Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Creemer LC et al. | Synthesis and in vitro antimicrobial activity of 3-keto 16-membered macrolides derived from tylosin. | 2002 | J. Antibiot. | pmid:12061552 |
Stephanopoulos G | Metabolic engineering by genome shuffling. | 2002 | Nat. Biotechnol. | pmid:12089547 |
Elzen PJ et al. | Method of application of tylosin, an antibiotic for American foulbrood control, with effects on small hive beetle (Coleoptera: Nitidulidae) populations. | 2002 | J. Econ. Entomol. | pmid:12539820 |
Shryock TR et al. | Minimum inhibitory concentration breakpoints and disk diffusion inhibitory zone interpretive criteria for tilmicosin susceptibility testing against Pasteurella multocida and Actinobacillus pleuropneumoniae associated with porcine respiratory disease. | 2002 | J. Vet. Diagn. Invest. | pmid:12296390 |
Prats C et al. | Tylosin depletion from edible pig tissues. | 2002 | Res. Vet. Sci. | pmid:12443694 |
Kowalski C et al. | Pharmacokinetics of tylosin in broiler chickens. | 2002 | Pol J Vet Sci | pmid:12448074 |
Dingwell RT et al. | The efficacy of intramammary tilmicosin at drying-off, and other risk factors for the prevention of new intramammary infections during the dry period. | 2002 | J. Dairy Sci. | pmid:12512598 |
Mandić Z et al. | New derivatives of tylosin: chemical and electrochemical oxidation products of desmycosin. | 2002 | J. Antibiot. | pmid:12458770 |
Ives SE et al. | Effects of virginiamycin and monensin plus tylosin on ruminal protein metabolism in steers fed corn-based finishing diets with or without wet corn gluten feed. | 2002 | J. Anim. Sci. | pmid:12462270 |
Schunich OC et al. | A comparison of prophylactic efficacy of tilmicosin and a new formulation of oxytetracycline in feedlot calves. | 2002 | Can. Vet. J. | pmid:12001501 |
Flint SA et al. | Expression of tylM genes during tylosin production: phantom promoters and enigmatic translational coupling motifs. | 2002 | J. Ind. Microbiol. Biotechnol. | pmid:12074090 |
Brumbaugh GW et al. | Effect of tilmicosin on chemotactic, phagocytic, and bactericidal activities of bovine and porcine alveolar macrophages. | 2002 | Am. J. Vet. Res. | pmid:16206777 |
Zielinski GC et al. | Efficacy of different dosage levels and administration routes of tilmicosin in a natural outbreak of infectious bovine keratoconjunctivitis (pinkeye). | 2002 | Vet. Ther. | pmid:19750751 |
Gautier-Bouchardon AV et al. | In vitro development of resistance to enrofloxacin, erythromycin, tylosin, tiamulin and oxytetracycline in Mycoplasma gallisepticum, Mycoplasma iowae and Mycoplasma synoviae. | 2002 | Vet. Microbiol. | pmid:12119137 |
Hwang YH et al. | Simultaneous determination of various macrolides by liquid chromatography/mass spectrometry. | 2002 | J. Vet. Sci. | pmid:12441679 |
Prats C et al. | Determination of tylosin residues in different animal tissues by high performance liquid chromatography. | 2002 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:11820296 |
Stratigopoulos G and Cundliffe E | Expression analysis of the tylosin-biosynthetic gene cluster: pivotal regulatory role of the tylQ product. | 2002 | Chem. Biol. | pmid:11841940 |
Carter JN et al. | Relationship of vitamin E supplementation and antimicrobial treatment with acute-phase protein responses in cattle affected by naturally acquired respiratory tract disease. | 2002 | Am. J. Vet. Res. | pmid:12171163 |
Loke ML et al. | Determination of the distribution coefficient (log Kd) of oxytetracycline, tylosin A, olaquindox and metronidazole in manure. | 2002 | Chemosphere | pmid:12146624 |
