Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Moats WA et al. | Comparison of liquid chromatographic and bioassay procedures for determining depletion of intramuscularly injected tylosin. | 1985 May-Jun | J Assoc Off Anal Chem | pmid:4019360 |
Itoh Z et al. | Structure-activity relation among macrolide antibiotics in initiation of interdigestive migrating contractions in the canine gastrointestinal tract. | 1985 | Am. J. Physiol. | pmid:3976891 |
Goodwin RF | In vitro activity of tiamulin against porcine mycoplasmas. | 1985 | Res. Vet. Sci. | pmid:3975477 |
Kietzmann M | [Comparative study of the distribution and excretion of tylosin of various origins]. | 1985 | DTW. Dtsch. Tierarztl. Wochenschr. | pmid:3899580 |
Tsuzuki K et al. | Syntheses and antimicrobial activities of 9-O-acyl derivatives of tylosin and demycarosyltylosin. | 1986 | J. Antibiot. | pmid:3818453 |
Jacks TM et al. | 3-Acetyl-4''-isovaleryl tylosin for prevention of swine dysentery. | 1986 | Am. J. Vet. Res. | pmid:3789492 |
Cummings TS et al. | Effect of medicated feed on tracheal infection and population of Mycoplasma gallisepticum in chickens. | 1986 Jul-Sep | Avian Dis. | pmid:3767816 |
Skelly BJ et al. | Prophylactic efficacy of 3-acetyl-4''-isovaleryl tylosin in a Mycoplasma gallisepticum-induced airsacculitis infection. | 1986 Jul-Sep | Avian Dis. | pmid:3767811 |
Burrows GE et al. | Antibiotic disposition in experimental pneumonic pasteurellosis: gentamicin and tylosin. | 1986 | Can. J. Vet. Res. | pmid:3756673 |
Tanaka Y et al. | Mechanism of nitrogen regulation of protylonolide biosynthesis in Streptomyces fradiae. | 1986 | J. Antibiot. | pmid:3733529 |
Effect of space allowance and tylosin feeding on performance of growing-finishing pigs. NCR-89 Committee on Confinement Management of Swine. | 1986 | J. Anim. Sci. | pmid:3710927 | |
Fish BJ and Carr GP | Pharmacopoeial procedure for the determination of tylosin factors by high-performance liquid chromatography. | 1986 | J. Chromatogr. | pmid:3700523 |
Takeuchi T et al. | 4''-O-(4-methoxyphenyl)-acetyltylosin, a new macrolide derivative of therapeutic importance. | 1987 | J. Antibiot. | pmid:3680047 |
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Kreuzman AJ et al. | Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis. Substrate specificity, enzyme inhibition, and kinetic mechanism. | 1988 | J. Biol. Chem. | pmid:3170602 |
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Nagaraja TG and Taylor MB | Susceptibility and resistance of ruminal bacteria to antimicrobial feed additives. | 1987 | Appl. Environ. Microbiol. | pmid:3116929 |
Kaukas A et al. | The effect of ampicillin and tylosin on the faecal enterococci of healthy young chickens. | 1987 | J. Appl. Bacteriol. | pmid:3112089 |
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Moats WA | Effect of the silica support of bonded reversed-phase columns on chromatography of some antibiotic compounds. | 1986 | J. Chromatogr. | pmid:3023412 |
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Guo X et al. | Sorption properties of tylosin on four different microplastics. | 2018 | Chemosphere | pmid:29933160 |
Zhang AJ and Warshaw EM | Pet Consort Dermatitis: The Importance of Asking About Pets. | Dermatitis | pmid:29901502 | |
Stromer BS et al. | Tylosin sorption to diatomaceous earth described by Langmuir isotherm and Freundlich isotherm models. | 2018 | Chemosphere | pmid:29874766 |
Müller HC et al. | Effects of intermittent feeding of tylosin phosphate during the finishing period on feedlot performance, carcass characteristics, antimicrobial resistance, and incidence and severity of liver abscesses in steers. | 2018 | J. Anim. Sci. | pmid:29718254 |
Yin Y et al. | Iron and manganese oxides modified maize straw to remove tylosin from aqueous solutions. | 2018 | Chemosphere | pmid:29689529 |
