Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kelemen GH et al. | Transcriptional attenuation control of the tylosin-resistance gene tlrA in Streptomyces fradiae. | 1994 | Mol. Microbiol. | pmid:7534372 |
Karahalios P et al. | On the mechanism of action of 9-O-arylalkyloxime derivatives of 6-O-mycaminosyltylonolide, a new class of 16-membered macrolide antibiotics. | 2006 | Mol. Pharmacol. | pmid:16873579 |
Dinos GP et al. | Insights into the mechanism of azithromycin interaction with an Escherichia coli functional ribosomal complex. | 2001 | Mol. Pharmacol. | pmid:11353804 |
Lemli B et al. | Noncovalent Interaction of Tilmicosin with Bovine Serum Albumin. | 2018 | Molecules | pmid:30065238 |
Nobel YR et al. | Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment. | 2015 | Nat Commun | pmid:26123276 |
Ruiz VE et al. | A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity. | 2017 | Nat Commun | pmid:28894149 |
Trefzer A et al. | Genes and enzymes involved in deoxysugar biosynthesis in bacteria. | 1999 | Nat Prod Rep | pmid:10399362 |
Stephanopoulos G | Metabolic engineering by genome shuffling. | 2002 | Nat. Biotechnol. | pmid:12089547 |
Zhang YX et al. | Genome shuffling leads to rapid phenotypic improvement in bacteria. | 2002 | Nature | pmid:11832946 |
Engi H | [Perspectives of inhibition of multidrug resistance during cancer chemotherapy, in vitro and in vivo experiments]. | 2009 | Orv Hetil | pmid:19293063 |
Westermarck E et al. | Effect of treatment on the jejunal and colonic bacterial flora of dogs with exocrine pancreatic insufficiency. | 1993 | Pancreas | pmid:8302792 |
Xie S et al. | Acute toxicity study of tilmicosin-loaded hydrogenated castor oil-solid lipid nanoparticles. | 2011 | Part Fibre Toxicol | pmid:22098626 |
Kempf I et al. | [Efficacy of spiramycin and tylosin in preventing mycoplasmosis in chicks experimentally infected with mycoplasma gallisepticum]. | 1989 | Pathol. Biol. | pmid:2797880 |
Muraina IA et al. | Antimycoplasmal activity of some plant species from northern Nigeria compared to the currently used therapeutic agent. | 2010 | Pharm Biol | pmid:20819025 |
Meisel ML et al. | Effects of tylosin on the pituitary-gonadal axis in male rats. | 1993 Apr-May | Pharmacol. Toxicol. | pmid:8372057 |
Menozzi A et al. | Effect of the macrolide antibacterial drug, tylosin, on TNBS-induced colitis in the rat. | 2005 | Pharmacology | pmid:15756055 |
Krongdang S et al. | Multilocus sequence typing, biochemical and antibiotic resistance characterizations reveal diversity of North American strains of the honey bee pathogen Paenibacillus larvae. | 2017 | PLoS ONE | pmid:28467471 |
Zhang N et al. | Determination of the Mutant Selection Window and Evaluation of the Killing of Mycoplasma gallisepticum by Danofloxacin, Doxycycline, Tilmicosin, Tylvalosin and Valnemulin. | 2017 | PLoS ONE | pmid:28052123 |
Galmozzi CV et al. | The Cyanobacterial Ribosomal-Associated Protein LrtA Is Involved in Post-Stress Survival in Synechocystis sp. PCC 6803. | 2016 | PLoS ONE | pmid:27442126 |
Danzeisen JL et al. | Modulations of the chicken cecal microbiome and metagenome in response to anticoccidial and growth promoter treatment. | 2011 | PLoS ONE | pmid:22114729 |