Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Li Y et al. | In vitro susceptibility of four antimicrobials against Riemerella anatipestifer isolates: a comparison of minimum inhibitory concentrations and mutant prevention concentrations for ceftiofur, cefquinome, florfenicol, and tilmicosin. | 2016 | BMC Vet. Res. | pmid:27829415 |
Gourlay RN et al. | Effect of a new macrolide antibiotic (tilmicosin) on pneumonia experimentally induced in calves by Mycoplasma bovis and Pasteurella haemolytica. | 1989 | Res. Vet. Sci. | pmid:2772410 |
Samii SS et al. | Effects of limonene on ruminal concentrations, fermentation, and lysine degradation in cattle. | 2016 | J. Anim. Sci. | pmid:27695807 |
Amarakoon ID et al. | Dissipation of Antimicrobials in a Seasonally Frozen Soil after Beef Cattle Manure Application. | 2016 | J. Environ. Qual. | pmid:27695746 |
Ling Z et al. | Preparation, characterization, and pharmacokinetics of tilmicosin- and florfenicol-loaded hydrogenated castor oil-solid lipid nanoparticles. | 2017 | J. Vet. Pharmacol. Ther. | pmid:27687707 |
El-Ela FI et al. | Investigating the potential role of vitamin E in modulating the immunosuppressive effects of tylvalosin and florfenicol in broiler chickens. | 2016 | Res. Vet. Sci. | pmid:27663366 |
Lee HS et al. | Occupational asthma due to tylosin tartrate. | 1989 | Br J Ind Med | pmid:2765423 |
Yao RC and Mahoney DF | Enzyme immunoassay for macrolide antibiotics: characterization of an antibody to 23-amino-O-mycaminosyltylonolide. | 1989 | Appl. Environ. Microbiol. | pmid:2764563 |
Mendoza J et al. | Concentrations of tilmicosin in mammary gland secretions of dairy cows following subcutaneous administration of one or two doses of an experimental preparation of tilmicosin and its efficacy against intramammary infections caused by Staphylococcus aureus. | 2016 | Am. J. Vet. Res. | pmid:27580103 |
Li B et al. | Determination of antibacterial agent tilmicosin in pig plasma by LC/MS/MS and its application to pharmacokinetics. | 2017 | Biomed. Chromatogr. | pmid:27564248 |
Zalacain M and Cundliffe E | Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae. | 1989 | J. Bacteriol. | pmid:2753855 |
Cleary DW et al. | Long-term antibiotic exposure in soil is associated with changes in microbial community structure and prevalence of class 1 integrons. | 2016 | FEMS Microbiol. Ecol. | pmid:27495240 |
Kim E et al. | Characterization of the Two Methylation Steps Involved in the Biosynthesis of Mycinose in Tylosin. | 2016 | J. Nat. Prod. | pmid:27453999 |
Angell JW et al. | Whole-flock, metaphylactic tilmicosin failed to eliminate contagious ovine digital dermatitis and footrot in sheep: a cluster randomised trial. | 2016 | Vet. Rec. | pmid:27450091 |
Galmozzi CV et al. | The Cyanobacterial Ribosomal-Associated Protein LrtA Is Involved in Post-Stress Survival in Synechocystis sp. PCC 6803. | 2016 | PLoS ONE | pmid:27442126 |
Ryoo JP et al. | Data acquisition and processing system for drug release characterization by thin layer chromatography. | 1989 | Biomed Sci Instrum | pmid:2742974 |
Kline A and Pinckney JL | Size-selective toxicity effects of the antimicrobial tylosin on estuarine phytoplankton communities. | 2016 | Environ. Pollut. | pmid:27376985 |
Synek M et al. | [Immunologic aspects of macrolide antibiotics]. | 1989 | Cas. Lek. Cesk. | pmid:2731206 |
Molognoni L et al. | Development of a LC-MS/MS method for the simultaneous determination of sorbic acid, natamycin and tylosin in Dulce de leche. | 2016 | Food Chem | pmid:27283692 |
Marshall VP et al. | Enzymic inactivation of lincosaminide and macrolide antibiotics: divalent metal cation and coenzyme specificities. | 1989 | J. Antibiot. | pmid:2722691 |
Besserer F et al. | Tilmicosin toxicity: a case of accidental human tilmicosin injection managed with calcium, high-dose insulin and intravenous lipid emulsion therapy. | 2016 | Clin Toxicol (Phila) | pmid:27207720 |
Guo X et al. | Sorption of tylosin and sulfamethazine on solid humic acid. | 2016 | J Environ Sci (China) | pmid:27155426 |
Cernicchiaro N et al. | Meta-analysis of the effects of laidlomycin propionate, fed alone or in combination with chlortetracycline, compared with monensin sodium, fed alone or in combination with tylosin, on growth performance, health, and carcass outcomes in finishing steers in North America. | 2016 | J. Anim. Sci. | pmid:27136025 |
Canning P et al. | Concentrations of tylvalosin and 3-O-acetyltylosin attained in the synovial fluid of swine after administration by oral gavage at 50 and 5Â mg/kg. | 2016 | J. Vet. Pharmacol. Ther. | pmid:27086612 |
Whitehead TR and Cotta MA | Examination of the Aerobic Microflora of Swine Feces and Stored Swine Manure. | 2016 | J. Environ. Qual. | pmid:27065407 |
