Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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McGuigan MA | Human exposures to tilmicosin (MICOTIL). | 1994 | Vet Hum Toxicol | pmid:7975134 |
Arisawa A et al. | Cloning of the macrolide antibiotic biosynthesis gene acyA, which encodes 3-O-acyltransferase, from Streptomyces thermotolerans and its use for direct fermentative production of a hybrid macrolide antibiotic. | 1994 | Appl. Environ. Microbiol. | pmid:8074537 |
Wardlaw AC et al. | Bactericidal activity in the pig roundworm Ascaris suum. | 1994 | J. Appl. Bacteriol. | pmid:8144403 |
Inouye M et al. | Cloning and sequences of two macrolide-resistance-encoding genes from mycinamicin-producing Micromonospora griseorubida. | 1994 | Gene | pmid:8163173 |
Scott PR | Field study of undifferentiated respiratory disease in housed beef calves. | 1994 | Vet. Rec. | pmid:8203107 |
Coronato S et al. | A simple method to eliminate mycoplasma from cell cultures. | 1994 | J. Virol. Methods | pmid:8175949 |
Tang L et al. | Amino acid catabolism and antibiotic synthesis: valine is a source of precursors for macrolide biosynthesis in Streptomyces ambofaciens and Streptomyces fradiae. | 1994 | J. Bacteriol. | pmid:7928973 |
Inamoto T et al. | Antibacterial activity of tilmicosin against Pasteurella multocida and Actinobacillus pleuropneumoniae isolated from pneumonic lesions in swine. | 1994 | J. Vet. Med. Sci. | pmid:7865594 |
Caraffini S et al. | Tylosin, an airborne contact allergen in veterinarians. | 1994 | Contact Derm. | pmid:7867337 |
Lee SH and Lee KJ | Kinetics of the repression of tylosin biosynthesis by ammonium ion in Streptomyces fradiae. | 1994 | J. Biotechnol. | pmid:7764561 |
Danese P et al. | Occupational contact dermatitis from tylosin. | 1994 | Contact Derm. | pmid:8187499 |
Tan ZL et al. | Serum neutralizing antibodies against Fusobacterium necrophorum leukotoxin in cattle with experimentally induced or naturally developed hepatic abscesses. | 1994 | J. Anim. Sci. | pmid:8157537 |
Shryock TR et al. | Effect of bentonite incorporated in a feed ration with tilmicosin in the prevention of induced Mycoplasma gallisepticum airsacculitis in broiler chickens. | 1994 Jul-Sep | Avian Dis. | pmid:7832702 |
Chan W et al. | Determination of tylosin and tilmicosin residues in animal tissues by reversed-phase liquid chromatography. | 1994 Mar-Apr | J AOAC Int | pmid:8199468 |
Nguyen LT et al. | The tylosin producer, Streptomyces fradiae, contains a second valine dehydrogenase. | 1995 | Microbiology (Reading, Engl.) | pmid:7773408 |
Paesen J et al. | Isolation of decomposition products of tylosin using liquid chromatography. | 1995 | J Chromatogr A | pmid:7757214 |
Shryock TR et al. | Proposed quality control guidelines for antimicrobial susceptibility tests using tilmicosin. | 1995 | J. Clin. Microbiol. | pmid:7714188 |
Bobillot S et al. | Chemical modification of tylosin. | 1995 | J. Antibiot. | pmid:7649866 |
Creemer LC et al. | Synthesis, antimicrobial activity and in vivo fluorine NMR of a hexafluorinated derivative of tilmicosin. | 1995 | J. Antibiot. | pmid:7649867 |
Narandja A et al. | 10,11,12,13-Tetrahydro derivatives of tylosin. II. Synthesis, antibacterial activity and tissue of 4'-deoxy-10,11,12,13-tetrahydrodesmycosin. | 1995 | J. Antibiot. | pmid:7730160 |
Paesen J et al. | Study of the stability of tylosin A in aqueous solutions. | 1995 | J Pharm Biomed Anal | pmid:8573642 |
