Tylosin
Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tylosin?
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (6)
- Appl. Environ. Microbiol. (2)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Others (6)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tylosin
PubChem Associated disorders and diseases
What pathways are associated with Tylosin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tylosin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tylosin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tylosin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Tylosin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (9)
- Microbiology (Reading, Engl.) (3)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Others (13)
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tylosin?
Knock-out
Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tylosin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shimada T et al. | Effects of the antimicrobial tylosin on the microbial community structure of an anaerobic sequencing batch reactor. | 2011 | Biotechnol. Bioeng. | pmid:20830676 |
| Kim EY et al. | Pharmacokinetics of a florfenicol-tylosin combination after intravenous and intramuscular administration to beagle dogs. | 2011 | J. Vet. Med. Sci. | pmid:21068517 |
| Bosi P et al. | Feed supplemented with 3 different antibiotics improved food intake and decreased the activation of the humoral immune response in healthy weaned pigs but had differing effects on intestinal microbiota. | 2011 | J. Anim. Sci. | pmid:21724943 |
| Park JW et al. | Generation of reduced macrolide analogs by regio-specific biotransformation. | 2011 | J. Antibiot. | pmid:21102594 |
| Ci X et al. | Anti-inflammatory effects of tilmicosin in a noninfectious mouse model of allergic asthma. | 2011 | Immunopharmacol Immunotoxicol | pmid:21428709 |
| Zheng Y et al. | Molecularly imprinted solid-phase extraction for determination of tilmicosin in feed using high performance liquid chromatography. | 2011 | Anal. Chim. Acta | pmid:21435486 |
| Kalmokoff M et al. | Continuous feeding of antimicrobial growth promoters to commercial swine during the growing/finishing phase does not modify faecal community erythromycin resistance or community structure. | 2011 | J. Appl. Microbiol. | pmid:21395944 |
| Juntunen P et al. | Longitudinal on-farm study of the development of antimicrobial resistance in Campylobacter coli from pigs before and after danofloxacin and tylosin treatments. | 2011 | Vet. Microbiol. | pmid:21397412 |
| Cooprider KL et al. | Feedlot efficiency implications on greenhouse gas emissions and sustainability. | 2011 | J. Anim. Sci. | pmid:21398565 |
| Bernal J et al. | Determination of tylosins A, B, C and D in bee larvae by liquid chromatography coupled to ion trap-tandem mass spectrometry. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21498134 |
| Smee NM and Towell TL | What is the evidence? Inflammatory bowel disease in a dog. | 2011 | J. Am. Vet. Med. Assoc. | pmid:21529230 |
| Kilpinen S et al. | Effect of tylosin on dogs with suspected tylosin-responsive diarrhea: a placebo-controlled, randomized, double-blinded, prospective clinical trial. | 2011 | Acta Vet. Scand. | pmid:21489311 |
| Hidalgo à et al. | Trends towards lower antimicrobial susceptibility and characterization of acquired resistance among clinical isolates of Brachyspira hyodysenteriae in Spain. | 2011 | Antimicrob. Agents Chemother. | pmid:21555771 |
| Danzeisen JL et al. | Modulations of the chicken cecal microbiome and metagenome in response to anticoccidial and growth promoter treatment. | 2011 | PLoS ONE | pmid:22114729 |
