| MeSH term | MeSH ID | Detail |
|---|---|---|
| Mycotoxicosis | D015651 | 5 associated lipids |
| Desulfovibrionaceae Infections | D045824 | 5 associated lipids |
| Pneumonia, Mycoplasma | D011019 | 6 associated lipids |
| Liver Abscess | D008100 | 6 associated lipids |
| Mycoplasmatales Infections | D009180 | 6 associated lipids |
| Facial Dermatoses | D005148 | 7 associated lipids |
| Bacteriuria | D001437 | 7 associated lipids |
| Pasteurella Infections | D010326 | 8 associated lipids |
| Lymphadenitis | D008199 | 8 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Campylobacter Infections | D002169 | 13 associated lipids |
| Mycoplasma Infections | D009175 | 13 associated lipids |
| Vasculitis | D014657 | 14 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Pneumonia, Bacterial | D018410 | 16 associated lipids |
| Ataxia | D001259 | 20 associated lipids |
| Poultry Diseases | D011201 | 21 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
Tylosin
Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tylosin?
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (6)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Appl. Environ. Microbiol. (2)
- Others (6)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tylosin
PubChem Associated disorders and diseases
What pathways are associated with Tylosin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tylosin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Tylosin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Tylosin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Tylosin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (9)
- Microbiology (Reading, Engl.) (3)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Others (13)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tylosin?
Knock-out
Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Tylosin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Arisawa A et al. | Cloning of the macrolide antibiotic biosynthesis gene acyA, which encodes 3-O-acyltransferase, from Streptomyces thermotolerans and its use for direct fermentative production of a hybrid macrolide antibiotic. | 1994 | Appl. Environ. Microbiol. | pmid:8074537 |
| Jackson CR et al. | Effects of tylosin use on erythromycin resistance in enterococci isolated from swine. | 2004 | Appl. Environ. Microbiol. | pmid:15240302 |
| Amachawadi RG et al. | Occurrence of the transferable copper resistance gene tcrB among fecal enterococci of U.S. feedlot cattle fed copper-supplemented diets. | 2013 | Appl. Environ. Microbiol. | pmid:23666328 |
| Nagaraja TG and Taylor MB | Susceptibility and resistance of ruminal bacteria to antimicrobial feed additives. | 1987 | Appl. Environ. Microbiol. | pmid:3116929 |
| DENNY CB et al. | Effects of tylosin and nisin on canned food spoilage bacteria. | 1961 | Appl Microbiol | pmid:13721908 |
| Whitehead TR et al. | Savagea faecisuis gen. nov., sp. nov., a tylosin- and tetracycline-resistant bacterium isolated from a swine-manure storage pit. | 2015 | Antonie Van Leeuwenhoek | pmid:25980832 |
| Baltz RH et al. | Applications of transposition mutagenesis in antibiotic producing streptomycetes. | 1997 | Antonie Van Leeuwenhoek | pmid:9049029 |
| Cundliffe E et al. | The tylosin-biosynthetic genes of Streptomyces fradiae. | 2001 | Antonie Van Leeuwenhoek | pmid:11816964 |
| Smith LK and Mankin AS | Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. | 2008 | Antimicrob. Agents Chemother. | pmid:18299405 |
| Jost BH et al. | A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes. | 2004 | Antimicrob. Agents Chemother. | pmid:14982756 |
| Ayling RD et al. | Assessing the in vitro effectiveness of antimicrobials against Mycoplasma mycoides subsp. mycoides small-colony type to reduce contagious bovine pleuropneumonia infection. | 2005 | Antimicrob. Agents Chemother. | pmid:16304194 |
| Chin AC et al. | Tilmicosin induces apoptosis in bovine peripheral neutrophils in the presence or in the absence of Pasteurella haemolytica and promotes neutrophil phagocytosis by macrophages. | 2000 | Antimicrob. Agents Chemother. | pmid:10952596 |
| Dotzlaf JE et al. | Incorporation of amino acid-derived carbon into tylactone by Streptomyces fradiae GS14. | 1984 | Antimicrob. Agents Chemother. | pmid:6424562 |
| Collier CT et al. | Effects of tylosin on bacterial mucolysis, Clostridium perfringens colonization, and intestinal barrier function in a chick model of necrotic enteritis. | 2003 | Antimicrob. Agents Chemother. | pmid:14506046 |
| Jost BH et al. | Tylosin resistance in Arcanobacterium pyogenes is encoded by an erm X determinant. | 2003 | Antimicrob. Agents Chemother. | pmid:14576111 |
| Elkins CA and Mullis LB | Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. | 2007 | Antimicrob. Agents Chemother. | pmid:17210767 |
| Kobayashi H et al. | Macrolide susceptibility of Mycoplasma hyorhinis isolated from piglets. | 1996 | Antimicrob. Agents Chemother. | pmid:8849222 |
| Shakya T and Wright GD | Nucleotide selectivity of antibiotic kinases. | 2010 | Antimicrob. Agents Chemother. | pmid:20231391 |
| Hidalgo à et al. | Trends towards lower antimicrobial susceptibility and characterization of acquired resistance among clinical isolates of Brachyspira hyodysenteriae in Spain. | 2011 | Antimicrob. Agents Chemother. | pmid:21555771 |
| Huber ML et al. | Branched-chain fatty acids produced by mutants of Streptomyces fradiae, putative precursors of the lactone ring of tylosin. | 1990 | Antimicrob. Agents Chemother. | pmid:2221862 |