Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ueda Y et al. | Effect of terdecamycin on experimentally induced Mycoplasma hyopneumoniae-infection in pigs. | 1994 | Zentralblatt Veterinarmedizin Reihe B | pmid:7839749 |
Tsinas AC et al. | Control of proliferative enteropathy in growing/fattening pigs using growth promoters. | 1998 | Zentralblatt Veterinarmedizin Reihe B | pmid:9557133 |
Wallgren P et al. | Experimental infections with Actinobacillus pleuropneumoniae in pigs--II. Comparison of antibiotics for oral strategic treatment. | 1999 | Zentralblatt Veterinarmedizin Reihe B | pmid:10379236 |
Baba T et al. | Effect of tylosin tartrate on humoral immune responses in chickens. | 1998 | Zentralblatt Veterinarmedizin Reihe B | pmid:9673579 |
Kreisner M and Kietzmann M | [Pharmacokinetics of chloramphenicol, tylosin and prednisolone in combined preparations. 1. Thin-layer chromatographic determination of chloramphenicol, tylosin and prednisolone in serum]. | 1983 | Zentralbl Veterinarmed A | pmid:6407241 |
Kietzmann M and Kreisner M | [Pharmacokinetics of chloramphenicol and tylosin in combined preparations. 2. Pharmacokinetic interaction between chloramphenicol and tylosin in calves and rats]. | 1983 | Zentralbl Veterinarmed A | pmid:6407242 |
Shimada T et al. | Modelling the effect of the antimicrobial tylosin on the performance of an anaerobic sequencing batch reactor. | 2008 | Water Sci. Technol. | pmid:18547919 |
GarcÃa-Sánchez L et al. | Tylosin effect on methanogenesis in an anaerobic biomass from swine wastewater treatment. | 2016 | Water Sci. Technol. | pmid:26819401 |
Pan R et al. | Extraction of trace tilmicosin in real water samples using ionic liquid-based aqueous two-phase systems. | 2013 | Water Sci. Technol. | pmid:23579819 |
GarcÃa-Sánchez L et al. | Occurrence of tylosin in swine wastewater in Mexico. | 2013 | Water Sci. Technol. | pmid:23985521 |
Alatrache A et al. | Tylosin abatement in water by photocatalytic process. | 2010 | Water Sci. Technol. | pmid:20651450 |
Chelliapan S et al. | Tolerance of the antibiotic tylosin on treatment performance of an up-flow anaerobic stage reactor (UASR). | 2011 | Water Sci. Technol. | pmid:21866757 |
Rooklidge SJ et al. | Modeling antimicrobial contaminant removal in slow sand filtration. | 2005 Jan-Feb | Water Res. | pmid:15644241 |
Chelliapan S et al. | Performance of an up-flow anaerobic stage reactor (UASR) in the treatment of pharmaceutical wastewater containing macrolide antibiotics. | 2006 | Water Res. | pmid:16387347 |
Hagenbuch IM and Pinckney JL | Toxic effect of the combined antibiotics ciprofloxacin, lincomycin, and tylosin on two species of marine diatoms. | 2012 | Water Res. | pmid:22819871 |
Stone JJ et al. | Effect of antimicrobial compounds tylosin and chlortetracycline during batch anaerobic swine manure digestion. | 2009 | Water Res. | pmid:19695662 |
Peltier E et al. | Zinc-induced antibiotic resistance in activated sludge bioreactors. | 2010 | Water Res. | pmid:20537675 |
Angenent LT et al. | Effect of the presence of the antimicrobial tylosin in swine waste on anaerobic treatment. | 2008 | Water Res. | pmid:18258277 |
Kolz AC et al. | Degradation and metabolite production of tylosin in anaerobic and aerobic swine-manure lagoons. | 2005 Jan-Feb | Water Environ. Res. | pmid:15765935 |