| Forrester CA et al. | Mycoplasma gallisepticum in pheasants and the efficacy of tylvalosin to treat the disease. | 2011 | Avian Pathol. | pmid:22107092 |
| Bohm DA et al. | Preparation and characterisation of in-house reference material of tylosin in honey and results of a proficiency test. | 2011 | Anal. Chim. Acta | pmid:21742117 |
| Dinh QT et al. | Measurement of trace levels of antibiotics in river water using on-line enrichment and triple-quadrupole LC-MS/MS. | 2011 | Talanta | pmid:21807177 |
| Gerchman I et al. | Characterization of in vivo-acquired resistance to macrolides of Mycoplasma gallisepticum strains isolated from poultry. | 2011 | Vet. Res. | pmid:21810258 |
| Ashenafi D et al. | An improved liquid chromatographic method for the analysis of tylosin and its impurities. | 2011 | J Sep Sci | pmid:21812113 |
| Chelliapan S et al. | Tolerance of the antibiotic tylosin on treatment performance of an up-flow anaerobic stage reactor (UASR). | 2011 | Water Sci. Technol. | pmid:21866757 |
| Stone JJ et al. | Land application of tylosin and chlortetracycline swine manure: Impacts to soil nutrients and soil microbial community structure. | 2011 | J Environ Sci Health B | pmid:21877979 |
| Han AR et al. | Biosynthesis of glycosylated derivatives of tylosin in Streptomyces venezuelae. | 2011 | J. Microbiol. Biotechnol. | pmid:21715968 |
| McClary DG et al. | Relationship of in vitro minimum inhibitory concentrations of tilmicosin against Mannheimia haemolytica and Pasteurella multocida and in vivo tilmicosin treatment outcome among calves with signs of bovine respiratory disease. | 2011 | J. Am. Vet. Med. Assoc. | pmid:21718206 |
| Reynaldi FJ et al. | [Binding of tylosin, tilmicosin and oxytetracycline to proteins from honeybees, larvae and beehive products]. | 2010 Oct-Dec | Rev. Argent. Microbiol. | pmid:21229198 |
| Sumbatian NV et al. | [Amino acid and peptide derivatives of the tylosin family of macrolide antibiotics modified at the aldehyde group]. | 2010 Mar-Apr | Bioorg. Khim. | pmid:20531486 |
| Barbour EK et al. | Impact of synergism of calcium phosphomycin/tylosin tartarate supplements on the performance of broilers in the Lebanon. | 2010 Jan-Mar | Vet. Ital. | pmid:20391366 |
| Muraina IA et al. | Antimycoplasmal activity of some plant species from northern Nigeria compared to the currently used therapeutic agent. | 2010 | Pharm Biol | pmid:20819025 |
| Stone JJ et al. | Tylosin and chlortetracycline effects during swine manure digestion: influence of sodium azide. | 2010 | Bioresour. Technol. | pmid:20728345 |
| Mazzilli M and Zecconi A | Assessment of epithelial cells' immune and inflammatory response to Staphylococcus aureus when exposed to a macrolide. | 2010 | J. Dairy Res. | pmid:20822561 |
| Juntunen P et al. | Antimicrobial resistance in Campylobacter coli selected by tylosin treatment at a pig farm. | 2010 | Vet. Microbiol. | pmid:20684867 |
| Scott BA et al. | Efficacy of tylosin tartrate on canine Staphylococcus intermedius isolates in vitro. | 2010 | Vet. Ther. | pmid:20960412 |
| Buret AG | Immuno-modulation and anti-inflammatory benefits of antibiotics: the example of tilmicosin. | 2010 | Can. J. Vet. Res. | pmid:20357951 |
| Cornick NA | Tylosin and chlorotetracycline decrease the duration of fecal shedding of E. coli O157:H7 by swine. | 2010 | Vet. Microbiol. | pmid:20018464 |
| Gallina G et al. | Kinetics and intrapulmonary disposition of tilmicosin after single and repeated oral bolus administrations to rabbits. | 2010 | Vet. Res. Commun. | pmid:20480234 |
| van der Grinten E et al. | Comparing the sensitivity of algal, cyanobacterial and bacterial bioassays to different groups of antibiotics. | 2010 | Chemosphere | pmid:20430416 |
