Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Lum AM et al. | Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays. | 2004 | Metab. Eng. | pmid:15256208 |
Baltadzhieva D et al. | [Analysis of immunological indices of occupational sensibilization to tylosin]. | 1999 | Med Tr Prom Ekol | pmid:10605285 |
Lowell JE et al. | Growth performance, carcass quality, fresh belly characteristics, and commercial bacon slicing yields of growing-finishing pigs fed a subtherapeutic dose of an antibiotic, a natural antimicrobial, or not fed an antibiotic or antimicrobial. | 2018 | Meat Sci. | pmid:29107868 |
Pinckney JL et al. | Sublethal effects of the antibiotic tylosin on estuarine benthic microalgal communities. | 2013 | Mar. Pollut. Bull. | pmid:23398744 |
Meisel ML et al. | Tylosin inhibits the steroidogenesis in mouse Leydig cells "in vitro". | 1993 | Life Sci. | pmid:8390595 |
Davies R and Roberts TA | Antimicrobial susceptibility of enterococci recovered from commercial swine carcasses: effect of feed additives. | 1999 | Lett. Appl. Microbiol. | pmid:10664974 |
Patterson J et al. | Selected culturable enteric bacterial populations are modified by diet acidification and the growth promotant Tylosin. | 2005 | Lett. Appl. Microbiol. | pmid:16033507 |
Lee SH | Ammonium ion affecting tylosin production by Streptomyces fradiae NRRL 2702 in continuous culture. | 1997 | Lett. Appl. Microbiol. | pmid:9418071 |
Whitehead TR and Cotta MA | Stored swine manure and swine faeces as reservoirs of antibiotic resistance genes. | 2013 | Lett. Appl. Microbiol. | pmid:23297734 |
Khaliq S et al. | Production of tylosin in solid-state fermentation by Streptomyces fradiae NRRL-2702 and its gamma-irradiated mutant (gamma-1). | 2009 | Lett. Appl. Microbiol. | pmid:19780953 |
Lee SH and Rho YT | Improvement of tylosin fermentation by mutation and medium optimization. | 1999 | Lett. Appl. Microbiol. | pmid:10206653 |
Mathieson PW et al. | Mercuric chloride-treated brown Norway rats develop widespread tissue injury including necrotizing vasculitis. | 1992 | Lab. Invest. | pmid:1625442 |
Modric S et al. | Effect of respiratory tract disease on pharmacokinetics of tilmicosin in rats. | 1999 | Lab. Anim. Sci. | pmid:10403438 |
Diagnosis | pasteurellosis. | 2008 | Lab Anim (NY) | pmid:18094697 | |
Takahashi I et al. | [In vitro resistance acquisition in Mycoplasma gallisepticum against ofloxacin, tylosin and spectinomycin]. | 2002 | Jpn J Antibiot | pmid:12199113 |
Neiffer DL | Clostridium perfringens enterotoxicosis in two Amur leopards (Panthera pardus orientalis). | 2001 | J. Zoo Wildl. Med. | pmid:12790411 |
Simpson EJ et al. | A simple method for the removal of mycoplasma contamination from paramyxovirus stocks. | 1983 | J. Virol. Methods | pmid:6190834 |
Coronato S et al. | A simple method to eliminate mycoplasma from cell cultures. | 1994 | J. Virol. Methods | pmid:8175949 |
Hwang YH et al. | Simultaneous determination of various macrolides by liquid chromatography/mass spectrometry. | 2002 | J. Vet. Sci. | pmid:12441679 |
Zhang L et al. | Pharmacokinetics of tilmicosin in healthy pigs and in pigs experimentally infected with . | 2017 | J. Vet. Sci. | pmid:28385011 |