Kim KR et al. | Decline in extractable antibiotics in manure-based composts during composting. | 2012 | Waste Manag | pmid:21865024 |
Lakritz J et al. | Tilmicosin reduces lipopolysaccharide-stimulated bovine alveolar macrophage prostaglandin E(2) production via a mechanism involving phospholipases. | 2002 | Vet. Ther. | pmid:12050824 |
Hibbard B et al. | Dose determination and confirmation for ceftiofur crystalline-free acid administered in the posterior aspect of the ear for control and treatment of bovine respiratory disease. | 2002 | Vet. Ther. | pmid:12050825 |
Godinho KS et al. | Efficacy of tulathromycin in the treatment and prevention of natural outbreaks of bovine respiratory disease in European cattle. | 2005 | Vet. Ther. | pmid:16094560 |
Kilgore WR et al. | Clinical effectiveness of tulathromycin, a novel triamilide antimicrobial, for the control of respiratory disease in cattle at high risk for developing bovine respiratory disease. | 2005 | Vet. Ther. | pmid:16094561 |
Kilgore WR et al. | Therapeutic efficacy of tulathromycin, a novel triamilide antimicrobial, against bovine respiratory disease in feeder calves. | 2005 | Vet. Ther. | pmid:16094562 |
Rooney KA et al. | Efficacy of tulathromycin compared with tilmicosin and florfenicol for the control of respiratory disease in cattle at high risk of developing bovine respiratory disease. | 2005 | Vet. Ther. | pmid:16094563 |
Nutsch RG et al. | Comparative efficacy of tulathromycin, tilmicosin, and florfenicol in the treatment of bovine respiratory disease in stocker cattle. | 2005 | Vet. Ther. | pmid:16094564 |
Skogerboe TL et al. | Comparative efficacy of tulathromycin versus florfenicol and tilmicosin against undifferentiated bovine respiratory disease in feedlot cattle. | 2005 | Vet. Ther. | pmid:16094565 |
Booker CW et al. | An evaluation of the metaphylactic effect of ceftiofur crystalline free Acid in feedlot calves. | 2006 | Vet. Ther. | pmid:17039449 |
Nickell JS et al. | Comparison of short-term health and performance effects related to prophylactic administration of tulathromycin versus tilmicosin in long-hauled, highly stressed beef stocker calves. | 2008 | Vet. Ther. | pmid:18597253 |
Scott BA et al. | Efficacy of tylosin tartrate on canine Staphylococcus intermedius isolates in vitro. | 2010 | Vet. Ther. | pmid:20960412 |
Van Donkersgoed J et al. | Comparative efficacy of tilmicosin versus tulathromycin as a metaphylactic antimicrobial in feedlot calves at moderate risk for respiratory disease. | 2008 | Vet. Ther. | pmid:19177334 |
Zielinski GC et al. | Efficacy of different dosage levels and administration routes of tilmicosin in a natural outbreak of infectious bovine keratoconjunctivitis (pinkeye). | 2002 | Vet. Ther. | pmid:19750751 |
Marsteller T et al. | Efficacy of intramuscular tylosin for the treatment and control of porcine proliferative enteropathy caused by Lawsonia intracellularis. | 2001 | Vet. Ther. | pmid:19753698 |
Thacker EL et al. | Evaluation of the ability of tilmicosin to prevent adherence of Mycoplasma hyopneumoniae to cilia using a differentiated swine respiratory epithelial culture system. | 2001 | Vet. Ther. | pmid:19746651 |
Booker CW et al. | Evaluation of the efficacy of tulathromycin as a metaphylactic antimicrobial in feedlot calves. | 2007 | Vet. Ther. | pmid:17926304 |