| Cerdá RO et al. | Impact of the type of catheter on the absorption of tylvalosin (acetylvaleryltylosin) administered orally to broiler chickens. | 2010 | J. Vet. Pharmacol. Ther. | pmid:20444046 |
| Shakya T and Wright GD | Nucleotide selectivity of antibiotic kinases. | 2010 | Antimicrob. Agents Chemother. | pmid:20231391 |
| Liu YM et al. | Sensitive determination of tilmicosin, erythromycin ethylsuccinate and clindamycin by CE with electrochemiluminescence detection using azithromycin as internal standard and its applications. | 2010 | J Sep Sci | pmid:20235137 |
| Catania S et al. | Treatment of eggshell abnormalities and reduced egg production caused by Mycoplasma synoviae infection. | 2010 | Avian Dis. | pmid:20608549 |
| Alatrache A et al. | Tylosin abatement in water by photocatalytic process. | 2010 | Water Sci. Technol. | pmid:20651450 |
| Kaizerman JA et al. | Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20594845 |
| Peltier E et al. | Zinc-induced antibiotic resistance in activated sludge bioreactors. | 2010 | Water Res. | pmid:20537675 |
| Logue CM et al. | Repeated therapeutic dosing selects macrolide-resistant Campylobacter spp. in a turkey facility. | 2010 | J. Appl. Microbiol. | pmid:20497488 |
| Gyémánt N et al. | In vitro and in vivo multidrug resistance reversal activity by a Betti-base derivative of tylosin. | 2010 | Br. J. Cancer | pmid:20551959 |
| Starosta AL et al. | Interplay between the ribosomal tunnel, nascent chain, and macrolides influences drug inhibition. | 2010 | Chem. Biol. | pmid:20534348 |
| Paraud C et al. | Evaluation of oral tilmicosin efficacy against severe cryptosporidiosis in neonatal kids under field conditions. | 2010 | Vet. Parasitol. | pmid:20149542 |
| Er A et al. | Effects of tylosin on serum cytokine levels in healthy and lipopolysaccharide-treated mice. | 2010 | Acta Vet. Hung. | pmid:20159741 |
| Van Donkersgoed J et al. | Drug residues recovered in feed after various feedlot mixer truck cleanout procedures. | 2010 | J. Food Prot. | pmid:20051207 |
| Lindemann MD et al. | Evaluation of antibiotic effects on phosphorus digestibility and utilization by growing-finishing pigs fed a phosphorus-deficient, corn-soybean meal diet. | 2010 | J. Anim. Sci. | pmid:20081078 |
| Elkins CA et al. | Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. | 2010 | Antimicrob. Agents Chemother. | pmid:20038628 |
| Giordano R et al. | Effect of a high dose of three antibiotics on the reproduction of a parthenogenetic strain of Folsomia candida (Isotomidae: Collembola). | 2010 | Environ. Entomol. | pmid:22127168 |
| Granja R et al. | Determination of erythromycin and tylosin residues in honey by LC/MS/MS. | 2009 May-Jun | J AOAC Int | pmid:19610392 |
| Sharma R et al. | Selected antimicrobial resistance during composting of manure from cattle administered sub-therapeutic antimicrobials. | 2009 Mar-Apr | J. Environ. Qual. | pmid:19202027 |
| Smith GW et al. | Elimination kinetics of tilmicosin following intramammary administration in lactating dairy cattle. | 2009 | J. Am. Vet. Med. Assoc. | pmid:19210246 |
| Kouvela EC et al. | Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. | 2009 | Antimicrob. Agents Chemother. | pmid:19164155 |
| Baggio A et al. | Residues of antibacterial drugs in honey from the Italian market. | 2009 | Food Addit Contam Part B Surveill | pmid:24784967 |
| Chemier JA et al. | Trends in microbial synthesis of natural products and biofuels. | 2009 | Adv. Enzymol. Relat. Areas Mol. Biol. | pmid:18990830 |
