Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Alatrache A et al. | Tylosin abatement in water by photocatalytic process. | 2010 | Water Sci. Technol. | pmid:20651450 |
Catania S et al. | Treatment of eggshell abnormalities and reduced egg production caused by Mycoplasma synoviae infection. | 2010 | Avian Dis. | pmid:20608549 |
Kaizerman JA et al. | Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20594845 |
Gyémánt N et al. | In vitro and in vivo multidrug resistance reversal activity by a Betti-base derivative of tylosin. | 2010 | Br. J. Cancer | pmid:20551959 |
Peltier E et al. | Zinc-induced antibiotic resistance in activated sludge bioreactors. | 2010 | Water Res. | pmid:20537675 |
Starosta AL et al. | Interplay between the ribosomal tunnel, nascent chain, and macrolides influences drug inhibition. | 2010 | Chem. Biol. | pmid:20534348 |
Sumbatian NV et al. | [Amino acid and peptide derivatives of the tylosin family of macrolide antibiotics modified at the aldehyde group]. | 2010 Mar-Apr | Bioorg. Khim. | pmid:20531486 |
Logue CM et al. | Repeated therapeutic dosing selects macrolide-resistant Campylobacter spp. in a turkey facility. | 2010 | J. Appl. Microbiol. | pmid:20497488 |
Gallina G et al. | Kinetics and intrapulmonary disposition of tilmicosin after single and repeated oral bolus administrations to rabbits. | 2010 | Vet. Res. Commun. | pmid:20480234 |
Cerdá RO et al. | Impact of the type of catheter on the absorption of tylvalosin (acetylvaleryltylosin) administered orally to broiler chickens. | 2010 | J. Vet. Pharmacol. Ther. | pmid:20444046 |
van der Grinten E et al. | Comparing the sensitivity of algal, cyanobacterial and bacterial bioassays to different groups of antibiotics. | 2010 | Chemosphere | pmid:20430416 |
Barbour EK et al. | Impact of synergism of calcium phosphomycin/tylosin tartarate supplements on the performance of broilers in the Lebanon. | 2010 Jan-Mar | Vet. Ital. | pmid:20391366 |
Schumann FJ et al. | Prophylactic medication of feedlot calves with tilmicosin. | 1991 | Vet. Rec. | pmid:2038809 |
Buret AG | Immuno-modulation and anti-inflammatory benefits of antibiotics: the example of tilmicosin. | 2010 | Can. J. Vet. Res. | pmid:20357951 |
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Suchodolski JS et al. | The effect of the macrolide antibiotic tylosin on microbial diversity in the canine small intestine as demonstrated by massive parallel 16S rRNA gene sequencing. | 2009 | BMC Microbiol. | pmid:19799792 |
Blackwood RS et al. | Effects of the macrolide drug tylosin on chronic diarrhea in rhesus macaques (Macaca mulatta). | 2008 | Comp. Med. | pmid:19793461 |
Khaliq S et al. | Production of tylosin in solid-state fermentation by Streptomyces fradiae NRRL-2702 and its gamma-irradiated mutant (gamma-1). | 2009 | Lett. Appl. Microbiol. | pmid:19780953 |
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Guedes RM et al. | Use of tylvalosin-medicated feed to control porcine proliferative enteropathy. | 2009 | Vet. Rec. | pmid:19767637 |
Khalifeh MS et al. | Assessment of humoral and cellular-mediated immune response in chickens treated with tilmicosin, florfenicol, or enrofloxacin at the time of Newcastle disease vaccination. | 2009 | Poult. Sci. | pmid:19762865 |
Marsteller T et al. | Efficacy of intramuscular tylosin for the treatment and control of porcine proliferative enteropathy caused by Lawsonia intracellularis. | 2001 | Vet. Ther. | pmid:19753698 |
Zielinski GC et al. | Efficacy of different dosage levels and administration routes of tilmicosin in a natural outbreak of infectious bovine keratoconjunctivitis (pinkeye). | 2002 | Vet. Ther. | pmid:19750751 |
Thacker EL et al. | Evaluation of the ability of tilmicosin to prevent adherence of Mycoplasma hyopneumoniae to cilia using a differentiated swine respiratory epithelial culture system. | 2001 | Vet. Ther. | pmid:19746651 |
Hu D and Coats JR | Laboratory evaluation of mobility and sorption for the veterinary antibiotic, tylosin, in agricultural soils. | 2009 | J Environ Monit | pmid:19724833 |
Atef M et al. | Effect of albendazole administration on pharmacokinetic aspects of tylosin in lactating goats. | 2009 | Drug Metab Lett | pmid:19702546 |
Stone JJ et al. | Effect of antimicrobial compounds tylosin and chlortetracycline during batch anaerobic swine manure digestion. | 2009 | Water Res. | pmid:19695662 |