Ishikawa NK et al. | Determination of tylosin excretion from sheep to assess tylosin spread to agricultural fields by manure application. | 2018 | Sci. Total Environ. | pmid:29579651 |
Canning P et al. | Variation in water disappearance, daily dose, and synovial fluid concentrations of tylvalosin and 3-O-acetyltylosin in commerical pigs during five day water medication with tylvalosin under field conditions. | 2018 | J. Vet. Pharmacol. Ther. | pmid:29572923 |
Dong H et al. | Synthesis and characterization of Ag/BiWO/GO composite for the fast degradation of tylosin under visible light. | 2018 | Environ Sci Pollut Res Int | pmid:29442310 |
Guo X et al. | Maize straw decorated with sulfide for tylosin removal from the water. | 2018 | Ecotoxicol. Environ. Saf. | pmid:29355772 |
Patyra E et al. | Development and validation of an LC-MS/MS method for the quantification of tiamulin, trimethoprim, tylosin, sulfadiazine and sulfamethazine in medicated feed. | 2018 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:29324179 |
Chen C et al. | Effect of composting and soil type on dissipation of veterinary antibiotics in land-applied manures. | 2018 | Chemosphere | pmid:29306199 |
Bhalsod GD et al. | Uptake and Accumulation of Pharmaceuticals in Overhead- and Surface-Irrigated Greenhouse Lettuce. | 2018 | J. Agric. Food Chem. | pmid:29293328 |
Zhang B et al. | The effects of bio-available copper on macrolide antibiotic resistance genes and mobile elements during tylosin fermentation dregs co-composting. | 2018 | Bioresour. Technol. | pmid:29278844 |
Qiu G et al. | Macrolide-Resistance Selection in Tibetan Pigs with a High Load of Mycoplasma hyopneumoniae. | 2018 | Microb. Drug Resist. | pmid:29271698 |
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Ling Z et al. | Tilmicosin- and florfenicol-loaded hydrogenated castor oil-solid lipid nanoparticles to pigs: Combined antibacterial activities and pharmacokinetics. | 2018 | J. Vet. Pharmacol. Ther. | pmid:29139136 |
de Zwart MA et al. | Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 2. Amidines. | 1989 | J. Med. Chem. | pmid:2913309 |
Cornejo J et al. | Depletion of tylosin residues in feathers, muscle and liver from broiler chickens after completion of antimicrobial therapy. | 2018 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:29111882 |
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Zhang YJ et al. | Temporal succession of soil antibiotic resistance genes following application of swine, cattle and poultry manures spiked with or without antibiotics. | 2017 | Environ. Pollut. | pmid:28964602 |
Makarov GI et al. | Structural Insight into Interaction between C20 Phenylalanyl Derivative of Tylosin and Ribosomal Tunnel. | 2017 | Biochemistry Mosc. | pmid:28941460 |
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Pérez RA et al. | Analysis of macrolide antibiotics in water by magnetic solid-phase extraction and liquid chromatography-tandem mass spectrometry. | 2017 | J Pharm Biomed Anal | pmid:28858671 |
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Ruggeri C et al. | Synthesis and antibacterial activity of 9-O-[(2-methoxyethoxy)methyl]-oximes of tylosin and demycarosyltylosin. | 1989 | J. Antibiot. | pmid:2793598 |
Liu B et al. | Copper exposure to soil under single and repeated application: Selection for the microbial community tolerance and effects on the dissipation of antibiotics. | 2017 | J. Hazard. Mater. | pmid:27930997 |
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Anti-infective drug use in relation to the risk of agranulocytosis and aplastic anemia. A report from the International Agranulocytosis and Aplastic Anemia Study. | 1989 | Arch. Intern. Med. | pmid:2785785 | |
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