Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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el-Sayed MG et al. | Pharmacokinetic profile of tylosin in mastitic cows. | 1986 | DTW. Dtsch. Tierarztl. Wochenschr. | pmid:3530702 |
Fishman SE et al. | Cloning genes for the biosynthesis of a macrolide antibiotic. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3479787 |
Stonesifer J et al. | High frequency conjugal transfer of tylosin genes and amplifiable DNA in Streptomyces fradiae. | 1986 | Mol. Gen. Genet. | pmid:3458997 |
Stipkovits L et al. | In vitro testing of the anti-mycoplasma effect of some anti-coccidial drugs. | 1987 | Vet. Microbiol. | pmid:3439016 |
Blaha T et al. | Swine dysentery control in the German Democratic Republic and the suitability of injections of tiamulin for the programme. | 1987 | Vet. Rec. | pmid:3424604 |
Kirst HA et al. | In vitro and in vivo evaluation of C-20- and C-23-modified derivatives of tylosin against veterinary pathogens. | 1988 | J. Antibiot. | pmid:3417566 |
Kirst HA et al. | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. | 1988 | J. Med. Chem. | pmid:3398001 |
de Zwart MA et al. | Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 1. Amides. | 1988 | J. Med. Chem. | pmid:3351847 |
Gershon P and Howells RE | Synergy of four macrolide antibiotics with chloroquine against chloroquine-resistant Plasmodium falciparum in vitro. | 1986 | Trans. R. Soc. Trop. Med. Hyg. | pmid:3299891 |
Ose EE and Tonkinson LV | Single-dose treatment of neonatal calf pneumonia with the new macrolide antibiotic tilmicosin. | 1988 | Vet. Rec. | pmid:3195026 |
Kreuzman AJ et al. | Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis. Substrate specificity, enzyme inhibition, and kinetic mechanism. | 1988 | J. Biol. Chem. | pmid:3170602 |
Bauer NJ et al. | Purification, characterization, and kinetic mechanism of S-adenosyl-L-methionine:macrocin O-methyltransferase from Streptomyces fradiae. | 1988 | J. Biol. Chem. | pmid:3170601 |
Nagaraja TG and Taylor MB | Susceptibility and resistance of ruminal bacteria to antimicrobial feed additives. | 1987 | Appl. Environ. Microbiol. | pmid:3116929 |
Kaukas A et al. | The effect of ampicillin and tylosin on the faecal enterococci of healthy young chickens. | 1987 | J. Appl. Bacteriol. | pmid:3112089 |
Huang L et al. | Pharmacokinetic-pharmacodynamic modeling of tylosin against Streptococcus suis in pigs. | 2018 | BMC Vet. Res. | pmid:30355326 |
Moats WA | Effect of the silica support of bonded reversed-phase columns on chromatography of some antibiotic compounds. | 1986 | J. Chromatogr. | pmid:3023412 |
Zhu L et al. | Evaluation of the antibacterial activity of tilmicosin-SLN against : in vitro and in vivo studies. | 2018 | Int J Nanomedicine | pmid:30147316 |
Lemli B et al. | Noncovalent Interaction of Tilmicosin with Bovine Serum Albumin. | 2018 | Molecules | pmid:30065238 |
De Baere S et al. | In vitro model to assess the adsorption of oral veterinary drugs to mycotoxin binders in a feed- and aflatoxin B1-containing buffered matrix. | 2018 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:30016205 |
Woolums AR et al. | Multidrug resistant Mannheimia haemolytica isolated from high-risk beef stocker cattle after antimicrobial metaphylaxis and treatment for bovine respiratory disease. | 2018 | Vet. Microbiol. | pmid:29981701 |