Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Creemer LC et al. | Synthesis and in vitro antimicrobial activity of 3-keto 16-membered macrolides derived from tylosin. | 2002 | J. Antibiot. | pmid:12061552 |
Mandić Z et al. | New derivatives of tylosin: chemical and electrochemical oxidation products of desmycosin. | 2002 | J. Antibiot. | pmid:12458770 |
Omura S et al. | Ammonium ions suppress the amino acid metabolism involved in the biosynthesis of protylonolide in a mutant of Streptomyces fradiae. | 1984 | J. Antibiot. | pmid:6511663 |
Arisawa A et al. | Direct fermentative production of acyltylosins by genetically-engineered strains of Streptomyces fradiae. | 1996 | J. Antibiot. | pmid:8641997 |
Tsuchiya M et al. | Binding of 3-O-acetyl-4"-O-isovaleryltylosin to ribosomes from a macrolide-resistant strain of Staphylococcus aureus. | 1982 | J. Antibiot. | pmid:7118723 |
Sadakane N et al. | Hybrid biosynthesis of derivatives of protylonolide and M-4365 by macrolide-producing microorganisms. | 1982 | J. Antibiot. | pmid:7118724 |
Vaughan RW et al. | Isolation and characterization of two 16-membered lactones: 20-deoxorosaramicin and 20-deoxo-12,13-desepoxy-12,13-dehydrorosaramicin aglycones, from a mutant strain of Micromonospora rosaria. | 1982 | J. Antibiot. | pmid:7076570 |
Tanaka Y et al. | Mechanism of nitrogen regulation of protylonolide biosynthesis in Streptomyces fradiae. | 1986 | J. Antibiot. | pmid:3733529 |
Lee BK et al. | Multistep bioconversion of 20-deoxo-20-dihydro-12,13-deepoxy-12,13-dehydrorosaranolide to 22-hydroxy-23-O-mycinosyl-20-deoxo-20-dihydro-12,13-deepoxy-rosaramicin. | 1983 | J. Antibiot. | pmid:6874596 |
Sadakane N et al. | Hybrid biosynthesis of a new macrolide antibiotic by a daunomycin-producing microorganism. | 1983 | J. Antibiot. | pmid:6885644 |
Norcia LJ et al. | In vitro microbiological characterization of novel macrolide CP-163,505 for animal health specific use. | 1998 | J. Antibiot. | pmid:9544934 |
Debono M et al. | Synthesis and antimicrobial evaluation of 20-deoxo-20-(3,5-dimethylpiperidin-1-yl)desmycosin (tilmicosin, EL-870) and related cyclic amino derivatives. | 1989 | J. Antibiot. | pmid:2668243 |
Naranda A and Lopotar N | New derivatives of tylosin. IV. Dihydro and tetrahydro desmycosin oximes. | 1999 | J. Antibiot. | pmid:10092201 |
Omura S et al. | Effect of ammonium ion, inorganic phosphate and amino acids on the biosynthesis of protylonolide, a precursor of tylosin aglycone. | 1984 | J. Antibiot. | pmid:6735923 |
Tsuzuki K et al. | Syntheses and antimicrobial activities of 9-O-acyl derivatives of tylosin and demycarosyltylosin. | 1986 | J. Antibiot. | pmid:3818453 |
Baltz RH and Stonesifer J | Phenotypic changes associated with loss of expression of tylosin biosynthesis and resistance genes in Streptomyces fradiae. | 1985 | J. Antibiot. | pmid:4066505 |
Chuard C et al. | In-vitro and in-vivo evaluation of the antistaphylococcal activity of S-5556, a new 16-membered macrolide. | 1992 | J. Antimicrob. Chemother. | pmid:1452498 |
Lüthje P and Schwarz S | Molecular analysis of constitutively expressed erm(C) genes selected in vitro in the presence of the non-inducers pirlimycin, spiramycin and tylosin. | 2007 | J. Antimicrob. Chemother. | pmid:17085767 |
Buß M et al. | Quality control ranges for tylosin 30 μg and 15 μg discs applicable to Staphylococcus aureus ATCC(R) 25923. | 2014 | J. Antimicrob. Chemother. | pmid:23928021 |
Tejedor F and Ballesta JP | Components of the macrolide binding site on the ribosome. | 1985 | J. Antimicrob. Chemother. | pmid:4055551 |
Wardlaw AC et al. | Bactericidal activity in the pig roundworm Ascaris suum. | 1994 | J. Appl. Bacteriol. | pmid:8144403 |
Kaukas A et al. | The effect of ampicillin and tylosin on the faecal enterococci of healthy young chickens. | 1987 | J. Appl. Bacteriol. | pmid:3112089 |
Poole TL et al. | Effect of subtherapeutic concentrations of tylosin on the inhibitory stringency of a mixed anaerobe continuous-flow culture of chicken microflora against Escherichia coli O157:H7. | 2003 | J. Appl. Microbiol. | pmid:12492926 |
Amachawadi RG et al. | Effects of in-feed copper and tylosin supplementations on copper and antimicrobial resistance in faecal enterococci of feedlot cattle. | 2015 | J. Appl. Microbiol. | pmid:25739516 |
Kalmokoff M et al. | Continuous feeding of antimicrobial growth promoters to commercial swine during the growing/finishing phase does not modify faecal community erythromycin resistance or community structure. | 2011 | J. Appl. Microbiol. | pmid:21395944 |
