Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Creemer LC et al. | Synthesis and in vitro antimicrobial activity of 3-keto 16-membered macrolides derived from tylosin. | 2002 | J. Antibiot. | pmid:12061552 |
Stephanopoulos G | Metabolic engineering by genome shuffling. | 2002 | Nat. Biotechnol. | pmid:12089547 |
Lakritz J et al. | Tilmicosin reduces lipopolysaccharide-stimulated bovine alveolar macrophage prostaglandin E(2) production via a mechanism involving phospholipases. | 2002 | Vet. Ther. | pmid:12050824 |
Hibbard B et al. | Dose determination and confirmation for ceftiofur crystalline-free acid administered in the posterior aspect of the ear for control and treatment of bovine respiratory disease. | 2002 | Vet. Ther. | pmid:12050825 |
Christodoulopoulos G et al. | Tilmicosin administration to young lambs with respiratory infection: safety and efficacy considerations. | 2002 | J. Vet. Pharmacol. Ther. | pmid:12423233 |
Liu M and Douthwaite S | Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12417742 |
Higgins HC and McEvoy JD | Accelerated solvent extraction of animal feedingstuffs for microbial growth inhibition screening for the presence of antimicrobial feed additives. | 2002 | Food Addit Contam | pmid:12396393 |
Shryock TR et al. | Minimum inhibitory concentration breakpoints and disk diffusion inhibitory zone interpretive criteria for tilmicosin susceptibility testing against Pasteurella multocida and Actinobacillus pleuropneumoniae associated with porcine respiratory disease. | 2002 | J. Vet. Diagn. Invest. | pmid:12296390 |
Prats C et al. | Tylosin depletion from edible pig tissues. | 2002 | Res. Vet. Sci. | pmid:12443694 |
Kowalski C et al. | Pharmacokinetics of tylosin in broiler chickens. | 2002 | Pol J Vet Sci | pmid:12448074 |
Dingwell RT et al. | The efficacy of intramammary tilmicosin at drying-off, and other risk factors for the prevention of new intramammary infections during the dry period. | 2002 | J. Dairy Sci. | pmid:12512598 |
Mandić Z et al. | New derivatives of tylosin: chemical and electrochemical oxidation products of desmycosin. | 2002 | J. Antibiot. | pmid:12458770 |
Ives SE et al. | Effects of virginiamycin and monensin plus tylosin on ruminal protein metabolism in steers fed corn-based finishing diets with or without wet corn gluten feed. | 2002 | J. Anim. Sci. | pmid:12462270 |
Schunich OC et al. | A comparison of prophylactic efficacy of tilmicosin and a new formulation of oxytetracycline in feedlot calves. | 2002 | Can. Vet. J. | pmid:12001501 |
Flint SA et al. | Expression of tylM genes during tylosin production: phantom promoters and enigmatic translational coupling motifs. | 2002 | J. Ind. Microbiol. Biotechnol. | pmid:12074090 |
Hwang YH et al. | Simultaneous determination of various macrolides by liquid chromatography/mass spectrometry. | 2002 | J. Vet. Sci. | pmid:12441679 |
Prats C et al. | Determination of tylosin residues in different animal tissues by high performance liquid chromatography. | 2002 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:11820296 |
Stratigopoulos G and Cundliffe E | Expression analysis of the tylosin-biosynthetic gene cluster: pivotal regulatory role of the tylQ product. | 2002 | Chem. Biol. | pmid:11841940 |
Saurit AR et al. | Some comparative aspects of the pharmacokinetics of tylosin in buffaloes and cattle. | 2002 | Vet. Res. Commun. | pmid:11860087 |
Zhang YX et al. | Genome shuffling leads to rapid phenotypic improvement in bacteria. | 2002 | Nature | pmid:11832946 |
Brumm MC et al. | Effect of wean-to-finish management on pig performance. | 2002 | J. Anim. Sci. | pmid:11881920 |
Stratigopoulos G et al. | Regulation of tylosin production and morphological differentiation in Streptomyces fradiae by TylP, a deduced gamma-butyrolactone receptor. | 2002 | Mol. Microbiol. | pmid:12139619 |
Müller AK et al. | The diversity and function of soil microbial communities exposed to different disturbances. | 2002 | Microb. Ecol. | pmid:11976785 |
Hranjec M et al. | New amidino-benzimidazolyl derivatives of tylosin and desmycosin. | 2002 | J. Antibiot. | pmid:12014447 |
Han H et al. | Carbohydrate fermentation and nitrogen metabolism of a finishing beef diet by ruminal microbes in continuous cultures as affected by ethoxyquin and(or) supplementation of monensin and tylosin. | 2002 | J. Anim. Sci. | pmid:12002320 |
