Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Lu L et al. | Autoinducer 2-like activity in poultry-associated enteric bacteria in response to subtherapeutic antibiotic exposure. | 2005 | Avian Dis. | pmid:15839416 |
Loftin KA et al. | Inhibition of microbial metabolism in anaerobic lagoons by selected sulfonamides, tetracyclines, lincomycin, and tylosin tartrate. | 2005 | Environ. Toxicol. Chem. | pmid:15839550 |
Halling-Sørensen B et al. | Dissipation and effects of chlortetracycline and tylosin in two agricultural soils: a field-scale study in southern Denmark. | 2005 | Environ. Toxicol. Chem. | pmid:15839553 |
Wang J et al. | Determination of five macrolide antibiotic residues in eggs using liquid chromatography/electrospray ionization tandem mass spectrometry. | 2005 | J. Agric. Food Chem. | pmid:15769104 |
Blackwell PA et al. | Evaluation of a lower tier exposure assessment model for veterinary medicines. | 2005 | J. Agric. Food Chem. | pmid:15769156 |
Kay P et al. | A lysimeter experiment to investigate the leaching of veterinary antibiotics through a clay soil and comparison with field data. | 2005 | Environ. Pollut. | pmid:15589660 |
Thompson TS et al. | Determination of lincomycin and tylosin residues in honey by liquid chromatography/tandem mass spectrometry. | 2005 | Rapid Commun. Mass Spectrom. | pmid:15645470 |
Beier RC et al. | Production and characterization of monoclonal antibodies against the antibiotic tilmicosin. | 2005 | J. Agric. Food Chem. | pmid:16332115 |
Rozeboom DW et al. | Effects of mannan oligosaccharide and an antimicrobial product in nursery diets on performance of pigs reared on three different farms. | 2005 | J. Anim. Sci. | pmid:16230663 |
Jensen LB and Aarestrup FM | Regulation of the erm(C) gene in Staphylococci from reservoir with different usage of macrolides. | 2005 | Acta Vet. Scand. | pmid:16261929 |
Ayling RD et al. | Assessing the in vitro effectiveness of antimicrobials against Mycoplasma mycoides subsp. mycoides small-colony type to reduce contagious bovine pleuropneumonia infection. | 2005 | Antimicrob. Agents Chemother. | pmid:16304194 |
Brain RA et al. | Aquatic microcosm assessment of the effects of tylosin on Lemna gibba and Myriophyllum spicatum. | 2005 | Environ. Pollut. | pmid:15519715 |
Nutsch RG et al. | Comparative efficacy of tulathromycin, tilmicosin, and florfenicol in the treatment of bovine respiratory disease in stocker cattle. | 2005 | Vet. Ther. | pmid:16094564 |
Skogerboe TL et al. | Comparative efficacy of tulathromycin versus florfenicol and tilmicosin against undifferentiated bovine respiratory disease in feedlot cattle. | 2005 | Vet. Ther. | pmid:16094565 |
Patterson J et al. | Selected culturable enteric bacterial populations are modified by diet acidification and the growth promotant Tylosin. | 2005 | Lett. Appl. Microbiol. | pmid:16033507 |
Kolz AC et al. | Sorption of tylosin onto swine manure. | 2005 | Chemosphere | pmid:15914248 |
Yong H et al. | Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15863336 |
Vicca J et al. | Efficacy of in-feed medication with tylosin for the treatment and control of Mycoplasma hyopneumoniae infections. | 2005 | Vet. Rec. | pmid:15879541 |
Fittipaldi N et al. | Assessment of the efficacy of tilmicosin phosphate to eliminate Actinobacillus pleuropneumoniae from carrier pigs. | 2005 | Can. J. Vet. Res. | pmid:15971680 |