Takahashi I et al. | [In vitro resistance acquisition in Mycoplasma gallisepticum against ofloxacin, tylosin and spectinomycin]. | 2002 | Jpn J Antibiot | pmid:12199113 |
Prats C et al. | Disposition kinetics of tylosin administered intravenously and intramuscularly to pigs. | 2002 | Res. Vet. Sci. | pmid:12204632 |
Stratigopoulos G et al. | Regulation of tylosin production and morphological differentiation in Streptomyces fradiae by TylP, a deduced gamma-butyrolactone receptor. | 2002 | Mol. Microbiol. | pmid:12139619 |
Müller AK et al. | The diversity and function of soil microbial communities exposed to different disturbances. | 2002 | Microb. Ecol. | pmid:11976785 |
Hranjec M et al. | New amidino-benzimidazolyl derivatives of tylosin and desmycosin. | 2002 | J. Antibiot. | pmid:12014447 |
Han H et al. | Carbohydrate fermentation and nitrogen metabolism of a finishing beef diet by ruminal microbes in continuous cultures as affected by ethoxyquin and(or) supplementation of monensin and tylosin. | 2002 | J. Anim. Sci. | pmid:12002320 |
Altunok V et al. | Investigation of haematological and biochemical side effects of tilmicosin in healthy New Zealand rabbits. | 2002 | J. Vet. Med. B Infect. Dis. Vet. Public Health | pmid:12002421 |
Bate N et al. | Differential roles of two SARP-encoding regulatory genes during tylosin biosynthesis. | 2002 | Mol. Microbiol. | pmid:11985721 |
Stratigopoulos G and Cundliffe E | Inactivation of a transcriptional repressor during empirical improvement of the tylosin producer, Streptomyces fradiae. | 2002 | J. Ind. Microbiol. Biotechnol. | pmid:11986923 |
Yazar E et al. | The effect of tilmicosin on cardiac superoxide dismutase and glutathione peroxidase activities. | 2002 | J. Vet. Med. B Infect. Dis. Vet. Public Health | pmid:12069277 |
Ragheb HS | Antibiotics in feeds. | 2001 Jan-Feb | J AOAC Int | pmid:11234833 |
Wang C et al. | In vitro susceptibility of avian mycoplasmas to enrofloxacin, sarafloxacin, tylosin, and oxytetracycline. | 2001 Apr-Jun | Avian Dis. | pmid:11417828 |
Whitehead TR and Cotta MA | Sequence analyses of a broad host-range plasmid containing ermT from a tylosin-resistant Lactobacillus sp. Isolated from swine feces. | 2001 | Curr. Microbiol. | pmid:11375658 |
Neiffer DL | Clostridium perfringens enterotoxicosis in two Amur leopards (Panthera pardus orientalis). | 2001 | J. Zoo Wildl. Med. | pmid:12790411 |
Lee SW et al. | Prevalence of porcine proliferative enteropathy and its control with tylosin in Korea. | 2001 | J. Vet. Sci. | pmid:12441690 |
Marsteller T et al. | Efficacy of intramuscular tylosin for the treatment and control of porcine proliferative enteropathy caused by Lawsonia intracellularis. | 2001 | Vet. Ther. | pmid:19753698 |
Thacker EL et al. | Evaluation of the ability of tilmicosin to prevent adherence of Mycoplasma hyopneumoniae to cilia using a differentiated swine respiratory epithelial culture system. | 2001 | Vet. Ther. | pmid:19746651 |
Ingerslev F and Halling-Sørensen B | Biodegradability of metronidazole, olaquindox, and tylosin and formation of tylosin degradation products in aerobic soil--manure slurries. | 2001 | Ecotoxicol. Environ. Saf. | pmid:11222042 |
Boerlin P et al. | Antimicrobial growth promoter ban and resistance to macrolides and vancomycin in enterococci from pigs. | 2001 | J. Clin. Microbiol. | pmid:11682559 |
Butler AR et al. | Influence of ancillary genes, encoding aspects of methionine metabolism, on tylosin biosynthesis in Streptomyces fradiae. | 2001 | J. Antibiot. | pmid:11594346 |
