Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.
To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tylosin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Aarestrup FM and Carstensen B | Effect of tylosin used as a growth promoter on the occurrence of macrolide-resistant enterococci and staphylococci in pigs. | 1998 | Microb. Drug Resist. | pmid:9988049 |
Modric S et al. | Pharmacokinetics and pharmacodynamics of tilmicosin in sheep and cattle. | 1998 | J. Vet. Pharmacol. Ther. | pmid:9885967 |
Jordan FT et al. | In vitro and in vivo comparisons of valnemulin, tiamulin, tylosin, enrofloxacin, and lincomycin/spectinomycin against Mycoplasma gallisepticum. | 1998 Oct-Dec | Avian Dis. | pmid:9876842 |
Koenen-Dierick K and De Beer JO | Optimization of an antibiotic residue screening test, based on inhibition of Bacillus subtilis BGA, with experimental design. | 1998 | Food Addit Contam | pmid:9829036 |
Oh TG et al. | Induction of ermAMR from a clinical strain of Enterococcus faecalis by 16-membered-ring macrolide antibiotics. | 1998 | J. Bacteriol. | pmid:9791136 |
Scorneaux B and Shryock TR | Intracellular accumulation, subcellular distribution, and efflux of tilmicosin in chicken phagocytes. | 1998 | Poult. Sci. | pmid:9776059 |
Berque I et al. | [Stereoselective synthesis of biologically active macrolides. Total synthesis of tylosine]. | 1998 | Ann Pharm Fr | pmid:9770007 |
De Liguoro M et al. | Determination of tylosin residues in pig tissues using high-performance liquid chromatography. | 1998 | Analyst | pmid:9764508 |
Baba T et al. | Effect of tylosin tartrate (Tylan Soluble) on cellular immune responses in chickens. | 1998 | Poult. Sci. | pmid:9733118 |
Grdisa M et al. | Effect of a 17-member azalide on tumor cell growth. | 1998 Sep-Oct | Chemotherapy | pmid:9732149 |
Scorneaux B and Shryock TR | Intracellular accumulation, subcellular distribution and efflux of tilmicosin in swine phagocytes. | 1998 | J. Vet. Pharmacol. Ther. | pmid:9731947 |
Gotoh Y et al. | Chemical transformation of tylosin derivatives into neutral macrolides having a 3'-methoxyl group. | 1998 | Carbohydr. Res. | pmid:9720235 |
Beharka AA and Nagaraja TG | Effect of Aspergillus oryzae extract alone or in combination with antimicrobial compounds on ruminal bacteria. | 1998 | J. Dairy Sci. | pmid:9684165 |
Baba T et al. | Effect of tylosin tartrate on humoral immune responses in chickens. | 1998 | Zentralblatt Veterinarmedizin Reihe B | pmid:9673579 |
Wilson VT and Cundliffe E | Characterization and targeted disruption of a glycosyltransferase gene in the tylosin producer, Streptomyces fradiae. | 1998 | Gene | pmid:9651492 |
Choi DB et al. | Effects of rapessed oil on activity of methylmalonyl-CoA carboxyltransferase in culture of Streptomyces fradiae. | 1998 | Biosci. Biotechnol. Biochem. | pmid:9648221 |
Shryock TR et al. | Antimicrobial susceptibility of Moraxella bovis. | 1998 | Vet. Microbiol. | pmid:9646479 |
Aarestrup FM and Friis NF | Antimicrobial susceptibility testing of Mycoplasma hyosynoviae isolated from pigs during 1968 to 1971 and during 1995 and 1996. | 1998 | Vet. Microbiol. | pmid:9646463 |
Vogel GJ et al. | Effects of tilmicosin on acute undifferentiated respiratory tract disease in newly arrived feedlot cattle. | 1998 | J. Am. Vet. Med. Assoc. | pmid:9638194 |
Esipov SE | [Novel mathematical approach to determination of antibiotics concentration by agar diffusion method. Analysis of graphical, table and mathematical options of relative biological activity estimation]. | 1998 | Antibiot. Khimioter. | pmid:9606490 |
Tsinas AC et al. | Control of proliferative enteropathy in growing/fattening pigs using growth promoters. | 1998 | Zentralblatt Veterinarmedizin Reihe B | pmid:9557133 |
Norcia LJ et al. | In vitro microbiological characterization of novel macrolide CP-163,505 for animal health specific use. | 1998 | J. Antibiot. | pmid:9544934 |
Hoar BR et al. | A comparison of the clinical field efficacy and safety of florfenicol and tilmicosin for the treatment of undifferentiated bovine respiratory disease of cattle in western Canada. | 1998 | Can. Vet. J. | pmid:9524721 |
Nagaraja TG and Chengappa MM | Liver abscesses in feedlot cattle: a review. | 1998 | J. Anim. Sci. | pmid:9464910 |