Abu-Basha EA et al. | Pharmacokinetics of tilmicosin (Provitil powder and Pulmotil liquid AC) oral formulations in chickens. | 2007 | Vet. Res. Commun. | pmid:17225089 |
Gallina G et al. | Acute toxicity evaluation of four antibacterials with Daphnia magna. | 2008 | Vet. Res. Commun. | pmid:18688742 |
Gallina G et al. | Kinetics and intrapulmonary disposition of tilmicosin after single and repeated oral bolus administrations to rabbits. | 2010 | Vet. Res. Commun. | pmid:20480234 |
Saurit AR et al. | Some comparative aspects of the pharmacokinetics of tylosin in buffaloes and cattle. | 2002 | Vet. Res. Commun. | pmid:11860087 |
Lee WD et al. | Tilmicosin-induced bovine neutrophil apoptosis is cell-specific and downregulates spontaneous LTB4 synthesis without increasing Fas expression. | 2004 Mar-Apr | Vet. Res. | pmid:15099497 |
Gerchman I et al. | Characterization of in vivo-acquired resistance to macrolides of Mycoplasma gallisepticum strains isolated from poultry. | 2011 | Vet. Res. | pmid:21810258 |
Angell JW et al. | Whole-flock, metaphylactic tilmicosin failed to eliminate contagious ovine digital dermatitis and footrot in sheep: a cluster randomised trial. | 2016 | Vet. Rec. | pmid:27450091 |
Scott PR | Field study of undifferentiated respiratory disease in housed beef calves. | 1994 | Vet. Rec. | pmid:8203107 |
Henderson JP and Ball HJ | Polyarthritis due to Mycoplasma bovis infection in adult dairy cattle in Northern Ireland. | 1999 | Vet. Rec. | pmid:10573196 |
Ayling RD et al. | Comparison of in vitro activity of danofloxacin, florfenicol, oxytetracycline, spectinomycin and tilmicosin against Mycoplasma mycoides subspecies mycoides small colony type. | 2000 | Vet. Rec. | pmid:10737293 |
Vicca J et al. | Efficacy of in-feed medication with tylosin for the treatment and control of Mycoplasma hyopneumoniae infections. | 2005 | Vet. Rec. | pmid:15879541 |
Industry guidance on the administration of tilmicosin. | 2006 | Vet. Rec. | pmid:16924727 | |
Ayling RD et al. | Comparison of in vitro activity of danofloxacin, florfenicol, oxytetracycline, spectinomycin and tilmicosin against recent field isolates of Mycoplasma bovis. | 2000 | Vet. Rec. | pmid:10909906 |
Couper A et al. | Treatment of pneumonia in pigs with long-acting injectable tylosin. | 2006 | Vet. Rec. | pmid:17158711 |
Mackie DP et al. | Mixed mycoplasma mastitis outbreak in a dairy herd. | 2000 | Vet. Rec. | pmid:11058024 |
Lawrence K | Change to user warning for Micotil. | 2004 | Vet. Rec. | pmid:15200081 |
Mackinnon JD et al. | Effect of tylosin on milk yield and dry matter intake of lactating dairy cows. | 1984 | Vet. Rec. | pmid:6495581 |
Giadinis ND et al. | Mortality in adult goats attributed to Mycoplasma capricolum subspecies capricolum. | 2008 | Vet. Rec. | pmid:18757908 |
Usui M et al. | Selection of macrolide-resistant Campylobacter in pigs treated with macrolides. | 2014 | Vet. Rec. | pmid:25163817 |
TavÃo MM et al. | In vitro activity of tylvalosin against Spanish field strains of Mycoplasma hyopneumoniae. | 2014 | Vet. Rec. | pmid:25185108 |
Harvey RG | Tylosin in the treatment of canine superficial pyoderma. | 1996 | Vet. Rec. | pmid:8873399 |
Del Pozo Sacristán R et al. | Efficacy of in-feed medication with chlortetracycline in a farrow-to-finish herd against a clinical outbreak of respiratory disease in fattening pigs. | 2012 Dec 22-29 | Vet. Rec. | pmid:23136309 |
