Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Pfister P et al. | 23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15795375 |
Thompson TS et al. | Determination of lincomycin and tylosin residues in honey by liquid chromatography/tandem mass spectrometry. | 2005 | Rapid Commun. Mass Spectrom. | pmid:15645470 |
Kiehl DE and Kennington AS | Analysis of tilmicosin in swine liver extracts by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry. | 1995 | Rapid Commun. Mass Spectrom. | pmid:8527821 |
Stoev G and Nazarov V | Identification of the related substances of tilmicosin by liquid chromatography/ion trap mass spectrometry. | 2008 | Rapid Commun. Mass Spectrom. | pmid:18491285 |
Song W et al. | Determination of amprolium, carbadox, monensin, and tylosin in surface water by liquid chromatography/tandem mass spectrometry. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17510929 |
Hao H et al. | Microbiological toxicity of tilmicosin on human colonic microflora in chemostats. | 2015 | Regul. Toxicol. Pharmacol. | pmid:26190303 |
Akhter S et al. | Effect of antibiotics in extender on bacterial and spermatozoal quality of cooled buffalo (Bubalus bubalis) bull semen. | 2008 | Reprod. Domest. Anim. | pmid:18042206 |
Yildiz S et al. | Tylosin does not affect GnRH-induced LH secretion in rams. | 2004 Jan-Feb | Reprod. Toxicol. | pmid:15013072 |
Loria GR et al. | In vitro susceptibilities of field isolates of Mycoplasma agalactiae to oxytetracycline, tylosin, enrofloxacin, spiramycin and lincomycin-spectinomycin. | 2003 | Res. Vet. Sci. | pmid:12801456 |
Prats C et al. | Tylosin depletion from edible pig tissues. | 2002 | Res. Vet. Sci. | pmid:12443694 |
Timsit E et al. | Effects of nasal instillation of a nitric oxide-releasing solution or parenteral administration of tilmicosin on the nasopharyngeal microbiota of beef feedlot cattle at high-risk of developing respiratory tract disease. | 2017 | Res. Vet. Sci. | pmid:28231472 |
Cooper AC et al. | In vitro activity of danofloxacin, tylosin and oxytetracycline against mycoplasmas of veterinary importance. | 1993 | Res. Vet. Sci. | pmid:8393208 |
El-Ela FI et al. | Investigating the potential role of vitamin E in modulating the immunosuppressive effects of tylvalosin and florfenicol in broiler chickens. | 2016 | Res. Vet. Sci. | pmid:27663366 |
Hannan PC et al. | Tylosin tartrate and tiamutilin effects on experimental piglet pneumonia induced with pneumonic pig lung homogenate containing mycoplasmas, bacteria and viruses. | 1982 | Res. Vet. Sci. | pmid:7134653 |
Zweers-Zeilmaker WM et al. | In vitro complex formation and inhibition of hepatic cytochrome P450 activity by different macrolides and tiamulin in goats and cattle. | 1999 | Res. Vet. Sci. | pmid:10088712 |
Allan EM and Pirie HM | In vitro activity of tiamulin against bovine respiratory tract mycoplasmas. | 1981 | Res. Vet. Sci. | pmid:7323463 |
Pringle M et al. | Tiamulin resistance in porcine Brachyspira pilosicoli isolates. | 2006 | Res. Vet. Sci. | pmid:16253666 |
Gourlay RN et al. | Effect of a new macrolide antibiotic (tilmicosin) on pneumonia experimentally induced in calves by Mycoplasma bovis and Pasteurella haemolytica. | 1989 | Res. Vet. Sci. | pmid:2772410 |
Prats C et al. | Disposition kinetics of tylosin administered intravenously and intramuscularly to pigs. | 2002 | Res. Vet. Sci. | pmid:12204632 |
Kempf I et al. | Efficacy of danofloxacin in the therapy of experimental mycoplasmosis in chicks. | 1992 | Res. Vet. Sci. | pmid:1332154 |