Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Guo X et al. | Sorption of tylosin and sulfamethazine on solid humic acid. | 2016 | J Environ Sci (China) | pmid:27155426 |
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Clay SA et al. | Tylosin sorption to silty clay loam soils, swine manure, and sand. | 2005 | J Environ Sci Health B | pmid:16194921 |
Hoese A et al. | Chlortetracycline and tylosin runoff from soils treated with antimicrobial containing manure. | 2009 | J Environ Sci Health B | pmid:19365753 |
Stone JJ et al. | Land application of tylosin and chlortetracycline swine manure: Impacts to soil nutrients and soil microbial community structure. | 2011 | J Environ Sci Health B | pmid:21877979 |
Krokidis M et al. | The slow dissociation rate of K-1602 contributes to the enhanced inhibitory activity of this novel alkyl-aryl-bearing fluoroketolide. | 2016 | J Enzyme Inhib Med Chem | pmid:25807301 |
Kolanović BS et al. | Tylosin content in meat and honey samples over a two-year period in Croatia. | 2014 | J Immunoassay Immunochem | pmid:24063615 |
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Gummow B et al. | The diagnosis and treatment of bovine genital ureaplasmosis: a case study. | 1992 | J S Afr Vet Assoc | pmid:1404223 |
Nozal Nalda MJ et al. | Trace analysis of antibacterial tylosin A, B, C and D in honey by liquid chromatography-electrospray ionization-mass spectrometry. | 2006 | J Sep Sci | pmid:16544883 |
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Liu YM et al. | Sensitive determination of tilmicosin, erythromycin ethylsuccinate and clindamycin by CE with electrochemiluminescence detection using azithromycin as internal standard and its applications. | 2010 | J Sep Sci | pmid:20235137 |
Ashenafi D et al. | An improved liquid chromatographic method for the analysis of tylosin and its impurities. | 2011 | J Sep Sci | pmid:21812113 |
Kart A et al. | The possible protective effect of L-carnitine on tilmicosin-induced cardiotoxicity in mice. | 2007 | J Vet Med A Physiol Pathol Clin Med | pmid:17381679 |
Litterio NJ et al. | Microbiological screening test validation for detection of tylosin excretion in milk of cows with low and high somatic cell counts. | 2007 | J Vet Med A Physiol Pathol Clin Med | pmid:17359452 |
Wang J et al. | Determination of five macrolide antibiotic residues in eggs using liquid chromatography/electrospray ionization tandem mass spectrometry. | 2005 | J. Agric. Food Chem. | pmid:15769104 |
Blackwell PA et al. | Evaluation of a lower tier exposure assessment model for veterinary medicines. | 2005 | J. Agric. Food Chem. | pmid:15769156 |
Beier RC et al. | Production and characterization of monoclonal antibodies against the antibiotic tilmicosin. | 2005 | J. Agric. Food Chem. | pmid:16332115 |
Peng Z and Bang-Ce Y | Small molecule microarrays for drug residue detection in foodstuffs. | 2006 | J. Agric. Food Chem. | pmid:16968051 |
Hamscher G et al. | Quantitative analysis of tylosin in eggs by high performance liquid chromatography with electrospray ionization tandem mass spectrometry: residue depletion kinetics after administration via feed and drinking water in laying hens. | 2006 | J. Agric. Food Chem. | pmid:17117786 |
Jiang H et al. | Residue depletion of tilmicosin in cattle after subcutaneous administration. | 2006 | J. Agric. Food Chem. | pmid:16819937 |
Caldow M et al. | Development and validation of an optical SPR biosensor assay for tylosin residues in honey. | 2005 | J. Agric. Food Chem. | pmid:16159159 |
Bhalsod GD et al. | Uptake and Accumulation of Pharmaceuticals in Overhead- and Surface-Irrigated Greenhouse Lettuce. | 2018 | J. Agric. Food Chem. | pmid:29293328 |
Van Poucke C et al. | Tylosin detection in animal feed by liquid chromatography-tandem mass spectrometry with enzymatic hydrolysis of the tylosin urea adduct. | 2004 | J. Agric. Food Chem. | pmid:15137817 |
Zhang Y et al. | Residue depletion of tilmicosin in chicken tissues. | 2004 | J. Agric. Food Chem. | pmid:15113165 |
Wang J | Determination of five macrolide antibiotic residues in honey by LC-ESI-MS and LC-ESI-MS/MS. | 2004 | J. Agric. Food Chem. | pmid:14733491 |
Granados-Chinchilla F et al. | A novel green chemistry method for nonaqueous extraction and high-performance liquid chromatography detection of first-, second-, and third-generation tetracyclines, 4-epitetracycline, and tylosin in animal feeds. | 2012 | J. Agric. Food Chem. | pmid:22738432 |
Peng D et al. | Development and validation of an indirect competitive enzyme-linked immunosorbent assay for the screening of tylosin and tilmicosin in muscle, liver, milk, honey and eggs. | 2012 | J. Agric. Food Chem. | pmid:22136611 |
Werner JJ et al. | Environmental photochemistry of tylosin: efficient, reversible photoisomerization to a less-active isomer, followed by photolysis. | 2007 | J. Agric. Food Chem. | pmid:17655244 |
Lowell AN et al. | Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization. | 2017 | J. Am. Chem. Soc. | pmid:28525276 |
Castonguay R et al. | Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase. | 2008 | J. Am. Chem. Soc. | pmid:18693734 |
Day FG | The value of tilmicosin in production medicine. | 1996 | J. Am. Vet. Med. Assoc. | pmid:8617615 |
Veenhuizen MF et al. | Analysis of reports of human exposure to Micotil 300 (tilmicosin injection). | 2006 | J. Am. Vet. Med. Assoc. | pmid:17144818 |
Morck DW et al. | Prophylactic efficacy of tilmicosin for bovine respiratory tract disease. | 1993 | J. Am. Vet. Med. Assoc. | pmid:8428833 |
Smee NM and Towell TL | What is the evidence? Inflammatory bowel disease in a dog. | 2011 | J. Am. Vet. Med. Assoc. | pmid:21529230 |
Smith GW et al. | Elimination kinetics of tilmicosin following intramammary administration in lactating dairy cattle. | 2009 | J. Am. Vet. Med. Assoc. | pmid:19210246 |
McClary DG et al. | Relationship of in vitro minimum inhibitory concentrations of tilmicosin against Mannheimia haemolytica and Pasteurella multocida and in vivo tilmicosin treatment outcome among calves with signs of bovine respiratory disease. | 2011 | J. Am. Vet. Med. Assoc. | pmid:21718206 |