| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Nocardia Infections | D009617 | 6 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Graft Occlusion, Vascular | D006083 | 11 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Takada Y et al. | Improvement of allograft viability with organs procured from non-heart-beating donors in porcine liver transplantation. | 2000 | Transplant. Proc. | pmid:10715416 |
| Morita H et al. | Acceptance of skin xenografts (from guinea pig to mice) by portal venous and intravenous injections of donor hematolymphoid cells. | 2000 | Transplant. Proc. | pmid:10715422 |
| Vela CG et al. | Prospective study of lipid disorders in FK506-versus cyclosporine-treated renal transplant patients. | 2000 | Transplant. Proc. | pmid:10715453 |
| Dunnett SB | The failure of axon regeneration in the CNS is not absolute. | 1999 | Neuroreport | pmid:10716198 |
| Sugawara T et al. | Immunosuppressants promote adult dorsal root regeneration into the spinal cord. | 1999 | Neuroreport | pmid:10716239 |
| Campbell G et al. | Spontaneous axonal regeneration after optic nerve injury in adult rat. | 1999 | Neuroreport | pmid:10716240 |
| Smythe GM et al. | Enhanced migration and fusion of donor myoblasts in dystrophic and normal host muscle. | 2000 | Muscle Nerve | pmid:10716768 |
| Lee M et al. | FK506 promotes functional recovery in crushed rat sciatic nerve. | 2000 | Muscle Nerve | pmid:10716776 |
| Carr DB et al. | Maternal hemodynamics and pregnancy outcome in women with prior orthotopic liver transplantation. | 2000 | Liver Transpl. | pmid:10719023 |
| Hale GA et al. | Blood tacrolimus concentrations in bone marrow transplant patients undergoing plasmapheresis. | 2000 | Bone Marrow Transplant. | pmid:10723590 |
| Inomata Y et al. | [Weaning of immunosuppression in living-related liver transplantation]. | 1999 | Nihon Rinsho Meneki Gakkai Kaishi | pmid:10726480 |
| Konrad T et al. | Evidence for impaired glucose effectiveness in cirrhotic patients after liver transplantation. | 2000 | Metab. Clin. Exp. | pmid:10726916 |
| Fukuda H et al. | Differences between lymphocyte subsets, after allogeneic bone marrow transplantation, in patients who received tacrolimus and patients who received cyclosporin A. | 2000 | Int. J. Hematol. | pmid:10729997 |
| Plosker GL and Foster RH | Tacrolimus: a further update of its pharmacology and therapeutic use in the management of organ transplantation. | 2000 | Drugs | pmid:10730553 |
| Bargalló N et al. | Cortical laminar necrosis caused by immunosuppressive therapy and chemotherapy. | 2000 | AJNR Am J Neuroradiol | pmid:10730638 |
| Ierardi E et al. | Oral tacrolimus (FK 506) in Crohn's disease complicated by fistulae of the perineum. | 2000 | J. Clin. Gastroenterol. | pmid:10730928 |
| Sigalet DL et al. | Impact of FK506 and steroids on adaptation after intestinal resection or segmental transplantation. | 2000 | Pediatr Transplant | pmid:10731053 |
| Pappas PA et al. | Sirolimus in pediatric gastrointestinal transplantation: the use of sirolimus for pediatric transplant patients with tacrolimus-related cardiomyopathy. | 2000 | Pediatr Transplant | pmid:10731058 |
| Eades SK et al. | Increased tacrolimus levels in a pediatric renal transplant patient attributed to chronic diarrhea. | 2000 | Pediatr Transplant | pmid:10731062 |
| Squadrito F et al. | Tacrolimus limits polymorphonuclear leucocyte accumulation and protects against myocardial ischaemia- reperfusion injury. | 2000 | J. Mol. Cell. Cardiol. | pmid:10731442 |
| Prima V et al. | Alteration of the glucocorticoid receptor subcellular localization by non steroidal compounds. | 2000 Jan-Feb | J. Steroid Biochem. Mol. Biol. | pmid:10731632 |
| Adalsteinsson H and Bruice TC | Generation and evaluation of putative neuroregenerative drugs. Part 1: virtual point mutations to the polyketide rapamycin. | 2000 | Bioorg. Med. Chem. | pmid:10732978 |
| Kawai T et al. | FK506-induced autoimmune diabetes. | 2000 | Ann. Intern. Med. | pmid:10733461 |
| Wong KM et al. | Abbreviated tacrolimus area-under-the-curve monitoring for renal transplant recipients. | 2000 | Am. J. Kidney Dis. | pmid:10739787 |
