Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sassman SA et al. | Sorption of tylosin A, D, and A-aldol and degradation of tylosin A in soils. | 2007 | Environ. Toxicol. Chem. | pmid:17702335 |
Ladely SR et al. | Development of macrolide-resistant Campylobacter in broilers administered subtherapeutic or therapeutic concentrations of tylosin. | 2007 | J. Food Prot. | pmid:17803155 |
MartÃnez MF and Barth AD | Early detection and treatment of vesicular adenitis in bulls. | 2007 | Anim. Reprod. Sci. | pmid:17027202 |
González de la Huebra MJ et al. | Sample preparation strategy for the simultaneous determination of macrolide antibiotics in animal feedingstuffs by liquid chromatography with electrochemical detection (HPLC-ECD). | 2007 | J Pharm Biomed Anal | pmid:17257795 |
Kart A et al. | The possible protective effect of L-carnitine on tilmicosin-induced cardiotoxicity in mice. | 2007 | J Vet Med A Physiol Pathol Clin Med | pmid:17381679 |
Lin J et al. | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. | 2007 | Antimicrob. Agents Chemother. | pmid:17353243 |
Litterio NJ et al. | Microbiological screening test validation for detection of tylosin excretion in milk of cows with low and high somatic cell counts. | 2007 | J Vet Med A Physiol Pathol Clin Med | pmid:17359452 |
Allaire SE et al. | Sorption kinetics of chlortetracyline and tylosin on sandy loam and heavy clay soils. | 2006 Jul-Aug | J. Environ. Qual. | pmid:16738380 |
Fu H et al. | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16343900 |
Chelliapan S et al. | Performance of an up-flow anaerobic stage reactor (UASR) in the treatment of pharmaceutical wastewater containing macrolide antibiotics. | 2006 | Water Res. | pmid:16387347 |
Peng Z and Bang-Ce Y | Small molecule microarrays for drug residue detection in foodstuffs. | 2006 | J. Agric. Food Chem. | pmid:16968051 |
DiLorenzo N et al. | Effects of feeding polyclonal antibody preparations on ruminal bacterial populations and ruminal pH of steers fed high-grain diets. | 2006 | J. Anim. Sci. | pmid:16864880 |
McAllister TA et al. | Shedding of escherichia coli O157:H7 by cattle fed diets containing monensin or tylosin. | 2006 | J. Food Prot. | pmid:16995508 |
Industry guidance on the administration of tilmicosin. | 2006 | Vet. Rec. | pmid:16924727 | |
Bate N et al. | Regulation of tylosin biosynthesis involving 'SARP-helper' activity. | 2006 | Mol. Microbiol. | pmid:16942604 |
Jacobsen AM and Halling-Sørensen B | Multi-component analysis of tetracyclines, sulfonamides and tylosin in swine manure by liquid chromatography-tandem mass spectrometry. | 2006 | Anal Bioanal Chem | pmid:16485090 |
Jung WS et al. | Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae. | 2006 | Appl. Microbiol. Biotechnol. | pmid:16493552 |
Carlson JC and Mabury SA | Dissipation kinetics and mobility of chlortetracycline, tylosin, and monensin in an agricultural soil in Northumberland County, Ontario, Canada. | 2006 | Environ. Toxicol. Chem. | pmid:16494218 |
Womble A et al. | Pulmonary disposition of tilmicosin in foals and in vitro activity against Rhodococcus equi and other common equine bacterial pathogens. | 2006 | J. Vet. Pharmacol. Ther. | pmid:17083461 |
Booker CW et al. | An evaluation of the metaphylactic effect of ceftiofur crystalline free Acid in feedlot calves. | 2006 | Vet. Ther. | pmid:17039449 |
Karahalios P et al. | On the mechanism of action of 9-O-arylalkyloxime derivatives of 6-O-mycaminosyltylonolide, a new class of 16-membered macrolide antibiotics. | 2006 | Mol. Pharmacol. | pmid:16873579 |
Hamscher G et al. | Quantitative analysis of tylosin in eggs by high performance liquid chromatography with electrospray ionization tandem mass spectrometry: residue depletion kinetics after administration via feed and drinking water in laying hens. | 2006 | J. Agric. Food Chem. | pmid:17117786 |
Veenhuizen MF et al. | Analysis of reports of human exposure to Micotil 300 (tilmicosin injection). | 2006 | J. Am. Vet. Med. Assoc. | pmid:17144818 |
Couper A et al. | Treatment of pneumonia in pigs with long-acting injectable tylosin. | 2006 | Vet. Rec. | pmid:17158711 |
Chun S et al. | Influence of agricultural antibiotics and 17beta-estradiol on the microbial community of soil. | 2006 | J Environ Sci Health B | pmid:16893780 |
