Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Arisawa A et al. | Cloning of the macrolide antibiotic biosynthesis gene acyA, which encodes 3-O-acyltransferase, from Streptomyces thermotolerans and its use for direct fermentative production of a hybrid macrolide antibiotic. | 1994 | Appl. Environ. Microbiol. | pmid:8074537 |
Lee SH and Lee KJ | Aspartate aminotransferase and tylosin biosynthesis in Streptomyces fradiae. | 1993 | Appl. Environ. Microbiol. | pmid:8481008 |
Amachawadi RG et al. | Occurrence of the transferable copper resistance gene tcrB among fecal enterococci of U.S. feedlot cattle fed copper-supplemented diets. | 2013 | Appl. Environ. Microbiol. | pmid:23666328 |
Wagner BA et al. | Effect of antimicrobial dosage regimen on Salmonella and Escherichia coli isolates from feeder swine. | 2008 | Appl. Environ. Microbiol. | pmid:18223115 |
DENNY CB et al. | Effects of tylosin and nisin on canned food spoilage bacteria. | 1961 | Appl Microbiol | pmid:13721908 |
Whitehead TR et al. | Savagea faecisuis gen. nov., sp. nov., a tylosin- and tetracycline-resistant bacterium isolated from a swine-manure storage pit. | 2015 | Antonie Van Leeuwenhoek | pmid:25980832 |
Baltz RH et al. | Applications of transposition mutagenesis in antibiotic producing streptomycetes. | 1997 | Antonie Van Leeuwenhoek | pmid:9049029 |
Cundliffe E et al. | The tylosin-biosynthetic genes of Streptomyces fradiae. | 2001 | Antonie Van Leeuwenhoek | pmid:11816964 |
Elkins CA and Mullis LB | Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. | 2007 | Antimicrob. Agents Chemother. | pmid:17210767 |
Memili E and Weisblum B | Essential role of endogenously synthesized tylosin for induction of ermSF in Streptomyces fradiae. | 1997 | Antimicrob. Agents Chemother. | pmid:9145902 |