Logue CM et al. | Repeated therapeutic dosing selects macrolide-resistant Campylobacter spp. in a turkey facility. | 2010 | J. Appl. Microbiol. | pmid:20497488 |
Riddell KP et al. | Antibiotic treatment of bovine embryos. | 1993 | J. Assist. Reprod. Genet. | pmid:8069094 |
Tang L et al. | Amino acid catabolism and antibiotic synthesis: valine is a source of precursors for macrolide biosynthesis in Streptomyces ambofaciens and Streptomyces fradiae. | 1994 | J. Bacteriol. | pmid:7928973 |
Hue KK and Bechhofer DH | Effect of ermC leader region mutations on induced mRNA stability. | 1991 | J. Bacteriol. | pmid:1711026 |
Oh TG et al. | Induction of ermAMR from a clinical strain of Enterococcus faecalis by 16-membered-ring macrolide antibiotics. | 1998 | J. Bacteriol. | pmid:9791136 |
Matsushima P et al. | Transduction and transformation of plasmid DNA in Streptomyces fradiae strains that express different levels of restriction. | 1989 | J. Bacteriol. | pmid:2542216 |
Zalacain M and Cundliffe E | Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae. | 1989 | J. Bacteriol. | pmid:2753855 |
Vancura A et al. | Fatty acids and production of tylosin-like compounds in Streptomyces fradiae. | 1987 | J. Basic Microbiol. | pmid:3625475 |
Huang SL et al. | Purification and properties of NADPH-dependent tylosin reductase from Streptomyces fradiae. | 1993 | J. Biol. Chem. | pmid:8360186 |
Bauer NJ et al. | Purification, characterization, and kinetic mechanism of S-adenosyl-L-methionine:macrocin O-methyltransferase from Streptomyces fradiae. | 1988 | J. Biol. Chem. | pmid:3170601 |
Kreuzman AJ et al. | Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis. Substrate specificity, enzyme inhibition, and kinetic mechanism. | 1988 | J. Biol. Chem. | pmid:3170602 |
Petropoulos AD et al. | Stepwise binding of tylosin and erythromycin to Escherichia coli ribosomes, characterized by kinetic and footprinting analysis. | 2008 | J. Biol. Chem. | pmid:18079110 |
Eguchi K et al. | Establishment of evaluation method to determine effects of veterinary medicinal products on manure fermentation using small-scale composting apparatus. | 2012 | J. Biosci. Bioeng. | pmid:22595343 |
Lee SH and Lee KJ | Threonine dehydratases in different strains of Streptomyces fradiae. | 1995 | J. Biotechnol. | pmid:8562022 |
Lee SH and Lee KJ | Kinetics of the repression of tylosin biosynthesis by ammonium ion in Streptomyces fradiae. | 1994 | J. Biotechnol. | pmid:7764561 |
Roets E et al. | Quantitative analysis of tylosin by column liquid chromatography. | 1993 | J. Chromatogr. | pmid:8445000 |
Fish BJ and Carr GP | Pharmacopoeial procedure for the determination of tylosin factors by high-performance liquid chromatography. | 1986 | J. Chromatogr. | pmid:3700523 |
Moats WA | Effect of the silica support of bonded reversed-phase columns on chromatography of some antibiotic compounds. | 1986 | J. Chromatogr. | pmid:3023412 |
Bernal J et al. | Determination of tylosins A, B, C and D in bee larvae by liquid chromatography coupled to ion trap-tandem mass spectrometry. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21498134 |
Qin Y et al. | Analysis of sulfonamides, tilmicosin and avermectins residues in typical animal matrices with multi-plug filtration cleanup by liquid chromatography-tandem mass spectrometry detection. | 2017 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:28410479 |
Prats C et al. | Determination of tylosin residues in different animal tissues by high performance liquid chromatography. | 2002 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:11820296 |
Herrera M et al. | Quantitative determination of tilmicosin in canine serum by high performance liquid chromatography-tandem mass spectrometry. | 2007 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:17627909 |
Shryock TR et al. | Proposed quality control guidelines for antimicrobial susceptibility tests using tilmicosin. | 1995 | J. Clin. Microbiol. | pmid:7714188 |
Boerlin P et al. | Antimicrobial growth promoter ban and resistance to macrolides and vancomycin in enterococci from pigs. | 2001 | J. Clin. Microbiol. | pmid:11682559 |
Tarabla H and Canavesio V | Prevalence of intramammary infections by major pathogens at parturition in dairy cows after intramuscular antibiotic therapy at drying-off: a preliminary report. | 2003 | J. Dairy Res. | pmid:12800878 |