Nozal Nalda MJ et al. | Trace analysis of antibacterial tylosin A, B, C and D in honey by liquid chromatography-electrospray ionization-mass spectrometry. | 2006 | J Sep Sci | pmid:16544883 |
Cao XY et al. | Tilmicosin and tylosin have anti-inflammatory properties via modulation of COX-2 and iNOS gene expression and production of cytokines in LPS-induced macrophages and monocytes. | 2006 | Int. J. Antimicrob. Agents | pmid:16647840 |
Dingwell RT et al. | Influence of the genotype of Staphylococcus aureus, determined by pulsed-field gel electrophoresis, on dry-period elimination of subclinical mastitis in Canadian dairy herds. | 2006 | Can. J. Vet. Res. | pmid:16639943 |
ter Laak TL et al. | The effect of pH and ionic strength on the sorption of sulfachloropyridazine, tylosin, and oxytetracycline to soil. | 2006 | Environ. Toxicol. Chem. | pmid:16629129 |
ter Laak TL et al. | Estimation of soil sorption coefficients of veterinary pharmaceuticals from soil properties. | 2006 | Environ. Toxicol. Chem. | pmid:16629132 |
Terui Y et al. | Synthesis of 2-methyl 16-membered macrolide derived from tylosin. | 2006 | J. Antibiot. | pmid:16629410 |
Jiang H et al. | Residue depletion of tilmicosin in cattle after subcutaneous administration. | 2006 | J. Agric. Food Chem. | pmid:16819937 |
Yang S et al. | Trace analysis and occurrence of anhydroerythromycin and tylosin in influent and effluent wastewater by liquid chromatography combined with electrospray tandem mass spectrometry. | 2006 | Anal Bioanal Chem | pmid:16715282 |
GarcÃa-Mayor MA et al. | Liquid chromatography-UV diode-array detection method for multi-residue determination of macrolide antibiotics in sheep's milk. | 2006 | J Chromatogr A | pmid:16682049 |
Shakeri-Nejad K and Stahlmann R | Drug interactions during therapy with three major groups of antimicrobial agents. | 2006 | Expert Opin Pharmacother | pmid:16556082 |
Pringle M et al. | Tiamulin resistance in porcine Brachyspira pilosicoli isolates. | 2006 | Res. Vet. Sci. | pmid:16253666 |
Kim D et al. | In vitro susceptibilities of Leptospira spp. and Borrelia burgdorferi isolates to amoxicillin, tilmicosin, and enrofloxacin. | 2006 | J. Vet. Sci. | pmid:17106227 |
Westermarck E et al. | Effect of diet and tylosin on chronic diarrhea in beagles. | 2005 Nov-Dec | J. Vet. Intern. Med. | pmid:16355675 |
Chander Y et al. | Antibacterial activity of soil-bound antibiotics. | 2005 Nov-Dec | J. Environ. Qual. | pmid:16221813 |
Kumar K et al. | Antibiotic uptake by plants from soil fertilized with animal manure. | 2005 Nov-Dec | J. Environ. Qual. | pmid:16221828 |
Westermarck E et al. | Tylosin-responsive chronic diarrhea in dogs. | 2005 Mar-Apr | J. Vet. Intern. Med. | pmid:15822561 |
Liutskanova DG et al. | [Increase in tylosin production by a commercial strain of Streptomyces fradiae]. | 2005 Mar-Apr | Prikl. Biokhim. Mikrobiol. | pmid:15859462 |
Kolz AC et al. | Degradation and metabolite production of tylosin in anaerobic and aerobic swine-manure lagoons. | 2005 Jan-Feb | Water Environ. Res. | pmid:15765935 |
Rooklidge SJ et al. | Modeling antimicrobial contaminant removal in slow sand filtration. | 2005 Jan-Feb | Water Res. | pmid:15644241 |
Menozzi A et al. | Effect of the macrolide antibacterial drug, tylosin, on TNBS-induced colitis in the rat. | 2005 | Pharmacology | pmid:15756055 |
Pfister P et al. | 23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15795375 |
Godinho KS et al. | Efficacy of tulathromycin in the treatment and prevention of natural outbreaks of bovine respiratory disease in European cattle. | 2005 | Vet. Ther. | pmid:16094560 |
Kilgore WR et al. | Clinical effectiveness of tulathromycin, a novel triamilide antimicrobial, for the control of respiratory disease in cattle at high risk for developing bovine respiratory disease. | 2005 | Vet. Ther. | pmid:16094561 |
Kilgore WR et al. | Therapeutic efficacy of tulathromycin, a novel triamilide antimicrobial, against bovine respiratory disease in feeder calves. | 2005 | Vet. Ther. | pmid:16094562 |
Rooney KA et al. | Efficacy of tulathromycin compared with tilmicosin and florfenicol for the control of respiratory disease in cattle at high risk of developing bovine respiratory disease. | 2005 | Vet. Ther. | pmid:16094563 |