Butler AR and Cundliffe E | Influence of dimethylsulfoxide on tylosin production in Streptomyces fradiae. | 2001 | J. Ind. Microbiol. Biotechnol. | pmid:11598810 |
Brennan J et al. | Efficacy of in-feed tylosin phosphate for the treatment of necrotic enteritis in broiler chickens. | 2001 | Poult. Sci. | pmid:11599704 |
Thomas E et al. | A field comparison of the efficacy and tolerance of marbofloxacin in the treatment of bovine respiratory disease. | 2001 | J. Vet. Pharmacol. Ther. | pmid:11696086 |
Beechinor JG and Bloomfield FJ | Variability in residue concentrations of tilmicosin in cattle muscle. | 2001 | Vet. Rec. | pmid:11530904 |
Alt DP et al. | Evaluation of antibiotics for treatment of cattle infected with Leptospira borgpetersenii serovar hardjo. | 2001 | J. Am. Vet. Med. Assoc. | pmid:11549093 |
Draisci R et al. | Confirmatory method for macrolide residues in bovine tissues by micro-liquid chromatography-tandem mass spectrometry. | 2001 | J Chromatogr A | pmid:11554423 |
Naccari F et al. | Effectiveness and kinetic behaviour of tilmicosin in the treatment of respiratory infections in sheep. | 2001 | Vet. Rec. | pmid:11465263 |
Mateusen B et al. | A comparative study of the preventive use of tilmicosin phosphate (Pulmotil premix) and Mycoplasma hyopneumoniae vaccination in a pig herd with chronic respiratory disease. | 2001 | J. Vet. Med. B Infect. Dis. Vet. Public Health | pmid:11846018 |
Draisci R et al. | A new electrochemical enzyme-linked immunosorbent assay for the screening of macrolide antibiotic residues in bovine meat. | 2001 | Analyst | pmid:11763071 |
Hoflack G et al. | Efficacy of tilmicosin phosphate (Pulmotil premix) in feed for the treatment of a clinical outbreak of Actinobacillus pleuropneumoniae infection in growing-finishing pigs. | 2001 | J. Vet. Med. B Infect. Dis. Vet. Public Health | pmid:11765801 |
Cundliffe E et al. | The tylosin-biosynthetic genes of Streptomyces fradiae. | 2001 | Antonie Van Leeuwenhoek | pmid:11816964 |
Niwa H et al. | Rapid detection of mutations associated with resistance to erythromycin in Campylobacter jejuni/coli by PCR and line probe assay. | 2001 | Int. J. Antimicrob. Agents | pmid:11691569 |
Morisaki N et al. | Glycosylative inactivation of chalcomycin and tylosin by a clinically isolated Nocardia asteroides strain. | 2001 | J. Antibiot. | pmid:11302489 |
Butler AR et al. | Feedback control of polyketide metabolism during tylosin production. | 2001 | Microbiology (Reading, Engl.) | pmid:11283275 |
Dinos GP et al. | Insights into the mechanism of azithromycin interaction with an Escherichia coli functional ribosomal complex. | 2001 | Mol. Pharmacol. | pmid:11353804 |
Vaidyanathan S et al. | Assessment of near-infrared spectral information for rapid monitoring of bioprocess quality. | 2001 | Biotechnol. Bioeng. | pmid:11427939 |
Lim J and Yun H | Postantibiotic effects and postantibiotic sub-MIC effects of erythromycin, roxithromycin, tilmicosin, and tylosin on Pasteurella multocida. | 2001 | Int. J. Antimicrob. Agents | pmid:11397617 |
Nolan PM et al. | Maintenance of a captive flock of house finches free of infection by Mycoplasma gallisepticum. | 2000 Oct-Dec | Avian Dis. | pmid:11195652 |
Stobba-Wiley CM and Readnour RS | Determination of tilmicosin residues in cow and sheep milk by liquid chromatography. | 2000 May-Jun | J AOAC Int | pmid:10868576 |
Stobba-Wiley CM et al. | Determination of tilmicosin residues in chicken, cattle, swine, and sheep tissues by liquid chromatography. | 2000 Jul-Aug | J AOAC Int | pmid:10995110 |