Amarakoon ID et al. | Dissipation of Antimicrobials in Feedlot Manure Compost after Oral Administration versus Fortification after Excretion. | 2016 | J. Environ. Qual. | pmid:27065397 |
Crepieux T et al. | Randomized, non-inferiority trial comparing a nitric oxide releasing solution with a macrolide antibiotic for control of bovine respiratory disease in beef feedlot calves at high-risk of developing respiratory tract disease. | 2016 | Res. Vet. Sci. | pmid:27033936 |
Confer AW et al. | Clinical disease and lung lesions in calves experimentally inoculated with Histophilus somni five days after metaphylactic administration of tildipirosin or tulathromycin. | 2016 | Am. J. Vet. Res. | pmid:27027834 |
Torres F et al. | Pharmacokinetics of tildipirosin in pig tonsils. | 2016 | J. Vet. Pharmacol. Ther. | pmid:26935349 |
Luby EM et al. | Fate and transport of tylosin-resistant bacteria and macrolide resistance genes in artificially drained agricultural fields receiving swine manure. | 2016 | Sci. Total Environ. | pmid:26874610 |
Kim J et al. | Effects of the Antibiotics Growth Promoter Tylosin on Swine Gut Microbiota. | 2016 | J. Microbiol. Biotechnol. | pmid:26869601 |
Kirst HA et al. | Structure-activity studies of 20-deoxo-20-amino derivatives of tylosin-related macrolides. | 1989 | J. Antibiot. | pmid:2684947 |
GarcÃa-Sánchez L et al. | Tylosin effect on methanogenesis in an anaerobic biomass from swine wastewater treatment. | 2016 | Water Sci. Technol. | pmid:26819401 |
Entorf M et al. | Comparative erythromycin and tylosin susceptibility testing of streptococci from bovine mastitis. | 2016 | Vet. Microbiol. | pmid:26732695 |
Debono M et al. | Synthesis and antimicrobial evaluation of 20-deoxo-20-(3,5-dimethylpiperidin-1-yl)desmycosin (tilmicosin, EL-870) and related cyclic amino derivatives. | 1989 | J. Antibiot. | pmid:2668243 |
Xia X et al. | Proteomic analysis of tylosin-resistant Mycoplasma gallisepticum reveals enzymatic activities associated with resistance. | 2015 | Sci Rep | pmid:26584633 |
Rose M et al. | A microbiological assay to estimate the antimicrobial activity of parenteral tildipirosin against foodborne pathogens and commensals in the colon of beef cattle and pigs. | 2016 | J. Vet. Pharmacol. Ther. | pmid:26538405 |
Lu C et al. | Identification of novel tylosin analogues generated by a wblA disruption mutant of Streptomyces ansochromogenes. | 2015 | Microb. Cell Fact. | pmid:26525981 |
El-Mahmoudy A and Gheith I | The anti-nociceptive potential of tilmicosin against chemical-induced but not thermal-induced pain in mice. | 2016 | Int J Immunopathol Pharmacol | pmid:26519523 |
Sehati N et al. | Application of hollow fiber membrane mediated with titanium dioxide nanowire/reduced graphene oxide nanocomposite in preconcentration of clotrimazole and tylosin. | 2015 | J Chromatogr A | pmid:26477522 |
Blondeau JM et al. | Bactericidal effects of various concentrations of enrofloxacin, florfenicol, tilmicosin phosphate, and tulathromycin on clinical isolates of Mannheimia haemolytica. | 2015 | Am. J. Vet. Res. | pmid:26413823 |
Salamakha OV et al. | [The study of the growth of tylosin producer using differential centrifugation of mycelium in a sucrose density gradient]. | 1989 Sep-Oct | Mikrobiologiia | pmid:2635267 |
Amachawadi RG et al. | Effects of In-Feed Copper, Chlortetracycline, and Tylosin on the Prevalence of Transferable Copper Resistance Gene, tcrB, Among Fecal Enterococci of Weaned Piglets. | 2015 | Foodborne Pathog. Dis. | pmid:26258261 |
Hao H et al. | Microbiological toxicity of tilmicosin on human colonic microflora in chemostats. | 2015 | Regul. Toxicol. Pharmacol. | pmid:26190303 |
Nobel YR et al. | Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment. | 2015 | Nat Commun | pmid:26123276 |
Gollins WJ | Occupational asthma due to tylosin tartrate. | 1989 | Br J Ind Med | pmid:2611166 |
Kilpinen S et al. | Oral tylosin administration is associated with an increase of faecal enterococci and lactic acid bacteria in dogs with tylosin-responsive diarrhoea. | 2015 | Vet. J. | pmid:26049259 |
Maxwell CL et al. | The effects of technology use in feedlot production systems on feedlot performance and carcass characteristics. | 2015 | J. Anim. Sci. | pmid:26020911 |
Pilcher CM et al. | The interaction of fiber, supplied by distillers dried grains with solubles, with an antimicrobial and a nutrient partitioning agent on nitrogen balance, water utilization, and energy digestibility in finishing pigs. | 2015 | J. Anim. Sci. | pmid:26020889 |
Mercadante VR et al. | Effects of anti-phospholipase A(2) antibody supplementation on dry matter intake feed efficiency, acute phase response, and blood differentials of steers fed forage- and grain-based diets. | 2015 | J. Anim. Sci. | pmid:26020758 |