Guedes RM et al. | Use of tylvalosin-medicated feed to control porcine proliferative enteropathy. | 2009 | Vet. Rec. | pmid:19767637 |
Fitzgerald J | Administration of micotil. | 2009 | Vet. Rec. | pmid:19767643 |
Warner K et al. | Control of Ornithobacterium rhinotracheale in poultry. | 2009 | Vet. Rec. | pmid:19946131 |
Molnár L | Sensitivity of strains of Serpulina hyodysenteriae isolated in Hungary to chemotherapeutic drugs. | 1996 | Vet. Rec. | pmid:8677605 |
Schumann FJ et al. | Prophylactic medication of feedlot calves with tilmicosin. | 1991 | Vet. Rec. | pmid:2038809 |
Laven R and Andrews AH | Long-acting antibiotic formulations in the treatment of calf pneumonia: a comparative study of tilmicosin and oxytetracycline. | 1991 | Vet. Rec. | pmid:1926728 |
Blaha T et al. | Swine dysentery control in the German Democratic Republic and the suitability of injections of tiamulin for the programme. | 1987 | Vet. Rec. | pmid:3424604 |
Rowan TG et al. | Efficacy of danofloxacin in the treatment of respiratory disease in European cattle. | 2004 | Vet. Rec. | pmid:15160844 |
Picavet T et al. | Efficacy of tilmicosin in treatment of pulmonary infections in calves. | 1991 | Vet. Rec. | pmid:1837391 |
Mee JF and O'Farrell K | Tilmicosin and calf pneumonia. | 1991 | Vet. Rec. | pmid:1858280 |
Ball HJ and Campbell JN | Antibiotic treatment of experimental Mycoplasma californicum mastitis. | 1989 | Vet. Rec. | pmid:2815518 |
Beechinor JG and Bloomfield FJ | Variability in residue concentrations of tilmicosin in cattle muscle. | 2001 | Vet. Rec. | pmid:11530904 |
Naccari F et al. | Effectiveness and kinetic behaviour of tilmicosin in the treatment of respiratory infections in sheep. | 2001 | Vet. Rec. | pmid:11465263 |
Ball HJ and McCaughey WJ | Experimental intramuscular inoculation of tylosin in the elimination of ureaplasmas from ewes. | 1987 | Vet. Rec. | pmid:3617407 |
Ose EE and Tonkinson LV | Single-dose treatment of neonatal calf pneumonia with the new macrolide antibiotic tilmicosin. | 1988 | Vet. Rec. | pmid:3195026 |
Lawrence K | Micotil: safe use and administration. | 2007 | Vet. Rec. | pmid:18037699 |
Paraud C et al. | Evaluation of oral tilmicosin efficacy against severe cryptosporidiosis in neonatal kids under field conditions. | 2010 | Vet. Parasitol. | pmid:20149542 |
Marks SL and Kather EJ | Antimicrobial susceptibilities of canine Clostridium difficile and Clostridium perfringens isolates to commonly utilized antimicrobial drugs. | 2003 | Vet. Microbiol. | pmid:12742714 |
Tanner AC et al. | Adaptation of the Sensititre broth microdilution technique to antimicrobial susceptibility testing of Mycoplasma hyopneumoniae. | 1993 | Vet. Microbiol. | pmid:8273275 |
Alippi AM et al. | In vitro and in vivo susceptibility of the honeybee bacterial pathogen Paenibacillus larvae subsp. larvae to the antibiotic tylosin. | 2005 | Vet. Microbiol. | pmid:15951140 |
Stipkovits L et al. | A comparison of the effect of tiamulin hydrogen fumarate and tylosin tartrate on mycoplasmas of ruminants and some animal ureaplasmas. | 1984 | Vet. Microbiol. | pmid:6730305 |
Reynaldi FJ et al. | Effectiveness of tilmicosin against Paenibacillus larvae, the causal agent of American Foulbrood disease of honeybees. | 2008 | Vet. Microbiol. | pmid:18539412 |