Fang XM et al. | [A study on space mutation of Streptomyces fradiae]. | 2005 | Space Med Med Eng (Beijing) | pmid:15977391 |
Alippi AM et al. | In vitro and in vivo susceptibility of the honeybee bacterial pathogen Paenibacillus larvae subsp. larvae to the antibiotic tylosin. | 2005 | Vet. Microbiol. | pmid:15951140 |
Wu CM et al. | Induction of macrolide resistance in Mycoplasma gallisepticum in vitro and its resistance-related mutations within domain V of 23S rRNA. | 2005 | FEMS Microbiol. Lett. | pmid:15936901 |
Forrester MB | Human exposures to tilmicosin reported to poison centres, Texas, 1998-2003. | 2005 | Hum Exp Toxicol | pmid:16004193 |
Shen J et al. | Pharmacokinetics of tilmicosin after oral administration in swine. | 2005 | Am. J. Vet. Res. | pmid:16008233 |
Caldow M et al. | Development and validation of an optical SPR biosensor assay for tylosin residues in honey. | 2005 | J. Agric. Food Chem. | pmid:16159159 |
Chun S et al. | Effect of agricultural antibiotics on the persistence and transformation of 17beta-estradiol in a Sequatchie loam. | 2005 | J Environ Sci Health B | pmid:16190018 |
Clay SA et al. | Tylosin sorption to silty clay loam soils, swine manure, and sand. | 2005 | J Environ Sci Health B | pmid:16194921 |
Gramse MJ et al. | Determination of tylosin in feeds by liquid chromatography with solid-phase extraction. | 2004 Mar-Apr | J AOAC Int | pmid:15164825 |
Lee WD et al. | Tilmicosin-induced bovine neutrophil apoptosis is cell-specific and downregulates spontaneous LTB4 synthesis without increasing Fas expression. | 2004 Mar-Apr | Vet. Res. | pmid:15099497 |
Yildiz S et al. | Tylosin does not affect GnRH-induced LH secretion in rams. | 2004 Jan-Feb | Reprod. Toxicol. | pmid:15013072 |
Dykman LA et al. | [Immunogenic properties of the colloidal gold]. | 2004 Jan-Feb | Izv. Akad. Nauk. Ser. Biol. | pmid:15049073 |
Kumar K et al. | Enzyme-linked immunosorbent assay for ultratrace determination of antibiotics in aqueous samples. | 2004 Jan-Feb | J. Environ. Qual. | pmid:14964379 |
Mathers JJ et al. | Inhibition of resistance plasmid transfer in Escherichia coli by ionophores, chlortetracycline, bacitracin, and ionophore/antimicrobial combinations. | 2004 Apr-Jun | Avian Dis. | pmid:15283418 |
Stratigopoulos G et al. | Positive control of tylosin biosynthesis: pivotal role of TylR. | 2004 | Mol. Microbiol. | pmid:15554972 |
Taniguchi K et al. | The role of histidine residues conserved in the putative ATP-binding region of macrolide 2'-phosphotransferase II. | 2004 | FEMS Microbiol. Lett. | pmid:15033229 |
Paradis MA et al. | Efficacy of tilmicosin in the control of experimentally induced Actinobacillus pleuropneumoniae infection in swine. | 2004 | Can. J. Vet. Res. | pmid:14979429 |
Jost BH et al. | A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes. | 2004 | Antimicrob. Agents Chemother. | pmid:14982756 |
Douthwaite S et al. | The tylosin-resistance methyltransferase RlmA(II) (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748. | 2004 | J. Mol. Biol. | pmid:15046978 |
Elitok B and Elitok OM | Clinical efficacy of carprofen as an adjunct to the antibacterial treatment of bovine respiratory disease. | 2004 | J. Vet. Pharmacol. Ther. | pmid:15500569 |
Clark C et al. | A preliminary investigation of the disposition of tilmicosin residues in elk tissues and serum. | 2004 | J. Vet. Pharmacol. Ther. | pmid:15500580 |
