tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Nocardia Infections D009617 6 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Graft Occlusion, Vascular D006083 11 associated lipids
Hypercalcemia D006934 13 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

Download all related citations
Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Srinivas NR Letter: sublingual dosing of tacrolimus in transplant patients-interesting concept to overcome first pass effects. 2017 Aliment. Pharmacol. Ther. pmid:28589592
Benítez C et al. Letter: sublingual dosing of tacrolimus in transplant patients-interesting concept to overcome first pass effects. Authors' reply. 2017 Aliment. Pharmacol. Ther. pmid:28589580
Ierardi E et al. Oral tacrolimus long-term therapy in patients with Crohn's disease and steroid resistance. 2001 Aliment. Pharmacol. Ther. pmid:11207512
Yamamoto S et al. Long-term effect of tacrolimus therapy in patients with refractory ulcerative colitis. 2008 Aliment. Pharmacol. Ther. pmid:18549460
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Firpi RJ et al. Sirolimus-induced hyperlipidaemia in liver transplant recipients is not dose-dependent. 2004 Aliment. Pharmacol. Ther. pmid:15113371
Herrlinger KR et al. Infliximab as rescue medication for patients with severe ulcerative/indeterminate colitis refractory to tacrolimus. 2010 Aliment. Pharmacol. Ther. pmid:20175769
Solari S et al. Sublingual tacrolimus administration provides similar drug exposure to per-oral route employing lower doses in liver transplantation: a pilot study. 2017 Aliment. Pharmacol. Ther. pmid:28261844
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Trotter JF et al. Effect of hepatitis C infection on tacrolimus doses and blood levels in liver transplantation recipients. 2005 Aliment. Pharmacol. Ther. pmid:15963078
Hoshino H et al. Effects of FK506 on an experimental model of colitis in rats. 1995 Aliment. Pharmacol. Ther. pmid:7544633
Liberal R et al. Expert clinical management of autoimmune hepatitis in the real world. 2017 Aliment. Pharmacol. Ther. pmid:28004405
Segal JP et al. Systematic review with meta-analysis: the management of chronic refractory pouchitis with an evidence-based treatment algorithm. 2017 Aliment. Pharmacol. Ther. pmid:28008631
Yamamoto T et al. Editorial: tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis--authors' reply. 2016 Aliment. Pharmacol. Ther. pmid:27040167
Taylor KM and Sparrow MP Editorial: tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis. 2016 Aliment. Pharmacol. Ther. pmid:27040166
Nakase H et al. Cytomegalovirus affects clinical outcome of infliximab in ulcerative colitis refractory to tacrolimus. 2010 Aliment. Pharmacol. Ther. pmid:20636704
Ortiz de Frutos FJ [New horizons in the treatment of atopic dermatitis]. Allergol Immunopathol (Madr) pmid:11988144
Mori F et al. Increase of natural killer cells in children with liver transplantation-acquired food allergy. Allergol Immunopathol (Madr) pmid:29456038
Regueiro-García A et al. Haploidentical stem cell transplantation in a boy with chronic granulomatous disease. Allergol Immunopathol (Madr) pmid:29373243
Inoue Y et al. Food allergy after cord blood stem cell transplantation with tacrolimus therapy in two patients who developed veno-occlusive disease. 2012 Allergol Int pmid:22722810
Tsuji T et al. Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 ointment (fingolimod) in NC/Nga mice. 2016 Allergol Int pmid:26666476
Miyachi Y et al. Suplatast/tacrolimus combination therapy for refractory facial erythema in adult patients with atopic dermatitis: a meta-analysis study. 2007 Allergol Int pmid:17582208
Ebihara N et al. Blood level of tacrolimus in patients with severe allergic conjunctivitis treated by 0.1% tacrolimus ophthalmic suspension. 2012 Allergol Int pmid:22361511
