Tylosin

Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tylosin?

Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tylosin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Diarrhea D003967 32 associated lipids
Bacterial Infections D001424 21 associated lipids
Colitis D003092 69 associated lipids
Cattle Diseases D002418 24 associated lipids
Body Weight D001835 333 associated lipids
Facial Dermatoses D005148 7 associated lipids
Occupational Diseases D009784 42 associated lipids
Asthma D001249 52 associated lipids
Weight Gain D015430 101 associated lipids
Foreign Bodies D005547 5 associated lipids
Hyperplasia D006965 34 associated lipids
Clostridium Infections D003015 5 associated lipids
Ataxia D001259 20 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Bacteriuria D001437 7 associated lipids
Pasteurella Infections D010326 8 associated lipids
Swine Diseases D013553 16 associated lipids
Poultry Diseases D011201 21 associated lipids
Vasculitis D014657 14 associated lipids
Pyoderma D011711 5 associated lipids
Lymphadenitis D008199 8 associated lipids
Campylobacter Infections D002169 13 associated lipids
Mycoplasma Infections D009175 13 associated lipids
Pasteurellosis, Pneumonic D012766 3 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Liver Abscess D008100 6 associated lipids
Treponemal Infections D014211 3 associated lipids
Dysentery D004403 4 associated lipids
Mycoplasmatales Infections D009180 6 associated lipids
Mycotoxicosis D015651 5 associated lipids
Porcine Reproductive and Respiratory Syndrome D019318 4 associated lipids
Ureaplasma Infections D016869 5 associated lipids
Pneumonia, Mycoplasma D011019 6 associated lipids
Tracheal Diseases D014133 3 associated lipids
Bacillaceae Infections D016863 1 associated lipids
Erysipelothrix Infections D004889 1 associated lipids
Keratoconjunctivitis, Infectious D007639 2 associated lipids
Neisseriaceae Infections D016870 3 associated lipids
Conjunctivitis, Viral D003236 1 associated lipids
Enterotoxemia D004767 1 associated lipids
Bovine Respiratory Disease Complex D048090 2 associated lipids
Desulfovibrionaceae Infections D045824 5 associated lipids
Primate Diseases D018419 2 associated lipids
Pneumonia of Calves, Enzootic D048089 2 associated lipids
Pneumonia of Swine, Mycoplasmal D045729 2 associated lipids
Digital Dermatitis D058066 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Tylosin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tylosin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Tylosin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Tylosin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Tylosin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tylosin?

Knock-out

Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Tylosin

Download all related citations
Per page 10 20 50 100 | Total 931
Authors Title Published Journal PubMed Link
Jackson CR et al. Effects of tylosin use on erythromycin resistance in enterococci isolated from swine. 2004 Appl. Environ. Microbiol. pmid:15240302
Lum AM et al. Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays. 2004 Metab. Eng. pmid:15256208
Mathers JJ et al. Inhibition of resistance plasmid transfer in Escherichia coli by ionophores, chlortetracycline, bacitracin, and ionophore/antimicrobial combinations. 2004 Apr-Jun Avian Dis. pmid:15283418
Poole TL et al. Competitive exclusion of a glycopeptide-resistant Enterococcus faecium in the presence of vancomycin but not equivalent concentrations of tylosin or gentamicin. 2004 Poult. Sci. pmid:15285499
Brumbaugh GW et al. Susceptibility of Mycobacterium avium sbsp paratuberculosis to monensin sodium or tilmicosin phosphate in vitro and resulting infectivity in a murine model. 2004 Can. J. Vet. Res. pmid:15352541
Novotny GW et al. Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA. 2004 Antimicrob. Agents Chemother. pmid:15388419
Kageyama S et al. Synthesis of 3,4'-dideoxymycaminosyl tylonolide, a novel type of macrolide derivative. 1992 J. Antibiot. pmid:1548187
Civitareale C et al. Identification and quantification method of spiramycin and tylosin in feedingstuffs with HPLC-UV/DAD at 1 ppm level. 2004 J Pharm Biomed Anal pmid:15496324
Elitok B and Elitok OM Clinical efficacy of carprofen as an adjunct to the antibacterial treatment of bovine respiratory disease. 2004 J. Vet. Pharmacol. Ther. pmid:15500569
Clark C et al. A preliminary investigation of the disposition of tilmicosin residues in elk tissues and serum. 2004 J. Vet. Pharmacol. Ther. pmid:15500580
Brain RA et al. Aquatic microcosm assessment of the effects of tylosin on Lemna gibba and Myriophyllum spicatum. 2005 Environ. Pollut. pmid:15519715
Stratigopoulos G et al. Positive control of tylosin biosynthesis: pivotal role of TylR. 2004 Mol. Microbiol. pmid:15554972
Kay P et al. A lysimeter experiment to investigate the leaching of veterinary antibiotics through a clay soil and comparison with field data. 2005 Environ. Pollut. pmid:15589660
Rooklidge SJ et al. Modeling antimicrobial contaminant removal in slow sand filtration. 2005 Jan-Feb Water Res. pmid:15644241
Thompson TS et al. Determination of lincomycin and tylosin residues in honey by liquid chromatography/tandem mass spectrometry. 2005 Rapid Commun. Mass Spectrom. pmid:15645470
Menozzi A et al. Effect of the macrolide antibacterial drug, tylosin, on TNBS-induced colitis in the rat. 2005 Pharmacology pmid:15756055
Kolz AC et al. Degradation and metabolite production of tylosin in anaerobic and aerobic swine-manure lagoons. 2005 Jan-Feb Water Environ. Res. pmid:15765935
Wang J et al. Determination of five macrolide antibiotic residues in eggs using liquid chromatography/electrospray ionization tandem mass spectrometry. 2005 J. Agric. Food Chem. pmid:15769104
Blackwell PA et al. Evaluation of a lower tier exposure assessment model for veterinary medicines. 2005 J. Agric. Food Chem. pmid:15769156
Pfister P et al. 23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:15795375