Bate N et al. | The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin. | 2000 | Microbiology (Reading, Engl.) | pmid:10658660 |
Ayling RD et al. | Comparison of in vitro activity of danofloxacin, florfenicol, oxytetracycline, spectinomycin and tilmicosin against Mycoplasma mycoides subspecies mycoides small colony type. | 2000 | Vet. Rec. | pmid:10737293 |
Fouces R et al. | Conjugation and transformation of Streptomyces species by tylosin resistance. | 2000 | FEMS Microbiol. Lett. | pmid:10802191 |
Frank GH et al. | Effects of tilmicosin treatment on Pasteurella haemolytica organisms in nasal secretion specimens of calves with respiratory tract disease. | 2000 | Am. J. Vet. Res. | pmid:10803647 |
Croft A et al. | The effect of tilmicosin administered to ewes prior to lambing on incidence of clinical mastitis and subsequent lamb performance. | 2000 | Can. Vet. J. | pmid:10769768 |
Pai MP et al. | Macrolide drug interactions: an update. | 2000 | Ann Pharmacother | pmid:10772438 |
Köhler B et al. | Antibacterials that are used as growth promoters in animal husbandry can affect the release of Shiga-toxin-2-converting bacteriophages and Shiga toxin 2 from Escherichia coli strains. | 2000 | Microbiology (Reading, Engl.) | pmid:10832635 |
Gaisser S et al. | A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea. | 2000 | Mol. Microbiol. | pmid:10792725 |
DeRosa DC et al. | In vitro susceptibility of porcine respiratory pathogens to tilmicosin. | 2000 | J. Vet. Diagn. Invest. | pmid:11108454 |
Fajt VR et al. | Effects of danofloxacin and tilmicosin on circulating neutrophils in beef heifers. | 2000 | J. Vet. Pharmacol. Ther. | pmid:11110107 |
Poulsen SM et al. | Inhibition of the ribosomal peptidyl transferase reaction by the mycarose moiety of the antibiotics carbomycin, spiramycin and tylosin. | 2000 | J. Mol. Biol. | pmid:11090288 |
Goubau S et al. | Tilmicosin does not inhibit interleukin-8 gene expression in the bovine lung experimentally infected with Mannheimia (Pasteurella) haemolytica. | 2000 | Can. J. Vet. Res. | pmid:11041503 |
Doak GA | Failure of antibiotics gentamicin, tylosin, lincomycin and spectinomycin (GTLS) to eliminate Mycoplasma bovis in artificially infected frozen bovine semen. | 2000 | Theriogenology | pmid:10990358 |
Kim S | Failure of antibiotics gentamicin, tylosin, lincomycin and spectinomycin to eliminate Mycoplasma bovis in artificially infected frozen bovine semen. | 2000 | Theriogenology | pmid:10990359 |
Rosenbusch RF | Failure of antibiotics gentamicin, tylosin, lincomycin and spectinomycin (GTLS) to eliminate Mycoplasma bovis in artificially infected frozen bovine semen. | 2000 | Theriogenology | pmid:10990360 |
Thomas CB | Failure of antibiotics gentamicin, tylosin, lincomycin and spectinomycin (GTLS) to eliminate Mycoplasma bovis in artificially infected frozen bovine semen. | 2000 | Theriogenology | pmid:10990361 |
Chin AC et al. | Tilmicosin induces apoptosis in bovine peripheral neutrophils in the presence or in the absence of Pasteurella haemolytica and promotes neutrophil phagocytosis by macrophages. | 2000 | Antimicrob. Agents Chemother. | pmid:10952596 |
Dinos GP and Kalpaxis DL | Kinetic studies on the interaction between a ribosomal complex active in peptide bond formation and the macrolide antibiotics tylosin and erythromycin. | 2000 | Biochemistry | pmid:10995229 |
Ayling RD et al. | Comparison of in vitro activity of danofloxacin, florfenicol, oxytetracycline, spectinomycin and tilmicosin against recent field isolates of Mycoplasma bovis. | 2000 | Vet. Rec. | pmid:10909906 |