Yamamoto M et al. A novel atopic dermatitis model induced by topical application with dermatophagoides farinae extract in NC/Nga mice. 2007 Allergol Int pmid:17460441
Wollenberg A et al. Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment. 2008 Allergy pmid:18445188
Jensen JM et al. Gene expression is differently affected by pimecrolimus and betamethasone in lesional skin of atopic dermatitis. 2012 Allergy pmid:22142306
Bieber T et al. Efficacy and safety of methylprednisolone aceponate ointment 0.1% compared to tacrolimus 0.03% in children and adolescents with an acute flare of severe atopic dermatitis. 2007 Allergy pmid:17298428
Wollenberg A et al. Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment. 2008 Allergy pmid:18592619
Bergstrand H and Lundquist B Human basophil histamine release is differently affected by inhibitors of calmodulin, diacylglycerol kinase and peptidyl prolyl cis-trans isomerase in a secretagogue specific manner. 1992 Allergy pmid:1280915
Kaufmann R et al. Onset of pruritus relief with pimecrolimus cream 1% in adult patients with atopic dermatitis: a randomized trial. 2006 Allergy pmid:16436149
Oldhoff JM et al. Modulation of the atopy patch test: tacrolimus 0.1% compared with triamcinolone acetonide 0.1%. 2006 Allergy pmid:16629794
Simon D et al. Inflammatory cell numbers and cytokine expression in atopic dermatitis after topical pimecrolimus treatment. 2005 Allergy pmid:15932386
Leonardi S et al. Efficacy and safety of tacrolimus ointment 0.03% treatment in a 1-month-old "red baby": a case report. 2006 Nov-Dec Allergy Asthma Proc pmid:17176789
Pacor ML et al. Tacrolimus ointment in nickel sulphate-induced steroid-resistant allergic contact dermatitis. 2006 Nov-Dec Allergy Asthma Proc pmid:17176790
Rico MJ and Lawrence I Tacrolimus ointment for the treatment of atopic dermatitis: clinical and pharmacologic effects. 2002 May-Jun Allergy Asthma Proc pmid:12125507
Szema AM Angioedema in a child with a liver transplant, intussusception, and normal c4 levels. 2010 Jul-Aug Allergy Asthma Proc pmid:20615276
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Wilhelmi E et al. Organotypic brain-slice cultures from adult rats: approaches for a prolonged culture time. 2002 May-Jun Altern Lab Anim pmid:12106005
Mcauliffe EP Is tacrolimus the best therapy for atopic dermatitis? 2003 Am Fam Physician pmid:12751651
Lane JE and Johnson J Persistent penile patch. 2008 Am Fam Physician pmid:19007056
Russell JJ Topical tacrolimus: a new therapy for atopic dermatitis. 2002 Am Fam Physician pmid:12469964
Berke R et al. Atopic dermatitis: an overview. 2012 Am Fam Physician pmid:22962911
Hitzeman N and Kinnevey C Topical Tacrolimus for Eczema. 2016 Am Fam Physician pmid:27929217
Baran DA et al. Calcineurin inhibitor-associated early renal insufficiency in cardiac transplant recipients: risk factors and strategies for prevention and treatment. 2004 Am J Cardiovasc Drugs pmid:14967063
Ramirez R et al. Posterior Reversible Encephalopathy Syndrome After Orthotopic Heart Transplantation: A Case Report. 2017 Am J Case Rep pmid:28465499
Kawamura H et al. Rapid Induction Therapy with Oral Tacrolimus in Elderly Patients with Refractory Ulcerative Colitis Can Easily Lead to Elevated Tacrolimus Concentrations in Blood: A Report of 5 Cases. 2017 Am J Case Rep pmid:28411286
Udomkarnjananun S et al. An Unusual Manifestation of Calcineurin Inhibitor-Induced Pain Syndrome in Kidney Transplantation: A Case Report and Literature Review. 2018 Am J Case Rep pmid:29654227
Ingram JR et al. Impact of topical calcineurin inhibitors on quality of life in patients with atopic dermatitis. 2009 Am J Clin Dermatol pmid:19489656
Reitamo S et al. Topical noncorticosteroid immunomodulation in the treatment of atopic dermatitis. 2002 Am J Clin Dermatol pmid:12113647
Wellington K and Jarvis B Spotlight on topical pimecrolimus in atopic dermatitis. 2002 Am J Clin Dermatol pmid:12113651