Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sura S et al. | Transport of three veterinary antimicrobials from feedlot pens via simulated rainfall runoff. | 2015 | Sci. Total Environ. | pmid:25839178 |
Li Q et al. | Co-addition of manure increases the dissipation rates of tylosin A and the numbers of resistance genes in laboratory incubation experiments. | 2015 | Sci. Total Environ. | pmid:25958362 |
Xia X et al. | Proteomic analysis of tylosin-resistant Mycoplasma gallisepticum reveals enzymatic activities associated with resistance. | 2015 | Sci Rep | pmid:26584633 |
Brown K et al. | Antimicrobial growth promoters modulate host responses in mice with a defined intestinal microbiota. | 2016 | Sci Rep | pmid:27929072 |
Huwyler U et al. | Efficacy evaluation of the use of oral tilmicosin in pneumonic calves. | 1999 | Schweiz. Arch. Tierheilkd. | pmid:10228400 |
Greer RT and Ryoo JP | Development of ocular inserts for cattle. | 1987 | Scanning Microsc. | pmid:3616580 |
Reynaldi FJ et al. | [Binding of tylosin, tilmicosin and oxytetracycline to proteins from honeybees, larvae and beehive products]. | 2010 Oct-Dec | Rev. Argent. Microbiol. | pmid:21229198 |
Loria GR et al. | In vitro susceptibilities of field isolates of Mycoplasma agalactiae to oxytetracycline, tylosin, enrofloxacin, spiramycin and lincomycin-spectinomycin. | 2003 | Res. Vet. Sci. | pmid:12801456 |
Timsit E et al. | Effects of nasal instillation of a nitric oxide-releasing solution or parenteral administration of tilmicosin on the nasopharyngeal microbiota of beef feedlot cattle at high-risk of developing respiratory tract disease. | 2017 | Res. Vet. Sci. | pmid:28231472 |
Cooper AC et al. | In vitro activity of danofloxacin, tylosin and oxytetracycline against mycoplasmas of veterinary importance. | 1993 | Res. Vet. Sci. | pmid:8393208 |
Cester CC et al. | Effect of stage of oestrous cycle on tylosin disposition in genital tract secretions of cows. | 1993 | Res. Vet. Sci. | pmid:8434145 |
Crepieux T et al. | Randomized, non-inferiority trial comparing a nitric oxide releasing solution with a macrolide antibiotic for control of bovine respiratory disease in beef feedlot calves at high-risk of developing respiratory tract disease. | 2016 | Res. Vet. Sci. | pmid:27033936 |
El-Ela FI et al. | Investigating the potential role of vitamin E in modulating the immunosuppressive effects of tylvalosin and florfenicol in broiler chickens. | 2016 | Res. Vet. Sci. | pmid:27663366 |
Ramadan A | Pharmacokinetics of tilmicosin in serum and milk of goats. | 1997 Jan-Feb | Res. Vet. Sci. | pmid:9160424 |
Hannan PC et al. | Tylosin tartrate and tiamutilin effects on experimental piglet pneumonia induced with pneumonic pig lung homogenate containing mycoplasmas, bacteria and viruses. | 1982 | Res. Vet. Sci. | pmid:7134653 |
Zweers-Zeilmaker WM et al. | In vitro complex formation and inhibition of hepatic cytochrome P450 activity by different macrolides and tiamulin in goats and cattle. | 1999 | Res. Vet. Sci. | pmid:10088712 |
Allan EM and Pirie HM | In vitro activity of tiamulin against bovine respiratory tract mycoplasmas. | 1981 | Res. Vet. Sci. | pmid:7323463 |
Gourlay RN et al. | Effect of a new macrolide antibiotic (tilmicosin) on pneumonia experimentally induced in calves by Mycoplasma bovis and Pasteurella haemolytica. | 1989 | Res. Vet. Sci. | pmid:2772410 |
Prats C et al. | Disposition kinetics of tylosin administered intravenously and intramuscularly to pigs. | 2002 | Res. Vet. Sci. | pmid:12204632 |
Kempf I et al. | Efficacy of danofloxacin in the therapy of experimental mycoplasmosis in chicks. | 1992 | Res. Vet. Sci. | pmid:1332154 |