| Montgomery JL et al. | Effects of dietary zilpaterol hydrochloride on feedlot performance and carcass characteristics of beef steers fed with and without monensin and tylosin. | 2009 | J. Anim. Sci. | pmid:18997069 |
| Boles JA et al. | Growth implants reduced tenderness of steaks from steers and heifers with different genetic potentials for growth and marbling. | 2009 | J. Anim. Sci. | pmid:18791138 |
| Han C et al. | Hydrogenated castor oil nanoparticles as carriers for the subcutaneous administration of tilmicosin: in vitro and in vivo studies. | 2009 | J. Vet. Pharmacol. Ther. | pmid:19290940 |
| Engi H | [Perspectives of inhibition of multidrug resistance during cancer chemotherapy, in vitro and in vivo experiments]. | 2009 | Orv Hetil | pmid:19293063 |
| Hoese A et al. | Chlortetracycline and tylosin runoff from soils treated with antimicrobial containing manure. | 2009 | J Environ Sci Health B | pmid:19365753 |
| Meyer NF et al. | Effect of essential oils, tylosin, and monensin on finishing steer performance, carcass characteristics, liver abscesses, ruminal fermentation, and digestibility. | 2009 | J. Anim. Sci. | pmid:19359504 |
| Christodoulopoulos G | Adverse outcome of using tilmicosin in a lamb with multiple ventricular septal defects. | 2009 | Can. Vet. J. | pmid:19337615 |
| Khaliq S et al. | Production of tylosin in solid-state fermentation by Streptomyces fradiae NRRL-2702 and its gamma-irradiated mutant (gamma-1). | 2009 | Lett. Appl. Microbiol. | pmid:19780953 |
| Hu D and Coats JR | Laboratory evaluation of mobility and sorption for the veterinary antibiotic, tylosin, in agricultural soils. | 2009 | J Environ Monit | pmid:19724833 |
| Khalifeh MS et al. | Assessment of humoral and cellular-mediated immune response in chickens treated with tilmicosin, florfenicol, or enrofloxacin at the time of Newcastle disease vaccination. | 2009 | Poult. Sci. | pmid:19762865 |
| Guedes RM et al. | Use of tylvalosin-medicated feed to control porcine proliferative enteropathy. | 2009 | Vet. Rec. | pmid:19767637 |
| Fitzgerald J | Administration of micotil. | 2009 | Vet. Rec. | pmid:19767643 |
| Stone JJ et al. | Effect of antimicrobial compounds tylosin and chlortetracycline during batch anaerobic swine manure digestion. | 2009 | Water Res. | pmid:19695662 |
| Atef M et al. | Effect of albendazole administration on pharmacokinetic aspects of tylosin in lactating goats. | 2009 | Drug Metab Lett | pmid:19702546 |
| Hilton GG et al. | Effects of feeding zilpaterol hydrochloride with and without monensin and tylosin on carcass cutability and meat palatability of beef steers. | 2009 | J. Anim. Sci. | pmid:19028853 |
| Byrne-Bailey KG et al. | Prevalence of sulfonamide resistance genes in bacterial isolates from manured agricultural soils and pig slurry in the United Kingdom. | 2009 | Antimicrob. Agents Chemother. | pmid:19064898 |
| Petropoulos AD et al. | Time-resolved binding of azithromycin to Escherichia coli ribosomes. | 2009 | J. Mol. Biol. | pmid:19071138 |
| Blackwell PA et al. | Effects of agricultural conditions on the leaching behaviour of veterinary antibiotics in soils. | 2009 | Chemosphere | pmid:19128817 |
| Chénier MR and Juteau P | Fate of chlortetracycline- and tylosin-resistant bacteria in an aerobic thermophilic sequencing batch reactor treating swine waste. | 2009 | Microb. Ecol. | pmid:19125305 |
| Liu F et al. | Effects of six selected antibiotics on plant growth and soil microbial and enzymatic activities. | 2009 | Environ. Pollut. | pmid:19157661 |
| Bodoor K et al. | Design and implementation of an ribonucleic acid (RNA) directed fragment library. | 2009 | J. Med. Chem. | pmid:19445516 |
| Hunter RP et al. | Letter to the editor. | 2009 | Br. Poult. Sci. | pmid:19904632 |