Ziv G et al. | Disposition kinetics of tylosin tartrate administered intravenously and intramuscularly to normal and water-deprived camels. | 1995 | J. Vet. Pharmacol. Ther. | pmid:8583543 |
Ziv G et al. | Tilmicosin antibacterial activity and pharmacokinetics in cows. | 1995 | J. Vet. Pharmacol. Ther. | pmid:8587151 |
Brown SA et al. | Characterization of plasma and lung concentrations after ceftiofur sodium and tilmicosin phosphate administered subcutaneously to mice. | 1995 | J. Vet. Pharmacol. Ther. | pmid:8587160 |
Blackall PJ et al. | In-vitro antibacterial properties of tilmicosin against Australian isolates of Pasteurella multocida and Actinobacillus pleuropneumoniae from pigs. | 1995 | Aust. Vet. J. | pmid:8787526 |
Tuomi ML and Räsänen L | Contact allergy to tylosin and cobalt in a pig-farmer. | 1995 | Contact Derm. | pmid:8654098 |
Lee SH and Lee KJ | Threonine dehydratases in different strains of Streptomyces fradiae. | 1995 | J. Biotechnol. | pmid:8562022 |
Kirchgessner M et al. | [Effect of avilamycin and tylosin on the metabolizable energy in growing and finishing pigs]. | 1995 | Arch Tierernahr | pmid:8526732 |
Kiehl DE and Kennington AS | Analysis of tilmicosin in swine liver extracts by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry. | 1995 | Rapid Commun. Mass Spectrom. | pmid:8527821 |
Harvey RB et al. | Influence of the antibiotics lincomycin and tylosin on aflatoxicosis when added to aflatoxin-contaminated diets of growing swine. | 1995 | J. Vet. Diagn. Invest. | pmid:7578454 |
Stock RA et al. | Effect of monensin and monensin and tylosin combination on feed intake variation of feedlot steers. | 1995 | J. Anim. Sci. | pmid:7601752 |
Zuzulova M et al. | In vitro activity of tylosin and its derivatives against Ureaplasma urealyticum. | 1995 | Arzneimittelforschung | pmid:8929244 |
Galyean ML et al. | Effects of arrival medication with tilmicosin phosphate on health and performance of newly received beef cattle. | 1995 | J. Anim. Sci. | pmid:7665351 |
Scott PR | Efficacy of strategic tilmicosin injection during an outbreak of respiratory disease in housed beef calves. | 1995 Sep-Oct | Br. Vet. J. | pmid:8556318 |
Moore GM et al. | Efficacy dose determination study of tilmicosin phosphate in feed for control of pneumonia caused by Actinobacillus pleuropneumoniae in swine. | 1996 | Am. J. Vet. Res. | pmid:8633812 |
Moore GM et al. | Clinical field trials with tilmicosin phosphate in feed for the control of naturally acquired pneumonia caused by Actinobacillus pleuropneumoniae and Pasteurella multocida in swine. | 1996 | Am. J. Vet. Res. | pmid:8633813 |
Day FG | The value of tilmicosin in production medicine. | 1996 | J. Am. Vet. Med. Assoc. | pmid:8617615 |
Solenberg PJ et al. | Transposition mutagenesis in Streptomyces fradiae: identification of a neutral site for the stable insertion of DNA by transposon exchange. | 1996 | Gene | pmid:8626067 |
Arisawa A et al. | Direct fermentative production of acyltylosins by genetically-engineered strains of Streptomyces fradiae. | 1996 | J. Antibiot. | pmid:8641997 |
Main BW et al. | Cardiovascular effects of the macrolide antibiotic tilmicosin, administered alone and in combination with propranolol or dobutamine, in conscious unrestrained dogs. | 1996 | J. Vet. Pharmacol. Ther. | pmid:8803881 |