Civitareale C et al. | Identification and quantification method of spiramycin and tylosin in feedingstuffs with HPLC-UV/DAD at 1 ppm level. | 2004 | J Pharm Biomed Anal | pmid:15496324 |
Novotny GW et al. | Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA. | 2004 | Antimicrob. Agents Chemother. | pmid:15388419 |
Montesissa C et al. | Metabolism of tilmicosin by rabbit liver microsomes and hepatocytes. | 2004 | Vet. J. | pmid:14623156 |
Mutak S et al. | Semisynthetic macrolide antibacterials derived from tylosin. Synthesis and structure-activity relationships of novel desmycosin analogues. | 2004 | J. Med. Chem. | pmid:14711312 |
Phan LT et al. | Synthesis and antibacterial activity of a novel class of 4'-substituted 16-membered ring macrolides derived from tylosin. | 2004 | J. Med. Chem. | pmid:15163176 |
Brumbaugh GW et al. | Susceptibility of Mycobacterium avium sbsp paratuberculosis to monensin sodium or tilmicosin phosphate in vitro and resulting infectivity in a murine model. | 2004 | Can. J. Vet. Res. | pmid:15352541 |
Poole TL et al. | Competitive exclusion of a glycopeptide-resistant Enterococcus faecium in the presence of vancomycin but not equivalent concentrations of tylosin or gentamicin. | 2004 | Poult. Sci. | pmid:15285499 |
Lum AM et al. | Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays. | 2004 | Metab. Eng. | pmid:15256208 |
Jackson CR et al. | Effects of tylosin use on erythromycin resistance in enterococci isolated from swine. | 2004 | Appl. Environ. Microbiol. | pmid:15240302 |
Lawrence K | Change to user warning for Micotil. | 2004 | Vet. Rec. | pmid:15200081 |
Kay P et al. | Fate of veterinary antibiotics in a macroporous tile drained clay soil. | 2004 | Environ. Toxicol. Chem. | pmid:15180364 |
Pettis JS et al. | Larval Apis mellifera L. (Hymenoptera: Apidae) mortality after topical application of antibiotics and dusts. | 2004 | J. Econ. Entomol. | pmid:15154433 |
Chirase NK et al. | Effect of simulated ambient particulate matter exposure on performance, rectal temperature, and leukocytosis of young Spanish goats with or without tilmicosin phosphate. | 2004 | J. Anim. Sci. | pmid:15080345 |
Fajt VR et al. | Effect of danofloxacin and tilmicosin on body temperatures of beef calves with pneumonia experimentally induced by inoculation with Mannheimia haemolytica. | 2004 | Am. J. Vet. Res. | pmid:15141881 |
Van Poucke C et al. | Tylosin detection in animal feed by liquid chromatography-tandem mass spectrometry with enzymatic hydrolysis of the tylosin urea adduct. | 2004 | J. Agric. Food Chem. | pmid:15137817 |
Cusack PM | Effect of mass medication with antibiotics at feedlot entry on the health and growth rate of cattle destined for the Australian domestic market. | 2004 | Aust. Vet. J. | pmid:15088981 |
Zhang Y et al. | Residue depletion of tilmicosin in chicken tissues. | 2004 | J. Agric. Food Chem. | pmid:15113165 |
Wang J | Determination of five macrolide antibiotic residues in honey by LC-ESI-MS and LC-ESI-MS/MS. | 2004 | J. Agric. Food Chem. | pmid:14733491 |
Moretto A et al. | Slow release of two antibiotics of veterinary interest from PVA hydrogels. | 2004 | Farmaco | pmid:14751309 |
Ammida NH et al. | Analysis of erythromycin and tylosin in bovine muscle using disposable screen printed electrodes. | 2004 | Analyst | pmid:14737577 |
Karlsson M et al. | Further characterization of porcine Brachyspira hyodysenteriae isolates with decreased susceptibility to tiamulin. | 2004 | J. Med. Microbiol. | pmid:15017283 |