| Böhmig GA et al. | Role of humoral immune reactions as target for antirejection therapy in recipients of a spousal-donor kidney graft. | 2000 | Am. J. Kidney Dis. | pmid:10739788 |
| Li ST et al. | High Ca(2+)/low Mg(2+) solution induces long-term depression in rat CA1 pyramidal neurons. | 2000 | Neurosci. Lett. | pmid:10739895 |
| Dubowchik GM et al. | Fluoresceinated FKBP12 ligands for a high-throughput fluorescence polarization assay. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10741553 |
| Weidelt T and Isenberg G | Augmentation of SR Ca(2+) release by rapamycin and FK506 causes K(+)-channel activation and membrane hyperpolarization in bladder smooth muscle. | 2000 | Br. J. Pharmacol. | pmid:10742283 |
| Yoshida EM et al. | Post-transplant diabetic ketoacidosis--a possible consequence of immunosuppression with calcineurin inhibiting agents: a case series. | 2000 | Transpl. Int. | pmid:10743693 |
| Emre S et al. | Treatment of tacrolimus-related adverse effects by conversion to cyclosporine in liver transplant recipients. | 2000 | Transpl. Int. | pmid:10743694 |
| Skuk D et al. | Myoblast transplantation in whole muscle of nonhuman primates. | 2000 | J. Neuropathol. Exp. Neurol. | pmid:10744058 |
| Gaziev D et al. | Chronic graft-versus-host disease: is there an alternative to the conventional treatment? | 2000 | Bone Marrow Transplant. | pmid:10745252 |
| Minematsu T et al. | Pharmacokinetic/pharmacodynamic analysis of tacrolimus-induced QT prolongation in guinea pigs. | 1999 | Biol. Pharm. Bull. | pmid:10746167 |
| Chiou WL et al. | Apparent lack of effect of P-glycoprotein on the gastrointestinal absorption of a substrate, tacrolimus, in normal mice. | 2000 | Pharm. Res. | pmid:10751036 |
| Shimizu T et al. | Clinical and histological analysis of acute tacrolimus (TAC) nephrotoxicity in renal allografts. | 1999 | Clin Transplant | pmid:10751057 |
| Wang MS and Gold BG | FK506 increases the regeneration of spinal cord axons in a predegenerated peripheral nerve autograft. | 1999 | J Spinal Cord Med | pmid:10751133 |
| Davis DL et al. | Biochemical characterization of the minor immunophilins. | 2000 | Clin. Biochem. | pmid:10751584 |
| Freeman EE and Grosskreutz CL | The effects of FK506 on retinal ganglion cells after optic nerve crush. | 2000 | Invest. Ophthalmol. Vis. Sci. | pmid:10752948 |
| Harmon JD et al. | Stuttering priapism in a liver transplant patient with toxic levels of fk506. | 1999 | Urology | pmid:10754131 |
| Johnson C et al. | Randomized trial of tacrolimus (Prograf) in combination with azathioprine or mycophenolate mofetil versus cyclosporine (Neoral) with mycophenolate mofetil after cadaveric kidney transplantation. | 2000 | Transplantation | pmid:10755536 |
| Miller J et al. | Safety and efficacy of tacrolimus in combination with mycophenolate mofetil (MMF) in cadaveric renal transplant recipients. FK506/MMF Dose-Ranging Kidney Transplant Study Group. | 2000 | Transplantation | pmid:10755543 |
| Mohamed MA et al. | TGF-beta expression in renal transplant biopsies: a comparative study between cyclosporin-A and tacrolimus. | 2000 | Transplantation | pmid:10755567 |
| Kano S et al. | [Role of FK506-binding protein (FKBP) in Ca+ oscillation in bronchial epithelial cells]. | 2000 | Jpn J Antibiot | pmid:10756444 |
| Takahashi N | [Macrolide compounds as inhibitors of the intracellular signal transmission pathway: the mechanism of actions of rapamycin and FK506]. | 2000 | Jpn J Antibiot | pmid:10756454 |
| Yamamoto K et al. | Immune response to adenovirus-delivered antigens upregulates utrophin and results in mitigation of muscle pathology in mdx mice. | 2000 | Hum. Gene Ther. | pmid:10757347 |
| Minervini MI et al. | Acute renal allograft rejection with severe tubulitis (Banff 1997 grade IB). | 2000 | Am. J. Surg. Pathol. | pmid:10757402 |
| Tchah H and Lim B | Effect of FK 506 on the cornea: use of topical FK 506 in corneal transplantation in a guinea pig-rat model. | 1999 | Korean J Ophthalmol | pmid:10761401 |
| Thorp M et al. | The effect of conversion from cyclosporine to tacrolimus on gingival hyperplasia, hirsutism and cholesterol. | 2000 | Transplantation | pmid:10762229 |
| Nevins TE | Overview of new immunosuppressive therapies. | 2000 | Curr. Opin. Pediatr. | pmid:10763765 |