Peng CY et al. | Laboratory and field studies on the effects of the antibiotic tylosin on honey bee Apis mellifera L. (Hymenoptera: Apidae) development and prevention of American foulbrood disease. | 1996 | J. Invertebr. Pathol. | pmid:8812572 |
Scott PR et al. | Use of tilmicosin in a severe outbreak of respiratory disease in weaned beef calves. | 1996 | Aust. Vet. J. | pmid:8660201 |
Wittum TE et al. | Haptoglobin response to clinical respiratory tract disease in feedlot cattle. | 1996 | Am. J. Vet. Res. | pmid:8723875 |
Musser J et al. | Comparison of tilmicosin with long-acting oxytetracycline for treatment of respiratory tract disease in calves. | 1996 | J. Am. Vet. Med. Assoc. | pmid:8682696 |
Fish SA and Cundliffe E | Structure-activity studies of tylosin-related macrolides. | 1996 | J. Antibiot. | pmid:8968399 |
Katoh T et al. | The fractional inhibitory concentration index of antimicrobial agents for bacteria and Mycoplasma isolated from the nasal swabs of cattle with respiratory diseases. | 1996 | J. Vet. Med. Sci. | pmid:8877979 |
Katoh T et al. | Effect of a combination of antimicrobial agents for the treatment of respiratory disease in cattle. | 1996 | J. Vet. Med. Sci. | pmid:8877980 |
McKay SG et al. | Use of tilmicosin for treatment of pasteurellosis in rabbits. | 1996 | Am. J. Vet. Res. | pmid:8836371 |
Shryock TR et al. | Minimum inhibitory concentration breakpoints and disk diffusion inhibitory zone interpretive criteria for tilmicosin susceptibility testing against Pasteurella spp. associated with bovine respiratory disease. | 1996 | J. Vet. Diagn. Invest. | pmid:8844577 |
Scott DW et al. | Further studies on the efficacy of tylosin tablets for the treatment of pyoderma due to Staphylococcus intermedius infection in dogs. | 1996 | Can. Vet. J. | pmid:8896878 |
Harvey RG | Tylosin in the treatment of canine superficial pyoderma. | 1996 | Vet. Rec. | pmid:8873399 |
Kobayashi H et al. | Macrolide susceptibility of Mycoplasma hyorhinis isolated from piglets. | 1996 | Antimicrob. Agents Chemother. | pmid:8849222 |
Gandecha AR and Cundliffe E | Molecular analysis of tlrD, an MLS resistance determinant from the tylosin producer, Streptomyces fradiae. | 1996 | Gene | pmid:8973363 |
Kobayashi H et al. | In vitro susceptibility of Mycoplasma hyosynoviae and M. hyorhinis to antimicrobial agents. | 1996 | J. Vet. Med. Sci. | pmid:8959659 |
Molnár L | Sensitivity of strains of Serpulina hyodysenteriae isolated in Hungary to chemotherapeutic drugs. | 1996 | Vet. Rec. | pmid:8677605 |
Kuhstoss S et al. | Production of a novel polyketide through the construction of a hybrid polyketide synthase. | 1996 | Gene | pmid:8996112 |
Jordan FT and Horrocks BK | The minimum inhibitory concentration of tilmicosin and tylosin for mycoplasma gallisepticum and Mycoplasma synoviae and a comparison of their efficacy in the control of Mycoplasma gallisepticum infection in broiler chicks. | 1996 Apr-Jun | Avian Dis. | pmid:8790882 |
Houglum JE and Tasler MK | Liquid chromatographic assay of tylosin in animal feeds. | 1996 Mar-Apr | J AOAC Int | pmid:8920123 |
Delépine B et al. | Multiresidue method for confirmation of macrolide antibiotics in bovine muscle by liquid chromatography/mass spectrometry. | 1996 Mar-Apr | J AOAC Int | pmid:8920126 |
Ngoh MA | Determination of tilmicosin in bovine milk by liquid chromatography with ultraviolet detection. | 1996 May-Jun | J AOAC Int | pmid:8634534 |