Pol-Hofstad I et al. | Collaborative study of a microbiological screening method (three-plate) for the banned antimicrobial growth promotors tylosin, virginiamycin, spiramycin, zinc bacitracin and avoparcin in animal feed. | 2008 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:19680856 |
Granja R et al. | Determination of erythromycin and tylosin residues in honey by LC/MS/MS. | 2009 May-Jun | J AOAC Int | pmid:19610392 |
Dzapo V and Reiner G | [The nutritive effect of avilamycin in swine breeding and fattening]. | 1991 | DTW. Dtsch. Tierarztl. Wochenschr. | pmid:1954859 |
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Hoese A et al. | Chlortetracycline and tylosin runoff from soils treated with antimicrobial containing manure. | 2009 | J Environ Sci Health B | pmid:19365753 |
Meyer NF et al. | Effect of essential oils, tylosin, and monensin on finishing steer performance, carcass characteristics, liver abscesses, ruminal fermentation, and digestibility. | 2009 | J. Anim. Sci. | pmid:19359504 |
Christodoulopoulos G | Adverse outcome of using tilmicosin in a lamb with multiple ventricular septal defects. | 2009 | Can. Vet. J. | pmid:19337615 |
Engi H | [Perspectives of inhibition of multidrug resistance during cancer chemotherapy, in vitro and in vivo experiments]. | 2009 | Orv Hetil | pmid:19293063 |
Han C et al. | Hydrogenated castor oil nanoparticles as carriers for the subcutaneous administration of tilmicosin: in vitro and in vivo studies. | 2009 | J. Vet. Pharmacol. Ther. | pmid:19290940 |
Laven R and Andrews AH | Long-acting antibiotic formulations in the treatment of calf pneumonia: a comparative study of tilmicosin and oxytetracycline. | 1991 | Vet. Rec. | pmid:1926728 |
Smith GW et al. | Elimination kinetics of tilmicosin following intramammary administration in lactating dairy cattle. | 2009 | J. Am. Vet. Med. Assoc. | pmid:19210246 |
Sharma R et al. | Selected antimicrobial resistance during composting of manure from cattle administered sub-therapeutic antimicrobials. | 2009 Mar-Apr | J. Environ. Qual. | pmid:19202027 |
Van Donkersgoed J et al. | Comparative efficacy of tilmicosin versus tulathromycin as a metaphylactic antimicrobial in feedlot calves at moderate risk for respiratory disease. | 2008 | Vet. Ther. | pmid:19177334 |
Crespo R and McMillan R | Facial cellulitis induced in chickens by Mycoplasma gallisepticum bacterin and its treatment. | 2008 | Avian Dis. | pmid:19166067 |
Kouvela EC et al. | Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. | 2009 | Antimicrob. Agents Chemother. | pmid:19164155 |
Liu F et al. | Effects of six selected antibiotics on plant growth and soil microbial and enzymatic activities. | 2009 | Environ. Pollut. | pmid:19157661 |
Blackwell PA et al. | Effects of agricultural conditions on the leaching behaviour of veterinary antibiotics in soils. | 2009 | Chemosphere | pmid:19128817 |
Chénier MR and Juteau P | Fate of chlortetracycline- and tylosin-resistant bacteria in an aerobic thermophilic sequencing batch reactor treating swine waste. | 2009 | Microb. Ecol. | pmid:19125305 |
Petropoulos AD et al. | Time-resolved binding of azithromycin to Escherichia coli ribosomes. | 2009 | J. Mol. Biol. | pmid:19071138 |
Catchpole I and Dyke KG | Replication mutants of Staphylococcus aureus macrolide-lincosamide-streptogramin B resistance plasmid pT48. | 1991 | Mol. Microbiol. | pmid:1906970 |
Byrne-Bailey KG et al. | Prevalence of sulfonamide resistance genes in bacterial isolates from manured agricultural soils and pig slurry in the United Kingdom. | 2009 | Antimicrob. Agents Chemother. | pmid:19064898 |
Oakes J and Seifert S | American association of poison control centers database characterization of human tilmicosin exposures, 2001-2005. | 2008 | J Med Toxicol | pmid:19031373 |
Hilton GG et al. | Effects of feeding zilpaterol hydrochloride with and without monensin and tylosin on carcass cutability and meat palatability of beef steers. | 2009 | J. Anim. Sci. | pmid:19028853 |
Nathues H and grosse Beilage E | Diagnosis of Lawsonia intracellularis infection in pigs after vaccination or antimicrobial treatment. | 2008 | DTW. Dtsch. Tierarztl. Wochenschr. | pmid:19024547 |
Fricke JA et al. | Pharmacokinetics and tissue depletion of tilmicosin in turkeys. | 2008 | J. Vet. Pharmacol. Ther. | pmid:19000285 |
Catry B et al. | Efficacy of metaphylactic florfenicol therapy during natural outbreaks of bovine respiratory disease. | 2008 | J. Vet. Pharmacol. Ther. | pmid:19000268 |