Altunok V et al. | Investigation of haematological and biochemical side effects of tilmicosin in healthy New Zealand rabbits. | 2002 | J. Vet. Med. B Infect. Dis. Vet. Public Health | pmid:12002421 |
Bate N et al. | Differential roles of two SARP-encoding regulatory genes during tylosin biosynthesis. | 2002 | Mol. Microbiol. | pmid:11985721 |
Stratigopoulos G and Cundliffe E | Inactivation of a transcriptional repressor during empirical improvement of the tylosin producer, Streptomyces fradiae. | 2002 | J. Ind. Microbiol. Biotechnol. | pmid:11986923 |
Yazar E et al. | The effect of tilmicosin on cardiac superoxide dismutase and glutathione peroxidase activities. | 2002 | J. Vet. Med. B Infect. Dis. Vet. Public Health | pmid:12069277 |
Ragheb HS | Antibiotics in feeds. | 2001 Jan-Feb | J AOAC Int | pmid:11234833 |
Wang C et al. | In vitro susceptibility of avian mycoplasmas to enrofloxacin, sarafloxacin, tylosin, and oxytetracycline. | 2001 Apr-Jun | Avian Dis. | pmid:11417828 |
Neiffer DL | Clostridium perfringens enterotoxicosis in two Amur leopards (Panthera pardus orientalis). | 2001 | J. Zoo Wildl. Med. | pmid:12790411 |
Marsteller T et al. | Efficacy of intramuscular tylosin for the treatment and control of porcine proliferative enteropathy caused by Lawsonia intracellularis. | 2001 | Vet. Ther. | pmid:19753698 |
Thacker EL et al. | Evaluation of the ability of tilmicosin to prevent adherence of Mycoplasma hyopneumoniae to cilia using a differentiated swine respiratory epithelial culture system. | 2001 | Vet. Ther. | pmid:19746651 |
Ingerslev F and Halling-Sørensen B | Biodegradability of metronidazole, olaquindox, and tylosin and formation of tylosin degradation products in aerobic soil--manure slurries. | 2001 | Ecotoxicol. Environ. Saf. | pmid:11222042 |
Boerlin P et al. | Antimicrobial growth promoter ban and resistance to macrolides and vancomycin in enterococci from pigs. | 2001 | J. Clin. Microbiol. | pmid:11682559 |
Butler AR et al. | Influence of ancillary genes, encoding aspects of methionine metabolism, on tylosin biosynthesis in Streptomyces fradiae. | 2001 | J. Antibiot. | pmid:11594346 |
Butler AR and Cundliffe E | Influence of dimethylsulfoxide on tylosin production in Streptomyces fradiae. | 2001 | J. Ind. Microbiol. Biotechnol. | pmid:11598810 |
Brennan J et al. | Efficacy of in-feed tylosin phosphate for the treatment of necrotic enteritis in broiler chickens. | 2001 | Poult. Sci. | pmid:11599704 |
Thomas E et al. | A field comparison of the efficacy and tolerance of marbofloxacin in the treatment of bovine respiratory disease. | 2001 | J. Vet. Pharmacol. Ther. | pmid:11696086 |
Beechinor JG and Bloomfield FJ | Variability in residue concentrations of tilmicosin in cattle muscle. | 2001 | Vet. Rec. | pmid:11530904 |
Alt DP et al. | Evaluation of antibiotics for treatment of cattle infected with Leptospira borgpetersenii serovar hardjo. | 2001 | J. Am. Vet. Med. Assoc. | pmid:11549093 |
Draisci R et al. | Confirmatory method for macrolide residues in bovine tissues by micro-liquid chromatography-tandem mass spectrometry. | 2001 | J Chromatogr A | pmid:11554423 |
Cundliffe E et al. | The tylosin-biosynthetic genes of Streptomyces fradiae. | 2001 | Antonie Van Leeuwenhoek | pmid:11816964 |
Niwa H et al. | Rapid detection of mutations associated with resistance to erythromycin in Campylobacter jejuni/coli by PCR and line probe assay. | 2001 | Int. J. Antimicrob. Agents | pmid:11691569 |
Morisaki N et al. | Glycosylative inactivation of chalcomycin and tylosin by a clinically isolated Nocardia asteroides strain. | 2001 | J. Antibiot. | pmid:11302489 |
Butler AR et al. | Feedback control of polyketide metabolism during tylosin production. | 2001 | Microbiology (Reading, Engl.) | pmid:11283275 |
Dinos GP et al. | Insights into the mechanism of azithromycin interaction with an Escherichia coli functional ribosomal complex. | 2001 | Mol. Pharmacol. | pmid:11353804 |
Vaidyanathan S et al. | Assessment of near-infrared spectral information for rapid monitoring of bioprocess quality. | 2001 | Biotechnol. Bioeng. | pmid:11427939 |
Lim J and Yun H | Postantibiotic effects and postantibiotic sub-MIC effects of erythromycin, roxithromycin, tilmicosin, and tylosin on Pasteurella multocida. | 2001 | Int. J. Antimicrob. Agents | pmid:11397617 |