Markakis PK | Microbiological method for determining macrolides in animal feeds in the presence of other drugs by thin-layer chromatography detection. | 1996 Nov-Dec | J AOAC Int | pmid:8946704 |
Lee SH | Ammonium ion affecting tylosin production by Streptomyces fradiae NRRL 2702 in continuous culture. | 1997 | Lett. Appl. Microbiol. | pmid:9418071 |
Naranda A et al. | New dihydro and tetrahydro derivatives of desmycosin. III. The opening of oxirane ring of 12,13-epoxydesmycosin. | 1997 | J. Antibiot. | pmid:9402992 |
Fish SA and Cundliffe E | Stimulation of polyketide metabolism in Streptomyces fradiae by tylosin and its glycosylated precursors. | 1997 | Microbiology (Reading, Engl.) | pmid:9421911 |
Residues of some veterinary drugs in animals and foods. Monographs prepared by the Forty-Seventh meeting of the Joint FAO/WHO Expert Committee on Food Additives. Rome, 4-13 June 1996. | 1997 | FAO Food Nutr Pap | pmid:9253593 | |
Mironov VA et al. | [Effect of Ca2+ ions on biosynthesis and component composition of tylosin in Streptomyces fradiae]. | 1997 | Antibiot. Khimioter. | pmid:9182505 |
McFarland JW et al. | Quantitative structure-activity relationships among macrolide antibacterial agents: in vitro and in vivo potency against Pasteurella multocida. | 1997 | J. Med. Chem. | pmid:9135031 |
McFarland JW et al. | Repromicin derivatives with potent antibacterial activity against Pasteurella multocida. | 1997 | J. Med. Chem. | pmid:9083494 |
Memili E and Weisblum B | Essential role of endogenously synthesized tylosin for induction of ermSF in Streptomyces fradiae. | 1997 | Antimicrob. Agents Chemother. | pmid:9145902 |
McOrist S et al. | Oral administration of tylosin phosphate for treatment and prevention of proliferative enteropathy in pigs. | 1997 | Am. J. Vet. Res. | pmid:9028475 |
Gandecha AR et al. | Analysis of four tylosin biosynthetic genes from the tylLM region of the Streptomyces fradiae genome. | 1997 | Gene | pmid:9031628 |
Baltz RH et al. | Applications of transposition mutagenesis in antibiotic producing streptomycetes. | 1997 | Antonie Van Leeuwenhoek | pmid:9049029 |
Morck DW et al. | Treatment of experimentally induced pneumonic pasteurellosis of young calves with tilmicosin. | 1997 | Can. J. Vet. Res. | pmid:9242998 |
Baltadzhieva D et al. | [Tylosin-specific proliferation in vitro of the peripheral blood mononuclear cells in occupational tylosin allergy]. | 1997 | Probl Khig | pmid:10202771 |
Ramadan A | Pharmacokinetics of tilmicosin in serum and milk of goats. | 1997 Jan-Feb | Res. Vet. Sci. | pmid:9160424 |
Readnour RS et al. | Liquid chromatographic determination of tilmicosin in swine feed at 200-400 mg/kg level: interlaboratory study. | 1997 Nov-Dec | J AOAC Int | pmid:9419853 |
Readnour RS et al. | Determination of tilmicosin in swine feeds by liquid chromatography. | 1997 Nov-Dec | J AOAC Int | pmid:9419854 |
Moran JW et al. | Determination of tilmicosin in bovine and porcine sera by liquid chromatography. | 1997 Nov-Dec | J AOAC Int | pmid:9419857 |
Yeh WK | Evolving enzyme technology for pharmaceutical applications: case studies. | 1997 Nov-Dec | J. Ind. Microbiol. Biotechnol. | pmid:9451830 |
Kempf I et al. | Efficacy of tilmicosin in the control of experimental Mycoplasma gallisepticum infection in chickens. | 1997 Oct-Dec | Avian Dis. | pmid:9454912 |