| Suchodolski JS et al. | The effect of the macrolide antibiotic tylosin on microbial diversity in the canine small intestine as demonstrated by massive parallel 16S rRNA gene sequencing. | 2009 | BMC Microbiol. | pmid:19799792 |
| Warner K et al. | Control of Ornithobacterium rhinotracheale in poultry. | 2009 | Vet. Rec. | pmid:19946131 |
| Hao H et al. | 23S rRNA mutation A2074C conferring high-level macrolide resistance and fitness cost in Campylobacter jejuni. | 2009 | Microb. Drug Resist. | pmid:19857128 |
| Khaliq S et al. | Change in colony morphology and kinetics of tylosin production after UV and gamma irradiation mutagenesis of Streptomyces fradiae NRRL-2702. | 2009 | Microbiol. Res. | pmid:17475458 |
| Aust MO et al. | Distribution of sulfamethazine, chlortetracycline and tylosin in manure and soil of Canadian feedlots after subtherapeutic use in cattle. | 2008 | Environ. Pollut. | pmid:18440678 |
| Douthwaite S et al. | Interaction of the tylosin-resistance methyltransferase RlmA II at its rRNA target differs from the orthologue RlmA I. | 2008 | J. Mol. Biol. | pmid:18406425 |
| Reuter RR et al. | Effects of dietary energy source and level and injection of tilmicosin phosphate on immune function in lipopolysaccharide-challenged beef steers. | 2008 | J. Anim. Sci. | pmid:18407986 |
| Chen J et al. | Technical note: Occurrence in fecal microbiota of genes conferring resistance to both macrolide-lincosamide-streptogramin B and tetracyclines concomitant with feeding of beef cattle with tylosin. | 2008 | J. Anim. Sci. | pmid:18469042 |
| Depenbusch BE et al. | Efficacy of monensin and tylosin in finishing diets based on steam-flaked corn with and without corn wet distillers grains with solubles. | 2008 | J. Anim. Sci. | pmid:18469059 |
| Shimada T et al. | Modelling the effect of the antimicrobial tylosin on the performance of an anaerobic sequencing batch reactor. | 2008 | Water Sci. Technol. | pmid:18547919 |
| Gallina G et al. | Acute toxicity evaluation of four antibacterials with Daphnia magna. | 2008 | Vet. Res. Commun. | pmid:18688742 |
| Stoev G and Nazarov V | Identification of the related substances of tilmicosin by liquid chromatography/ion trap mass spectrometry. | 2008 | Rapid Commun. Mass Spectrom. | pmid:18491285 |
| Achard A et al. | Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene. | 2008 | Antimicrob. Agents Chemother. | pmid:18519724 |
| Shimada T et al. | Inhibitory effects of the macrolide antimicrobial tylosin on anaerobic treatment. | 2008 | Biotechnol. Bioeng. | pmid:18646223 |
| Caldwell DB et al. | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. | 2008 | Antimicrob. Agents Chemother. | pmid:18779354 |
| Giadinis ND et al. | Mortality in adult goats attributed to Mycoplasma capricolum subspecies capricolum. | 2008 | Vet. Rec. | pmid:18757908 |
| Crespo R and McMillan R | Facial cellulitis induced in chickens by Mycoplasma gallisepticum bacterin and its treatment. | 2008 | Avian Dis. | pmid:19166067 |
| Oakes J and Seifert S | American association of poison control centers database characterization of human tilmicosin exposures, 2001-2005. | 2008 | J Med Toxicol | pmid:19031373 |
| Catry B et al. | Efficacy of metaphylactic florfenicol therapy during natural outbreaks of bovine respiratory disease. | 2008 | J. Vet. Pharmacol. Ther. | pmid:19000268 |
| Fricke JA et al. | Pharmacokinetics and tissue depletion of tilmicosin in turkeys. | 2008 | J. Vet. Pharmacol. Ther. | pmid:19000285 |
| Beltran-Alcrudo D et al. | A persistent outbreak of ulcerative enteritis in bobwhite quail (Colinus virginianus). | 2008 | Avian Dis. | pmid:18939648 |