Marosevic D et al. | In vivo spread of macrolide-lincosamide-streptogramin B (MLSB) resistance--a model study in chickens. | 2014 | Vet. Microbiol. | pmid:24467930 |
Juntunen P et al. | Antimicrobial resistance in Campylobacter coli selected by tylosin treatment at a pig farm. | 2010 | Vet. Microbiol. | pmid:20684867 |
Woolums AR et al. | Multidrug resistant Mannheimia haemolytica isolated from high-risk beef stocker cattle after antimicrobial metaphylaxis and treatment for bovine respiratory disease. | 2018 | Vet. Microbiol. | pmid:29981701 |
Juntunen P et al. | Longitudinal on-farm study of the development of antimicrobial resistance in Campylobacter coli from pigs before and after danofloxacin and tylosin treatments. | 2011 | Vet. Microbiol. | pmid:21397412 |
Blondeau JM et al. | Comparative minimum inhibitory and mutant prevention drug concentrations of enrofloxacin, ceftiofur, florfenicol, tilmicosin and tulathromycin against bovine clinical isolates of Mannheimia haemolytica. | 2012 | Vet. Microbiol. | pmid:22677482 |
Prats-van der Ham M et al. | Molecular resistance mechanisms of Mycoplasma agalactiae to macrolides and lincomycin. | 2017 | Vet. Microbiol. | pmid:29102109 |
Entorf M et al. | Tylosin susceptibility of Staphylococci from bovine mastitis. | 2014 | Vet. Microbiol. | pmid:24461550 |
Ozaki H et al. | Antimicrobial resistance in fecal Escherichia coli isolated from growing chickens on commercial broiler farms. | 2011 | Vet. Microbiol. | pmid:21232883 |
Svartström O et al. | Characterization of Treponema spp. isolates from pigs with ear necrosis and shoulder ulcers. | 2013 | Vet. Microbiol. | pmid:23948134 |
Lerner U et al. | Acquired resistance to the 16-membered macrolides tylosin and tilmicosin by Mycoplasma bovis. | 2014 | Vet. Microbiol. | pmid:24393633 |
Gautier-Bouchardon AV et al. | In vitro development of resistance to enrofloxacin, erythromycin, tylosin, tiamulin and oxytetracycline in Mycoplasma gallisepticum, Mycoplasma iowae and Mycoplasma synoviae. | 2002 | Vet. Microbiol. | pmid:12119137 |
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Aarestrup FM and Friis NF | Antimicrobial susceptibility testing of Mycoplasma hyosynoviae isolated from pigs during 1968 to 1971 and during 1995 and 1996. | 1998 | Vet. Microbiol. | pmid:9646463 |
Cornick NA | Tylosin and chlorotetracycline decrease the duration of fecal shedding of E. coli O157:H7 by swine. | 2010 | Vet. Microbiol. | pmid:20018464 |
Aarestrup FM and Jensen NE | Susceptibility testing of Actinobacillus pleuropneumoniae in Denmark. Evaluation of three different media of MIC-determinations and tablet diffusion tests. | 1999 | Vet. Microbiol. | pmid:10063535 |
Shryock TR et al. | Antimicrobial susceptibility of Moraxella bovis. | 1998 | Vet. Microbiol. | pmid:9646479 |
Stipkovits L et al. | In vitro testing of the anti-mycoplasma effect of some anti-coccidial drugs. | 1987 | Vet. Microbiol. | pmid:3439016 |
Entorf M et al. | Comparative erythromycin and tylosin susceptibility testing of streptococci from bovine mastitis. | 2016 | Vet. Microbiol. | pmid:26732695 |
Short CR | Comparative pharmacokinetics--sorting the sheep from the goats. | 1999 | Vet. J. | pmid:10558834 |
Fodor L et al. | Efficacy evaluations of the use of oral tilmicosin in pneumonic calves. | 2000 | Vet. J. | pmid:10712808 |