Choi DB et al. | Effects of rapessed oil on activity of methylmalonyl-CoA carboxyltransferase in culture of Streptomyces fradiae. | 1998 | Biosci. Biotechnol. Biochem. | pmid:9648221 |
De Liguoro M et al. | Determination of tylosin residues in pig tissues using high-performance liquid chromatography. | 1998 | Analyst | pmid:9764508 |
Beharka AA and Nagaraja TG | Effect of Aspergillus oryzae extract alone or in combination with antimicrobial compounds on ruminal bacteria. | 1998 | J. Dairy Sci. | pmid:9684165 |
Norcia LJ et al. | In vitro microbiological characterization of novel macrolide CP-163,505 for animal health specific use. | 1998 | J. Antibiot. | pmid:9544934 |
Hoar BR et al. | A comparison of the clinical field efficacy and safety of florfenicol and tilmicosin for the treatment of undifferentiated bovine respiratory disease of cattle in western Canada. | 1998 | Can. Vet. J. | pmid:9524721 |
Tsinas AC et al. | Control of proliferative enteropathy in growing/fattening pigs using growth promoters. | 1998 | Zentralblatt Veterinarmedizin Reihe B | pmid:9557133 |
Oh TG et al. | Induction of ermAMR from a clinical strain of Enterococcus faecalis by 16-membered-ring macrolide antibiotics. | 1998 | J. Bacteriol. | pmid:9791136 |
Berque I et al. | [Stereoselective synthesis of biologically active macrolides. Total synthesis of tylosine]. | 1998 | Ann Pharm Fr | pmid:9770007 |
Scorneaux B and Shryock TR | Intracellular accumulation, subcellular distribution, and efflux of tilmicosin in chicken phagocytes. | 1998 | Poult. Sci. | pmid:9776059 |
Scorneaux B and Shryock TR | Intracellular accumulation, subcellular distribution and efflux of tilmicosin in swine phagocytes. | 1998 | J. Vet. Pharmacol. Ther. | pmid:9731947 |
Baba T et al. | Effect of tylosin tartrate (Tylan Soluble) on cellular immune responses in chickens. | 1998 | Poult. Sci. | pmid:9733118 |
Aarestrup FM and Friis NF | Antimicrobial susceptibility testing of Mycoplasma hyosynoviae isolated from pigs during 1968 to 1971 and during 1995 and 1996. | 1998 | Vet. Microbiol. | pmid:9646463 |
Baba T et al. | Effect of tylosin tartrate on humoral immune responses in chickens. | 1998 | Zentralblatt Veterinarmedizin Reihe B | pmid:9673579 |
Esipov SE | [Novel mathematical approach to determination of antibiotics concentration by agar diffusion method. Analysis of graphical, table and mathematical options of relative biological activity estimation]. | 1998 | Antibiot. Khimioter. | pmid:9606490 |
Shryock TR et al. | Antimicrobial susceptibility of Moraxella bovis. | 1998 | Vet. Microbiol. | pmid:9646479 |
Wilson VT and Cundliffe E | Characterization and targeted disruption of a glycosyltransferase gene in the tylosin producer, Streptomyces fradiae. | 1998 | Gene | pmid:9651492 |
Gotoh Y et al. | Chemical transformation of tylosin derivatives into neutral macrolides having a 3'-methoxyl group. | 1998 | Carbohydr. Res. | pmid:9720235 |
Modric S et al. | Pharmacokinetics and pharmacodynamics of tilmicosin in sheep and cattle. | 1998 | J. Vet. Pharmacol. Ther. | pmid:9885967 |
Koenen-Dierick K and De Beer JO | Optimization of an antibiotic residue screening test, based on inhibition of Bacillus subtilis BGA, with experimental design. | 1998 | Food Addit Contam | pmid:9829036 |
Aarestrup FM and Carstensen B | Effect of tylosin used as a growth promoter on the occurrence of macrolide-resistant enterococci and staphylococci in pigs. | 1998 | Microb. Drug Resist. | pmid:9988049 |