calcineurin inhibitor, such as new-onset diabetes after kidney transplantation. | 2014 | Acta Physiol Hung | pmid:25183511 |
| Drake M et al. | The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain. | 1996 | Acta Physiol. Scand. | pmid:8899062 |
| Ibarra FR et al. | Intracellular sodium modulates the state of protein kinase C phosphorylation of rat proximal tubule Na+,K+-ATPase. | 2002 | Acta Physiol. Scand. | pmid:12028137 |
| Folwarczna J et al. | Effect of low-dose tacrolimus coadministered with raloxifene on the skeletal system in male rats. | 2009 Mar-Apr | Acta Pol Pharm | pmid:19719057 |
| Turło J et al. | Submerged cultivation of Streptomyces tsukubaensis in media composed of waste products of food industry. | 2006 Sep-Oct | Acta Pol Pharm | pmid:17357618 |
| Kaczmarczyk-Sedlak I et al. | Raloxifene does not affect the changes in bone histomorphometric parameters induced by low dose tacrolimus in male rats. | 2006 Jul-Aug | Acta Pol Pharm | pmid:17203868 |
| Wartenberg KE et al. | Transient diffusion-weighted imaging changes in a patient with reversible leukoencephalopathy syndrome. | 2004 | Acta Radiol | pmid:15587428 |
| Radziejewski K et al. | Assessment of corneal and conjunctival metaplasia by impression cytology during the treatment of canine keratoconjunctivitis sicca. | 2018 | Acta Vet. Hung. | pmid:29958527 |
| Radziejewski K and Balicki I | Comparative clinical evaluation of tacrolimus and cyclosporine eye drops for the treatment of canine keratoconjunctivitis sicca. | 2016 | Acta Vet. Hung. | pmid:27653428 |
| Kageyama S et al. | Augmentation of natural killer cell activity induced by cytomegalovirus infection in mice treated with FK506. | 1997 | Acta Virol. | pmid:9391652 |
| Tejera-Vaquerizo A et al. | [Adult blaschkitis (lichen striatus) successfully treated with topical tacrolimus]. | 2009 | Actas Dermosifiliogr | pmid:19715657 |
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| Ormaechea-Pérez N et al. | Superficial granulomatous pyoderma. Report of 2 cases treated with topical tacrolimus. | 2013 | Actas Dermosifiliogr | pmid:23933249 |
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| GarcÃa-Rabasco AE et al. | [Pyoderma gangrenosum associated with hidradenitis suppurativa: a case report and review of the literature]. | 2010 | Actas Dermosifiliogr | pmid:20965015 |
| Blasco-Morente G et al. | Long-Standing Presternal Plaque. | 2015 | Actas Dermosifiliogr | pmid:25917959 |
| Gómez-Sánchez ME et al. | Intralymphatic Histiocytosis: A Report of 2 Cases. | Actas Dermosifiliogr | pmid:28256202 | |
| Turrión-Merino L et al. | A Case Series of 4 Patients With Peristomal Pyoderma Gangrenosum: Review of Risk Factors and Treatment Response. | 2016 | Actas Dermosifiliogr | pmid:26626501 |
| Salgüero Fernández I et al. | Rapidly progressive infiltrated plaques in a transplant recipient. | 2017 | Actas Dermosifiliogr | pmid:27677210 |
| Pitarch G and Giner F | Periorbital necrobiosis lipoidica. | 2013 | Actas Dermosifiliogr | pmid:23871211 |
| Varela-Veiga A et al. | Long-standing Papules on the Scrotum. | 2017 | Actas Dermosifiliogr | pmid:27328825 |
| Alomar A | [Role of topical calcineurin inhibitors in dermatology]. | 2008 | Actas Dermosifiliogr | pmid:18346422 |
| Undre NA | [Pharmacokinetics of tacrolimus following topical application of tacrolimus ointment in adult and paediatric patients with atopic dermatitis]. | 2008 | Actas Dermosifiliogr | pmid:18346423 |
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| GarcÃa-Delgado R et al. | Systemic Absorption of Topical Tacrolimus in Metastatic Crohn Disease With Skin Ulcers. | 2016 | Actas Dermosifiliogr | pmid:27372545 |
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| Almeida P et al. | [Vitiligo. Treatment of 12 cases with topical tacrolimus]. | 2005 | Actas Dermosifiliogr | pmid:16476357 |
| Pérez-López I et al. | Koebner phenomenon in a patient with lichen sclerosus following a jellyfish sting: an exceptional morphology. | 2015 | Actas Dermosifiliogr | pmid:25597413 |
| Ojeda T et al. | [Ulcerative lichen planus of the sole treated with tacrolimus, 0.1%]. | 2011 | Actas Dermosifiliogr | pmid:21345398 |
| Apalla Z et al. | Psoriatic cheilitis: a report of 2 cases treated successfully with topical tacrolimus and a review of the literature. | 2015 | Actas Dermosifiliogr | pmid:26164836 |
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| Yigitaslan S et al. | The Effect of P-Glycoprotein Inhibition and Activation on the Absorption and Serum Levels of Cyclosporine and Tacrolimus in Rats. | Adv Clin Exp Med | pmid:27627555 | |
| Heath M and Raugi GJ | Evidence-based evaluation of immunomodulatory therapy for the cutaneous manifestations of lupus. | 2004 | Adv Dermatol | pmid:15544204 |