Rowan TG et al. | Efficacy of danofloxacin in the treatment of respiratory disease in European cattle. | 2004 | Vet. Rec. | pmid:15160844 |
German AJ et al. | Comparison of direct and indirect tests for small intestinal bacterial overgrowth and antibiotic-responsive diarrhea in dogs. | 2003 Jan-Feb | J. Vet. Intern. Med. | pmid:12564725 |
Onan LJ and LaPara TM | Tylosin-resistant bacteria cultivated from agricultural soil. | 2003 | FEMS Microbiol. Lett. | pmid:12644222 |
Von Essen S et al. | Unintentional human exposure to tilmicosin (Micotil 300). | 2003 | J. Toxicol. Clin. Toxicol. | pmid:12807303 |
Del Vecchio F et al. | Active-site residue, domain and module swaps in modular polyketide synthases. | 2003 | J. Ind. Microbiol. Biotechnol. | pmid:12811585 |
Anderegg TR and Jones RN | Initial disk diffusion quality control guidelines for tylosin tested against Staphylococcus aureus ATCC 25923 and Streptococcus pneumoniae ATCC 49619. | 2003 | Int. J. Antimicrob. Agents | pmid:12791478 |
Tarabla H and Canavesio V | Prevalence of intramammary infections by major pathogens at parturition in dairy cows after intramuscular antibiotic therapy at drying-off: a preliminary report. | 2003 | J. Dairy Res. | pmid:12800878 |
Loria GR et al. | In vitro susceptibilities of field isolates of Mycoplasma agalactiae to oxytetracycline, tylosin, enrofloxacin, spiramycin and lincomycin-spectinomycin. | 2003 | Res. Vet. Sci. | pmid:12801456 |
Althaus RL et al. | Detection limits of antimicrobials in ewe milk by delvotest photometric measurements. | 2003 | J. Dairy Sci. | pmid:12647952 |
Horie M et al. | [Determination of spiramycin and tilmicosin in meat and fish by LC/MS]. | 2003 | Shokuhin Eiseigaku Zasshi | pmid:12968469 |
Marks SL and Kather EJ | Antimicrobial susceptibilities of canine Clostridium difficile and Clostridium perfringens isolates to commonly utilized antimicrobial drugs. | 2003 | Vet. Microbiol. | pmid:12742714 |
Iveković D et al. | Electrochemical reduction of desmycosin, structure investigation and antibacterial evaluation of the resulting products. | 2003 | Eur J Pharm Sci | pmid:12694884 |
Rodriguez E et al. | Rapid engineering of polyketide overproduction by gene transfer to industrially optimized strains. | 2003 | J. Ind. Microbiol. Biotechnol. | pmid:12698320 |
De Liguoro M et al. | Use of oxytetracycline and tylosin in intensive calf farming: evaluation of transfer to manure and soil. | 2003 | Chemosphere | pmid:12729703 |
Fajt VR et al. | The effects of danofloxacin and tilmicosin on neutrophil function and lung consolidation in beef heifer calves with induced Pasteurella (Mannheimia) haemolytica pneumonia. | 2003 | J. Vet. Pharmacol. Ther. | pmid:12755900 |
Dingwell RT et al. | Efficacy of intramammary tilmicosin and risk factors for cure of Staphylococcus aureus infection in the dry period. | 2003 | J. Dairy Sci. | pmid:12613861 |
Poole TL et al. | Effect of subtherapeutic concentrations of tylosin on the inhibitory stringency of a mixed anaerobe continuous-flow culture of chicken microflora against Escherichia coli O157:H7. | 2003 | J. Appl. Microbiol. | pmid:12492926 |
Lebars I et al. | Structure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII. | 2003 | EMBO J. | pmid:12514124 |
Moubareck C et al. | Multiple antibiotic resistance gene transfer from animal to human enterococci in the digestive tract of gnotobiotic mice. | 2003 | Antimicrob. Agents Chemother. | pmid:12937011 |