Montgomery JL et al. | Effects of dietary zilpaterol hydrochloride on feedlot performance and carcass characteristics of beef steers fed with and without monensin and tylosin. | 2009 | J. Anim. Sci. | pmid:18997069 |
Chemier JA et al. | Trends in microbial synthesis of natural products and biofuels. | 2009 | Adv. Enzymol. Relat. Areas Mol. Biol. | pmid:18990830 |
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Demoling LA and Bååth E | No long-term persistence of bacterial pollution-induced community tolerance in tylosin-polluted soil. | 2008 | Environ. Sci. Technol. | pmid:18853809 |
Cundliffe E | Control of tylosin biosynthesis in Streptomyces fradiae. | 2008 | J. Microbiol. Biotechnol. | pmid:18852501 |
Lilia G et al. | Circadian serum concentrations of tylosin in broilers after feed or water medication. | 2008 | Br. Poult. Sci. | pmid:18836909 |
Boles JA et al. | Growth implants reduced tenderness of steaks from steers and heifers with different genetic potentials for growth and marbling. | 2009 | J. Anim. Sci. | pmid:18791138 |
Atef M et al. | Disposition of tylosin in goats. | 1991 May-Jun | Br. Vet. J. | pmid:1878767 |
Caldwell DB et al. | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. | 2008 | Antimicrob. Agents Chemother. | pmid:18779354 |
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Castonguay R et al. | Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase. | 2008 | J. Am. Chem. Soc. | pmid:18693734 |
Gallina G et al. | Acute toxicity evaluation of four antibacterials with Daphnia magna. | 2008 | Vet. Res. Commun. | pmid:18688742 |
Shimada T et al. | Inhibitory effects of the macrolide antimicrobial tylosin on anaerobic treatment. | 2008 | Biotechnol. Bioeng. | pmid:18646223 |
Rosteck PR et al. | Homology between proteins controlling Streptomyces fradiae tylosin resistance and ATP-binding transport. | 1991 | Gene | pmid:1864505 |
Nickell JS et al. | Comparison of short-term health and performance effects related to prophylactic administration of tulathromycin versus tilmicosin in long-hauled, highly stressed beef stocker calves. | 2008 | Vet. Ther. | pmid:18597253 |
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Mir PS et al. | Effects of dietary sunflower seeds and tylosin phosphate on production variables, carcass characteristics, fatty acid composition, and liver abscess incidence in crossbred steers. | 2008 | J. Anim. Sci. | pmid:18567724 |
Shimada T et al. | Modelling the effect of the antimicrobial tylosin on the performance of an anaerobic sequencing batch reactor. | 2008 | Water Sci. Technol. | pmid:18547919 |
Reynaldi FJ et al. | Effectiveness of tilmicosin against Paenibacillus larvae, the causal agent of American Foulbrood disease of honeybees. | 2008 | Vet. Microbiol. | pmid:18539412 |
Achard A et al. | Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene. | 2008 | Antimicrob. Agents Chemother. | pmid:18519724 |
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Stoev G and Nazarov V | Identification of the related substances of tilmicosin by liquid chromatography/ion trap mass spectrometry. | 2008 | Rapid Commun. Mass Spectrom. | pmid:18491285 |
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Aust MO et al. | Distribution of sulfamethazine, chlortetracycline and tylosin in manure and soil of Canadian feedlots after subtherapeutic use in cattle. | 2008 | Environ. Pollut. | pmid:18440678 |
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Douthwaite S et al. | Interaction of the tylosin-resistance methyltransferase RlmA II at its rRNA target differs from the orthologue RlmA I. | 2008 | J. Mol. Biol. | pmid:18406425 |
Smith SC et al. | In-vitro antimicrobial susceptibility of Australian isolates of Treponema hyodysenteriae. | 1991 | Aust. Vet. J. | pmid:1839652 |
Picavet T et al. | Efficacy of tilmicosin in treatment of pulmonary infections in calves. | 1991 | Vet. Rec. | pmid:1837391 |
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Ramlachan N et al. | A comparative study on the effects of tylosin on select bacteria during continuous flow culture of mixed populations of gut microflora derived from a feral and a domestic pig. | 2008 | Foodborne Pathog. Dis. | pmid:18260812 |
Angenent LT et al. | Effect of the presence of the antimicrobial tylosin in swine waste on anaerobic treatment. | 2008 | Water Res. | pmid:18258277 |
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