Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wang J et al. | Determination of five macrolide antibiotic residues in eggs using liquid chromatography/electrospray ionization tandem mass spectrometry. | 2005 | J. Agric. Food Chem. | pmid:15769104 |
Blackwell PA et al. | Evaluation of a lower tier exposure assessment model for veterinary medicines. | 2005 | J. Agric. Food Chem. | pmid:15769156 |
Beier RC et al. | Production and characterization of monoclonal antibodies against the antibiotic tilmicosin. | 2005 | J. Agric. Food Chem. | pmid:16332115 |
Peng Z and Bang-Ce Y | Small molecule microarrays for drug residue detection in foodstuffs. | 2006 | J. Agric. Food Chem. | pmid:16968051 |
Jiang H et al. | Residue depletion of tilmicosin in cattle after subcutaneous administration. | 2006 | J. Agric. Food Chem. | pmid:16819937 |
Caldow M et al. | Development and validation of an optical SPR biosensor assay for tylosin residues in honey. | 2005 | J. Agric. Food Chem. | pmid:16159159 |
Van Poucke C et al. | Tylosin detection in animal feed by liquid chromatography-tandem mass spectrometry with enzymatic hydrolysis of the tylosin urea adduct. | 2004 | J. Agric. Food Chem. | pmid:15137817 |
Zhang Y et al. | Residue depletion of tilmicosin in chicken tissues. | 2004 | J. Agric. Food Chem. | pmid:15113165 |
Wang J | Determination of five macrolide antibiotic residues in honey by LC-ESI-MS and LC-ESI-MS/MS. | 2004 | J. Agric. Food Chem. | pmid:14733491 |
Granados-Chinchilla F et al. | A novel green chemistry method for nonaqueous extraction and high-performance liquid chromatography detection of first-, second-, and third-generation tetracyclines, 4-epitetracycline, and tylosin in animal feeds. | 2012 | J. Agric. Food Chem. | pmid:22738432 |
Peng D et al. | Development and validation of an indirect competitive enzyme-linked immunosorbent assay for the screening of tylosin and tilmicosin in muscle, liver, milk, honey and eggs. | 2012 | J. Agric. Food Chem. | pmid:22136611 |
Werner JJ et al. | Environmental photochemistry of tylosin: efficient, reversible photoisomerization to a less-active isomer, followed by photolysis. | 2007 | J. Agric. Food Chem. | pmid:17655244 |
Lowell AN et al. | Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization. | 2017 | J. Am. Chem. Soc. | pmid:28525276 |
Castonguay R et al. | Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase. | 2008 | J. Am. Chem. Soc. | pmid:18693734 |
Musser J et al. | Comparison of tilmicosin with long-acting oxytetracycline for treatment of respiratory tract disease in calves. | 1996 | J. Am. Vet. Med. Assoc. | pmid:8682696 |
Veenhuizen MF et al. | Analysis of reports of human exposure to Micotil 300 (tilmicosin injection). | 2006 | J. Am. Vet. Med. Assoc. | pmid:17144818 |
Morck DW et al. | Prophylactic efficacy of tilmicosin for bovine respiratory tract disease. | 1993 | J. Am. Vet. Med. Assoc. | pmid:8428833 |
Smee NM and Towell TL | What is the evidence? Inflammatory bowel disease in a dog. | 2011 | J. Am. Vet. Med. Assoc. | pmid:21529230 |
Smith GW et al. | Elimination kinetics of tilmicosin following intramammary administration in lactating dairy cattle. | 2009 | J. Am. Vet. Med. Assoc. | pmid:19210246 |
Vogel GJ et al. | Effects of tilmicosin on acute undifferentiated respiratory tract disease in newly arrived feedlot cattle. | 1998 | J. Am. Vet. Med. Assoc. | pmid:9638194 |