Van Lunen TA | Growth performance of pigs fed diets with and without tylosin phosphate supplementation and reared in a biosecure all-in all-out housing system. | 2003 | Can. Vet. J. | pmid:12892287 |
Teeter JS and Meyerhoff RD | Aerobic degradation of tylosin in cattle, chicken, and swine excreta. | 2003 | Environ. Res. | pmid:12865047 |
Creemer LC et al. | Facile synthesis of tilmicosin and tylosin related haptens for use as protein conjugates. | 2003 | J. Antibiot. | pmid:12870814 |
Collier CT et al. | Effects of tylosin on bacterial mucolysis, Clostridium perfringens colonization, and intestinal barrier function in a chick model of necrotic enteritis. | 2003 | Antimicrob. Agents Chemother. | pmid:14506046 |
Thompson TS et al. | Determination of lincomycin and tylosin residues in honey using solid-phase extraction and liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. | 2003 | J Chromatogr A | pmid:14661747 |
Sumbatyan NV et al. | Peptide derivatives of antibiotics tylosin and desmycosin, protein synthesis inhibitors. | 2003 | Biochemistry Mosc. | pmid:14616087 |
Jost BH et al. | Tylosin resistance in Arcanobacterium pyogenes is encoded by an erm X determinant. | 2003 | Antimicrob. Agents Chemother. | pmid:14576111 |
Lee HJ and Jin HJ | Renaturation of recombinant ErmSF and its refolding behavior. | 2003 | Mol. Cells | pmid:14651260 |
Prapasarakul N et al. | In vitro susceptibility and a new point mutation associated with tylosin-resistance in Japanese canine intestinal spirochetes. | 2003 | J. Vet. Med. Sci. | pmid:14709813 |
Clark SB et al. | Interlaboratory comparison of methods for the determination of incurred tilmicosin residues in bovine liver. | 2002 Nov-Dec | J AOAC Int | pmid:12477187 |
Evans RD et al. | Field evaluation of tylosin premix in layers previously vaccinated with a live Mycoplasma gallisepticum vaccine. | 2002 Jan-Mar | Avian Dis. | pmid:11922337 |
Cerdá RO et al. | In vitro antibiotic susceptibility of field isolates of Mycoplasma synoviae in Argentina. | 2002 Jan-Mar | Avian Dis. | pmid:11922338 |
Christodoulopoulos G et al. | Tilmicosin administration to young lambs with respiratory infection: safety and efficacy considerations. | 2002 | J. Vet. Pharmacol. Ther. | pmid:12423233 |
Liu M and Douthwaite S | Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12417742 |
Higgins HC and McEvoy JD | Accelerated solvent extraction of animal feedingstuffs for microbial growth inhibition screening for the presence of antimicrobial feed additives. | 2002 | Food Addit Contam | pmid:12396393 |
Gautier-Bouchardon AV et al. | In vitro development of resistance to enrofloxacin, erythromycin, tylosin, tiamulin and oxytetracycline in Mycoplasma gallisepticum, Mycoplasma iowae and Mycoplasma synoviae. | 2002 | Vet. Microbiol. | pmid:12119137 |
Zhang YX et al. | Genome shuffling leads to rapid phenotypic improvement in bacteria. | 2002 | Nature | pmid:11832946 |
Brumm MC et al. | Effect of wean-to-finish management on pig performance. | 2002 | J. Anim. Sci. | pmid:11881920 |
Carter JN et al. | Relationship of vitamin E supplementation and antimicrobial treatment with acute-phase protein responses in cattle affected by naturally acquired respiratory tract disease. | 2002 | Am. J. Vet. Res. | pmid:12171163 |
Loke ML et al. | Determination of the distribution coefficient (log Kd) of oxytetracycline, tylosin A, olaquindox and metronidazole in manure. | 2002 | Chemosphere | pmid:12146624 |