Rabølle M and Spliid NH | Sorption and mobility of metronidazole, olaquindox, oxytetracycline and tylosin in soil. | 2000 | Chemosphere | pmid:10705549 |
Baguer AJ et al. | Effects of the antibiotics oxytetracycline and tylosin on soil fauna. | 2000 | Chemosphere | pmid:10705553 |
Loke ML et al. | Stability of Tylosin A in manure containing test systems determined by high performance liquid chromatography. | 2000 | Chemosphere | pmid:10705554 |
Vissiennon T et al. | Effect of avilamycin, tylosin and ionophore anticoccidials on Clostridium perfringens enterotoxaemia in chickens. | 2000 | Berl. Munch. Tierarztl. Wochenschr. | pmid:10684178 |
Duff GC et al. | Effects of preshipping vs. arrival medication with tilmicosin phosphate and feeding chlortetracycline on health and performance of newly received beef cattle. | 2000 | J. Anim. Sci. | pmid:10709916 |
Fodor L et al. | Efficacy evaluations of the use of oral tilmicosin in pneumonic calves. | 2000 | Vet. J. | pmid:10712808 |
Mackie DP et al. | Mixed mycoplasma mastitis outbreak in a dairy herd. | 2000 | Vet. Rec. | pmid:11058024 |
Halling-Sørensen B | Algal toxicity of antibacterial agents used in intensive farming. | 2000 | Chemosphere | pmid:10705551 |
Frank GH and Duff GC | Effects of tilmicosin phosphate, administered prior to transport or at time of arrival, and feeding of chlortetracycline, after arrival in a feedlot, on Mannheimia haemolytica in nasal secretions of transported steers. | 2000 | Am. J. Vet. Res. | pmid:11131584 |
Juhel-Gaugain M et al. | Multiresidue chromatographic method for the determination of macrolide residues in muscle by high-performance liquid chromatography with UV detection. | 1999 Sep-Oct | J AOAC Int | pmid:10513006 |
Dudriková E et al. | Liquid chromatographic determination of tylosin in mastitic cow's milk following therapy. | 1999 Nov-Dec | J AOAC Int | pmid:10589481 |
Jordan FT et al. | The comparison of an aqueous preparation of tilmicosin with tylosin in the treatment of Mycoplasma gallisepticum infection of turkey poults. | 1999 Jul-Sep | Avian Dis. | pmid:10494422 |
Davies R and Roberts TA | Antimicrobial susceptibility of enterococci recovered from commercial swine carcasses: effect of feed additives. | 1999 | Lett. Appl. Microbiol. | pmid:10664974 |
Short CR | Comparative pharmacokinetics--sorting the sheep from the goats. | 1999 | Vet. J. | pmid:10558834 |
Mandić Z et al. | Tylosin derivatives. V. Electrochemical opening of oxirane ring. | 1999 | J. Antibiot. | pmid:10695679 |
Naranda A and Lopotar N | New derivatives of tylosin. IV. Dihydro and tetrahydro desmycosin oximes. | 1999 | J. Antibiot. | pmid:10092201 |
Owens WE et al. | Efficacy of parenterally or intramammarily administered tilmicosin or ceftiofur against Staphylococcus aureus mastitis during lactation. | 1999 | J. Dairy Sci. | pmid:10194686 |
Karlsson M et al. | Genetic basis of macrolide and lincosamide resistance in Brachyspira (Serpulina) hyodysenteriae. | 1999 | FEMS Microbiol. Lett. | pmid:10188254 |
Jim GK et al. | A comparison of florfenicol and tilmicosin for the treatment of undifferentiated fever in feedlot calves in western Canada. | 1999 | Can. Vet. J. | pmid:10086218 |
Crown LA and Smith RB | Accidental veterinary antibiotic injection into a farm worker. | 1999 | Tenn Med | pmid:10474305 |
Atef M et al. | Elimination of tilmicosin in lactating ewes. | 1999 | DTW. Dtsch. Tierarztl. Wochenschr. | pmid:10481373 |
Tobback K et al. | Micellar electrokinetic capillary chromatography of macrolide antibiotics. Separation of tylosin, erythromycin and their related substances. | 1999 | J Chromatogr A | pmid:10536850 |