| Gordjani N et al. | Cyclosporin-A-induced effects on the free Ca2+ concentration in LLC-PK1-cells and their mechanisms. | 2000 | Pflugers Arch. | pmid:10764223 |
| Brazis PW et al. | A case of bilateral optic neuropathy in a patient on tacrolimus (FK506) therapy after liver transplantation. | 2000 | Am. J. Ophthalmol. | pmid:10764869 |
| Klein BC et al. | Influence of mycophenolic acid and FK-506 on human platelet activation in vitro. | 2000 | Kidney Blood Press. Res. | pmid:10765114 |
| Fernández-Miranda C et al. | Plasma homocysteine levels in renal transplanted patients on cyclosporine or tacrolimus therapy: effect of treatment with folic acid. | 2000 | Clin Transplant | pmid:10770414 |
| Outeda MacÃas M et al. | Tacrolimus-itraconazole interaction in a kidney transplant patient. | 2000 | Ann Pharmacother | pmid:10772445 |
| pmid:10773614 | ||||
| Kraiss LW et al. | Fluid flow activates a regulator of translation, p70/p85 S6 kinase, in human endothelial cells. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10775131 |
| Yamani MH et al. | Efficacy of tacrolimus in patients with steroid-resistant cardiac allograft cellular rejection. | 2000 | J. Heart Lung Transplant. | pmid:10775813 |
| Attur MG et al. | Differential anti-inflammatory effects of immunosuppressive drugs: cyclosporin, rapamycin and FK-506 on inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and PGE2 production. | 2000 | Inflamm. Res. | pmid:10778917 |
| Peters D et al. | Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506. | 2000 | Blood | pmid:10779414 |
| Chini EN and Walker H | FK506 (tacrolimus) increases halothane-induced Ca2+ release from skeletal muscle sarcoplasmic reticulum. | 2000 | Anesthesiology | pmid:10781282 |
| Vestergaard C et al. | The NC/Nga mouse: a model for atopic dermatitis. | 2000 | Mol Med Today | pmid:10782068 |
| Gonin JM | Maintenance immunosuppression: new agents and persistent dilemmas. | 2000 | Adv Ren Replace Ther | pmid:10782729 |
| Kataoka T and Nagai K | Involvement of FK506-sensitive and insensitive granule exocytosis pathways in perforin-dependent target cell lysis mediated by a CD8+ CTL clone. | 2000 | Immunol. Lett. | pmid:10789681 |
| Katayama Y et al. | [Studies on brain pyruvate dehydrogenase (PDH) activity and energy metabolites during ischemia and reperfusion]. | 1999 | Rinsho Shinkeigaku | pmid:10791103 |
| Neckermann G et al. | Atopic dermatitis-like symptoms in hypomagnesaemic hairless rats are prevented and inhibited by systemic or topical SDZ ASM 981. | 2000 | Br. J. Dermatol. | pmid:10792216 |
| Ramsay HM and Harden PN | Cyclosporin-induced flushing in a renal transplant recipient resolving after substitution with tacrolimus. | 2000 | Br. J. Dermatol. | pmid:10792253 |
| Yoshizawa K et al. | Time-specific occurrence of alopecia in neonatal C57BL mice treated with N-methyl-N-nitrosourea and the therapeutic efficacy of tacrolimus hydrate. | 2000 | Pathol. Int. | pmid:10792780 |
| Kiani A et al. | Manipulating immune responses with immunosuppressive agents that target NFAT. | 2000 | Immunity | pmid:10795734 |
| Gaweco AS et al. | Intragraft localization of activated nuclear factor kappaB in recurrent hepatitis C virus disease following liver transplantation. | 2000 | Hepatology | pmid:10796896 |
| Lu YM et al. | Calcineurin-mediated LTD of GABAergic inhibition underlies the increased excitability of CA1 neurons associated with LTP. | 2000 | Neuron | pmid:10798404 |
| Qi S et al. | Effect of tacrolimus (FK506) and sirolimus (rapamycin) mono- and combination therapy in prolongation of renal allograft survival in the monkey. | 2000 | Transplantation | pmid:10798741 |
| Borger P et al. | Cyclosporine, FK506, mycophenolate mofetil, and prednisolone differentially modulate cytokine gene expression in human airway-derived epithelial cells. | 2000 | Transplantation | pmid:10798763 |
| Moffatt SD et al. | STAT 6 up-regulation by FK506 in the presence of interleukin-4. | 2000 | Transplantation | pmid:10798785 |
| Adachi S et al. | Successive expression and activation of NFAT family members during thymocyte differentiation. | 2000 | J. Biol. Chem. | pmid:10799559 |
| Biggar SR and Crabtree GR | Chemically regulated transcription factors reveal the persistence of repressor-resistant transcription after disrupting activator function. | 2000 | J. Biol. Chem. | pmid:10801867 |