Kempf I et al. | Efficacy of tilmicosin in the control of experimental Mycoplasma gallisepticum infection in chickens. | 1997 Oct-Dec | Avian Dis. | pmid:9454912 |
Yeh WK | Evolving enzyme technology for pharmaceutical applications: case studies. | 1997 Nov-Dec | J. Ind. Microbiol. Biotechnol. | pmid:9451830 |
Fish SA and Cundliffe E | Stimulation of polyketide metabolism in Streptomyces fradiae by tylosin and its glycosylated precursors. | 1997 | Microbiology (Reading, Engl.) | pmid:9421911 |
Moran JW et al. | Determination of tilmicosin in bovine and porcine sera by liquid chromatography. | 1997 Nov-Dec | J AOAC Int | pmid:9419857 |
Readnour RS et al. | Determination of tilmicosin in swine feeds by liquid chromatography. | 1997 Nov-Dec | J AOAC Int | pmid:9419854 |
Readnour RS et al. | Liquid chromatographic determination of tilmicosin in swine feed at 200-400 mg/kg level: interlaboratory study. | 1997 Nov-Dec | J AOAC Int | pmid:9419853 |
Lee SH | Ammonium ion affecting tylosin production by Streptomyces fradiae NRRL 2702 in continuous culture. | 1997 | Lett. Appl. Microbiol. | pmid:9418071 |
Naranda A et al. | New dihydro and tetrahydro derivatives of desmycosin. III. The opening of oxirane ring of 12,13-epoxydesmycosin. | 1997 | J. Antibiot. | pmid:9402992 |
Residues of some veterinary drugs in animals and foods. Monographs prepared by the Forty-Seventh meeting of the Joint FAO/WHO Expert Committee on Food Additives. Rome, 4-13 June 1996. | 1997 | FAO Food Nutr Pap | pmid:9253593 | |
Morck DW et al. | Treatment of experimentally induced pneumonic pasteurellosis of young calves with tilmicosin. | 1997 | Can. J. Vet. Res. | pmid:9242998 |
Mironov VA et al. | [Effect of Ca2+ ions on biosynthesis and component composition of tylosin in Streptomyces fradiae]. | 1997 | Antibiot. Khimioter. | pmid:9182505 |
Ramadan A | Pharmacokinetics of tilmicosin in serum and milk of goats. | 1997 Jan-Feb | Res. Vet. Sci. | pmid:9160424 |
Memili E and Weisblum B | Essential role of endogenously synthesized tylosin for induction of ermSF in Streptomyces fradiae. | 1997 | Antimicrob. Agents Chemother. | pmid:9145902 |
McFarland JW et al. | Quantitative structure-activity relationships among macrolide antibacterial agents: in vitro and in vivo potency against Pasteurella multocida. | 1997 | J. Med. Chem. | pmid:9135031 |
McFarland JW et al. | Repromicin derivatives with potent antibacterial activity against Pasteurella multocida. | 1997 | J. Med. Chem. | pmid:9083494 |
Baltz RH et al. | Applications of transposition mutagenesis in antibiotic producing streptomycetes. | 1997 | Antonie Van Leeuwenhoek | pmid:9049029 |
Gandecha AR et al. | Analysis of four tylosin biosynthetic genes from the tylLM region of the Streptomyces fradiae genome. | 1997 | Gene | pmid:9031628 |
McOrist S et al. | Oral administration of tylosin phosphate for treatment and prevention of proliferative enteropathy in pigs. | 1997 | Am. J. Vet. Res. | pmid:9028475 |
Kuhstoss S et al. | Production of a novel polyketide through the construction of a hybrid polyketide synthase. | 1996 | Gene | pmid:8996112 |
Gandecha AR and Cundliffe E | Molecular analysis of tlrD, an MLS resistance determinant from the tylosin producer, Streptomyces fradiae. | 1996 | Gene | pmid:8973363 |
Fish SA and Cundliffe E | Structure-activity studies of tylosin-related macrolides. | 1996 | J. Antibiot. | pmid:8968399 |
Kobayashi H et al. | In vitro susceptibility of Mycoplasma hyosynoviae and M. hyorhinis to antimicrobial agents. | 1996 | J. Vet. Med. Sci. | pmid:8959659 |
Markakis PK | Microbiological method for determining macrolides in animal feeds in the presence of other drugs by thin-layer chromatography detection. | 1996 Nov-Dec | J AOAC Int | pmid:8946704 |
Zuzulova M et al. | In vitro activity of tylosin and its derivatives against Ureaplasma urealyticum. | 1995 | Arzneimittelforschung | pmid:8929244 |
Delépine B et al. | Multiresidue method for confirmation of macrolide antibiotics in bovine muscle by liquid chromatography/mass spectrometry. | 1996 Mar-Apr | J AOAC Int | pmid:8920126 |
Houglum JE and Tasler MK | Liquid chromatographic assay of tylosin in animal feeds. | 1996 Mar-Apr | J AOAC Int | pmid:8920123 |