Tylosin

Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tylosin?

Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tylosin

MeSH term MeSH ID Detail
Conjunctivitis, Viral D003236 1 associated lipids
Enterotoxemia D004767 1 associated lipids
Bacillaceae Infections D016863 1 associated lipids
Erysipelothrix Infections D004889 1 associated lipids
Bovine Respiratory Disease Complex D048090 2 associated lipids
Primate Diseases D018419 2 associated lipids
Pneumonia of Calves, Enzootic D048089 2 associated lipids
Pneumonia of Swine, Mycoplasmal D045729 2 associated lipids
Keratoconjunctivitis, Infectious D007639 2 associated lipids
Neisseriaceae Infections D016870 3 associated lipids
Pasteurellosis, Pneumonic D012766 3 associated lipids
Tracheal Diseases D014133 3 associated lipids
Treponemal Infections D014211 3 associated lipids
Digital Dermatitis D058066 3 associated lipids
Porcine Reproductive and Respiratory Syndrome D019318 4 associated lipids
Dysentery D004403 4 associated lipids
Mycotoxicosis D015651 5 associated lipids
Desulfovibrionaceae Infections D045824 5 associated lipids
Ureaplasma Infections D016869 5 associated lipids
Foreign Bodies D005547 5 associated lipids
Clostridium Infections D003015 5 associated lipids
Pyoderma D011711 5 associated lipids
Pneumonia, Mycoplasma D011019 6 associated lipids
Liver Abscess D008100 6 associated lipids
Mycoplasmatales Infections D009180 6 associated lipids
Facial Dermatoses D005148 7 associated lipids
Bacteriuria D001437 7 associated lipids
Pasteurella Infections D010326 8 associated lipids
Lymphadenitis D008199 8 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Campylobacter Infections D002169 13 associated lipids
Mycoplasma Infections D009175 13 associated lipids
Vasculitis D014657 14 associated lipids
Swine Diseases D013553 16 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Ataxia D001259 20 associated lipids
Poultry Diseases D011201 21 associated lipids
Bacterial Infections D001424 21 associated lipids
Cattle Diseases D002418 24 associated lipids
Diarrhea D003967 32 associated lipids
Hyperplasia D006965 34 associated lipids
Occupational Diseases D009784 42 associated lipids
Asthma D001249 52 associated lipids
Colitis D003092 69 associated lipids
Weight Gain D015430 101 associated lipids
Hemolysis D006461 131 associated lipids
Body Weight D001835 333 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Tylosin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tylosin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Tylosin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Tylosin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Tylosin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tylosin?

Knock-out

Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Tylosin

Download all related citations
Per page 10 20 50 100 | Total 931
Authors Title Published Journal PubMed Link
Womble A et al. Pulmonary disposition of tilmicosin in foals and in vitro activity against Rhodococcus equi and other common equine bacterial pathogens. 2006 J. Vet. Pharmacol. Ther. pmid:17083461
Lüthje P and Schwarz S Molecular analysis of constitutively expressed erm(C) genes selected in vitro in the presence of the non-inducers pirlimycin, spiramycin and tylosin. 2007 J. Antimicrob. Chemother. pmid:17085767
Szczepanowski R et al. Novel macrolide resistance module carried by the IncP-1beta resistance plasmid pRSB111, isolated from a wastewater treatment plant. 2007 Antimicrob. Agents Chemother. pmid:17101677
Kim D et al. In vitro susceptibilities of Leptospira spp. and Borrelia burgdorferi isolates to amoxicillin, tilmicosin, and enrofloxacin. 2006 J. Vet. Sci. pmid:17106227
Hue KK and Bechhofer DH Effect of ermC leader region mutations on induced mRNA stability. 1991 J. Bacteriol. pmid:1711026
Hamscher G et al. Quantitative analysis of tylosin in eggs by high performance liquid chromatography with electrospray ionization tandem mass spectrometry: residue depletion kinetics after administration via feed and drinking water in laying hens. 2006 J. Agric. Food Chem. pmid:17117786
Veenhuizen MF et al. Analysis of reports of human exposure to Micotil 300 (tilmicosin injection). 2006 J. Am. Vet. Med. Assoc. pmid:17144818
Couper A et al. Treatment of pneumonia in pigs with long-acting injectable tylosin. 2006 Vet. Rec. pmid:17158711
Bignell DR et al. Regulation of tylosin production: role of a TylP-interactive ligand. 2007 Mol. Microbiol. pmid:17181783
Blackwell PA et al. The dissipation and transport of veterinary antibiotics in a sandy loam soil. 2007 Chemosphere pmid:17204303
Elkins CA and Mullis LB Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. 2007 Antimicrob. Agents Chemother. pmid:17210767
Abu-Basha EA et al. Pharmacokinetics of tilmicosin (Provitil powder and Pulmotil liquid AC) oral formulations in chickens. 2007 Vet. Res. Commun. pmid:17225089
McDougall S et al. Parenteral treatment of clinical mastitis with tylosin base or penethamate hydriodide in dairy cattle. 2007 J. Dairy Sci. pmid:17235155
González de la Huebra MJ et al. Sample preparation strategy for the simultaneous determination of macrolide antibiotics in animal feedingstuffs by liquid chromatography with electrochemical detection (HPLC-ECD). 2007 J Pharm Biomed Anal pmid:17257795
Lin J et al. Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. 2007 Antimicrob. Agents Chemother. pmid:17353243
Litterio NJ et al. Microbiological screening test validation for detection of tylosin excretion in milk of cows with low and high somatic cell counts. 2007 J Vet Med A Physiol Pathol Clin Med pmid:17359452
Kart A et al. The possible protective effect of L-carnitine on tilmicosin-induced cardiotoxicity in mice. 2007 J Vet Med A Physiol Pathol Clin Med pmid:17381679
Thompson TS et al. Degradation of incurred tylosin to desmycosin--implications for residue analysis of honey. 2007 Anal. Chim. Acta pmid:17386728
Vincent U et al. Validation of an analytical method for the determination of spiramycin, virginiamycin and tylosin in feeding-stuffs by thin-layer chromatography and bio-autography. 2007 Food Addit Contam pmid:17454108
Khaliq S et al. Change in colony morphology and kinetics of tylosin production after UV and gamma irradiation mutagenesis of Streptomyces fradiae NRRL-2702. 2009 Microbiol. Res. pmid:17475458