| Pirsch J et al. | Coadministration of tacrolimus and mycophenolate mofetil in stable kidney transplant patients: pharmacokinetics and tolerability. | 2000 | J Clin Pharmacol | pmid:10806606 |
| Riley L et al. | Cross-sensitivity reaction between tacrolimus and macrolide antibiotics. | 2000 | Bone Marrow Transplant. | pmid:10808214 |
| Chen XJ et al. | Positive and negative control of multidrug resistance by the Sit4 protein phosphatase in Kluyveromyces lactis. | 2000 | J. Biol. Chem. | pmid:10809730 |
| Glanemann M et al. | Higher immunosuppressive efficacy of mycophenolate mofetil in combination with FK 506 than in combination with cyclosporine A. | 2000 | Transplant. Proc. | pmid:10812095 |
| White SA et al. | Randomized trial comparing neoral and tacrolimus immunousuppression for recipients of renal transplants procured from different donor groups. | 2000 | Transplant. Proc. | pmid:10812132 |
| Taber DJ et al. | Drug-drug interaction between chloramphenicol and tacrolimus in a liver transplant recipient. | 2000 | Transplant. Proc. | pmid:10812156 |
| Soran A et al. | Renal retransplantation in elderly recipients under tacrolimus-based immunosuppression. | 2000 | Transplant. Proc. | pmid:10812157 |
| McLaughlin GE et al. | Use of phenobarbital in the management of acute tacrolimus toxicity: a case report. | 2000 | Transplant. Proc. | pmid:10812158 |
| Levy GA | Neoral use in the liver transplant recipient. | 2000 | Transplant. Proc. | pmid:10814745 |
| Przepiorka D et al. | Tacrolimus does not abrogate the increased risk of acute graft-versus-host disease after unrelated-donor marrow transplantation with allelic mismatching at HLA-DRB1 and HLA-DQB1. | 2000 | Biol. Blood Marrow Transplant. | pmid:10816027 |
| Küsters E et al. | Purification of an ascomycin derivative with simulated moving bed chromatography. A case study. | 2000 | J Chromatogr A | pmid:10817355 |
| Wang JJ et al. | Dimerization-dependent block of the proapoptotic effect of p75(NTR). | 2000 | J. Neurosci. Res. | pmid:10820429 |
| Ortega-Pérez I and Redondo JM | [The NFAT transcription factor family as immunosuppression target]. | 2000 | Nefrologia | pmid:10822734 |
| Bang H et al. | Prolyl isomerases in a minimal cell. Catalysis of protein folding by trigger factor from Mycoplasma genitalium. | 2000 | Eur. J. Biochem. | pmid:10824113 |
| Otley CC and Pittelkow MR | Skin cancer in liver transplant recipients. | 2000 | Liver Transpl. | pmid:10827224 |
| Eckhoff DE et al. | The safety and efficacy of a two-dose daclizumab (zenapax) induction therapy in liver transplant recipients. | 2000 | Transplantation | pmid:10830224 |
| Nakata Y et al. | Tacrolimus and myocardial hypertrophy. | 2000 | Transplantation | pmid:10830241 |
| Blaheta RA et al. | Mycophenolate mofetil decreases endothelial prostaglandin E2 in response to allogeneic T cells or cytokines. | 2000 | Transplantation | pmid:10830246 |
| Jindal RM and Dubernard JM | Towards a specific immunosuppression for pancreas and islet grafts. | 2000 | Clin Transplant | pmid:10831083 |
| Rerolle JP et al. | Tacrolimus-induced hemolytic uremic syndrome and end-stage renal failure after liver transplantation. | 2000 | Clin Transplant | pmid:10831087 |
| Filler G et al. | Tacrolimus reversibly reduces insulin secretion in paediatric renal transplant recipients. | 2000 | Nephrol. Dial. Transplant. | pmid:10831643 |
| Gallagher H et al. | Post-transplantation lymphoproliferative disorder: an unusual presentation in a patient receiving tacrolimus. | 2000 | Nephrol. Dial. Transplant. | pmid:10831670 |
| Chen H et al. | Compromised kidney graft rejection response in Vervet monkeys after withdrawal of immunosuppressants tacrolimus and sirolimus. | 2000 | Transplantation | pmid:10836361 |
| Moffatt SD and Metcalfe SM | Comparison between tacrolimus and cyclosporine as immunosuppressive agents compatible with tolerance induction by CD4/CD8 blockade. | 2000 | Transplantation | pmid:10836388 |
| Higgins RM et al. | Conversion from tacrolimus to cyclosporine in stable renal transplant patients: safety, metabolic changes, and pharmacokinetic comparison. | 2000 | Transplantation | pmid:10836393 |