Tylosin

Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tylosin?

Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tylosin

MeSH term MeSH ID Detail
Bacillaceae Infections D016863 1 associated lipids
Erysipelothrix Infections D004889 1 associated lipids
Conjunctivitis, Viral D003236 1 associated lipids
Enterotoxemia D004767 1 associated lipids
Bovine Respiratory Disease Complex D048090 2 associated lipids
Primate Diseases D018419 2 associated lipids
Pneumonia of Calves, Enzootic D048089 2 associated lipids
Keratoconjunctivitis, Infectious D007639 2 associated lipids
Pneumonia of Swine, Mycoplasmal D045729 2 associated lipids
Tracheal Diseases D014133 3 associated lipids
Treponemal Infections D014211 3 associated lipids
Neisseriaceae Infections D016870 3 associated lipids
Digital Dermatitis D058066 3 associated lipids
Pasteurellosis, Pneumonic D012766 3 associated lipids
Dysentery D004403 4 associated lipids
Porcine Reproductive and Respiratory Syndrome D019318 4 associated lipids
Foreign Bodies D005547 5 associated lipids
Desulfovibrionaceae Infections D045824 5 associated lipids
Clostridium Infections D003015 5 associated lipids
Pyoderma D011711 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Tylosin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tylosin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Tylosin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Tylosin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Tylosin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tylosin?

Knock-out

Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Tylosin

Download all related citations
Per page 10 20 50 100 | Total 931
Authors Title Published Journal PubMed Link
Lee HJ and Jin HJ Renaturation of recombinant ErmSF and its refolding behavior. 2003 Mol. Cells pmid:14651260
Salamakha OV et al. [The study of the growth of tylosin producer using differential centrifugation of mycelium in a sucrose density gradient]. 1989 Sep-Oct Mikrobiologiia pmid:2635267
Nguyen LT et al. The tylosin producer, Streptomyces fradiae, contains a second valine dehydrogenase. 1995 Microbiology (Reading, Engl.) pmid:7773408
Bate N et al. The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin. 2000 Microbiology (Reading, Engl.) pmid:10658660
Köhler B et al. Antibacterials that are used as growth promoters in animal husbandry can affect the release of Shiga-toxin-2-converting bacteriophages and Shiga toxin 2 from Escherichia coli strains. 2000 Microbiology (Reading, Engl.) pmid:10832635
Fish SA and Cundliffe E Stimulation of polyketide metabolism in Streptomyces fradiae by tylosin and its glycosylated precursors. 1997 Microbiology (Reading, Engl.) pmid:9421911
Fouces R et al. The tylosin biosynthetic cluster from Streptomyces fradiae: genetic organization of the left region. 1999 Microbiology (Reading, Engl.) pmid:10220165
Butler AR et al. Feedback control of polyketide metabolism during tylosin production. 2001 Microbiology (Reading, Engl.) pmid:11283275
Trovatelli LD et al. The effect of some antibiotics on Enterococcus faecium SF 68 inoculated in germ-free mice. 1994 Microbiol. Res. pmid:7987613
Khaliq S et al. Change in colony morphology and kinetics of tylosin production after UV and gamma irradiation mutagenesis of Streptomyces fradiae NRRL-2702. 2009 Microbiol. Res. pmid:17475458
Sato T et al. Mycoplasma bovis isolates from dairy calves in Japan have less susceptibility than a reference strain to all approved macrolides associated with a point mutation (G748A) combined with multiple species-specific nucleotide alterations in 23S rRNA. 2017 Microbiol. Immunol. pmid:28504455
Pakpour S et al. Frequency of antibiotic resistance in a swine facility 2.5 years after a ban on antibiotics. 2012 Microb. Ecol. pmid:21997543
Chénier MR and Juteau P Fate of chlortetracycline- and tylosin-resistant bacteria in an aerobic thermophilic sequencing batch reactor treating swine waste. 2009 Microb. Ecol. pmid:19125305
Müller AK et al. The diversity and function of soil microbial communities exposed to different disturbances. 2002 Microb. Ecol. pmid:11976785
Lysnyansky I et al. Decreased Susceptibility to Macrolide-Lincosamide in Mycoplasma synoviae Is Associated with Mutations in 23S Ribosomal RNA. 2015 Microb. Drug Resist. pmid:25734368
Liu Y et al. Transcriptional profiling of Haemophilus parasuis SH0165 response to tilmicosin. 2012 Microb. Drug Resist. pmid:22935051
Qiu G et al. Macrolide-Resistance Selection in Tibetan Pigs with a High Load of Mycoplasma hyopneumoniae. 2018 Microb. Drug Resist. pmid:29271698
Hao H et al. 23S rRNA mutation A2074C conferring high-level macrolide resistance and fitness cost in Campylobacter jejuni. 2009 Microb. Drug Resist. pmid:19857128
Aarestrup FM and Carstensen B Effect of tylosin used as a growth promoter on the occurrence of macrolide-resistant enterococci and staphylococci in pigs. 1998 Microb. Drug Resist. pmid:9988049
Lu C et al. Identification of novel tylosin analogues generated by a wblA disruption mutant of Streptomyces ansochromogenes. 2015 Microb. Cell Fact. pmid:26525981